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Oocyte maturation defect 5(OOMD5; OZEMA5)

MedGen UID:
1644330
Concept ID:
C4693865
Gene or Genome
Synonym: OOCYTE/ZYGOTE/EMBRYO MATURATION ARREST 5
 
Gene (location): WEE2 (7q34)
 
Monarch Initiative: MONDO:0020837
OMIM®: 617996

Definition

Oocyte/zygote/embryo maturation arrest-5 (OZEMA5) is characterized by female infertility due to inability of the oocyte to exit metaphase II, resulting in fertilization failure (Sang et al., 2018). For a discussion of genetic heterogeneity of OZEMA, see 615774. [from OMIM]

Clinical features

From HPO
Female infertility
MedGen UID:
5795
Concept ID:
C0021361
Pathologic Function
Infertility in a woman.
Lack of oocyte pronucleus formation
MedGen UID:
1842028
Concept ID:
C5826611
Cell or Molecular Dysfunction
An abnormality of oocyte maturation characterized by the inability of oocytes to form pronuclei after in vitro fertilization procedures. Oocytes normally show two pronuclei 17 to 20 hours after in vitro insemination.

Professional guidelines

PubMed

Fesahat F, Montazeri F, Hoseini SM
J Gynecol Obstet Hum Reprod 2020 May;49(5):101723. Epub 2020 Feb 26 doi: 10.1016/j.jogoh.2020.101723. PMID: 32113002
Tesarik J, Mendoza C
Front Biosci 2007 Jan 1;12:105-14. doi: 10.2741/2051. PMID: 17127286

Recent clinical studies

Etiology

Yang M, Shen X, Lu D, Peng J, Zhou S, Xu L, Zhang J
Front Endocrinol (Lausanne) 2023;14:1148556. Epub 2023 Aug 1 doi: 10.3389/fendo.2023.1148556. PMID: 37593349Free PMC Article
Chico-Sordo L, Polonio AM, Córdova-Oriz I, Medrano M, Herraiz S, Bronet F, García-Velasco JA, Varela E
Reproduction 2022 Nov 1;164(5):259-267. Epub 2022 Oct 17 doi: 10.1530/REP-22-0243. PMID: 36136831
Vanni VS, Alteri A, De Santis L, Cermisoni GC, Rabellotti E, Delprato D, Parma M, Papaleo E, Fedele L, Candiani M
J Vis Exp 2022 May 10;(183) doi: 10.3791/63634. PMID: 35635474
Pivonello C, Muscogiuri G, Nardone A, Garifalos F, Provvisiero DP, Verde N, de Angelis C, Conforti A, Piscopo M, Auriemma RS, Colao A, Pivonello R
Reprod Biol Endocrinol 2020 Mar 14;18(1):22. doi: 10.1186/s12958-019-0558-8. PMID: 32171313Free PMC Article
Plachot M
Mol Cell Endocrinol 2001 Oct 22;183 Suppl 1:S59-63. doi: 10.1016/s0303-7207(01)00577-9. PMID: 11576735

Diagnosis

Capalbo A, Buonaiuto S, Figliuzzi M, Damaggio G, Girardi L, Caroselli S, Poli M, Patassini C, Cetinkaya M, Yuksel B, Azad A, Grøndahl ML, Hoffmann ER, Simón C, Colonna V, Kahraman S
Reprod Biomed Online 2022 Sep;45(3):508-518. Epub 2022 May 21 doi: 10.1016/j.rbmo.2022.05.009. PMID: 35798635
Pivonello C, Muscogiuri G, Nardone A, Garifalos F, Provvisiero DP, Verde N, de Angelis C, Conforti A, Piscopo M, Auriemma RS, Colao A, Pivonello R
Reprod Biol Endocrinol 2020 Mar 14;18(1):22. doi: 10.1186/s12958-019-0558-8. PMID: 32171313Free PMC Article
Guerri G, Maniscalchi T, Barati S, Gerli S, Di Renzo GC, Della Morte C, Marceddu G, Casadei A, Laganà AS, Sturla D, Ghezzi F, Garzon S, Unfer V, Bertelli M
Acta Biomed 2019 Sep 30;90(10-S):68-74. doi: 10.23750/abm.v90i10-S.8763. PMID: 31577258Free PMC Article
Yeste M, Jones C, Amdani SN, Patel S, Coward K
Hum Reprod Update 2016 Jan-Feb;22(1):23-47. Epub 2015 Sep 7 doi: 10.1093/humupd/dmv040. PMID: 26346057
Plachot M
Mol Cell Endocrinol 2001 Oct 22;183 Suppl 1:S59-63. doi: 10.1016/s0303-7207(01)00577-9. PMID: 11576735

