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Refractory Ependymoma

MedGen UID:
1637579
•Concept ID:
C4687708
•
Neoplastic Process

Definition

Ependymoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Ependymoma

Professional guidelines

PubMed

Nimotuzumab therapy in the treatment of pediatric central nervous system tumors: single-center experience.
Susam-Sen H, Varan A, Bajin İ, Göçmen R, Aydın B, Yalcin B, Kurucu N, Kutluk T, Bayhan T, Akyuz C
Naunyn Schmiedebergs Arch Pharmacol 2021 Aug;394(8):1769-1777. Epub 2021 Jun 21 doi: 10.1007/s00210-021-02109-y. PMID: 34151393
Nivolumab in the Treatment of Recurrent or Refractory Pediatric Brain Tumors: A Single Institutional Experience.
Gorsi HS, Malicki DM, Barsan V, Tumblin M, Yeh-Nayre L, Milburn M, Elster JD, Crawford JR
J Pediatr Hematol Oncol 2019 May;41(4):e235-e241. doi: 10.1097/MPH.0000000000001339. PMID: 30681550

Recent clinical studies

Etiology

Brain Tumors in Adolescents and Young Adults: A Review.
Rousseau J, Bennett J, Lim-Fat MJ
Semin Neurol 2023 Dec;43(6):909-928. Epub 2023 Nov 10 doi: 10.1055/s-0043-1776775. PMID: 37949116
Metronomic Cyclophosphamide With Cisplatin and Bevacizumab for Refractory Anaplastic Ependymoma: A Retrospective Study.
DE Laclos XC, Frappaz D, Ahle G, Bronnimann C, Catry-Thomas I, Joncour A, Ghiringhelli F, Vauleon E
Anticancer Res 2022 Aug;42(8):3863-3867. doi: 10.21873/anticanres.15878. PMID: 35896241
Nimotuzumab therapy in the treatment of pediatric central nervous system tumors: single-center experience.
Susam-Sen H, Varan A, Bajin İ, Göçmen R, Aydın B, Yalcin B, Kurucu N, Kutluk T, Bayhan T, Akyuz C
Naunyn Schmiedebergs Arch Pharmacol 2021 Aug;394(8):1769-1777. Epub 2021 Jun 21 doi: 10.1007/s00210-021-02109-y. PMID: 34151393
Ependymomas: development of immunotherapeutic strategies.
Pollack IF, Jakacki RI, Butterfield LH, Okada H
Expert Rev Neurother 2013 Oct;13(10):1089-98. doi: 10.1586/14737175.2013.840420. PMID: 24117271Free PMC Article
Bevacizumab for recurrent ependymoma.
Green RM, Cloughesy TF, Stupp R, DeAngelis LM, Woyshner EA, Ney DE, Lassman AB
Neurology 2009 Nov 17;73(20):1677-80. doi: 10.1212/WNL.0b013e3181c1df34. PMID: 19917990Free PMC Article

Diagnosis

Brain Tumors in Adolescents and Young Adults: A Review.
Rousseau J, Bennett J, Lim-Fat MJ
Semin Neurol 2023 Dec;43(6):909-928. Epub 2023 Nov 10 doi: 10.1055/s-0043-1776775. PMID: 37949116
Facing CAR T Cell Challenges on the Deadliest Paediatric Brain Tumours.
Ferreras C, Fernández L, Clares-Villa L, Ibáñez-Navarro M, Martín-Cortázar C, Esteban-Rodríguez I, Saceda J, Pérez-Martínez A
Cells 2021 Oct 29;10(11) doi: 10.3390/cells10112940. PMID: 34831165Free PMC Article
A phase I study of sirolimus in combination with metronomic therapy (CHOAnome) in children with recurrent or refractory solid and brain tumors.
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM
Pediatr Blood Cancer 2020 Apr;67(4):e28134. Epub 2019 Dec 25 doi: 10.1002/pbc.28134. PMID: 31876107
Primary Intracranial Extra-Axial Anaplastic Ependymomas.
Yang Y, Tian KB, Hao SY, Wu Z, Li D, Zhang JT
World Neurosurg 2016 Jun;90:704.e1-704.e9. Epub 2016 Mar 4 doi: 10.1016/j.wneu.2016.02.095. PMID: 26947725
Ependymomas: development of immunotherapeutic strategies.
Pollack IF, Jakacki RI, Butterfield LH, Okada H
Expert Rev Neurother 2013 Oct;13(10):1089-98. doi: 10.1586/14737175.2013.840420. PMID: 24117271Free PMC Article

