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Confluent hyperintensity of cerebral white matter on MRI

MedGen UID:
1647724
Concept ID:
C4703612
Finding
HPO: HP:0040330

Definition

Areas of brighter than expected MRI signal in the white matter of the brain whereby individual patches run together. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConfluent hyperintensity of cerebral white matter on MRI

Recent clinical studies

Etiology

Ding L, Hou B, Zang J, Su T, Feng F, Zhu Z, Peng B
J Am Heart Assoc 2023 Nov 7;12(21):e028569. Epub 2023 Oct 27 doi: 10.1161/JAHA.122.028569. PMID: 37889177Free PMC Article
Yang Y, Cai X, Zhou M, Chen Y, Pi J, Zhao M, Shi Y, Wang S, Jing J, Chen W, Meng X, Wang Y, Pan Y, Wang Y
Neuroepidemiology 2023;57(6):413-422. Epub 2023 Sep 21 doi: 10.1159/000533678. PMID: 37734325
Heng LC, Lim SH, Foo H, Kandiah N
Alzheimer Dis Assoc Disord 2021 Jan-Mar 01;35(1):8-13. doi: 10.1097/WAD.0000000000000409. PMID: 33009038
Tomimoto H
Geriatr Gerontol Int 2015 Dec;15 Suppl 1:3-9. doi: 10.1111/ggi.12661. PMID: 26671151
Prins ND, Scheltens P
Nat Rev Neurol 2015 Mar;11(3):157-65. Epub 2015 Feb 17 doi: 10.1038/nrneurol.2015.10. PMID: 25686760

Diagnosis

Hartung TJ, Bartels F, Kuchling J, Krohn S, Leidel J, Mantwill M, Wurdack K, Yogeshwar S, Scheel M, Finke C
Rev Neurol (Paris) 2024 Nov;180(9):895-907. Epub 2024 Oct 2 doi: 10.1016/j.neurol.2024.08.006. PMID: 39358087
Iwasaki Y
Neuropathology 2017 Apr;37(2):174-188. Epub 2016 Dec 28 doi: 10.1111/neup.12355. PMID: 28028861
Tomimoto H
Geriatr Gerontol Int 2015 Dec;15 Suppl 1:3-9. doi: 10.1111/ggi.12661. PMID: 26671151
Prins ND, Scheltens P
Nat Rev Neurol 2015 Mar;11(3):157-65. Epub 2015 Feb 17 doi: 10.1038/nrneurol.2015.10. PMID: 25686760
Weber T
Neurol Clin 2008 Aug;26(3):833-54, x-xi. doi: 10.1016/j.ncl.2008.03.007. PMID: 18657729

Therapy

Hong H, Tozer DJ, Markus HS
Stroke 2024 Apr;55(4):1032-1040. Epub 2024 Mar 11 doi: 10.1161/STROKEAHA.123.045857. PMID: 38465597Free PMC Article
Kornej J, Friedrich K, Schroeter ML, Witte AV, Polyakova M, Villringer A, Löffler M, Zeynalova S
PLoS One 2022;17(6):e0269815. Epub 2022 Jun 15 doi: 10.1371/journal.pone.0269815. PMID: 35704643Free PMC Article
Knaak C, Kant IM, Lammers-Lietz F, Spies C, Witkamp TD, Winterer G, Lachmann G, de Bresser J
Int J Med Sci 2021;18(6):1332-1338. Epub 2021 Jan 21 doi: 10.7150/ijms.51364. PMID: 33628088Free PMC Article
Ghaznawi R, Geerlings MI, Jaarsma-Coes MG, Zwartbol MH, Kuijf HJ, van der Graaf Y, Witkamp TD, Hendrikse J, de Bresser J
J Cereb Blood Flow Metab 2019 Dec;39(12):2486-2496. Epub 2018 Sep 11 doi: 10.1177/0271678X18800463. PMID: 30204039Free PMC Article
Benjamin P, Zeestraten E, Lambert C, Ster IC, Williams OA, Lawrence AJ, Patel B, MacKinnon AD, Barrick TR, Markus HS
J Cereb Blood Flow Metab 2016 Jan;36(1):228-40. doi: 10.1038/jcbfm.2015.113. PMID: 26036939Free PMC Article

Prognosis

Hartung TJ, Bartels F, Kuchling J, Krohn S, Leidel J, Mantwill M, Wurdack K, Yogeshwar S, Scheel M, Finke C
Rev Neurol (Paris) 2024 Nov;180(9):895-907. Epub 2024 Oct 2 doi: 10.1016/j.neurol.2024.08.006. PMID: 39358087
Keller JA, Sigurdsson S, Klaassen K, Hirschler L, van Buchem MA, Launer LJ, van Osch MJP, Gudnason V, de Bresser J
Alzheimers Dement 2023 Dec;19(12):5632-5641. Epub 2023 Jun 12 doi: 10.1002/alz.13345. PMID: 37303267Free PMC Article
Tomimoto H
Geriatr Gerontol Int 2015 Dec;15 Suppl 1:3-9. doi: 10.1111/ggi.12661. PMID: 26671151
Prins ND, Scheltens P
Nat Rev Neurol 2015 Mar;11(3):157-65. Epub 2015 Feb 17 doi: 10.1038/nrneurol.2015.10. PMID: 25686760
Weber T
Neurol Clin 2008 Aug;26(3):833-54, x-xi. doi: 10.1016/j.ncl.2008.03.007. PMID: 18657729

Clinical prediction guides

Hartung TJ, Bartels F, Kuchling J, Krohn S, Leidel J, Mantwill M, Wurdack K, Yogeshwar S, Scheel M, Finke C
Rev Neurol (Paris) 2024 Nov;180(9):895-907. Epub 2024 Oct 2 doi: 10.1016/j.neurol.2024.08.006. PMID: 39358087
Hong H, Tozer DJ, Markus HS
Stroke 2024 Apr;55(4):1032-1040. Epub 2024 Mar 11 doi: 10.1161/STROKEAHA.123.045857. PMID: 38465597Free PMC Article
Yang Y, Cai X, Zhou M, Chen Y, Pi J, Zhao M, Shi Y, Wang S, Jing J, Chen W, Meng X, Wang Y, Pan Y, Wang Y
Neuroepidemiology 2023;57(6):413-422. Epub 2023 Sep 21 doi: 10.1159/000533678. PMID: 37734325
Heng LC, Lim SH, Foo H, Kandiah N
Alzheimer Dis Assoc Disord 2021 Jan-Mar 01;35(1):8-13. doi: 10.1097/WAD.0000000000000409. PMID: 33009038
Iwasaki Y
Neuropathology 2017 Apr;37(2):174-188. Epub 2016 Dec 28 doi: 10.1111/neup.12355. PMID: 28028861

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