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Bulimia

MedGen UID:
684
Concept ID:
C0006370
Mental or Behavioral Dysfunction
Synonyms: Binge Eating; Bulimias; Eating, Binge
SNOMED CT: Bulimia (78004001)
 
HPO: HP:0100739

Definition

A form of anomalous eating behavior characterized by binge eating is followed by self-induced vomiting or other compensatory behavior intended to prevent weight gain (purging, fasting or exercising or a combination of these). [from HPO]

Conditions with this feature

Deafness-encephaloneuropathy-obesity-valvulopathy syndrome
MedGen UID:
766268
Concept ID:
C3553354
Disease or Syndrome
Primary coenzyme Q10 (CoQ10) deficiency is usually associated with multisystem involvement, including neurologic manifestations such as fatal neonatal encephalopathy with hypotonia; a late-onset slowly progressive multiple-system atrophy-like phenotype (neurodegeneration with autonomic failure and various combinations of parkinsonism and cerebellar ataxia, and pyramidal dysfunction); and dystonia, spasticity, seizures, and intellectual disability. Steroid-resistant nephrotic syndrome (SRNS), the hallmark renal manifestation, is often the initial manifestation either as isolated renal involvement that progresses to end-stage renal disease (ESRD), or associated with encephalopathy (seizures, stroke-like episodes, severe neurologic impairment) resulting in early death. Hypertrophic cardiomyopathy (HCM), retinopathy or optic atrophy, and sensorineural hearing loss can also be seen.
X-linked intellectual disability, Cantagrel type
MedGen UID:
813060
Concept ID:
C3806730
Disease or Syndrome
X-linked intellectual developmental disorder-98 (XLID98) is a neurodevelopmental disorder characterized by delayed psychomotor development, poor speech, behavioral abnormalities, poor overall growth, dysmorphic facial features, and often early-onset seizures. Some carrier females are unaffected, whereas other females with mutations are affected; males tend to be more severely affected than females. It is believed that the phenotypic variability and disease manifestations in female carriers results from skewed X-inactivation or cellular mosaicism (summary by de Lange et al., 2016).
Susceptibility to bulimia nervosa
MedGen UID:
1646891
Concept ID:
C4551963
Finding
Bulimia nervosa (BN) is a psychiatric disorder characterized by episodes of binge-eating (eating an unusually large amount of food in a discrete period of time and feeling out of control), compensatory behavior (e.g., self-induced vomiting or laxative abuse), and over-concern with weight and shape. Eating disorders such as bulimia nervosa are complex disorders that can be influenced by many genes.

Professional guidelines

PubMed

Muratore AF, Attia E
Curr Psychiatry Rep 2022 Jul;24(7):345-351. Epub 2022 May 16 doi: 10.1007/s11920-022-01340-5. PMID: 35576089Free PMC Article
Klein DA, Sylvester JE, Schvey NA
Am Fam Physician 2021 Jan 1;103(1):22-32. PMID: 33382560
Mairs R, Nicholls D
Arch Dis Child 2016 Dec;101(12):1168-1175. Epub 2016 Jun 28 doi: 10.1136/archdischild-2015-309481. PMID: 27381185

Curated

UK NICE Guideline NG69, Eating disorders: recognition and treatment, 2020

Recent clinical studies

Etiology

van Eeden AE, van Hoeken D, Hoek HW
Curr Opin Psychiatry 2021 Nov 1;34(6):515-524. doi: 10.1097/YCO.0000000000000739. PMID: 34419970Free PMC Article
Nitsch A, Dlugosz H, Gibson D, Mehler PS
Cleve Clin J Med 2021 Jun 2;88(6):333-343. doi: 10.3949/ccjm.88a.20168. PMID: 34078617
Timko CA, DeFilipp L, Dakanalis A
Curr Psychiatry Rep 2019 Jan 12;21(1):1. doi: 10.1007/s11920-019-0988-1. PMID: 30637488Free PMC Article
Castillo M, Weiselberg E
Curr Probl Pediatr Adolesc Health Care 2017 Apr;47(4):85-94. doi: 10.1016/j.cppeds.2017.02.004. PMID: 28532966
Volpe U, Tortorella A, Manchia M, Monteleone AM, Albert U, Monteleone P
Psychiatry Res 2016 Apr 30;238:225-227. Epub 2016 Feb 22 doi: 10.1016/j.psychres.2016.02.048. PMID: 27086237

