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Recurrent Childhood Malignant Solid Neoplasm

MedGen UID:
1638936
•Concept ID:
C4688333
•
Neoplastic Process
Synonyms: Childhood Recurrent Malignant Solid Neoplasm; Childhood Recurrent Malignant Solid Tumor

Definition

The reemergence of a childhood malignant solid neoplasm after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Childhood Malignant Solid Neoplasm

Professional guidelines

PubMed

Oncolytic virotherapy for the treatment of pediatric brainstem gliomas.
Gállego Pérez-Larraya J, García-Moure M, Alonso MM
Rev Neurol (Paris) 2023 Jun;179(5):475-480. Epub 2023 Apr 13 doi: 10.1016/j.neurol.2023.03.016. PMID: 37061388
Advances in emerging drugs for the treatment of neuroblastoma.
Berlanga P, Cañete A, Castel V
Expert Opin Emerg Drugs 2017 Mar;22(1):63-75. Epub 2017 Feb 22 doi: 10.1080/14728214.2017.1294159. PMID: 28253830
MIBG scintigraphy for the diagnosis and follow-up of children with neuroblastoma.
Boubaker A, Bischof Delaloye A
Q J Nucl Med Mol Imaging 2008 Dec;52(4):388-402. PMID: 19088693

Recent clinical studies

Etiology

Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile.
Nussbaumer G, Benesch M, Grabovska Y, Mackay A, Castel D, Grill J, Alonso MM, Antonelli M, Bailey S, Baugh JN, Biassoni V, Blattner-Johnson M, Broniscer A, Carai A, Colafati GS, Colditz N, Corbacioglu S, Crampsie S, Entz-Werle N, Eyrich M, Friker LL, Frühwald MC, Garrè ML, Gerber NU, Giangaspero F, Gil-da-Costa MJ, Graf N, Hargrave D, Hauser P, Herrlinger U, Hoffmann M, Hulleman E, Izquierdo E, Jacobs S, Karremann M, Kattamis A, Kebudi R, Kortmann RD, Kwiecien R, Massimino M, Mastronuzzi A, Miele E, Morana G, Noack CM, Pentikainen V, Perwein T, Pfister SM, Pietsch T, Roka K, Rossi S, Rutkowski S, Schiavello E, Seidel C, Štěrba J, Sturm D, Sumerauer D, Tacke A, Temelso S, Valentini C, van Vuurden D, Varlet P, Veldhuijzen van Zanten SEM, Vinci M, von Bueren AO, Warmuth-Metz M, Wesseling P, Wiese M, Wolff JEA, Zamecnik J, Morales La Madrid A, Bison B, Gielen GH, Jones DTW, Jones C, Kramm CM
Neuro Oncol 2024 Sep 5;26(9):1723-1737. doi: 10.1093/neuonc/noae080. PMID: 38717379Free PMC Article
Association between local treatment modalities and event-free survival, overall survival, and local recurrence in patients with localised Ewing Sarcoma. Report from the Ewing 2008 trial.
Heesen P, Ranft A, Bhadri V, Brichard B, Collaud S, Cyprova S, Eich H, Ek T, Gelderblom H, Hardes J, Haveman L, Jabar S, Hartmann W, Andreou D, Hauser P, Kersting J, Juergens H, Kanerva J, Kühne T, Raciborska A, Rascon J, Streitbürger A, Timmermann B, Uhlenbruch Y, Dirksen U
Eur J Cancer 2023 Oct;192:113260. Epub 2023 Jul 27 doi: 10.1016/j.ejca.2023.113260. PMID: 37595489
Top advances of the year: Pediatric oncology.
Pappo AS, Karol SE, Bertrand KC
Cancer 2022 Oct;128(20):3593-3596. Epub 2022 Sep 8 doi: 10.1002/cncr.34425. PMID: 36074012
Advances in emerging drugs for the treatment of neuroblastoma.
Berlanga P, Cañete A, Castel V
Expert Opin Emerg Drugs 2017 Mar;22(1):63-75. Epub 2017 Feb 22 doi: 10.1080/14728214.2017.1294159. PMID: 28253830
Wilms tumor.
Green DM, D'Angio GJ, Beckwith JB, Breslow NE, Grundy PE, Ritchey ML, Thomas PR
CA Cancer J Clin 1996 Jan-Feb;46(1):46-63. doi: 10.3322/canjclin.46.1.46. PMID: 8548525

