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Increased stool alpha1-antitrypsin concentration

MedGen UID:
1639400
•Concept ID:
C4703479
•
Finding
HPO: HP:0031686

Definition

An abnormally elevated amount of alpha1-antitrypsin in the feces. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased stool alpha1-antitrypsin concentration

Recent clinical studies

Etiology

A Randomized Controlled Trial of Dietary Rice Bran Intake on Microbiota Diversity, Enteric Dysfunction, and Fecal Secretory IgA in Malian and Nicaraguan Infants.
Vilander AC, Hess A, Abdo Z, Ibrahim H, Doumbia L, Douyon S, Koné K, Boré A, Zambrana LE, Vilchez S, Koita O, Ryan EP
J Nutr 2022 Jul 6;152(7):1792-1800. doi: 10.1093/jn/nxac087. PMID: 35441218Free PMC Article
Fecal lactoferrin for diagnosis of symptomatic patients with ileal pouch-anal anastomosis.
Parsi MA, Shen B, Achkar JP, Remzi FF, Goldblum JR, Boone J, Lin D, Connor JT, Fazio VW, Lashner BA
Gastroenterology 2004 May;126(5):1280-6. doi: 10.1053/j.gastro.2004.02.012. PMID: 15131788
Increased concentration of fecal alpha1-antitrypsin is associated with cow's milk allergy in infants with atopic eczema.
Majamaa H, Aittoniemi J, Miettinen A
Clin Exp Allergy 2001 Apr;31(4):590-2. doi: 10.1046/j.1365-2222.2001.01035.x. PMID: 11359427
Gastrointestinal mucosal integrity after prolonged exercise with fluid supplementation.
Peters HP, Wiersma WC, Akkermans LM, Bol E, Kraaijenhagen RJ, Mosterd WL, de Vries WR, Wielders JP
Med Sci Sports Exerc 2000 Jan;32(1):134-42. doi: 10.1097/00005768-200001000-00020. PMID: 10647540
Pancreatic dysfunction and its association with fat malabsorption in HIV infected children.
Carroccio A, Fontana M, Spagnuolo MI, Zuin G, Montalto G, Canani RB, Verghi F, Di Martino D, Bastoni K, Buffardi F, Guarino A
Gut 1998 Oct;43(4):558-63. doi: 10.1136/gut.43.4.558. PMID: 9824586Free PMC Article

Diagnosis

Fecal lactoferrin for diagnosis of symptomatic patients with ileal pouch-anal anastomosis.
Parsi MA, Shen B, Achkar JP, Remzi FF, Goldblum JR, Boone J, Lin D, Connor JT, Fazio VW, Lashner BA
Gastroenterology 2004 May;126(5):1280-6. doi: 10.1053/j.gastro.2004.02.012. PMID: 15131788
Fecal alpha1-antitrypsin concentrations as a measure of enteric protein loss after modified fontan operations.
Fujii T, Shimizu T, Takahashi K, Kishiro M, Ohkubo M, Akimoto K, Yamashiro Y
J Pediatr Gastroenterol Nutr 2003 Nov;37(5):577-80. doi: 10.1097/00005176-200311000-00014. PMID: 14581800
Markers of inflammation in the feces of infants with cow's milk allergy.
Saarinen KM, Sarnesto A, Savilahti E
Pediatr Allergy Immunol 2002 Jun;13(3):188-94. doi: 10.1034/j.1399-3038.2002.01027.x. PMID: 12144641
Fecal eosinophil granule-derived proteins reflect disease activity in inflammatory bowel disease.
Saitoh O, Kojima K, Sugi K, Matsuse R, Uchida K, Tabata K, Nakagawa K, Kayazawa M, Hirata I, Katsu K
Am J Gastroenterol 1999 Dec;94(12):3513-20. doi: 10.1111/j.1572-0241.1999.01640.x. PMID: 10606313
Clinical and biological characteristics of immunopathological disease-related erythema nodosum in children.
Picco P, Gattorno M, Vignola S, Barabino A, Marazzi MG, Bondi E, Pistoia V, Buoncompagni A
Scand J Rheumatol 1999;28(1):27-32. PMID: 10092161

