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Increased glucose-6-phosphate dehydrogenase level in leukocytes

MedGen UID:
1638267
•Concept ID:
C4703677
•
Finding
Synonym: Increased G6PD level in leukocytes
 
HPO: HP:0410191

Definition

An increase in the level of glucose-6-phosphate dehydrogenase in leukocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased glucose-6-phosphate dehydrogenase level in leukocytes

Recent clinical studies

Etiology

Glucose-6-Phosphate Dehydrogenase Deficiency Activates Endothelial Cell and Leukocyte Adhesion Mediated via the TGFβ/NADPH Oxidases/ROS Signaling Pathway.
Parsanathan R, Jain SK
Int J Mol Sci 2020 Oct 10;21(20) doi: 10.3390/ijms21207474. PMID: 33050491Free PMC Article
Oxidative DNA damage and oxidative stress in lead-exposed workers.
Dobrakowski M, Pawlas N, Kasperczyk A, Kozłowska A, Olewińska E, Machoń-Grecka A, Kasperczyk S
Hum Exp Toxicol 2017 Jul;36(7):744-754. Epub 2016 Sep 5 doi: 10.1177/0960327116665674. PMID: 27596070
Cell growth and cholesterol metabolism in human glucose-6-phosphate dehydrogenase deficient lymphomononuclear cells.
Batetta B, Bonatesta RR, Sanna F, Putzolu M, Mulas MF, Collu M, Dessì S
Cell Prolif 2002 Jun;35(3):143-54. doi: 10.1046/j.1365-2184.2002.00231.x. PMID: 12027950Free PMC Article
Glutathione peroxidase and reductase, glucose-6-phosphate dehydrogenase and catalase activities in multiple sclerosis.
Jensen GE, Clausen J
J Neurol Sci 1984 Jan;63(1):45-53. doi: 10.1016/0022-510x(84)90107-2. PMID: 6699653
In vivo lability of glucose-6-phosphate dehydrogenase in GdA- and GdMediterranean deficiency.
Piomelli S, Corash LM, Davenport DD, Miraglia J, Amorosi EL
J Clin Invest 1968 Apr;47(4):940-8. doi: 10.1172/JCI105786. PMID: 5641629Free PMC Article

Diagnosis

Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure.
Díaz-Flores M, Cruz M, Duran-Reyes G, Munguia-Miranda C, Loza-Rodríguez H, Pulido-Casas E, Torres-Ramírez N, Gaja-Rodriguez O, Kumate J, Baiza-Gutman LA, Hernández-Saavedra D
Can J Physiol Pharmacol 2013 Oct;91(10):855-60. Epub 2013 Jun 17 doi: 10.1139/cjpp-2012-0341. PMID: 24144057
Oxidative markers in spontaneous intracerebral hemorrhage: leukocyte 8-hydroxy-2'-deoxyguanosine as an independent predictor of the 30-day outcome.
Chen YC, Chen CM, Liu JL, Chen ST, Cheng ML, Chiu DT
J Neurosurg 2011 Dec;115(6):1184-90. Epub 2011 Aug 26 doi: 10.3171/2011.7.JNS11718. PMID: 21962000
Leukocyte glucose 6 phosphate dehydrogenase as prognostic indicator in ANLL and CML.
Devi GS, Prasad MH, Reddy PP, Rao DN
Indian J Exp Biol 1997 Feb;35(2):155-8. PMID: 9315224
Glutathione levels and sensitivity to apoptosis are regulated by changes in transaldolase expression.
Banki K, Hutter E, Colombo E, Gonchoroff NJ, Perl A
J Biol Chem 1996 Dec 20;271(51):32994-3001. doi: 10.1074/jbc.271.51.32994. PMID: 8955144
The relation of the natriuretic hormone to essential hypertension.
de Wardener HE, MacGregor GA
Postgrad Med J 1983;59 Suppl 2:74-7. PMID: 6310538

Therapy

mTOR inhibition downregulates glucose-6-phosphate dehydrogenase and induces ROS-dependent death in T-cell acute lymphoblastic leukemia cells.
Silic-Benussi M, Sharova E, Ciccarese F, Cavallari I, Raimondi V, Urso L, Corradin A, Kotler H, Scattolin G, Buldini B, Francescato S, Basso G, Minuzzo SA, Indraccolo S, D'Agostino DM, Ciminale V
Redox Biol 2022 May;51:102268. Epub 2022 Feb 24 doi: 10.1016/j.redox.2022.102268. PMID: 35248829Free PMC Article
Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling.
Yen WC, Wu YH, Wu CC, Lin HR, Stern A, Chen SH, Shu JC, Tsun-Yee Chiu D
Redox Biol 2020 Jan;28:101363. Epub 2019 Nov 2 doi: 10.1016/j.redox.2019.101363. PMID: 31707353Free PMC Article
Oxidative DNA damage and oxidative stress in lead-exposed workers.
Dobrakowski M, Pawlas N, Kasperczyk A, Kozłowska A, Olewińska E, Machoń-Grecka A, Kasperczyk S
Hum Exp Toxicol 2017 Jul;36(7):744-754. Epub 2016 Sep 5 doi: 10.1177/0960327116665674. PMID: 27596070
Glutathione, glutathione-related enzymes, and oxidative stress in individuals with subacute occupational exposure to lead.
Dobrakowski M, Pawlas N, Hudziec E, Kozłowska A, Mikołajczyk A, Birkner E, Kasperczyk S
Environ Toxicol Pharmacol 2016 Jul;45:235-40. Epub 2016 Jun 7 doi: 10.1016/j.etap.2016.06.008. PMID: 27331344
DNA damage and apoptosis in mononuclear cells from glucose-6-phosphate dehydrogenase-deficient patients (G6PD Aachen variant) after UV irradiation.
Efferth T, Fabry U, Osieka R
J Leukoc Biol 2001 Mar;69(3):340-2. PMID: 11261779

