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Abnormal stool composition

MedGen UID:
702847
•Concept ID:
C1279843
•
Finding
Synonyms: Abnormal composition of feces; Abnormal faecal test result; Abnormal faeces composition; Abnormal fecal test result; Abnormal feces composition
SNOMED CT: Abnormal composition of feces (228250006)
 
HPO: HP:0031685

Definition

Abnormal level of metabolite or other abnormal analyte result in a stool test. [from HPO]

Professional guidelines

PubMed

Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article
Precise strategies for selecting probiotic bacteria in treatment of intestinal bacterial dysfunctional diseases.
Yang J, Qin S, Zhang H
Front Immunol 2022;13:1034727. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.1034727. PMID: 36341458Free PMC Article
Changes in metabolism and microbiota after 24-week risperidone treatment in drug naïve, normal weight patients with first episode schizophrenia.
Yuan X, Zhang P, Wang Y, Liu Y, Li X, Kumar BU, Hei G, Lv L, Huang XF, Fan X, Song X
Schizophr Res 2018 Nov;201:299-306. Epub 2018 May 30 doi: 10.1016/j.schres.2018.05.017. PMID: 29859859

Recent clinical studies

Etiology

Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article
Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins.
Yang J, Hou L, Wang J, Xiao L, Zhang J, Yin N, Yao S, Cheng K, Zhang W, Shi Z, Wang J, Jiang H, Huang N, You Y, Lin M, Shang R, Wei Y, Zhao Y, Zhao F
Gut 2022 Dec;71(12):2451-2462. Epub 2022 Apr 6 doi: 10.1136/gutjnl-2021-326482. PMID: 35387876Free PMC Article
Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension.
Yan X, Jin J, Su X, Yin X, Gao J, Wang X, Zhang S, Bu P, Wang M, Zhang Y, Wang Z, Zhang Q
Circ Res 2020 Mar 27;126(7):839-853. Epub 2020 Feb 13 doi: 10.1161/CIRCRESAHA.119.316394. PMID: 32078445
Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities.
Zeng Q, Li D, He Y, Li Y, Yang Z, Zhao X, Liu Y, Wang Y, Sun J, Feng X, Wang F, Chen J, Zheng Y, Yang Y, Sun X, Xu X, Wang D, Kenney T, Jiang Y, Gu H, Li Y, Zhou K, Li S, Dai W
Sci Rep 2019 Sep 17;9(1):13424. doi: 10.1038/s41598-019-49462-w. PMID: 31530820Free PMC Article
Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease.
Dubinkina VB, Tyakht AV, Odintsova VY, Yarygin KS, Kovarsky BA, Pavlenko AV, Ischenko DS, Popenko AS, Alexeev DG, Taraskina AY, Nasyrova RF, Krupitsky EM, Shalikiani NV, Bakulin IG, Shcherbakov PL, Skorodumova LO, Larin AK, Kostryukova ES, Abdulkhakov RA, Abdulkhakov SR, Malanin SY, Ismagilova RK, Grigoryeva TV, Ilina EN, Govorun VM
Microbiome 2017 Oct 17;5(1):141. doi: 10.1186/s40168-017-0359-2. PMID: 29041989Free PMC Article

Diagnosis

The role of the microbiota in glaucoma.
Huang L, Hong Y, Fu X, Tan H, Chen Y, Wang Y, Chen D
Mol Aspects Med 2023 Dec;94:101221. Epub 2023 Oct 21 doi: 10.1016/j.mam.2023.101221. PMID: 37866106
Integrated Analysis of Colorectal Cancer Reveals Cross-Cohort Gut Microbial Signatures and Associated Serum Metabolites.
Gao R, Wu C, Zhu Y, Kong C, Zhu Y, Gao Y, Zhang X, Yang R, Zhong H, Xiong X, Chen C, Xu Q, Qin H
Gastroenterology 2022 Oct;163(4):1024-1037.e9. Epub 2022 Jul 1 doi: 10.1053/j.gastro.2022.06.069. PMID: 35788345
Development of the gut microbiome in early life.
Ahearn-Ford S, Berrington JE, Stewart CJ
Exp Physiol 2022 May;107(5):415-421. Epub 2022 Jan 30 doi: 10.1113/EP089919. PMID: 35041771Free PMC Article
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragón L, Jacquelot N, Qu B, Ferrere G, Clémenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G, Zitvogel L
Science 2018 Jan 5;359(6371):91-97. Epub 2017 Nov 2 doi: 10.1126/science.aan3706. PMID: 29097494
Endemic skeletal fluorosis.
Teotia M, Teotia SP, Kunwar KB
Arch Dis Child 1971 Oct;46(249):686-91. doi: 10.1136/adc.46.249.686. PMID: 5118057Free PMC Article

