U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Refractory Ependymoma

MedGen UID:
1637579
•Concept ID:
C4687708
•
Neoplastic Process

Definition

Ependymoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Ependymoma

Professional guidelines

PubMed

Nimotuzumab therapy in the treatment of pediatric central nervous system tumors: single-center experience.
Susam-Sen H, Varan A, Bajin İ, Göçmen R, Aydın B, Yalcin B, Kurucu N, Kutluk T, Bayhan T, Akyuz C
Naunyn Schmiedebergs Arch Pharmacol 2021 Aug;394(8):1769-1777. Epub 2021 Jun 21 doi: 10.1007/s00210-021-02109-y. PMID: 34151393
Nivolumab in the Treatment of Recurrent or Refractory Pediatric Brain Tumors: A Single Institutional Experience.
Gorsi HS, Malicki DM, Barsan V, Tumblin M, Yeh-Nayre L, Milburn M, Elster JD, Crawford JR
J Pediatr Hematol Oncol 2019 May;41(4):e235-e241. doi: 10.1097/MPH.0000000000001339. PMID: 30681550

Recent clinical studies

Etiology

Metronomic Cyclophosphamide With Cisplatin and Bevacizumab for Refractory Anaplastic Ependymoma: A Retrospective Study.
DE Laclos XC, Frappaz D, Ahle G, Bronnimann C, Catry-Thomas I, Joncour A, Ghiringhelli F, Vauleon E
Anticancer Res 2022 Aug;42(8):3863-3867. doi: 10.21873/anticanres.15878. PMID: 35896241
Nimotuzumab therapy in the treatment of pediatric central nervous system tumors: single-center experience.
Susam-Sen H, Varan A, Bajin İ, Göçmen R, Aydın B, Yalcin B, Kurucu N, Kutluk T, Bayhan T, Akyuz C
Naunyn Schmiedebergs Arch Pharmacol 2021 Aug;394(8):1769-1777. Epub 2021 Jun 21 doi: 10.1007/s00210-021-02109-y. PMID: 34151393
An open-label, two-stage, phase II study of bevacizumab and lapatinib in children with recurrent or refractory ependymoma: a collaborative ependymoma research network study (CERN).
DeWire M, Fouladi M, Turner DC, Wetmore C, Hawkins C, Jacobs C, Yuan Y, Liu D, Goldman S, Fisher P, Rytting M, Bouffet E, Khakoo Y, Hwang EI, Foreman N, Stewart CF, Gilbert MR, Gilbertson R, Gajjar A
J Neurooncol 2015 May;123(1):85-91. Epub 2015 Apr 10 doi: 10.1007/s11060-015-1764-7. PMID: 25859842Free PMC Article
Ependymomas: development of immunotherapeutic strategies.
Pollack IF, Jakacki RI, Butterfield LH, Okada H
Expert Rev Neurother 2013 Oct;13(10):1089-98. doi: 10.1586/14737175.2013.840420. PMID: 24117271Free PMC Article
Bevacizumab for recurrent ependymoma.
Green RM, Cloughesy TF, Stupp R, DeAngelis LM, Woyshner EA, Ney DE, Lassman AB
Neurology 2009 Nov 17;73(20):1677-80. doi: 10.1212/WNL.0b013e3181c1df34. PMID: 19917990Free PMC Article

Diagnosis

Facing CAR T Cell Challenges on the Deadliest Paediatric Brain Tumours.
Ferreras C, Fernández L, Clares-Villa L, Ibáñez-Navarro M, Martín-Cortázar C, Esteban-Rodríguez I, Saceda J, Pérez-Martínez A
Cells 2021 Oct 29;10(11) doi: 10.3390/cells10112940. PMID: 34831165Free PMC Article
A phase I study of sirolimus in combination with metronomic therapy (CHOAnome) in children with recurrent or refractory solid and brain tumors.
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM
Pediatr Blood Cancer 2020 Apr;67(4):e28134. Epub 2019 Dec 25 doi: 10.1002/pbc.28134. PMID: 31876107
Primary Intracranial Extra-Axial Anaplastic Ependymomas.
Yang Y, Tian KB, Hao SY, Wu Z, Li D, Zhang JT
World Neurosurg 2016 Jun;90:704.e1-704.e9. Epub 2016 Mar 4 doi: 10.1016/j.wneu.2016.02.095. PMID: 26947725
18F-FDG PET and MR imaging associations across a spectrum of pediatric brain tumors: a report from the pediatric brain tumor consortium.
Zukotynski K, Fahey F, Kocak M, Kun L, Boyett J, Fouladi M, Vajapeyam S, Treves T, Poussaint TY
J Nucl Med 2014 Sep;55(9):1473-80. Epub 2014 Jul 28 doi: 10.2967/jnumed.114.139626. PMID: 25071098Free PMC Article
Ependymomas: development of immunotherapeutic strategies.
Pollack IF, Jakacki RI, Butterfield LH, Okada H
Expert Rev Neurother 2013 Oct;13(10):1089-98. doi: 10.1586/14737175.2013.840420. PMID: 24117271Free PMC Article