Prognosis

Determinants, profile and outcomes of hepatitis A virus-associated severe acute liver injury in adults.
Roy A, Ghoshal UC, Kulkarni AV, Lohia K, Tiwary I, Tiwari S, Tewari A, Sonthalia N, Goenka MK
Indian J Gastroenterol 2024 Apr;43(2):505-512. Epub 2024 Apr 26 doi: 10.1007/s12664-024-01577-3. PMID: 38664345
Oxidative markers in spontaneous intracerebral hemorrhage: leukocyte 8-hydroxy-2'-deoxyguanosine as an independent predictor of the 30-day outcome.
Chen YC, Chen CM, Liu JL, Chen ST, Cheng ML, Chiu DT
J Neurosurg 2011 Dec;115(6):1184-90. Epub 2011 Aug 26 doi: 10.3171/2011.7.JNS11718. PMID: 21962000
Deletion of leucine 61 in glucose-6-phosphate dehydrogenase leads to chronic nonspherocytic anemia, granulocyte dysfunction, and increased susceptibility to infections.
van Bruggen R, Bautista JM, Petropoulou T, de Boer M, van Zwieten R, Gómez-Gallego F, Belohradsky BH, Hartwig NG, Stevens D, Mason PJ, Roos D
Blood 2002 Aug 1;100(3):1026-30. doi: 10.1182/blood.v100.3.1026. PMID: 12130518
Increased incidence of sepsis and altered monocyte functions in severely injured type A- glucose-6-phosphate dehydrogenase-deficient African American trauma patients.
Spolarics Z, Siddiqi M, Siegel JH, Garcia ZC, Stein DS, Ong H, Livingston DH, Denny T, Deitch EA
Crit Care Med 2001 Apr;29(4):728-36. doi: 10.1097/00003246-200104000-00005. PMID: 11373456
Leukocyte glucose 6 phosphate dehydrogenase as prognostic indicator in ANLL and CML.
Devi GS, Prasad MH, Reddy PP, Rao DN
Indian J Exp Biol 1997 Feb;35(2):155-8. PMID: 9315224

Clinical prediction guides

Impaired inflammasome activation and bacterial clearance in G6PD deficiency due to defective NOX/p38 MAPK/AP-1 redox signaling.
Yen WC, Wu YH, Wu CC, Lin HR, Stern A, Chen SH, Shu JC, Tsun-Yee Chiu D
Redox Biol 2020 Jan;28:101363. Epub 2019 Nov 2 doi: 10.1016/j.redox.2019.101363. PMID: 31707353Free PMC Article
Role of hexokinase-1 in the survival of HIV-1-infected macrophages.
Sen S, Kaminiski R, Deshmane S, Langford D, Khalili K, Amini S, Datta PK
Cell Cycle 2015;14(7):980-9. doi: 10.1080/15384101.2015.1006971. PMID: 25602755Free PMC Article
Deletion of leucine 61 in glucose-6-phosphate dehydrogenase leads to chronic nonspherocytic anemia, granulocyte dysfunction, and increased susceptibility to infections.
van Bruggen R, Bautista JM, Petropoulou T, de Boer M, van Zwieten R, Gómez-Gallego F, Belohradsky BH, Hartwig NG, Stevens D, Mason PJ, Roos D
Blood 2002 Aug 1;100(3):1026-30. doi: 10.1182/blood.v100.3.1026. PMID: 12130518
Increased incidence of sepsis and altered monocyte functions in severely injured type A- glucose-6-phosphate dehydrogenase-deficient African American trauma patients.
Spolarics Z, Siddiqi M, Siegel JH, Garcia ZC, Stein DS, Ong H, Livingston DH, Denny T, Deitch EA
Crit Care Med 2001 Apr;29(4):728-36. doi: 10.1097/00003246-200104000-00005. PMID: 11373456
The NAD+ precursors, nicotinic acid and nicotinamide upregulate glyceraldehyde-3-phosphate dehydrogenase and glucose-6-phosphate dehydrogenase mRNA in Jurkat cells.
Yan Q, Briehl M, Crowley CL, Payne CM, Bernstein H, Bernstein C
Biochem Biophys Res Commun 1999 Feb 5;255(1):133-6. doi: 10.1006/bbrc.1999.0154. PMID: 10082668

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