Therapy

Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article
Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension.
Yan X, Jin J, Su X, Yin X, Gao J, Wang X, Zhang S, Bu P, Wang M, Zhang Y, Wang Z, Zhang Q
Circ Res 2020 Mar 27;126(7):839-853. Epub 2020 Feb 13 doi: 10.1161/CIRCRESAHA.119.316394. PMID: 32078445
Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors.
Routy B, Le Chatelier E, Derosa L, Duong CPM, Alou MT, Daillère R, Fluckiger A, Messaoudene M, Rauber C, Roberti MP, Fidelle M, Flament C, Poirier-Colame V, Opolon P, Klein C, Iribarren K, Mondragón L, Jacquelot N, Qu B, Ferrere G, Clémenson C, Mezquita L, Masip JR, Naltet C, Brosseau S, Kaderbhai C, Richard C, Rizvi H, Levenez F, Galleron N, Quinquis B, Pons N, Ryffel B, Minard-Colin V, Gonin P, Soria JC, Deutsch E, Loriot Y, Ghiringhelli F, Zalcman G, Goldwasser F, Escudier B, Hellmann MD, Eggermont A, Raoult D, Albiges L, Kroemer G, Zitvogel L
Science 2018 Jan 5;359(6371):91-97. Epub 2017 Nov 2 doi: 10.1126/science.aan3706. PMID: 29097494
Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease.
Dubinkina VB, Tyakht AV, Odintsova VY, Yarygin KS, Kovarsky BA, Pavlenko AV, Ischenko DS, Popenko AS, Alexeev DG, Taraskina AY, Nasyrova RF, Krupitsky EM, Shalikiani NV, Bakulin IG, Shcherbakov PL, Skorodumova LO, Larin AK, Kostryukova ES, Abdulkhakov RA, Abdulkhakov SR, Malanin SY, Ismagilova RK, Grigoryeva TV, Ilina EN, Govorun VM
Microbiome 2017 Oct 17;5(1):141. doi: 10.1186/s40168-017-0359-2. PMID: 29041989Free PMC Article
Artificial sweeteners induce glucose intolerance by altering the gut microbiota.
Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E
Nature 2014 Oct 9;514(7521):181-6. Epub 2014 Sep 17 doi: 10.1038/nature13793. PMID: 25231862

Prognosis

Gut Microbiome Alterations and Functional Prediction in Chronic Spontaneous Urticaria Patients.
Zhang X, Zhang J, Chu Z, Shi L, Geng S, Guo K
J Microbiol Biotechnol 2021 May 28;31(5):747-755. doi: 10.4014/jmb.2012.12022. PMID: 33746191Free PMC Article
Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities.
Zeng Q, Li D, He Y, Li Y, Yang Z, Zhao X, Liu Y, Wang Y, Sun J, Feng X, Wang F, Chen J, Zheng Y, Yang Y, Sun X, Xu X, Wang D, Kenney T, Jiang Y, Gu H, Li Y, Zhou K, Li S, Dai W
Sci Rep 2019 Sep 17;9(1):13424. doi: 10.1038/s41598-019-49462-w. PMID: 31530820Free PMC Article
Meconium microbiome as a new source of information about long-term health and disease: questions and answers.
Wilczyńska P, Skarżyńska E, Lisowska-Myjak B
J Matern Fetal Neonatal Med 2019 Feb;32(4):681-686. Epub 2018 May 15 doi: 10.1080/14767058.2017.1387888. PMID: 28969463
Intestinal Microbiota in Hirschsprung Disease.
Neuvonen MI, Korpela K, Kyrklund K, Salonen A, de Vos W, Rintala RJ, Pakarinen MP
J Pediatr Gastroenterol Nutr 2018 Nov;67(5):594-600. doi: 10.1097/MPG.0000000000001999. PMID: 29652728
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.
Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Ter Horst R, Jansen T, Jacobs L, Bonder MJ, Kurilshikov A, Fu J, Joosten LAB, Zhernakova A, Huttenhower C, Wijmenga C, Netea MG, Xavier RJ
Cell 2016 Nov 3;167(4):1125-1136.e8. doi: 10.1016/j.cell.2016.10.020. PMID: 27814509Free PMC Article

Clinical prediction guides

Gut Microbiome Alterations and Functional Prediction in Chronic Spontaneous Urticaria Patients.
Zhang X, Zhang J, Chu Z, Shi L, Geng S, Guo K
J Microbiol Biotechnol 2021 May 28;31(5):747-755. doi: 10.4014/jmb.2012.12022. PMID: 33746191Free PMC Article
Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder.
Dan Z, Mao X, Liu Q, Guo M, Zhuang Y, Liu Z, Chen K, Chen J, Xu R, Tang J, Qin L, Gu B, Liu K, Su C, Zhang F, Xia Y, Hu Z, Liu X
Gut Microbes 2020 Sep 2;11(5):1246-1267. Epub 2020 Apr 21 doi: 10.1080/19490976.2020.1747329. PMID: 32312186Free PMC Article
Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities.
Zeng Q, Li D, He Y, Li Y, Yang Z, Zhao X, Liu Y, Wang Y, Sun J, Feng X, Wang F, Chen J, Zheng Y, Yang Y, Sun X, Xu X, Wang D, Kenney T, Jiang Y, Gu H, Li Y, Zhou K, Li S, Dai W
Sci Rep 2019 Sep 17;9(1):13424. doi: 10.1038/s41598-019-49462-w. PMID: 31530820Free PMC Article
Intestinal Microbiota in Hirschsprung Disease.
Neuvonen MI, Korpela K, Kyrklund K, Salonen A, de Vos W, Rintala RJ, Pakarinen MP
J Pediatr Gastroenterol Nutr 2018 Nov;67(5):594-600. doi: 10.1097/MPG.0000000000001999. PMID: 29652728
Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity.
Schirmer M, Smeekens SP, Vlamakis H, Jaeger M, Oosting M, Franzosa EA, Ter Horst R, Jansen T, Jacobs L, Bonder MJ, Kurilshikov A, Fu J, Joosten LAB, Zhernakova A, Huttenhower C, Wijmenga C, Netea MG, Xavier RJ
Cell 2016 Nov 3;167(4):1125-1136.e8. doi: 10.1016/j.cell.2016.10.020. PMID: 27814509Free PMC Article

Recent systematic reviews

Fecal transplantation for treatment of inflammatory bowel disease.
Imdad A, Pandit NG, Zaman M, Minkoff NZ, Tanner-Smith EE, Gomez-Duarte OG, Acra S, Nicholson MR
Cochrane Database Syst Rev 2023 Apr 25;4(4):CD012774. doi: 10.1002/14651858.CD012774.pub3. PMID: 37094824Free PMC Article

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