Therapy

Metronomic Cyclophosphamide With Cisplatin and Bevacizumab for Refractory Anaplastic Ependymoma: A Retrospective Study.
DE Laclos XC, Frappaz D, Ahle G, Bronnimann C, Catry-Thomas I, Joncour A, Ghiringhelli F, Vauleon E
Anticancer Res 2022 Aug;42(8):3863-3867. doi: 10.21873/anticanres.15878. PMID: 35896241
Facing CAR T Cell Challenges on the Deadliest Paediatric Brain Tumours.
Ferreras C, Fernández L, Clares-Villa L, Ibáñez-Navarro M, Martín-Cortázar C, Esteban-Rodríguez I, Saceda J, Pérez-Martínez A
Cells 2021 Oct 29;10(11) doi: 10.3390/cells10112940. PMID: 34831165Free PMC Article
Nimotuzumab therapy in the treatment of pediatric central nervous system tumors: single-center experience.
Susam-Sen H, Varan A, Bajin İ, Göçmen R, Aydın B, Yalcin B, Kurucu N, Kutluk T, Bayhan T, Akyuz C
Naunyn Schmiedebergs Arch Pharmacol 2021 Aug;394(8):1769-1777. Epub 2021 Jun 21 doi: 10.1007/s00210-021-02109-y. PMID: 34151393
A phase I study of sirolimus in combination with metronomic therapy (CHOAnome) in children with recurrent or refractory solid and brain tumors.
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM
Pediatr Blood Cancer 2020 Apr;67(4):e28134. Epub 2019 Dec 25 doi: 10.1002/pbc.28134. PMID: 31876107
Bevacizumab for recurrent ependymoma.
Green RM, Cloughesy TF, Stupp R, DeAngelis LM, Woyshner EA, Ney DE, Lassman AB
Neurology 2009 Nov 17;73(20):1677-80. doi: 10.1212/WNL.0b013e3181c1df34. PMID: 19917990Free PMC Article

Prognosis

Nimotuzumab therapy in the treatment of pediatric central nervous system tumors: single-center experience.
Susam-Sen H, Varan A, Bajin İ, Göçmen R, Aydın B, Yalcin B, Kurucu N, Kutluk T, Bayhan T, Akyuz C
Naunyn Schmiedebergs Arch Pharmacol 2021 Aug;394(8):1769-1777. Epub 2021 Jun 21 doi: 10.1007/s00210-021-02109-y. PMID: 34151393
Angiocentric glioma transformed into anaplastic ependymoma: Review of the evidence for malignant potential.
McCracken JA, Gonzales MF, Phal PM, Drummond KJ
J Clin Neurosci 2016 Dec;34:47-52. Epub 2016 Oct 11 doi: 10.1016/j.jocn.2016.08.012. PMID: 27742374
An open-label, two-stage, phase II study of bevacizumab and lapatinib in children with recurrent or refractory ependymoma: a collaborative ependymoma research network study (CERN).
DeWire M, Fouladi M, Turner DC, Wetmore C, Hawkins C, Jacobs C, Yuan Y, Liu D, Goldman S, Fisher P, Rytting M, Bouffet E, Khakoo Y, Hwang EI, Foreman N, Stewart CF, Gilbert MR, Gilbertson R, Gajjar A
J Neurooncol 2015 May;123(1):85-91. Epub 2015 Apr 10 doi: 10.1007/s11060-015-1764-7. PMID: 25859842Free PMC Article
Ependymomas: development of immunotherapeutic strategies.
Pollack IF, Jakacki RI, Butterfield LH, Okada H
Expert Rev Neurother 2013 Oct;13(10):1089-98. doi: 10.1586/14737175.2013.840420. PMID: 24117271Free PMC Article
Bevacizumab for recurrent ependymoma.
Green RM, Cloughesy TF, Stupp R, DeAngelis LM, Woyshner EA, Ney DE, Lassman AB
Neurology 2009 Nov 17;73(20):1677-80. doi: 10.1212/WNL.0b013e3181c1df34. PMID: 19917990Free PMC Article

Clinical prediction guides

B7-H3 in Brain Malignancies: Immunology and Immunotherapy.
Guo X, Chang M, Wang Y, Xing B, Ma W
Int J Biol Sci 2023;19(12):3762-3780. Epub 2023 Jul 24 doi: 10.7150/ijbs.85813. PMID: 37564196Free PMC Article
Nimotuzumab therapy in the treatment of pediatric central nervous system tumors: single-center experience.
Susam-Sen H, Varan A, Bajin İ, Göçmen R, Aydın B, Yalcin B, Kurucu N, Kutluk T, Bayhan T, Akyuz C
Naunyn Schmiedebergs Arch Pharmacol 2021 Aug;394(8):1769-1777. Epub 2021 Jun 21 doi: 10.1007/s00210-021-02109-y. PMID: 34151393
Primary Intracranial Extra-Axial Anaplastic Ependymomas.
Yang Y, Tian KB, Hao SY, Wu Z, Li D, Zhang JT
World Neurosurg 2016 Jun;90:704.e1-704.e9. Epub 2016 Mar 4 doi: 10.1016/j.wneu.2016.02.095. PMID: 26947725
Ependymomas: development of immunotherapeutic strategies.
Pollack IF, Jakacki RI, Butterfield LH, Okada H
Expert Rev Neurother 2013 Oct;13(10):1089-98. doi: 10.1586/14737175.2013.840420. PMID: 24117271Free PMC Article
Bevacizumab for recurrent ependymoma.
Green RM, Cloughesy TF, Stupp R, DeAngelis LM, Woyshner EA, Ney DE, Lassman AB
Neurology 2009 Nov 17;73(20):1677-80. doi: 10.1212/WNL.0b013e3181c1df34. PMID: 19917990Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...