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Refractory Ependymoma

MedGen UID:
1637579
•Concept ID:
C4687708
•
Neoplastic Process

Definition

Ependymoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Ependymoma

Professional guidelines

PubMed

Nimotuzumab therapy in the treatment of pediatric central nervous system tumors: single-center experience.
Susam-Sen H, Varan A, Bajin İ, Göçmen R, Aydın B, Yalcin B, Kurucu N, Kutluk T, Bayhan T, Akyuz C
Naunyn Schmiedebergs Arch Pharmacol 2021 Aug;394(8):1769-1777. Epub 2021 Jun 21 doi: 10.1007/s00210-021-02109-y. PMID: 34151393
Nivolumab in the Treatment of Recurrent or Refractory Pediatric Brain Tumors: A Single Institutional Experience.
Gorsi HS, Malicki DM, Barsan V, Tumblin M, Yeh-Nayre L, Milburn M, Elster JD, Crawford JR
J Pediatr Hematol Oncol 2019 May;41(4):e235-e241. doi: 10.1097/MPH.0000000000001339. PMID: 30681550

Recent clinical studies

Etiology

Severe Pneumonia Caused by Methicillin-Resistant Staphylococcus pseudintermedius in an Oncology Patient: Case Report and Literature Review.
Asleh M, Feinstein Y, Lazar I, Rokney A, Baum M, Sagi O, Leibovitz E, Danino D
Microb Drug Resist 2022 Feb;28(2):222-228. Epub 2021 Oct 4 doi: 10.1089/mdr.2020.0469. PMID: 34609906
Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors.
Han J, Yu M, Bai Y, Yu J, Jin F, Li C, Zeng R, Peng J, Li A, Song X, Li H, Wu D, Li L
Cancer Cell 2020 Dec 14;38(6):844-856.e7. Epub 2020 Nov 12 doi: 10.1016/j.ccell.2020.10.009. PMID: 33186520Free PMC Article
Nivolumab in the Treatment of Recurrent or Refractory Pediatric Brain Tumors: A Single Institutional Experience.
Gorsi HS, Malicki DM, Barsan V, Tumblin M, Yeh-Nayre L, Milburn M, Elster JD, Crawford JR
J Pediatr Hematol Oncol 2019 May;41(4):e235-e241. doi: 10.1097/MPH.0000000000001339. PMID: 30681550
Single-agent erlotinib versus oral etoposide in patients with recurrent or refractory pediatric ependymoma: a randomized open-label study.
Jakacki RI, Foley MA, Horan J, Wang J, Kieran MW, Bowers DC, Bouffet E, Zacharoulis S, Gill SC
J Neurooncol 2016 Aug;129(1):131-8. Epub 2016 Jun 10 doi: 10.1007/s11060-016-2155-4. PMID: 27287856
Epilepsy surgery following brain tumor resection in children.
Tian AG, Edwards MS, Williams NJ, Olson DM
J Neurosurg Pediatr 2011 Mar;7(3):229-34. doi: 10.3171/2010.12.PEDS10293. PMID: 21361758

Diagnosis

Brain Tumors in Adolescents and Young Adults: A Review.
Rousseau J, Bennett J, Lim-Fat MJ
Semin Neurol 2023 Dec;43(6):909-928. Epub 2023 Nov 10 doi: 10.1055/s-0043-1776775. PMID: 37949116
Severe Pneumonia Caused by Methicillin-Resistant Staphylococcus pseudintermedius in an Oncology Patient: Case Report and Literature Review.
Asleh M, Feinstein Y, Lazar I, Rokney A, Baum M, Sagi O, Leibovitz E, Danino D
Microb Drug Resist 2022 Feb;28(2):222-228. Epub 2021 Oct 4 doi: 10.1089/mdr.2020.0469. PMID: 34609906
Facing CAR T Cell Challenges on the Deadliest Paediatric Brain Tumours.
Ferreras C, Fernández L, Clares-Villa L, Ibáñez-Navarro M, Martín-Cortázar C, Esteban-Rodríguez I, Saceda J, Pérez-Martínez A
Cells 2021 Oct 29;10(11) doi: 10.3390/cells10112940. PMID: 34831165Free PMC Article
Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors.
Han J, Yu M, Bai Y, Yu J, Jin F, Li C, Zeng R, Peng J, Li A, Song X, Li H, Wu D, Li L
Cancer Cell 2020 Dec 14;38(6):844-856.e7. Epub 2020 Nov 12 doi: 10.1016/j.ccell.2020.10.009. PMID: 33186520Free PMC Article
Intracranial papillary endothelial hyperplasia (Masson's tumour) following gamma knife radiosurgery for temporal lobe epilepsy.
Barritt AW, Merve A, Epaliyanage P, Aram J
Pract Neurol 2017 Jun;17(3):214-217. Epub 2017 Feb 23 doi: 10.1136/practneurol-2016-001573. PMID: 28232387