Diagnosis

Gorgas DL
Emerg Med Clin North Am 2024 Feb;42(1):163-179. Epub 2023 Aug 14 doi: 10.1016/j.emc.2023.06.024. PMID: 37977748
Baenas I, Etxandi M, Fernández-Aranda F
Med Clin (Barc) 2024 Jan 26;162(2):67-72. Epub 2023 Aug 17 doi: 10.1016/j.medcli.2023.07.028. PMID: 37598049
Mitchell JE, Peterson CB
N Engl J Med 2020 Apr 2;382(14):1343-1351. doi: 10.1056/NEJMcp1803175. PMID: 32242359
Wade TD
Psychiatr Clin North Am 2019 Mar;42(1):21-32. Epub 2018 Dec 3 doi: 10.1016/j.psc.2018.10.002. PMID: 30704637
Castillo M, Weiselberg E
Curr Probl Pediatr Adolesc Health Care 2017 Apr;47(4):85-94. doi: 10.1016/j.cppeds.2017.02.004. PMID: 28532966

Therapy

Fornaro M, Mondin AM, Billeci M, Fusco A, De Prisco M, Caiazza C, Micanti F, Calati R, Carvalho AF, de Bartolomeis A
J Affect Disord 2023 Oct 1;338:526-545. Epub 2023 Jun 30 doi: 10.1016/j.jad.2023.06.068. PMID: 37393954
Grider HS, Douglas SM, Raynor HA
J Acad Nutr Diet 2021 Apr;121(4):709-727.e1. Epub 2020 Dec 3 doi: 10.1016/j.jand.2020.10.019. PMID: 33279464
Mathisen TF, Rosenvinge JH, Friborg O, Vrabel K, Bratland-Sanda S, Pettersen G, Sundgot-Borgen J
Int J Eat Disord 2020 Apr;53(4):574-585. Epub 2020 Jan 16 doi: 10.1002/eat.23228. PMID: 31944339Free PMC Article
Costa MB, Melnik T
Einstein (Sao Paulo) 2016 Apr-Jun;14(2):235-77. doi: 10.1590/S1679-45082016RW3120. PMID: 27462898Free PMC Article
Vancampfort D, Vanderlinden J, De Hert M, Soundy A, Adámkova M, Skjaerven LH, Catalán-Matamoros D, Lundvik Gyllensten A, Gómez-Conesa A, Probst M
Disabil Rehabil 2014;36(8):628-34. Epub 2013 Jul 4 doi: 10.3109/09638288.2013.808271. PMID: 23826882

Prognosis

van Eeden AE, van Hoeken D, Hoek HW
Curr Opin Psychiatry 2021 Nov 1;34(6):515-524. doi: 10.1097/YCO.0000000000000739. PMID: 34419970Free PMC Article
Eddy KT, Tabri N, Thomas JJ, Murray HB, Keshaviah A, Hastings E, Edkins K, Krishna M, Herzog DB, Keel PK, Franko DL
J Clin Psychiatry 2017 Feb;78(2):184-189. doi: 10.4088/JCP.15m10393. PMID: 28002660Free PMC Article
Stice E, Gau JM, Rohde P, Shaw H
J Abnorm Psychol 2017 Jan;126(1):38-51. Epub 2016 Oct 6 doi: 10.1037/abn0000219. PMID: 27709979Free PMC Article
Smink FR, van Hoeken D, Hoek HW
Curr Opin Psychiatry 2013 Nov;26(6):543-8. doi: 10.1097/YCO.0b013e328365a24f. PMID: 24060914
Smink FR, van Hoeken D, Hoek HW
Curr Psychiatry Rep 2012 Aug;14(4):406-14. doi: 10.1007/s11920-012-0282-y. PMID: 22644309Free PMC Article