Therapy

Hatirnaz S, Hatirnaz E, Urkmez SS, Calıskan CS, Celik S, Hatirnaz K, Cao M, Tan SL, Dahan MH
Reprod Biomed Online 2024 Mar;48(3):103620. Epub 2023 Oct 14 doi: 10.1016/j.rbmo.2023.103620. PMID: 38194886
Yang M, Shen X, Lu D, Peng J, Zhou S, Xu L, Zhang J
Front Endocrinol (Lausanne) 2023;14:1148556. Epub 2023 Aug 1 doi: 10.3389/fendo.2023.1148556. PMID: 37593349Free PMC Article
Gao L, Zhang C, Yu S, Liu S, Wang G, Lan H, Zheng X, Li S
Environ Pollut 2022 Sep 15;309:119756. Epub 2022 Jul 12 doi: 10.1016/j.envpol.2022.119756. PMID: 35839969
Capalbo A, Buonaiuto S, Figliuzzi M, Damaggio G, Girardi L, Caroselli S, Poli M, Patassini C, Cetinkaya M, Yuksel B, Azad A, Grøndahl ML, Hoffmann ER, Simón C, Colonna V, Kahraman S
Reprod Biomed Online 2022 Sep;45(3):508-518. Epub 2022 May 21 doi: 10.1016/j.rbmo.2022.05.009. PMID: 35798635
Pivonello C, Muscogiuri G, Nardone A, Garifalos F, Provvisiero DP, Verde N, de Angelis C, Conforti A, Piscopo M, Auriemma RS, Colao A, Pivonello R
Reprod Biol Endocrinol 2020 Mar 14;18(1):22. doi: 10.1186/s12958-019-0558-8. PMID: 32171313Free PMC Article

Prognosis

Shats M, Fenchel D, Katz G, Haas J, Machtinger R, Gat I, Orvieto R, Kedem A
Gynecol Endocrinol 2021 Jan;37(1):41-45. Epub 2020 Apr 27 doi: 10.1080/09513590.2020.1756248. PMID: 32338095
Torra-Massana M, Cornet-Bartolomé D, Barragán M, Durban M, Ferrer-Vaquer A, Zambelli F, Rodriguez A, Oliva R, Vassena R
Hum Reprod 2019 Aug 1;34(8):1494-1504. doi: 10.1093/humrep/dez094. PMID: 31347677
Gill K, Rosiak A, Gaczarzewicz D, Jakubik J, Kurzawa R, Kazienko A, Rymaszewska A, Laszczynska M, Grochans E, Piasecka M
Hum Cell 2018 Jul;31(3):220-231. Epub 2018 Mar 29 doi: 10.1007/s13577-018-0203-4. PMID: 29594950
Buckett WM, Chian RC, Dean NL, Sylvestre C, Holzer HE, Tan SL
Fertil Steril 2008 Sep;90(3):546-50. Epub 2007 Sep 27 doi: 10.1016/j.fertnstert.2007.06.107. PMID: 17904128
Chillarón J, Estévez R, Samarzija I, Waldegger S, Testar X, Lang F, Zorzano A, Busch A, Palacín M
J Biol Chem 1997 Apr 4;272(14):9543-9. doi: 10.1074/jbc.272.14.9543. PMID: 9083097

Clinical prediction guides

Yang M, Shen X, Lu D, Peng J, Zhou S, Xu L, Zhang J
Front Endocrinol (Lausanne) 2023;14:1148556. Epub 2023 Aug 1 doi: 10.3389/fendo.2023.1148556. PMID: 37593349Free PMC Article
Wang L, Li L, Zhao Y, Xu B, Yue J, Zhang H, Jin L
BMC Pregnancy Childbirth 2022 Dec 26;22(1):965. doi: 10.1186/s12884-022-05297-4. PMID: 36572853Free PMC Article
Torra-Massana M, Cornet-Bartolomé D, Barragán M, Durban M, Ferrer-Vaquer A, Zambelli F, Rodriguez A, Oliva R, Vassena R
Hum Reprod 2019 Aug 1;34(8):1494-1504. doi: 10.1093/humrep/dez094. PMID: 31347677
Steffann J, Monnot S, Bonnefont JP
Clin Genet 2015 Nov;88(5):416-24. Epub 2015 Feb 3 doi: 10.1111/cge.12557. PMID: 25523230
Espeel M, Depreter M, Nardacci R, D'Herde K, Kerckaert I, Stefanini S, Roels F
Microsc Res Tech 1997 Dec 1;39(5):453-66. doi: 10.1002/(SICI)1097-0029(19971201)39:5<453::AID-JEMT8>3.0.CO;2-H. PMID: 9408912

Recent systematic reviews

Yang M, Shen X, Lu D, Peng J, Zhou S, Xu L, Zhang J
Front Endocrinol (Lausanne) 2023;14:1148556. Epub 2023 Aug 1 doi: 10.3389/fendo.2023.1148556. PMID: 37593349Free PMC Article
Irani M, Robles A, Gunnala V, Chung P, Rosenwaks Z
Gynecol Endocrinol 2018 Feb;34(2):92-99. Epub 2017 Oct 24 doi: 10.1080/09513590.2017.1390738. PMID: 29063807

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