Therapy

Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors.
Han J, Yu M, Bai Y, Yu J, Jin F, Li C, Zeng R, Peng J, Li A, Song X, Li H, Wu D, Li L
Cancer Cell 2020 Dec 14;38(6):844-856.e7. Epub 2020 Nov 12 doi: 10.1016/j.ccell.2020.10.009. PMID: 33186520Free PMC Article
Nivolumab in the Treatment of Recurrent or Refractory Pediatric Brain Tumors: A Single Institutional Experience.
Gorsi HS, Malicki DM, Barsan V, Tumblin M, Yeh-Nayre L, Milburn M, Elster JD, Crawford JR
J Pediatr Hematol Oncol 2019 May;41(4):e235-e241. doi: 10.1097/MPH.0000000000001339. PMID: 30681550
Single-agent erlotinib versus oral etoposide in patients with recurrent or refractory pediatric ependymoma: a randomized open-label study.
Jakacki RI, Foley MA, Horan J, Wang J, Kieran MW, Bowers DC, Bouffet E, Zacharoulis S, Gill SC
J Neurooncol 2016 Aug;129(1):131-8. Epub 2016 Jun 10 doi: 10.1007/s11060-016-2155-4. PMID: 27287856
Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma or leukemia.
Witt O, Milde T, Deubzer HE, Oehme I, Witt R, Kulozik A, Eisenmenger A, Abel U, Karapanagiotou-Schenkel I
Klin Padiatr 2012 Oct;224(6):398-403. Epub 2012 Aug 22 doi: 10.1055/s-0032-1323692. PMID: 22915450
Promoter methylation and expression analysis of MGMT in advanced pediatric brain tumors.
Sardi I, Cetica V, Massimino M, Buccoliero AM, Giunti L, Genitori L, Aricò M
Oncol Rep 2009 Oct;22(4):773-9. doi: 10.3892/or_00000499. PMID: 19724855

Prognosis

Angiocentric glioma transformed into anaplastic ependymoma: Review of the evidence for malignant potential.
McCracken JA, Gonzales MF, Phal PM, Drummond KJ
J Clin Neurosci 2016 Dec;34:47-52. Epub 2016 Oct 11 doi: 10.1016/j.jocn.2016.08.012. PMID: 27742374
Single-agent erlotinib versus oral etoposide in patients with recurrent or refractory pediatric ependymoma: a randomized open-label study.
Jakacki RI, Foley MA, Horan J, Wang J, Kieran MW, Bowers DC, Bouffet E, Zacharoulis S, Gill SC
J Neurooncol 2016 Aug;129(1):131-8. Epub 2016 Jun 10 doi: 10.1007/s11060-016-2155-4. PMID: 27287856
Ependymomas: development of immunotherapeutic strategies.
Pollack IF, Jakacki RI, Butterfield LH, Okada H
Expert Rev Neurother 2013 Oct;13(10):1089-98. doi: 10.1586/14737175.2013.840420. PMID: 24117271Free PMC Article
Promoter methylation and expression analysis of MGMT in advanced pediatric brain tumors.
Sardi I, Cetica V, Massimino M, Buccoliero AM, Giunti L, Genitori L, Aricò M
Oncol Rep 2009 Oct;22(4):773-9. doi: 10.3892/or_00000499. PMID: 19724855
Stepwise accumulation of distinct genomic aberrations in a patient with progressively metastasizing ependymoma.
Milde T, Pfister S, Korshunov A, Deubzer HE, Oehme I, Ernst A, Starzinski-Powitz A, Seitz A, Lichter P, von Deimling A, Witt O
Genes Chromosomes Cancer 2009 Mar;48(3):229-38. doi: 10.1002/gcc.20635. PMID: 19025795

Clinical prediction guides

Brain Tumors in Adolescents and Young Adults: A Review.
Rousseau J, Bennett J, Lim-Fat MJ
Semin Neurol 2023 Dec;43(6):909-928. Epub 2023 Nov 10 doi: 10.1055/s-0043-1776775. PMID: 37949116
B7-H3 in Brain Malignancies: Immunology and Immunotherapy.
Guo X, Chang M, Wang Y, Xing B, Ma W
Int J Biol Sci 2023;19(12):3762-3780. Epub 2023 Jul 24 doi: 10.7150/ijbs.85813. PMID: 37564196Free PMC Article
Nivolumab in the Treatment of Recurrent or Refractory Pediatric Brain Tumors: A Single Institutional Experience.
Gorsi HS, Malicki DM, Barsan V, Tumblin M, Yeh-Nayre L, Milburn M, Elster JD, Crawford JR
J Pediatr Hematol Oncol 2019 May;41(4):e235-e241. doi: 10.1097/MPH.0000000000001339. PMID: 30681550
Single-agent erlotinib versus oral etoposide in patients with recurrent or refractory pediatric ependymoma: a randomized open-label study.
Jakacki RI, Foley MA, Horan J, Wang J, Kieran MW, Bowers DC, Bouffet E, Zacharoulis S, Gill SC
J Neurooncol 2016 Aug;129(1):131-8. Epub 2016 Jun 10 doi: 10.1007/s11060-016-2155-4. PMID: 27287856
Ependymomas: development of immunotherapeutic strategies.
Pollack IF, Jakacki RI, Butterfield LH, Okada H
Expert Rev Neurother 2013 Oct;13(10):1089-98. doi: 10.1586/14737175.2013.840420. PMID: 24117271Free PMC Article

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