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Breast Carcinoma Metastatic in the Spine

MedGen UID:
1650310
•Concept ID:
C4727105
•
Neoplastic Process

Definition

A carcinoma that arises from the breast and has spread to the spine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Carcinoma Metastatic in the Spine

Professional guidelines

PubMed

Assessment of Spinal Metastases Surgery Risk Stratification Tools in Breast Cancer by Molecular Subtype.
Duvall JB, Massaad E, Siraj L, Kiapour A, Connolly I, Hadzipasic M, Elsamadicy AA, Williamson T, Shankar GM, Schoenfeld AJ, Fourman MS, Shin JH
Neurosurgery 2023 Jan 1;92(1):83-91. Epub 2022 Oct 28 doi: 10.1227/neu.0000000000002180. PMID: 36305664Free PMC Article
Systemic management of brain metastases in HER2+ breast cancer in 2022.
Alder L, Sammons S, Van Swearingen AED, Anders CK
Clin Adv Hematol Oncol 2022 May;20(5):325-336. PMID: 35579591
Metastatic disease in the thoracic and lumbar spine: evaluation and management.
Rose PS, Buchowski JM
J Am Acad Orthop Surg 2011 Jan;19(1):37-48. doi: 10.5435/00124635-201101000-00005. PMID: 21205766

Recent clinical studies

Etiology

Stereotactic Body Radiation Therapy for Metastases in Long Bones.
Madani I, Sahgal A, Erler D, Stish BJ, Olivier KR, Park SS, Eppinga WSC, Seravalli E, Redmond KJ, Cao Y, Siva S, Chang D, Nguyen TK, O'Neil M, Guckenberger M
Int J Radiat Oncol Biol Phys 2022 Nov 15;114(4):738-746. Epub 2022 Jul 16 doi: 10.1016/j.ijrobp.2022.07.003. PMID: 35850362
Readmission-Free Survival Analysis in Metastatic Spine Tumour Surgical Patients: A Novel Concept.
Kumar N, Thomas AC, Ramos MRD, Tan JYH, Shen L, Madhu S, Lopez KG, Villanueva A, Tan JH, Vellayappan BA
Ann Surg Oncol 2021 May;28(5):2474-2482. Epub 2021 Jan 3 doi: 10.1245/s10434-020-09404-7. PMID: 33393052
The rise of metastatic bone disease in Ireland.
McCabe FJ, Jadaan DY, Jadaan MM, McCabe JP
Clin Exp Metastasis 2020 Dec;37(6):693-702. Epub 2020 Oct 24 doi: 10.1007/s10585-020-10059-7. PMID: 33099723
The surgical treatment of metastatic spine tumors within the intramedullary compartment.
Strickland BA, McCutcheon IE, Chakrabarti I, Rhines LD, Weinberg JS
J Neurosurg Spine 2018 Jan;28(1):79-87. Epub 2017 Nov 10 doi: 10.3171/2017.5.SPINE161161. PMID: 29125427
Reirradiation of the spine with stereotactic radiosurgery: Efficacy and toxicity.
Boyce-Fappiano D, Elibe E, Zhao B, Siddiqui MS, Lee I, Rock J, Ryu S, Siddiqui F
Pract Radiat Oncol 2017 Nov-Dec;7(6):e409-e417. Epub 2017 May 25 doi: 10.1016/j.prro.2017.05.007. PMID: 28673511

