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Abnormal stool composition

MedGen UID:
702847
•Concept ID:
C1279843
•
Finding
Synonyms: Abnormal composition of feces; Abnormal faecal test result; Abnormal faeces composition; Abnormal fecal test result; Abnormal feces composition
SNOMED CT: Abnormal composition of feces (228250006)
 
HPO: HP:0031685

Definition

Abnormal level of metabolite or other abnormal analyte result in a stool test. [from HPO]

Professional guidelines

PubMed

Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article
Precise strategies for selecting probiotic bacteria in treatment of intestinal bacterial dysfunctional diseases.
Yang J, Qin S, Zhang H
Front Immunol 2022;13:1034727. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.1034727. PMID: 36341458Free PMC Article
Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment.
Li N, Yang J, Zhang J, Liang C, Wang Y, Chen B, Zhao C, Wang J, Zhang G, Zhao D, Liu Y, Zhang L, Yang J, Li G, Gai Z, Zhang L, Zhao G
Genomics Proteomics Bioinformatics 2019 Feb;17(1):26-38. Epub 2019 Apr 23 doi: 10.1016/j.gpb.2019.01.002. PMID: 31026579Free PMC Article

Recent clinical studies

Etiology

Immunoregulatory role of the gut microbiota in inflammatory depression.
Liu P, Liu Z, Wang J, Wang J, Gao M, Zhang Y, Yang C, Zhang A, Li G, Li X, Liu S, Liu L, Sun N, Zhang K
Nat Commun 2024 Apr 8;15(1):3003. doi: 10.1038/s41467-024-47273-w. PMID: 38589368Free PMC Article
The role of the microbiota in glaucoma.
Huang L, Hong Y, Fu X, Tan H, Chen Y, Wang Y, Chen D
Mol Aspects Med 2023 Dec;94:101221. Epub 2023 Oct 21 doi: 10.1016/j.mam.2023.101221. PMID: 37866106
Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins.
Yang J, Hou L, Wang J, Xiao L, Zhang J, Yin N, Yao S, Cheng K, Zhang W, Shi Z, Wang J, Jiang H, Huang N, You Y, Lin M, Shang R, Wei Y, Zhao Y, Zhao F
Gut 2022 Dec;71(12):2451-2462. Epub 2022 Apr 6 doi: 10.1136/gutjnl-2021-326482. PMID: 35387876Free PMC Article
Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder.
Dan Z, Mao X, Liu Q, Guo M, Zhuang Y, Liu Z, Chen K, Chen J, Xu R, Tang J, Qin L, Gu B, Liu K, Su C, Zhang F, Xia Y, Hu Z, Liu X
Gut Microbes 2020 Sep 2;11(5):1246-1267. Epub 2020 Apr 21 doi: 10.1080/19490976.2020.1747329. PMID: 32312186Free PMC Article
Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension.
Yan X, Jin J, Su X, Yin X, Gao J, Wang X, Zhang S, Bu P, Wang M, Zhang Y, Wang Z, Zhang Q
Circ Res 2020 Mar 27;126(7):839-853. Epub 2020 Feb 13 doi: 10.1161/CIRCRESAHA.119.316394. PMID: 32078445

Diagnosis

The role of the microbiota in glaucoma.
Huang L, Hong Y, Fu X, Tan H, Chen Y, Wang Y, Chen D
Mol Aspects Med 2023 Dec;94:101221. Epub 2023 Oct 21 doi: 10.1016/j.mam.2023.101221. PMID: 37866106
Integrated Analysis of Colorectal Cancer Reveals Cross-Cohort Gut Microbial Signatures and Associated Serum Metabolites.
Gao R, Wu C, Zhu Y, Kong C, Zhu Y, Gao Y, Zhang X, Yang R, Zhong H, Xiong X, Chen C, Xu Q, Qin H
Gastroenterology 2022 Oct;163(4):1024-1037.e9. Epub 2022 Jul 1 doi: 10.1053/j.gastro.2022.06.069. PMID: 35788345
Development of the gut microbiome in early life.
Ahearn-Ford S, Berrington JE, Stewart CJ
Exp Physiol 2022 May;107(5):415-421. Epub 2022 Jan 30 doi: 10.1113/EP089919. PMID: 35041771Free PMC Article
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragón L, Jacquelot N, Qu B, Ferrere G, Clémenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G, Zitvogel L
Science 2018 Jan 5;359(6371):91-97. Epub 2017 Nov 2 doi: 10.1126/science.aan3706. PMID: 29097494
Endemic skeletal fluorosis.
Teotia M, Teotia SP, Kunwar KB
Arch Dis Child 1971 Oct;46(249):686-91. doi: 10.1136/adc.46.249.686. PMID: 5118057Free PMC Article