Diagnosis

SETD2 mutations do not contribute to clonal fitness in response to chemotherapy in childhood B cell acute lymphoblastic leukemia.
Contreras Yametti GP, Robbins G, Chowdhury A, Narang S, Ostrow TH, Kilberg H, Greenberg J, Kramer L, Raetz E, Tsirigos A, Evensen NA, Carroll WL
Leuk Lymphoma 2024 Jan;65(1):78-90. Epub 2024 Jan 10 doi: 10.1080/10428194.2023.2273752. PMID: 37874744
Association between local treatment modalities and event-free survival, overall survival, and local recurrence in patients with localised Ewing Sarcoma. Report from the Ewing 2008 trial.
Heesen P, Ranft A, Bhadri V, Brichard B, Collaud S, Cyprova S, Eich H, Ek T, Gelderblom H, Hardes J, Haveman L, Jabar S, Hartmann W, Andreou D, Hauser P, Kersting J, Juergens H, Kanerva J, Kühne T, Raciborska A, Rascon J, Streitbürger A, Timmermann B, Uhlenbruch Y, Dirksen U
Eur J Cancer 2023 Oct;192:113260. Epub 2023 Jul 27 doi: 10.1016/j.ejca.2023.113260. PMID: 37595489
Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells.
Berlak M, Tucker E, Dorel M, Winkler A, McGearey A, Rodriguez-Fos E, da Costa BM, Barker K, Fyle E, Calton E, Eising S, Ober K, Hughes D, Koutroumanidou E, Carter P, Stankunaite R, Proszek P, Jain N, Rosswog C, Dorado-Garcia H, Molenaar JJ, Hubank M, Barone G, Anderson J, Lang P, Deubzer HE, Künkele A, Fischer M, Eggert A, Kloft C, Henssen AG, Boettcher M, Hertwig F, Blüthgen N, Chesler L, Schulte JH
Mol Cancer 2022 Jun 10;21(1):126. doi: 10.1186/s12943-022-01583-z. PMID: 35689207Free PMC Article
Advances in emerging drugs for the treatment of neuroblastoma.
Berlanga P, Cañete A, Castel V
Expert Opin Emerg Drugs 2017 Mar;22(1):63-75. Epub 2017 Feb 22 doi: 10.1080/14728214.2017.1294159. PMID: 28253830
Towards diagnostic application of non-coding RNAs in neuroblastoma.
Althoff K, Schulte JH, Schramm A
Expert Rev Mol Diagn 2016 Dec;16(12):1307-1313. Epub 2016 Nov 15 doi: 10.1080/14737159.2016.1256207. PMID: 27813435

Therapy

Targeting pediatric solid tumors in the new era of RNA therapeutics.
Chaiyawat P, Sangkhathat S, Chiangjong W, Wongtrakoongate P, Hongeng S, Pruksakorn D, Chutipongtanate S
Crit Rev Oncol Hematol 2024 Aug;200:104406. Epub 2024 Jun 2 doi: 10.1016/j.critrevonc.2024.104406. PMID: 38834094
In vivo cisplatin-resistant neuroblastoma metastatic model reveals tumour necrosis factor receptor superfamily member 4 (TNFRSF4) as an independent prognostic factor of survival in neuroblastoma.
Murphy C, Devis-Jauregui L, Struck R, Boloix A, Gallagher C, Gavin C, Cottone F, Fernandez AS, Madden S, Roma J, Segura MF, Piskareva O
PLoS One 2024;19(5):e0303643. Epub 2024 May 29 doi: 10.1371/journal.pone.0303643. PMID: 38809883Free PMC Article
Locoregional CAR T cells for children with CNS tumors: Clinical procedure and catheter safety.
Vitanza NA, Ronsley R, Choe M, Henson C, Breedt M, Barrios-Anderson A, Wein A, Brown C, Beebe A, Kong A, Kirkey D, Lee BM, Leary SES, Crotty EE, Hoeppner C, Holtzclaw S, Wilson AL, Gustafson JA, Foster JB, Iliff JJ, Goldstein HE, Browd SR, Lee A, Ojemann JG, Pinto N, Gust J, Gardner RA, Jensen MC, Hauptman JS, Park JR
Neoplasia 2023 Feb;36:100870. Epub 2023 Jan 3 doi: 10.1016/j.neo.2022.100870. PMID: 36599192Free PMC Article
Advances in emerging drugs for the treatment of neuroblastoma.
Berlanga P, Cañete A, Castel V
Expert Opin Emerg Drugs 2017 Mar;22(1):63-75. Epub 2017 Feb 22 doi: 10.1080/14728214.2017.1294159. PMID: 28253830
Recent advances in the treatment of pediatric brain tumors.
Gururangan S, Friedman HS
Oncology (Williston Park) 2004 Nov;18(13):1649-61; discussion 1662, 1665-6, 1668. PMID: 15648297

