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Sarcopenia

MedGen UID:
163711
Concept ID:
C0872084
Disease or Syndrome
Synonym: Sarcopenias
SNOMED CT: Sarcopenia (772791006); Loss of skeletal muscle mass (772791006)

Definition

A condition characterised by loss of skeletal muscle mass, primarily in the elderly but can be associated with other conditions that are not exclusively seen in older people. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSarcopenia

Professional guidelines

PubMed

Cho MR, Lee S, Song SK
J Korean Med Sci 2022 May 9;37(18):e146. doi: 10.3346/jkms.2022.37.e146. PMID: 35535373Free PMC Article
Chen LK, Woo J, Assantachai P, Auyeung TW, Chou MY, Iijima K, Jang HC, Kang L, Kim M, Kim S, Kojima T, Kuzuya M, Lee JSW, Lee SY, Lee WJ, Lee Y, Liang CK, Lim JY, Lim WS, Peng LN, Sugimoto K, Tanaka T, Won CW, Yamada M, Zhang T, Akishita M, Arai H
J Am Med Dir Assoc 2020 Mar;21(3):300-307.e2. Epub 2020 Feb 4 doi: 10.1016/j.jamda.2019.12.012. PMID: 32033882
Cederholm T, Jensen GL, Correia MITD, Gonzalez MC, Fukushima R, Higashiguchi T, Baptista G, Barazzoni R, Blaauw R, Coats A, Crivelli A, Evans DC, Gramlich L, Fuchs-Tarlovsky V, Keller H, Llido L, Malone A, Mogensen KM, Morley JE, Muscaritoli M, Nyulasi I, Pirlich M, Pisprasert V, de van der Schueren MAE, Siltharm S, Singer P, Tappenden K, Velasco N, Waitzberg D, Yamwong P, Yu J, Van Gossum A, Compher C; GLIM Core Leadership Committee; GLIM Working Group
Clin Nutr 2019 Feb;38(1):1-9. Epub 2018 Sep 3 doi: 10.1016/j.clnu.2018.08.002. PMID: 30181091

Recent clinical studies

Etiology

Yuan S, Larsson SC
Metabolism 2023 Jul;144:155533. Epub 2023 Mar 11 doi: 10.1016/j.metabol.2023.155533. PMID: 36907247
Sayer AA, Cruz-Jentoft A
Age Ageing 2022 Oct 6;51(10) doi: 10.1093/ageing/afac220. PMID: 36273495Free PMC Article
Hu Y, Peng W, Ren R, Wang Y, Wang G
J Cachexia Sarcopenia Muscle 2022 Dec;13(6):2944-2952. Epub 2022 Sep 4 doi: 10.1002/jcsm.13081. PMID: 36058563Free PMC Article
Petermann-Rocha F, Balntzi V, Gray SR, Lara J, Ho FK, Pell JP, Celis-Morales C
J Cachexia Sarcopenia Muscle 2022 Feb;13(1):86-99. Epub 2021 Nov 23 doi: 10.1002/jcsm.12783. PMID: 34816624Free PMC Article
Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinková E, Vandewoude M, Zamboni M; European Working Group on Sarcopenia in Older People
Age Ageing 2010 Jul;39(4):412-23. Epub 2010 Apr 13 doi: 10.1093/ageing/afq034. PMID: 20392703Free PMC Article

Diagnosis

Sayer AA, Cruz-Jentoft A
Age Ageing 2022 Oct 6;51(10) doi: 10.1093/ageing/afac220. PMID: 36273495Free PMC Article
Cho MR, Lee S, Song SK
J Korean Med Sci 2022 May 9;37(18):e146. doi: 10.3346/jkms.2022.37.e146. PMID: 35535373Free PMC Article
Petermann-Rocha F, Balntzi V, Gray SR, Lara J, Ho FK, Pell JP, Celis-Morales C
J Cachexia Sarcopenia Muscle 2022 Feb;13(1):86-99. Epub 2021 Nov 23 doi: 10.1002/jcsm.12783. PMID: 34816624Free PMC Article
Xie WQ, He M, Yu DJ, Wu YX, Wang XH, Lv S, Xiao WF, Li YS
J Cachexia Sarcopenia Muscle 2021 Jun;12(3):538-554. Epub 2021 May 5 doi: 10.1002/jcsm.12709. PMID: 33951340Free PMC Article
Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinková E, Vandewoude M, Zamboni M; European Working Group on Sarcopenia in Older People
Age Ageing 2010 Jul;39(4):412-23. Epub 2010 Apr 13 doi: 10.1093/ageing/afq034. PMID: 20392703Free PMC Article

