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Confluent hyperintensity of cerebral white matter on MRI

MedGen UID:
1647724
Concept ID:
C4703612
Finding
HPO: HP:0040330

Definition

Areas of brighter than expected MRI signal in the white matter of the brain whereby individual patches run together. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConfluent hyperintensity of cerebral white matter on MRI

Recent clinical studies

Etiology

Zwartbol MHT, Ghaznawi R, Jaarsma-Coes M, Kuijf H, Hendrikse J, de Bresser J, Geerlings MI; UCC-SMART Study Group
Neurobiol Aging 2022 Dec;120:81-87. Epub 2022 Aug 23 doi: 10.1016/j.neurobiolaging.2022.08.009. PMID: 36152446
Heng LC, Lim SH, Foo H, Kandiah N
Alzheimer Dis Assoc Disord 2021 Jan-Mar 01;35(1):8-13. doi: 10.1097/WAD.0000000000000409. PMID: 33009038
Tomimoto H
Geriatr Gerontol Int 2015 Dec;15 Suppl 1:3-9. doi: 10.1111/ggi.12661. PMID: 26671151
Prins ND, Scheltens P
Nat Rev Neurol 2015 Mar;11(3):157-65. Epub 2015 Feb 17 doi: 10.1038/nrneurol.2015.10. PMID: 25686760
Schmidt R, Schmidt H, Kapeller P, Lechner A, Fazekas F
Cerebrovasc Dis 2002;13 Suppl 2:16-20. doi: 10.1159/000049145. PMID: 11901238

Diagnosis

Iwasaki Y
Neuropathology 2017 Apr;37(2):174-188. Epub 2016 Dec 28 doi: 10.1111/neup.12355. PMID: 28028861
Tomimoto H
Geriatr Gerontol Int 2015 Dec;15 Suppl 1:3-9. doi: 10.1111/ggi.12661. PMID: 26671151
Kirshner HS, Bradshaw M
Curr Neurol Neurosci Rep 2015 Aug;15(8):54. doi: 10.1007/s11910-015-0572-y. PMID: 26096511
Prins ND, Scheltens P
Nat Rev Neurol 2015 Mar;11(3):157-65. Epub 2015 Feb 17 doi: 10.1038/nrneurol.2015.10. PMID: 25686760
Weber T
Neurol Clin 2008 Aug;26(3):833-54, x-xi. doi: 10.1016/j.ncl.2008.03.007. PMID: 18657729

Therapy

Knaak C, Kant IM, Lammers-Lietz F, Spies C, Witkamp TD, Winterer G, Lachmann G, de Bresser J
Int J Med Sci 2021;18(6):1332-1338. Epub 2021 Jan 21 doi: 10.7150/ijms.51364. PMID: 33628088Free PMC Article
Kumon Y, Watanabe H, Tagawa M, Inoue A, Ohnishi T, Kunieda T
Neurol Med Chir (Tokyo) 2021 Feb 15;61(2):152-161. Epub 2020 Dec 30 doi: 10.2176/nmc.oa.2020-0290. PMID: 33390419Free PMC Article
Ghaznawi R, Geerlings MI, Jaarsma-Coes MG, Zwartbol MH, Kuijf HJ, van der Graaf Y, Witkamp TD, Hendrikse J, de Bresser J
J Cereb Blood Flow Metab 2019 Dec;39(12):2486-2496. Epub 2018 Sep 11 doi: 10.1177/0271678X18800463. PMID: 30204039Free PMC Article
Croall ID, Lohner V, Moynihan B, Khan U, Hassan A, O'Brien JT, Morris RG, Tozer DJ, Cambridge VC, Harkness K, Werring DJ, Blamire AM, Ford GA, Barrick TR, Markus HS
Clin Sci (Lond) 2017 Jun 1;131(12):1361-1373. Epub 2017 Jun 7 doi: 10.1042/CS20170146. PMID: 28487471Free PMC Article
Benjamin P, Zeestraten E, Lambert C, Ster IC, Williams OA, Lawrence AJ, Patel B, MacKinnon AD, Barrick TR, Markus HS
J Cereb Blood Flow Metab 2016 Jan;36(1):228-40. doi: 10.1038/jcbfm.2015.113. PMID: 26036939Free PMC Article

Prognosis

Zhong G, Lou M
Stroke Vasc Neurol 2016 Jun;1(2):59-63. Epub 2016 Jun 24 doi: 10.1136/svn-2016-000021. PMID: 28959465Free PMC Article
Tomimoto H
Geriatr Gerontol Int 2015 Dec;15 Suppl 1:3-9. doi: 10.1111/ggi.12661. PMID: 26671151
Prins ND, Scheltens P
Nat Rev Neurol 2015 Mar;11(3):157-65. Epub 2015 Feb 17 doi: 10.1038/nrneurol.2015.10. PMID: 25686760
Weber T
Neurol Clin 2008 Aug;26(3):833-54, x-xi. doi: 10.1016/j.ncl.2008.03.007. PMID: 18657729
Schmidt R, Schmidt H, Kapeller P, Enzinger C, Ropele S, Saurugg R, Fazekas F
J Neurol Sci 2002 Nov 15;203-204:253-7. doi: 10.1016/s0022-510x(02)00300-3. PMID: 12417393

Clinical prediction guides

Zwartbol MHT, Ghaznawi R, Jaarsma-Coes M, Kuijf H, Hendrikse J, de Bresser J, Geerlings MI; UCC-SMART Study Group
Neurobiol Aging 2022 Dec;120:81-87. Epub 2022 Aug 23 doi: 10.1016/j.neurobiolaging.2022.08.009. PMID: 36152446
Heng LC, Lim SH, Foo H, Kandiah N
Alzheimer Dis Assoc Disord 2021 Jan-Mar 01;35(1):8-13. doi: 10.1097/WAD.0000000000000409. PMID: 33009038
Iwasaki Y
Neuropathology 2017 Apr;37(2):174-188. Epub 2016 Dec 28 doi: 10.1111/neup.12355. PMID: 28028861
Zhong G, Lou M
Stroke Vasc Neurol 2016 Jun;1(2):59-63. Epub 2016 Jun 24 doi: 10.1136/svn-2016-000021. PMID: 28959465Free PMC Article
Schmidt R, Schmidt H, Kapeller P, Enzinger C, Ropele S, Saurugg R, Fazekas F
J Neurol Sci 2002 Nov 15;203-204:253-7. doi: 10.1016/s0022-510x(02)00300-3. PMID: 12417393

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