Clinical prediction guides

Mushtaq T, Ashraf S, Hameed H, Irfan A, Shahid M, Kanwal R, Aslam MA, Shahid H, Koh-E-Noor, Shazly GA, Khan MA, Jardan YAB
Nutrients 2023 Nov 5;15(21) doi: 10.3390/nu15214687. PMID: 37960340Free PMC Article
Craba A, Mazza M, Marano G, Crosta ML, Moroni F, Di Pietro S, Balocchi M, Della Casa S, Rinaldi L, Janiri L, Sani G
J Nerv Ment Dis 2023 Mar 1;211(3):174-181. doi: 10.1097/NMD.0000000000001597. PMID: 36827633
Silverii GA, Benvenuti F, Morandin G, Ricca V, Monami M, Mannucci E, Rotella F
Eat Weight Disord 2022 Mar;27(2):405-414. Epub 2021 May 22 doi: 10.1007/s40519-021-01213-5. PMID: 34021904Free PMC Article
Hessler-Kaufmann JB, Meule A, Greetfeld M, Schlegl S, Voderholzer U
J Psychosom Res 2021 Jan;140:110317. Epub 2020 Nov 29 doi: 10.1016/j.jpsychores.2020.110317. PMID: 33278658
Ricca V, Castellini G, Mannucci E, Monami M, Ravaldi C, Gorini Amedei S, Lo Sauro C, Rotella CM, Faravelli C
Appetite 2009 Apr;52(2):405-9. Epub 2008 Dec 3 doi: 10.1016/j.appet.2008.11.013. PMID: 19103239

Recent systematic reviews

J Devoe D, Han A, Anderson A, Katzman DK, Patten SB, Soumbasis A, Flanagan J, Paslakis G, Vyver E, Marcoux G, Dimitropoulos G
Int J Eat Disord 2023 Jan;56(1):5-25. Epub 2022 Apr 5 doi: 10.1002/eat.23704. PMID: 35384016Free PMC Article
Monteleone AM, Pellegrino F, Croatto G, Carfagno M, Hilbert A, Treasure J, Wade T, Bulik CM, Zipfel S, Hay P, Schmidt U, Castellini G, Favaro A, Fernandez-Aranda F, Il Shin J, Voderholzer U, Ricca V, Moretti D, Busatta D, Abbate-Daga G, Ciullini F, Cascino G, Monaco F, Correll CU, Solmi M
Neurosci Biobehav Rev 2022 Nov;142:104857. Epub 2022 Sep 6 doi: 10.1016/j.neubiorev.2022.104857. PMID: 36084848Free PMC Article
di Giacomo E, Aliberti F, Pescatore F, Santorelli M, Pessina R, Placenti V, Colmegna F, Clerici M
Eat Weight Disord 2022 Aug;27(6):1963-1970. Epub 2022 Jan 18 doi: 10.1007/s40519-021-01354-7. PMID: 35041154Free PMC Article
GBD 2019 Mental Disorders Collaborators
Lancet Psychiatry 2022 Feb;9(2):137-150. Epub 2022 Jan 10 doi: 10.1016/S2215-0366(21)00395-3. PMID: 35026139Free PMC Article
Solmi M, Radua J, Stubbs B, Ricca V, Moretti D, Busatta D, Carvalho AF, Dragioti E, Favaro A, Monteleone AM, Shin JI, Fusar-Poli P, Castellini G
Braz J Psychiatry 2021 May-Jun;43(3):314-323. doi: 10.1590/1516-4446-2020-1099. PMID: 32997075Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2020
      UK NICE Guideline NG69, Eating disorders: recognition and treatment, 2020

    Consumer resources

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