Prognosis

Targeting pediatric solid tumors in the new era of RNA therapeutics.
Chaiyawat P, Sangkhathat S, Chiangjong W, Wongtrakoongate P, Hongeng S, Pruksakorn D, Chutipongtanate S
Crit Rev Oncol Hematol 2024 Aug;200:104406. Epub 2024 Jun 2 doi: 10.1016/j.critrevonc.2024.104406. PMID: 38834094
In vivo cisplatin-resistant neuroblastoma metastatic model reveals tumour necrosis factor receptor superfamily member 4 (TNFRSF4) as an independent prognostic factor of survival in neuroblastoma.
Murphy C, Devis-Jauregui L, Struck R, Boloix A, Gallagher C, Gavin C, Cottone F, Fernandez AS, Madden S, Roma J, Segura MF, Piskareva O
PLoS One 2024;19(5):e0303643. Epub 2024 May 29 doi: 10.1371/journal.pone.0303643. PMID: 38809883Free PMC Article
Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile.
Nussbaumer G, Benesch M, Grabovska Y, Mackay A, Castel D, Grill J, Alonso MM, Antonelli M, Bailey S, Baugh JN, Biassoni V, Blattner-Johnson M, Broniscer A, Carai A, Colafati GS, Colditz N, Corbacioglu S, Crampsie S, Entz-Werle N, Eyrich M, Friker LL, Frühwald MC, Garrè ML, Gerber NU, Giangaspero F, Gil-da-Costa MJ, Graf N, Hargrave D, Hauser P, Herrlinger U, Hoffmann M, Hulleman E, Izquierdo E, Jacobs S, Karremann M, Kattamis A, Kebudi R, Kortmann RD, Kwiecien R, Massimino M, Mastronuzzi A, Miele E, Morana G, Noack CM, Pentikainen V, Perwein T, Pfister SM, Pietsch T, Roka K, Rossi S, Rutkowski S, Schiavello E, Seidel C, Štěrba J, Sturm D, Sumerauer D, Tacke A, Temelso S, Valentini C, van Vuurden D, Varlet P, Veldhuijzen van Zanten SEM, Vinci M, von Bueren AO, Warmuth-Metz M, Wesseling P, Wiese M, Wolff JEA, Zamecnik J, Morales La Madrid A, Bison B, Gielen GH, Jones DTW, Jones C, Kramm CM
Neuro Oncol 2024 Sep 5;26(9):1723-1737. doi: 10.1093/neuonc/noae080. PMID: 38717379Free PMC Article
Extensive Clonal Branching Shapes the Evolutionary History of High-Risk Pediatric Cancers.
Andersson N, Bakker B, Karlsson J, Valind A, Holmquist Mengelbier L, Spierings DCJ, Foijer F, Gisselsson D
Cancer Res 2020 Apr 1;80(7):1512-1523. Epub 2020 Feb 10 doi: 10.1158/0008-5472.CAN-19-3468. PMID: 32041836
Detection of recurrence in childhood solid tumors.
Howell L, Mensah A, Brennan B, Makin G
Cancer 2005 Mar 15;103(6):1274-9. doi: 10.1002/cncr.20896. PMID: 15674854