Therapy

A Randomized Controlled Trial of Dietary Rice Bran Intake on Microbiota Diversity, Enteric Dysfunction, and Fecal Secretory IgA in Malian and Nicaraguan Infants.
Vilander AC, Hess A, Abdo Z, Ibrahim H, Doumbia L, Douyon S, Koné K, Boré A, Zambrana LE, Vilchez S, Koita O, Ryan EP
J Nutr 2022 Jul 6;152(7):1792-1800. doi: 10.1093/jn/nxac087. PMID: 35441218Free PMC Article
Fecal alpha1-antitrypsin concentrations as a measure of enteric protein loss after modified fontan operations.
Fujii T, Shimizu T, Takahashi K, Kishiro M, Ohkubo M, Akimoto K, Yamashiro Y
J Pediatr Gastroenterol Nutr 2003 Nov;37(5):577-80. doi: 10.1097/00005176-200311000-00014. PMID: 14581800
Intestinal function in glycogen storage disease type I.
Visser G, Rake JP, Kokke FT, Nikkels PG, Sauer PJ, Smit GP
J Inherit Metab Dis 2002 Aug;25(4):261-7. doi: 10.1023/a:1016572706488. PMID: 12227456
Markers of inflammation in the feces of infants with cow's milk allergy.
Saarinen KM, Sarnesto A, Savilahti E
Pediatr Allergy Immunol 2002 Jun;13(3):188-94. doi: 10.1034/j.1399-3038.2002.01027.x. PMID: 12144641
Gastrointestinal mucosal integrity after prolonged exercise with fluid supplementation.
Peters HP, Wiersma WC, Akkermans LM, Bol E, Kraaijenhagen RJ, Mosterd WL, de Vries WR, Wielders JP
Med Sci Sports Exerc 2000 Jan;32(1):134-42. doi: 10.1097/00005768-200001000-00020. PMID: 10647540

Prognosis

Fecal eosinophil granule-derived proteins reflect disease activity in inflammatory bowel disease.
Saitoh O, Kojima K, Sugi K, Matsuse R, Uchida K, Tabata K, Nakagawa K, Kayazawa M, Hirata I, Katsu K
Am J Gastroenterol 1999 Dec;94(12):3513-20. doi: 10.1111/j.1572-0241.1999.01640.x. PMID: 10606313

Clinical prediction guides

A Randomized Controlled Trial of Dietary Rice Bran Intake on Microbiota Diversity, Enteric Dysfunction, and Fecal Secretory IgA in Malian and Nicaraguan Infants.
Vilander AC, Hess A, Abdo Z, Ibrahim H, Doumbia L, Douyon S, Koné K, Boré A, Zambrana LE, Vilchez S, Koita O, Ryan EP
J Nutr 2022 Jul 6;152(7):1792-1800. doi: 10.1093/jn/nxac087. PMID: 35441218Free PMC Article
Fecal alpha1-antitrypsin concentrations as a measure of enteric protein loss after modified fontan operations.
Fujii T, Shimizu T, Takahashi K, Kishiro M, Ohkubo M, Akimoto K, Yamashiro Y
J Pediatr Gastroenterol Nutr 2003 Nov;37(5):577-80. doi: 10.1097/00005176-200311000-00014. PMID: 14581800
Fecal eosinophil granule-derived proteins reflect disease activity in inflammatory bowel disease.
Saitoh O, Kojima K, Sugi K, Matsuse R, Uchida K, Tabata K, Nakagawa K, Kayazawa M, Hirata I, Katsu K
Am J Gastroenterol 1999 Dec;94(12):3513-20. doi: 10.1111/j.1572-0241.1999.01640.x. PMID: 10606313
Ritonavir combination therapy restores intestinal function in children with advanced HIV disease.
Canani RB, Spagnuolo MI, Cirillo P, Guarino A
J Acquir Immune Defic Syndr 1999 Aug 1;21(4):307-12. doi: 10.1097/00126334-199908010-00008. PMID: 10428109

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