Diagnosis

Triple Negative Breast Cancer and Brain Metastases.
Bansal R, Van Swearingen AED, Anders CK
Clin Breast Cancer 2023 Dec;23(8):825-831. Epub 2023 Aug 4 doi: 10.1016/j.clbc.2023.07.008. PMID: 37586926
Advances in the study of biomarkers related to bone metastasis in breast cancer.
Xu D, Tang M
Br J Radiol 2023 Oct;96(1150):20230117. Epub 2023 Jul 3 doi: 10.1259/bjr.20230117. PMID: 37393528Free PMC Article
Identification of Bone Metastatic and Prognostic Alternative Splicing Signatures in Prostate Adenocarcinoma.
Zhu J, Zhang J, Hu P, Fan M, Song D, Yin H, Yan P, Xian S, Li Z, Guo J, Long C, Xu R, Huang R, Meng T, Zhang J, Huang Z
Biochem Genet 2023 Dec;61(6):2242-2259. Epub 2023 Apr 3 doi: 10.1007/s10528-023-10367-z. PMID: 37010714Free PMC Article
The rise of metastatic bone disease in Ireland.
McCabe FJ, Jadaan DY, Jadaan MM, McCabe JP
Clin Exp Metastasis 2020 Dec;37(6):693-702. Epub 2020 Oct 24 doi: 10.1007/s10585-020-10059-7. PMID: 33099723
Metastatic disease in the thoracic and lumbar spine: evaluation and management.
Rose PS, Buchowski JM
J Am Acad Orthop Surg 2011 Jan;19(1):37-48. doi: 10.5435/00124635-201101000-00005. PMID: 21205766

Therapy

Prognostic Factors for Bone Survival and Functional Outcomes in Patients With Breast Cancer Spine Metastases.
Qiao RQ, Zhang HR, Ma RX, Li RF, Hu YC
Technol Cancer Res Treat 2022 Jan-Dec;21:15330338221122642. doi: 10.1177/15330338221122642. PMID: 36214255Free PMC Article
Stereotactic Body Radiation Therapy for Metastases in Long Bones.
Madani I, Sahgal A, Erler D, Stish BJ, Olivier KR, Park SS, Eppinga WSC, Seravalli E, Redmond KJ, Cao Y, Siva S, Chang D, Nguyen TK, O'Neil M, Guckenberger M
Int J Radiat Oncol Biol Phys 2022 Nov 15;114(4):738-746. Epub 2022 Jul 16 doi: 10.1016/j.ijrobp.2022.07.003. PMID: 35850362
Systemic management of brain metastases in HER2+ breast cancer in 2022.
Alder L, Sammons S, Van Swearingen AED, Anders CK
Clin Adv Hematol Oncol 2022 May;20(5):325-336. PMID: 35579591
Association Between BMP-2 and Carcinogenicity.
Skovrlj B, Koehler SM, Anderson PA, Qureshi SA, Hecht AC, Iatridis JC, Cho SK
Spine (Phila Pa 1976) 2015 Dec;40(23):1862-71. doi: 10.1097/BRS.0000000000001126. PMID: 26274524Free PMC Article
Infusion-embolization.
Wallace S, Charnsangavej C, Carrasco CH, Bechtel W
Cancer 1984 Dec 1;54(11 Suppl):2751-65. doi: 10.1002/1097-0142(19841201)54:2+<2751::aid-cncr2820541423>3.0.co;2-5. PMID: 6093984

Prognosis

Triple Negative Breast Cancer and Brain Metastases.
Bansal R, Van Swearingen AED, Anders CK
Clin Breast Cancer 2023 Dec;23(8):825-831. Epub 2023 Aug 4 doi: 10.1016/j.clbc.2023.07.008. PMID: 37586926
Advances in the study of biomarkers related to bone metastasis in breast cancer.
Xu D, Tang M
Br J Radiol 2023 Oct;96(1150):20230117. Epub 2023 Jul 3 doi: 10.1259/bjr.20230117. PMID: 37393528Free PMC Article
Identification of Bone Metastatic and Prognostic Alternative Splicing Signatures in Prostate Adenocarcinoma.
Zhu J, Zhang J, Hu P, Fan M, Song D, Yin H, Yan P, Xian S, Li Z, Guo J, Long C, Xu R, Huang R, Meng T, Zhang J, Huang Z
Biochem Genet 2023 Dec;61(6):2242-2259. Epub 2023 Apr 3 doi: 10.1007/s10528-023-10367-z. PMID: 37010714Free PMC Article
Papillary Thyroid Carcinoma With Breast and Bone Metastasis.
Zhang D, Zhu XL, Jiang J
Ear Nose Throat J 2023 Apr;102(4):259-262. Epub 2022 Dec 7 doi: 10.1177/01455613221145273. PMID: 36476071
Metastatic disease in the thoracic and lumbar spine: evaluation and management.
Rose PS, Buchowski JM
J Am Acad Orthop Surg 2011 Jan;19(1):37-48. doi: 10.5435/00124635-201101000-00005. PMID: 21205766