Therapy

Systematic characterization of antibody-drug conjugate targets in central nervous system tumors.
Coy S, Lee JS, Chan SJ, Woo T, Jones J, Alexandrescu S, Wen PY, Sorger PK, Ligon KL, Santagata S
Neuro Oncol 2024 Mar 4;26(3):458-472. doi: 10.1093/neuonc/noad205. PMID: 37870091Free PMC Article
Metronomic Cyclophosphamide With Cisplatin and Bevacizumab for Refractory Anaplastic Ependymoma: A Retrospective Study.
DE Laclos XC, Frappaz D, Ahle G, Bronnimann C, Catry-Thomas I, Joncour A, Ghiringhelli F, Vauleon E
Anticancer Res 2022 Aug;42(8):3863-3867. doi: 10.21873/anticanres.15878. PMID: 35896241
Facing CAR T Cell Challenges on the Deadliest Paediatric Brain Tumours.
Ferreras C, Fernández L, Clares-Villa L, Ibáñez-Navarro M, Martín-Cortázar C, Esteban-Rodríguez I, Saceda J, Pérez-Martínez A
Cells 2021 Oct 29;10(11) doi: 10.3390/cells10112940. PMID: 34831165Free PMC Article
Nimotuzumab therapy in the treatment of pediatric central nervous system tumors: single-center experience.
Susam-Sen H, Varan A, Bajin İ, Göçmen R, Aydın B, Yalcin B, Kurucu N, Kutluk T, Bayhan T, Akyuz C
Naunyn Schmiedebergs Arch Pharmacol 2021 Aug;394(8):1769-1777. Epub 2021 Jun 21 doi: 10.1007/s00210-021-02109-y. PMID: 34151393
Bevacizumab for recurrent ependymoma.
Green RM, Cloughesy TF, Stupp R, DeAngelis LM, Woyshner EA, Ney DE, Lassman AB
Neurology 2009 Nov 17;73(20):1677-80. doi: 10.1212/WNL.0b013e3181c1df34. PMID: 19917990Free PMC Article

Prognosis

Nimotuzumab therapy in the treatment of pediatric central nervous system tumors: single-center experience.
Susam-Sen H, Varan A, Bajin İ, Göçmen R, Aydın B, Yalcin B, Kurucu N, Kutluk T, Bayhan T, Akyuz C
Naunyn Schmiedebergs Arch Pharmacol 2021 Aug;394(8):1769-1777. Epub 2021 Jun 21 doi: 10.1007/s00210-021-02109-y. PMID: 34151393
Quantitative assessment and clinical relevance of VEGFRs-positive tumor cells in refractory brain tumors.
Tamura R, Sato M, Morimoto Y, Ohara K, Kosugi K, Oishi Y, Kuranari Y, Murase M, Yoshida K, Toda M
Exp Mol Pathol 2020 Jun;114:104408. Epub 2020 Feb 21 doi: 10.1016/j.yexmp.2020.104408. PMID: 32088190
An open-label, two-stage, phase II study of bevacizumab and lapatinib in children with recurrent or refractory ependymoma: a collaborative ependymoma research network study (CERN).
DeWire M, Fouladi M, Turner DC, Wetmore C, Hawkins C, Jacobs C, Yuan Y, Liu D, Goldman S, Fisher P, Rytting M, Bouffet E, Khakoo Y, Hwang EI, Foreman N, Stewart CF, Gilbert MR, Gilbertson R, Gajjar A
J Neurooncol 2015 May;123(1):85-91. Epub 2015 Apr 10 doi: 10.1007/s11060-015-1764-7. PMID: 25859842Free PMC Article
Ependymomas: development of immunotherapeutic strategies.
Pollack IF, Jakacki RI, Butterfield LH, Okada H
Expert Rev Neurother 2013 Oct;13(10):1089-98. doi: 10.1586/14737175.2013.840420. PMID: 24117271Free PMC Article
Bevacizumab for recurrent ependymoma.
Green RM, Cloughesy TF, Stupp R, DeAngelis LM, Woyshner EA, Ney DE, Lassman AB
Neurology 2009 Nov 17;73(20):1677-80. doi: 10.1212/WNL.0b013e3181c1df34. PMID: 19917990Free PMC Article

Clinical prediction guides

Brain Tumors in Adolescents and Young Adults: A Review.
Rousseau J, Bennett J, Lim-Fat MJ
Semin Neurol 2023 Dec;43(6):909-928. Epub 2023 Nov 10 doi: 10.1055/s-0043-1776775. PMID: 37949116
B7-H3 in Brain Malignancies: Immunology and Immunotherapy.
Guo X, Chang M, Wang Y, Xing B, Ma W
Int J Biol Sci 2023;19(12):3762-3780. Epub 2023 Jul 24 doi: 10.7150/ijbs.85813. PMID: 37564196Free PMC Article
Primary Intracranial Extra-Axial Anaplastic Ependymomas.
Yang Y, Tian KB, Hao SY, Wu Z, Li D, Zhang JT
World Neurosurg 2016 Jun;90:704.e1-704.e9. Epub 2016 Mar 4 doi: 10.1016/j.wneu.2016.02.095. PMID: 26947725
Ependymomas: development of immunotherapeutic strategies.
Pollack IF, Jakacki RI, Butterfield LH, Okada H
Expert Rev Neurother 2013 Oct;13(10):1089-98. doi: 10.1586/14737175.2013.840420. PMID: 24117271Free PMC Article
Bevacizumab for recurrent ependymoma.
Green RM, Cloughesy TF, Stupp R, DeAngelis LM, Woyshner EA, Ney DE, Lassman AB
Neurology 2009 Nov 17;73(20):1677-80. doi: 10.1212/WNL.0b013e3181c1df34. PMID: 19917990Free PMC Article

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