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Decreased glucose-6-phosphate dehydrogenase level in leukocytes

MedGen UID:
1636963
•Concept ID:
C4703676
•
Finding
Synonym: Decreased G6PD level in leukocytes
 
HPO: HP:0410190

Definition

A decrease in the level of glucose-6-phosphate dehydrogenase in leukocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDecreased glucose-6-phosphate dehydrogenase level in leukocytes

Recent clinical studies

Etiology

Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway.
Xu C, Ye Z, Jiang W, Wang S, Zhang H
Mol Med 2023 Dec 13;29(1):169. doi: 10.1186/s10020-023-00758-8. PMID: 38093197Free PMC Article
Glucose-6-Phosphate Dehydrogenase Deficiency Activates Endothelial Cell and Leukocyte Adhesion Mediated via the TGFβ/NADPH Oxidases/ROS Signaling Pathway.
Parsanathan R, Jain SK
Int J Mol Sci 2020 Oct 10;21(20) doi: 10.3390/ijms21207474. PMID: 33050491Free PMC Article
Increased incidence of sepsis and altered monocyte functions in severely injured type A- glucose-6-phosphate dehydrogenase-deficient African American trauma patients.
Spolarics Z, Siddiqi M, Siegel JH, Garcia ZC, Stein DS, Ong H, Livingston DH, Denny T, Deitch EA
Crit Care Med 2001 Apr;29(4):728-36. doi: 10.1097/00003246-200104000-00005. PMID: 11373456
Glutathione peroxidase and reductase, glucose-6-phosphate dehydrogenase and catalase activities in multiple sclerosis.
Jensen GE, Clausen J
J Neurol Sci 1984 Jan;63(1):45-53. doi: 10.1016/0022-510x(84)90107-2. PMID: 6699653
In vivo lability of glucose-6-phosphate dehydrogenase in GdA- and GdMediterranean deficiency.
Piomelli S, Corash LM, Davenport DD, Miraglia J, Amorosi EL
J Clin Invest 1968 Apr;47(4):940-8. doi: 10.1172/JCI105786. PMID: 5641629Free PMC Article

Diagnosis

A novel mutation of the ITGB2 gene in a Chinese Zhuang minority patient with leukocyte adhesion deficiency type 1 and glucose-6-phosphate dehydrogenase deficiency.
Zhang Y, Yang X, He X, Liu H, Guo P, Liu X, Xiao Y, Feng X, Wang Y, Li L
Gene 2019 Oct 5;715:144027. Epub 2019 Jul 30 doi: 10.1016/j.gene.2019.144027. PMID: 31374327
New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension.
Kurdyukov S, Eccles CA, Desai AA, Gonzalez-Garay M, Yuan JX, Garcia JGN, Rafikova O, Rafikov R
PLoS One 2018;13(8):e0203493. Epub 2018 Aug 30 doi: 10.1371/journal.pone.0203493. PMID: 30161219Free PMC Article
Oxidative markers in spontaneous intracerebral hemorrhage: leukocyte 8-hydroxy-2'-deoxyguanosine as an independent predictor of the 30-day outcome.
Chen YC, Chen CM, Liu JL, Chen ST, Cheng ML, Chiu DT
J Neurosurg 2011 Dec;115(6):1184-90. Epub 2011 Aug 26 doi: 10.3171/2011.7.JNS11718. PMID: 21962000
Leukocyte glucose 6 phosphate dehydrogenase as prognostic indicator in ANLL and CML.
Devi GS, Prasad MH, Reddy PP, Rao DN
Indian J Exp Biol 1997 Feb;35(2):155-8. PMID: 9315224
Control of glucose-6-phosphate dehydrogenase deficiency on the formation of mutagenic and carcinogenic metabolites derived from benzo(a)pyrene.
Pirisi L, Garcea R, Pascale R, Ruggiu ME, Feo F
Toxicol Pathol 1987;15(1):115-9. doi: 10.1177/019262338701500118. PMID: 3576073

Therapy

Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway.
Xu C, Ye Z, Jiang W, Wang S, Zhang H
Mol Med 2023 Dec 13;29(1):169. doi: 10.1186/s10020-023-00758-8. PMID: 38093197Free PMC Article
mTOR inhibition downregulates glucose-6-phosphate dehydrogenase and induces ROS-dependent death in T-cell acute lymphoblastic leukemia cells.
Silic-Benussi M, Sharova E, Ciccarese F, Cavallari I, Raimondi V, Urso L, Corradin A, Kotler H, Scattolin G, Buldini B, Francescato S, Basso G, Minuzzo SA, Indraccolo S, D'Agostino DM, Ciminale V
Redox Biol 2022 May;51:102268. Epub 2022 Feb 24 doi: 10.1016/j.redox.2022.102268. PMID: 35248829Free PMC Article
Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling.
Yen WC, Wu YH, Wu CC, Lin HR, Stern A, Chen SH, Shu JC, Tsun-Yee Chiu D
Redox Biol 2020 Jan;28:101363. Epub 2019 Nov 2 doi: 10.1016/j.redox.2019.101363. PMID: 31707353Free PMC Article
Glutathione, glutathione-related enzymes, and oxidative stress in individuals with subacute occupational exposure to lead.
Dobrakowski M, Pawlas N, Hudziec E, Kozłowska A, Mikołajczyk A, Birkner E, Kasperczyk S
Environ Toxicol Pharmacol 2016 Jul;45:235-40. Epub 2016 Jun 7 doi: 10.1016/j.etap.2016.06.008. PMID: 27331344
Marked decrease in specific activity contributes to disease phenotype in two human glucose 6-phosphate dehydrogenase mutants, G6PD(Union) and G6PD(Andalus).
Wang XT, Lam VM, Engel PC
Hum Mutat 2005 Sep;26(3):284. doi: 10.1002/humu.9367. PMID: 16088936