Therapy

Huang CY, Mayer PK, Wu MY, Liu DH, Wu PC, Yen HR
Ageing Res Rev 2022 Dec;82:101747. Epub 2022 Oct 9 doi: 10.1016/j.arr.2022.101747. PMID: 36223875
Nunes EA, Colenso-Semple L, McKellar SR, Yau T, Ali MU, Fitzpatrick-Lewis D, Sherifali D, Gaudichon C, Tomé D, Atherton PJ, Robles MC, Naranjo-Modad S, Braun M, Landi F, Phillips SM
J Cachexia Sarcopenia Muscle 2022 Apr;13(2):795-810. Epub 2022 Feb 20 doi: 10.1002/jcsm.12922. PMID: 35187864Free PMC Article
Lu L, Mao L, Feng Y, Ainsworth BE, Liu Y, Chen N
BMC Geriatr 2021 Dec 15;21(1):708. doi: 10.1186/s12877-021-02642-8. PMID: 34911483Free PMC Article
Hanna RM, Ghobry L, Wassef O, Rhee CM, Kalantar-Zadeh K
Blood Purif 2020;49(1-2):202-211. Epub 2019 Dec 18 doi: 10.1159/000504240. PMID: 31851983
Arends J, Bachmann P, Baracos V, Barthelemy N, Bertz H, Bozzetti F, Fearon K, Hütterer E, Isenring E, Kaasa S, Krznaric Z, Laird B, Larsson M, Laviano A, Mühlebach S, Muscaritoli M, Oldervoll L, Ravasco P, Solheim T, Strasser F, de van der Schueren M, Preiser JC
Clin Nutr 2017 Feb;36(1):11-48. Epub 2016 Aug 6 doi: 10.1016/j.clnu.2016.07.015. PMID: 27637832

Prognosis

Papadopoulou SK, Papadimitriou K, Voulgaridou G, Georgaki E, Tsotidou E, Zantidou O, Papandreou D
Nutrients 2021 Dec 16;13(12) doi: 10.3390/nu13124499. PMID: 34960050Free PMC Article
Bhasin S, Travison TG, Manini TM, Patel S, Pencina KM, Fielding RA, Magaziner JM, Newman AB, Kiel DP, Cooper C, Guralnik JM, Cauley JA, Arai H, Clark BC, Landi F, Schaap LA, Pereira SL, Rooks D, Woo J, Woodhouse LJ, Binder E, Brown T, Shardell M, Xue QL, DʼAgostino RB Sr, Orwig D, Gorsicki G, Correa-De-Araujo R, Cawthon PM
J Am Geriatr Soc 2020 Jul;68(7):1410-1418. Epub 2020 Mar 9 doi: 10.1111/jgs.16372. PMID: 32150289
Caan BJ, Cespedes Feliciano EM, Prado CM, Alexeeff S, Kroenke CH, Bradshaw P, Quesenberry CP, Weltzien EK, Castillo AL, Olobatuyi TA, Chen WY
JAMA Oncol 2018 Jun 1;4(6):798-804. doi: 10.1001/jamaoncol.2018.0137. PMID: 29621380Free PMC Article
Tanaka T, Takahashi K, Hirano H, Kikutani T, Watanabe Y, Ohara Y, Furuya H, Tetsuo T, Akishita M, Iijima K
J Gerontol A Biol Sci Med Sci 2018 Nov 10;73(12):1661-1667. doi: 10.1093/gerona/glx225. PMID: 29161342
Cruz-Jentoft AJ, Kiesswetter E, Drey M, Sieber CC
Aging Clin Exp Res 2017 Feb;29(1):43-48. Epub 2017 Feb 2 doi: 10.1007/s40520-016-0709-0. PMID: 28155181

Clinical prediction guides

Holmes CJ, Racette SB
Nutrients 2021 Jul 22;13(8) doi: 10.3390/nu13082493. PMID: 34444653Free PMC Article
Hanna RM, Ghobry L, Wassef O, Rhee CM, Kalantar-Zadeh K
Blood Purif 2020;49(1-2):202-211. Epub 2019 Dec 18 doi: 10.1159/000504240. PMID: 31851983
Choi KM
Korean J Intern Med 2016 Nov;31(6):1054-1060. Epub 2016 Nov 1 doi: 10.3904/kjim.2016.193. PMID: 27809450Free PMC Article
Dodds RM, Syddall HE, Cooper R, Kuh D, Cooper C, Sayer AA
Age Ageing 2016 Mar;45(2):209-16. Epub 2016 Jan 19 doi: 10.1093/ageing/afv192. PMID: 26790455Free PMC Article
Roberts HC, Denison HJ, Martin HJ, Patel HP, Syddall H, Cooper C, Sayer AA
Age Ageing 2011 Jul;40(4):423-9. Epub 2011 May 30 doi: 10.1093/ageing/afr051. PMID: 21624928

Recent systematic reviews

Shen Y, Shi Q, Nong K, Li S, Yue J, Huang J, Dong B, Beauchamp M, Hao Q
J Cachexia Sarcopenia Muscle 2023 Jun;14(3):1199-1211. Epub 2023 Apr 14 doi: 10.1002/jcsm.13225. PMID: 37057640Free PMC Article
Yuan S, Larsson SC
Metabolism 2023 Jul;144:155533. Epub 2023 Mar 11 doi: 10.1016/j.metabol.2023.155533. PMID: 36907247
Petermann-Rocha F, Balntzi V, Gray SR, Lara J, Ho FK, Pell JP, Celis-Morales C
J Cachexia Sarcopenia Muscle 2022 Feb;13(1):86-99. Epub 2021 Nov 23 doi: 10.1002/jcsm.12783. PMID: 34816624Free PMC Article
Lu L, Mao L, Feng Y, Ainsworth BE, Liu Y, Chen N
BMC Geriatr 2021 Dec 15;21(1):708. doi: 10.1186/s12877-021-02642-8. PMID: 34911483Free PMC Article
Liu C, Cheung WH, Li J, Chow SK, Yu J, Wong SH, Ip M, Sung JJY, Wong RMY
J Cachexia Sarcopenia Muscle 2021 Dec;12(6):1393-1407. Epub 2021 Sep 14 doi: 10.1002/jcsm.12784. PMID: 34523250Free PMC Article

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