Therapy

Immunoregulatory role of the gut microbiota in inflammatory depression.
Liu P, Liu Z, Wang J, Wang J, Gao M, Zhang Y, Yang C, Zhang A, Li G, Li X, Liu S, Liu L, Sun N, Zhang K
Nat Commun 2024 Apr 8;15(1):3003. doi: 10.1038/s41467-024-47273-w. PMID: 38589368Free PMC Article
Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension.
Yan X, Jin J, Su X, Yin X, Gao J, Wang X, Zhang S, Bu P, Wang M, Zhang Y, Wang Z, Zhang Q
Circ Res 2020 Mar 27;126(7):839-853. Epub 2020 Feb 13 doi: 10.1161/CIRCRESAHA.119.316394. PMID: 32078445
Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities.
Zeng Q, Li D, He Y, Li Y, Yang Z, Zhao X, Liu Y, Wang Y, Sun J, Feng X, Wang F, Chen J, Zheng Y, Yang Y, Sun X, Xu X, Wang D, Kenney T, Jiang Y, Gu H, Li Y, Zhou K, Li S, Dai W
Sci Rep 2019 Sep 17;9(1):13424. doi: 10.1038/s41598-019-49462-w. PMID: 31530820Free PMC Article
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragón L, Jacquelot N, Qu B, Ferrere G, Clémenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G, Zitvogel L
Science 2018 Jan 5;359(6371):91-97. Epub 2017 Nov 2 doi: 10.1126/science.aan3706. PMID: 29097494
Artificial sweeteners induce glucose intolerance by altering the gut microbiota.
Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E
Nature 2014 Oct 9;514(7521):181-6. Epub 2014 Sep 17 doi: 10.1038/nature13793. PMID: 25231862

Prognosis

Fecal Coprococcus, hidden behind abdominal symptoms in patients with small intestinal bacterial overgrowth.
Guo H, Chen Y, Dong W, Lu S, Du Y, Duan L
J Transl Med 2024 May 25;22(1):496. doi: 10.1186/s12967-024-05316-2. PMID: 38796441Free PMC Article
Gut Microbiome Alterations and Functional Prediction in Chronic Spontaneous Urticaria Patients.
Zhang X, Zhang J, Chu Z, Shi L, Geng S, Guo K
J Microbiol Biotechnol 2021 May 28;31(5):747-755. doi: 10.4014/jmb.2012.12022. PMID: 33746191Free PMC Article
Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities.
Zeng Q, Li D, He Y, Li Y, Yang Z, Zhao X, Liu Y, Wang Y, Sun J, Feng X, Wang F, Chen J, Zheng Y, Yang Y, Sun X, Xu X, Wang D, Kenney T, Jiang Y, Gu H, Li Y, Zhou K, Li S, Dai W
Sci Rep 2019 Sep 17;9(1):13424. doi: 10.1038/s41598-019-49462-w. PMID: 31530820Free PMC Article
Intestinal Microbiota in Hirschsprung Disease.
Neuvonen MI, Korpela K, Kyrklund K, Salonen A, de Vos W, Rintala RJ, Pakarinen MP
J Pediatr Gastroenterol Nutr 2018 Nov;67(5):594-600. doi: 10.1097/MPG.0000000000001999. PMID: 29652728
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.
Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Ter Horst R, Jansen T, Jacobs L, Bonder MJ, Kurilshikov A, Fu J, Joosten LAB, Zhernakova A, Huttenhower C, Wijmenga C, Netea MG, Xavier RJ
Cell 2016 Nov 3;167(4):1125-1136.e8. doi: 10.1016/j.cell.2016.10.020. PMID: 27814509Free PMC Article

Clinical prediction guides

Immunoregulatory role of the gut microbiota in inflammatory depression.
Liu P, Liu Z, Wang J, Wang J, Gao M, Zhang Y, Yang C, Zhang A, Li G, Li X, Liu S, Liu L, Sun N, Zhang K
Nat Commun 2024 Apr 8;15(1):3003. doi: 10.1038/s41467-024-47273-w. PMID: 38589368Free PMC Article
Gut microbiota composition is associated with disease severity and host immune responses in COVID-19.
Fan R, Liu S, Sun N, Yang Y, Deng X, Hu B, Sun C, Wen C, Li H, Cheng D, Huang C, Hou P, Zhang T
Front Cell Infect Microbiol 2023;13:1274690. Epub 2023 Dec 12 doi: 10.3389/fcimb.2023.1274690. PMID: 38149007Free PMC Article
Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder.
Dan Z, Mao X, Liu Q, Guo M, Zhuang Y, Liu Z, Chen K, Chen J, Xu R, Tang J, Qin L, Gu B, Liu K, Su C, Zhang F, Xia Y, Hu Z, Liu X
Gut Microbes 2020 Sep 2;11(5):1246-1267. Epub 2020 Apr 21 doi: 10.1080/19490976.2020.1747329. PMID: 32312186Free PMC Article
Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities.
Zeng Q, Li D, He Y, Li Y, Yang Z, Zhao X, Liu Y, Wang Y, Sun J, Feng X, Wang F, Chen J, Zheng Y, Yang Y, Sun X, Xu X, Wang D, Kenney T, Jiang Y, Gu H, Li Y, Zhou K, Li S, Dai W
Sci Rep 2019 Sep 17;9(1):13424. doi: 10.1038/s41598-019-49462-w. PMID: 31530820Free PMC Article
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.
Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Ter Horst R, Jansen T, Jacobs L, Bonder MJ, Kurilshikov A, Fu J, Joosten LAB, Zhernakova A, Huttenhower C, Wijmenga C, Netea MG, Xavier RJ
Cell 2016 Nov 3;167(4):1125-1136.e8. doi: 10.1016/j.cell.2016.10.020. PMID: 27814509Free PMC Article

Recent systematic reviews

Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article

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