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Susceptibility to bulimia nervosa(BULN)

MedGen UID:
1646891
•Concept ID:
C4551963
•
Finding
Synonym: BULN
 
OMIM®: 607499

Definition

Bulimia nervosa (BN) is a psychiatric disorder characterized by episodes of binge-eating (eating an unusually large amount of food in a discrete period of time and feeling out of control), compensatory behavior (e.g., self-induced vomiting or laxative abuse), and over-concern with weight and shape. Eating disorders such as bulimia nervosa are complex disorders that can be influenced by many genes. [from OMIM]

Clinical features

From HPO
Bulimia
MedGen UID:
684
•Concept ID:
C0006370
•
Mental or Behavioral Dysfunction
A form of anomalous eating behavior characterized by binge eating is followed by self-induced vomiting or other compensatory behavior intended to prevent weight gain (purging, fasting or exercising or a combination of these).
See: Feature record | Search on this feature
  • Abnormality of the nervous system

Professional guidelines

PubMed

A systematic review on the role of microbiota in the pathogenesis and treatment of eating disorders.
Carbone EA, D'Amato P, Vicchio G, De Fazio P, Segura-Garcia C
Eur Psychiatry 2020 Dec 16;64(1):e2. doi: 10.1192/j.eurpsy.2020.109. PMID: 33416044Free PMC Article
Eating disorders, serotonin transporter polymorphisms and potential treatment response.
Gorwood P
Am J Pharmacogenomics 2004;4(1):9-17. doi: 10.2165/00129785-200404010-00002. PMID: 14987118
Serotonin neuronal function and selective serotonin reuptake inhibitor treatment in anorexia and bulimia nervosa.
Kaye W, Gendall K, Strober M
Biol Psychiatry 1998 Nov 1;44(9):825-38. doi: 10.1016/s0006-3223(98)00195-4. PMID: 9807638

Curated

UK NICE Guideline NG69, Eating disorders: recognition and treatment, 2020

Recent clinical studies

Etiology

Eating Disorders in Male Athletes.
Eichstadt M, Luzier J, Cho D, Weisenmuller C
Sports Health 2020 Jul/Aug;12(4):327-333. Epub 2020 Jun 11 doi: 10.1177/1941738120928991. PMID: 32525767Free PMC Article
Sex Differences in Adolescent Anorexia and Bulimia Nervosa: Beyond the Signs and Symptoms.
Timko CA, DeFilipp L, Dakanalis A
Curr Psychiatry Rep 2019 Jan 12;21(1):1. doi: 10.1007/s11920-019-0988-1. PMID: 30637488Free PMC Article
Eating disorders: progress and challenges.
Dalle Grave R
Eur J Intern Med 2011 Apr;22(2):153-60. Epub 2011 Jan 14 doi: 10.1016/j.ejim.2010.12.010. PMID: 21402245
The genetics of eating disorders.
Helder SG, Collier DA
Curr Top Behav Neurosci 2011;6:157-75. doi: 10.1007/7854_2010_79. PMID: 21243475
Eating disorders.
Fairburn CG, Harrison PJ
Lancet 2003 Feb 1;361(9355):407-16. doi: 10.1016/S0140-6736(03)12378-1. PMID: 12573387

Diagnosis

Eating Disorders in Male Athletes.
Eichstadt M, Luzier J, Cho D, Weisenmuller C
Sports Health 2020 Jul/Aug;12(4):327-333. Epub 2020 Jun 11 doi: 10.1177/1941738120928991. PMID: 32525767Free PMC Article
Eating disorders: progress and challenges.
Dalle Grave R
Eur J Intern Med 2011 Apr;22(2):153-60. Epub 2011 Jan 14 doi: 10.1016/j.ejim.2010.12.010. PMID: 21402245
The genetics of eating disorders.
Helder SG, Collier DA
Curr Top Behav Neurosci 2011;6:157-75. doi: 10.1007/7854_2010_79. PMID: 21243475
Genetic susceptibility to eating disorders: associated polymorphisms and pharmacogenetic suggestions.
Monteleone P, Maj M
Pharmacogenomics 2008 Oct;9(10):1487-520. doi: 10.2217/14622416.9.10.1487. PMID: 18855537
Eating disorders.
Fairburn CG, Harrison PJ
Lancet 2003 Feb 1;361(9355):407-16. doi: 10.1016/S0140-6736(03)12378-1. PMID: 12573387

Therapy

Eating disorders, serotonin transporter polymorphisms and potential treatment response.
Gorwood P
Am J Pharmacogenomics 2004;4(1):9-17. doi: 10.2165/00129785-200404010-00002. PMID: 14987118
Eating disorders.
Fairburn CG, Harrison PJ
Lancet 2003 Feb 1;361(9355):407-16. doi: 10.1016/S0140-6736(03)12378-1. PMID: 12573387
A search for susceptibility loci for anorexia nervosa: methods and sample description.
Kaye WH, Lilenfeld LR, Berrettini WH, Strober M, Devlin B, Klump KL, Goldman D, Bulik CM, Halmi KA, Fichter MM, Kaplan A, Woodside DB, Treasure J, Plotnicov KH, Pollice C, Rao R, McConaha CW
Biol Psychiatry 2000 May 1;47(9):794-803. doi: 10.1016/s0006-3223(99)00240-1. PMID: 10812038
New directions in treatment research of anorexia and bulimia nervosa.
Kaye W, Strober M, Stein D, Gendall K
Biol Psychiatry 1999 May 15;45(10):1285-92. doi: 10.1016/s0006-3223(99)00048-7. PMID: 10349034
Serotonin neuronal function and selective serotonin reuptake inhibitor treatment in anorexia and bulimia nervosa.
Kaye W, Gendall K, Strober M
Biol Psychiatry 1998 Nov 1;44(9):825-38. doi: 10.1016/s0006-3223(98)00195-4. PMID: 9807638

