Lack of oocyte pronucleus formation

MedGen UID:: 1842028
•Concept ID:: C5826611
•: Cell or Molecular Dysfunction

HPO:	HP:0034719

Definition

An abnormality of oocyte maturation characterized by the inability of oocytes to form pronuclei after in vitro fertilization procedures. Oocytes normally show two pronuclei 17 to 20 hours after in vitro insemination. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVLack of oocyte pronucleus formation

Abnormality of the genitourinary system
- Abnormality of the genital system
  - Abnormality of reproductive system physiology
    - Abnormal gametogenesis
      - Abnormal meiosis
        Abnormal female meiosis
        Lack of oocyte pronucleus formation

Conditions with this feature

Oocyte maturation defect 5

MedGen UID:: 1644330
•Concept ID:: C4693865
•: Gene or Genome

Oocyte/zygote/embryo maturation arrest-5 (OZEMA5) is characterized by female infertility due to inability of the oocyte to exit metaphase II, resulting in fertilization failure (Sang et al., 2018). For a discussion of genetic heterogeneity of OZEMA, see 615774.

Oocyte maturation defect 5