Prognosis

Oxidative markers in spontaneous intracerebral hemorrhage: leukocyte 8-hydroxy-2'-deoxyguanosine as an independent predictor of the 30-day outcome.
Chen YC, Chen CM, Liu JL, Chen ST, Cheng ML, Chiu DT
J Neurosurg 2011 Dec;115(6):1184-90. Epub 2011 Aug 26 doi: 10.3171/2011.7.JNS11718. PMID: 21962000
Deletion of leucine 61 in glucose-6-phosphate dehydrogenase leads to chronic nonspherocytic anemia, granulocyte dysfunction, and increased susceptibility to infections.
van Bruggen R, Bautista JM, Petropoulou T, de Boer M, van Zwieten R, Gómez-Gallego F, Belohradsky BH, Hartwig NG, Stevens D, Mason PJ, Roos D
Blood 2002 Aug 1;100(3):1026-30. doi: 10.1182/blood.v100.3.1026. PMID: 12130518
Increased incidence of sepsis and altered monocyte functions in severely injured type A- glucose-6-phosphate dehydrogenase-deficient African American trauma patients.
Spolarics Z, Siddiqi M, Siegel JH, Garcia ZC, Stein DS, Ong H, Livingston DH, Denny T, Deitch EA
Crit Care Med 2001 Apr;29(4):728-36. doi: 10.1097/00003246-200104000-00005. PMID: 11373456
Molecular basis and enzymatic properties of glucose 6-phosphate dehydrogenase volendam, leading to chronic nonspherocytic anemia, granulocyte dysfunction, and increased susceptibility to infections.
Roos D, van Zwieten R, Wijnen JT, Gómez-Gallego F, de Boer M, Stevens D, Pronk-Admiraal CJ, de Rijk T, van Noorden CJ, Weening RS, Vulliamy TJ, Ploem JE, Mason PJ, Bautista JM, Khan PM, Beutler E
Blood 1999 Nov 1;94(9):2955-62. PMID: 10556177
Leukocyte glucose 6 phosphate dehydrogenase as prognostic indicator in ANLL and CML.
Devi GS, Prasad MH, Reddy PP, Rao DN
Indian J Exp Biol 1997 Feb;35(2):155-8. PMID: 9315224

Clinical prediction guides

Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling.
Yen WC, Wu YH, Wu CC, Lin HR, Stern A, Chen SH, Shu JC, Tsun-Yee Chiu D
Redox Biol 2020 Jan;28:101363. Epub 2019 Nov 2 doi: 10.1016/j.redox.2019.101363. PMID: 31707353Free PMC Article
Deletion of leucine 61 in glucose-6-phosphate dehydrogenase leads to chronic nonspherocytic anemia, granulocyte dysfunction, and increased susceptibility to infections.
van Bruggen R, Bautista JM, Petropoulou T, de Boer M, van Zwieten R, Gómez-Gallego F, Belohradsky BH, Hartwig NG, Stevens D, Mason PJ, Roos D
Blood 2002 Aug 1;100(3):1026-30. doi: 10.1182/blood.v100.3.1026. PMID: 12130518
Increased incidence of sepsis and altered monocyte functions in severely injured type A- glucose-6-phosphate dehydrogenase-deficient African American trauma patients.
Spolarics Z, Siddiqi M, Siegel JH, Garcia ZC, Stein DS, Ong H, Livingston DH, Denny T, Deitch EA
Crit Care Med 2001 Apr;29(4):728-36. doi: 10.1097/00003246-200104000-00005. PMID: 11373456
Control of glucose-6-phosphate dehydrogenase deficiency on the formation of mutagenic and carcinogenic metabolites derived from benzo(a)pyrene.
Pirisi L, Garcea R, Pascale R, Ruggiu ME, Feo F
Toxicol Pathol 1987;15(1):115-9. doi: 10.1177/019262338701500118. PMID: 3576073
Effect of chronologic age on induction of cystathionine synthase, uroporphyrinogen I synthase, and glucose-6-phosphate dehydrogenase activities in lymphocytes.
Gartler SM, Hornung SK, Motulsky AG
Proc Natl Acad Sci U S A 1981 Mar;78(3):1916-9. doi: 10.1073/pnas.78.3.1916. PMID: 6940198Free PMC Article

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