Prognosis

A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders.
Rozenblat V, Ong D, Fuller-Tyszkiewicz M, Akkermann K, Collier D, Engels RCME, Fernandez-Aranda F, Harro J, Homberg JR, Karwautz A, Kiive E, Klump KL, Larson CL, Racine SE, Richardson J, Steiger H, Stoltenberg SF, van Strien T, Wagner G, Treasure J, Krug I
J Psychiatr Res 2017 Jan;84:62-72. Epub 2016 Sep 24 doi: 10.1016/j.jpsychires.2016.09.023. PMID: 27701012Free PMC Article
Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating- and personality-related psychopathology.
Thaler L, Groleau P, Badawi G, Sycz L, Zeramdini N, Too A, Israel M, Joober R, Bruce KR, Steiger H
Prog Neuropsychopharmacol Biol Psychiatry 2012 Oct 1;39(1):120-8. Epub 2012 Jun 6 doi: 10.1016/j.pnpbp.2012.05.019. PMID: 22683321
An introduction to eating disorders: clinical presentation, epidemiology, and prognosis.
Miller CA, Golden NH
Nutr Clin Pract 2010 Apr;25(2):110-5. doi: 10.1177/0884533609357566. PMID: 20413691
Genetic susceptibility to eating disorders: associated polymorphisms and pharmacogenetic suggestions.
Monteleone P, Maj M
Pharmacogenomics 2008 Oct;9(10):1487-520. doi: 10.2217/14622416.9.10.1487. PMID: 18855537
Suicide attempts in anorexia nervosa.
Bulik CM, Thornton L, Pinheiro AP, Plotnicov K, Klump KL, Brandt H, Crawford S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, Mitchell J, Nutzinger D, Strober M, Treasure J, Woodside DB, Berrettini WH, Kaye WH
Psychosom Med 2008 Apr;70(3):378-83. Epub 2008 Feb 6 doi: 10.1097/PSY.0b013e3181646765. PMID: 18256339

Clinical prediction guides

Association of 5-HTR2A -1438A/G polymorphism with anorexia nervosa and bulimia nervosa: A meta-analysis.
Yan P, Gao B, Wang S, Wang S, Li J, Song M
Neurosci Lett 2021 Jun 11;755:135918. Epub 2021 Apr 30 doi: 10.1016/j.neulet.2021.135918. PMID: 33940056
A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders.
Rozenblat V, Ong D, Fuller-Tyszkiewicz M, Akkermann K, Collier D, Engels RCME, Fernandez-Aranda F, Harro J, Homberg JR, Karwautz A, Kiive E, Klump KL, Larson CL, Racine SE, Richardson J, Steiger H, Stoltenberg SF, van Strien T, Wagner G, Treasure J, Krug I
J Psychiatr Res 2017 Jan;84:62-72. Epub 2016 Sep 24 doi: 10.1016/j.jpsychires.2016.09.023. PMID: 27701012Free PMC Article
Eating disorders: progress and challenges.
Dalle Grave R
Eur J Intern Med 2011 Apr;22(2):153-60. Epub 2011 Jan 14 doi: 10.1016/j.ejim.2010.12.010. PMID: 21402245
Interspecies genetics of eating disorder traits.
Kas MJ, Kaye WH, Foulds Mathes W, Bulik CM
Am J Med Genet B Neuropsychiatr Genet 2009 Apr 5;150B(3):318-27. doi: 10.1002/ajmg.b.30832. PMID: 18646037Free PMC Article
Genetic susceptibility to eating disorders: associated polymorphisms and pharmacogenetic suggestions.
Monteleone P, Maj M
Pharmacogenomics 2008 Oct;9(10):1487-520. doi: 10.2217/14622416.9.10.1487. PMID: 18855537

Recent systematic reviews

A systematic review on the role of microbiota in the pathogenesis and treatment of eating disorders.
Carbone EA, D'Amato P, Vicchio G, De Fazio P, Segura-Garcia C
Eur Psychiatry 2020 Dec 16;64(1):e2. doi: 10.1192/j.eurpsy.2020.109. PMID: 33416044Free PMC Article
A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders.
Rozenblat V, Ong D, Fuller-Tyszkiewicz M, Akkermann K, Collier D, Engels RCME, Fernandez-Aranda F, Harro J, Homberg JR, Karwautz A, Kiive E, Klump KL, Larson CL, Racine SE, Richardson J, Steiger H, Stoltenberg SF, van Strien T, Wagner G, Treasure J, Krug I
J Psychiatr Res 2017 Jan;84:62-72. Epub 2016 Sep 24 doi: 10.1016/j.jpsychires.2016.09.023. PMID: 27701012Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Guideline NG69, Eating disorders: recognition and treatment, 2020

    Consumer resources

    Reviews

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