Clinical prediction guides

Gliomatosis cerebri in children: A poor prognostic phenotype of diffuse gliomas with a distinct molecular profile.
Nussbaumer G, Benesch M, Grabovska Y, Mackay A, Castel D, Grill J, Alonso MM, Antonelli M, Bailey S, Baugh JN, Biassoni V, Blattner-Johnson M, Broniscer A, Carai A, Colafati GS, Colditz N, Corbacioglu S, Crampsie S, Entz-Werle N, Eyrich M, Friker LL, Frühwald MC, Garrè ML, Gerber NU, Giangaspero F, Gil-da-Costa MJ, Graf N, Hargrave D, Hauser P, Herrlinger U, Hoffmann M, Hulleman E, Izquierdo E, Jacobs S, Karremann M, Kattamis A, Kebudi R, Kortmann RD, Kwiecien R, Massimino M, Mastronuzzi A, Miele E, Morana G, Noack CM, Pentikainen V, Perwein T, Pfister SM, Pietsch T, Roka K, Rossi S, Rutkowski S, Schiavello E, Seidel C, Štěrba J, Sturm D, Sumerauer D, Tacke A, Temelso S, Valentini C, van Vuurden D, Varlet P, Veldhuijzen van Zanten SEM, Vinci M, von Bueren AO, Warmuth-Metz M, Wesseling P, Wiese M, Wolff JEA, Zamecnik J, Morales La Madrid A, Bison B, Gielen GH, Jones DTW, Jones C, Kramm CM
Neuro Oncol 2024 Sep 5;26(9):1723-1737. doi: 10.1093/neuonc/noae080. PMID: 38717379Free PMC Article
SETD2 mutations do not contribute to clonal fitness in response to chemotherapy in childhood B cell acute lymphoblastic leukemia.
Contreras Yametti GP, Robbins G, Chowdhury A, Narang S, Ostrow TH, Kilberg H, Greenberg J, Kramer L, Raetz E, Tsirigos A, Evensen NA, Carroll WL
Leuk Lymphoma 2024 Jan;65(1):78-90. Epub 2024 Jan 10 doi: 10.1080/10428194.2023.2273752. PMID: 37874744
Association between local treatment modalities and event-free survival, overall survival, and local recurrence in patients with localised Ewing Sarcoma. Report from the Ewing 2008 trial.
Heesen P, Ranft A, Bhadri V, Brichard B, Collaud S, Cyprova S, Eich H, Ek T, Gelderblom H, Hardes J, Haveman L, Jabar S, Hartmann W, Andreou D, Hauser P, Kersting J, Juergens H, Kanerva J, Kühne T, Raciborska A, Rascon J, Streitbürger A, Timmermann B, Uhlenbruch Y, Dirksen U
Eur J Cancer 2023 Oct;192:113260. Epub 2023 Jul 27 doi: 10.1016/j.ejca.2023.113260. PMID: 37595489
A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.
Davis KL, Fox E, Isikwei E, Reid JM, Liu X, Minard CG, Voss S, Berg SL, Weigel BJ, Mackall CL
Clin Cancer Res 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164. PMID: 36190525Free PMC Article
Advances in emerging drugs for the treatment of neuroblastoma.
Berlanga P, Cañete A, Castel V
Expert Opin Emerg Drugs 2017 Mar;22(1):63-75. Epub 2017 Feb 22 doi: 10.1080/14728214.2017.1294159. PMID: 28253830

Recent systematic reviews

A systematic review of evidence for and against routine surveillance imaging after completing treatment for childhood extracranial solid tumors.
Morgan JE, Walker R, Harden M, Phillips RS
Cancer Med 2020 Jul;9(14):4949-4961. Epub 2020 May 19 doi: 10.1002/cam4.3110. PMID: 32431088Free PMC Article
Solid Pseudopapillary Neoplasm of the Pancreas in a Young Pediatric Patient: A Case Report and Systematic Review of the Literature.
Bender AM, Thompson ED, Hackam DJ, Cameron JL, Rhee DS
Pancreas 2018 Nov/Dec;47(10):1364-1368. doi: 10.1097/MPA.0000000000001183. PMID: 30325866
Solid pseudopapillary and malignant pancreatic tumors in childhood: A systematic review and evidence quality assessment.
Mylonas KS, Doulamis IP, Tsilimigras DI, Nasioudis D, Schizas D, Masiakos PT, Kelleher CM
Pediatr Blood Cancer 2018 Oct;65(10):e27114. Epub 2018 Apr 26 doi: 10.1002/pbc.27114. PMID: 29697193
123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma.
Bleeker G, Tytgat GA, Adam JA, Caron HN, Kremer LC, Hooft L, van Dalen EC
Cochrane Database Syst Rev 2015 Sep 29;2015(9):CD009263. doi: 10.1002/14651858.CD009263.pub2. PMID: 26417712Free PMC Article

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