Clinical prediction guides

FGF2 drives osteosarcoma metastasis through activating FGFR1-4 receptor pathway-mediated ICAM-1 expression.
Huang YC, Chen WC, Yu CL, Chang TK, I-Chin Wei A, Chang TM, Liu JF, Wang SW
Biochem Pharmacol 2023 Dec;218:115853. Epub 2023 Oct 11 doi: 10.1016/j.bcp.2023.115853. PMID: 37832794
A vertebral skeletal stem cell lineage driving metastasis.
Sun J, Hu L, Bok S, Yallowitz AR, Cung M, McCormick J, Zheng LJ, Debnath S, Niu Y, Tan AY, Lalani S, Morse KW, Shinn D, Pajak A, Hammad M, Suhardi VJ, Li Z, Li N, Wang L, Zou W, Mittal V, Bostrom MPG, Xu R, Iyer S, Greenblatt MB
Nature 2023 Sep;621(7979):602-609. Epub 2023 Sep 13 doi: 10.1038/s41586-023-06519-1. PMID: 37704733Free PMC Article
Identification of Bone Metastatic and Prognostic Alternative Splicing Signatures in Prostate Adenocarcinoma.
Zhu J, Zhang J, Hu P, Fan M, Song D, Yin H, Yan P, Xian S, Li Z, Guo J, Long C, Xu R, Huang R, Meng T, Zhang J, Huang Z
Biochem Genet 2023 Dec;61(6):2242-2259. Epub 2023 Apr 3 doi: 10.1007/s10528-023-10367-z. PMID: 37010714Free PMC Article
Effect of Minimally Invasive Spine Stabilization in Metastatic Spinal Tumors.
Nakanishi K, Uchino K, Watanabe S, Misaki K, Iba H
Medicina (Kaunas) 2022 Mar 1;58(3) doi: 10.3390/medicina58030358. PMID: 35334534Free PMC Article
Molecular Markers and Targeted Therapeutics in Metastatic Tumors of the Spine: Changing the Treatment Paradigms.
Goodwin CR, Abu-Bonsrah N, Rhines LD, Verlaan JJ, Bilsky MH, Laufer I, Boriani S, Sciubba DM, Bettegowda C
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20:S218-S223. doi: 10.1097/BRS.0000000000001833. PMID: 27488299

Recent systematic reviews

The Role of Cytokines in the Metastasis of Solid Tumors to the Spine: Systematic Review.
Łabędź W, Przybyla A, Zimna A, Dąbrowski M, Kubaszewski Ł
Int J Mol Sci 2023 Feb 14;24(4) doi: 10.3390/ijms24043785. PMID: 36835198Free PMC Article
Leptomeningeal Metastases of the Spine: A Systematic Review.
Palmisciano P, Sagoo NS, Kharbat AF, Kenfack YJ, Bin Alamer O, Scalia G, Umana GE, Aoun SG, Haider AS
Anticancer Res 2022 Feb;42(2):619-628. doi: 10.21873/anticanres.15519. PMID: 35093859
The Potential of Minimally Invasive Surgery to Treat Metastatic Spinal Disease versus Open Surgery: A Systematic Review and Meta-Analysis.
Lu VM, Alvi MA, Goyal A, Kerezoudis P, Bydon M
World Neurosurg 2018 Apr;112:e859-e868. Epub 2018 Feb 24 doi: 10.1016/j.wneu.2018.01.176. PMID: 29408300
Decompression surgery for spinal metastases: a systematic review.
Bakar D, Tanenbaum JE, Phan K, Alentado VJ, Steinmetz MP, Benzel EC, Mroz TE
Neurosurg Focus 2016 Aug;41(2):E2. doi: 10.3171/2016.6.FOCUS16166. PMID: 27476844
Association Between BMP-2 and Carcinogenicity.
Skovrlj B, Koehler SM, Anderson PA, Qureshi SA, Hecht AC, Iatridis JC, Cho SK
Spine (Phila Pa 1976) 2015 Dec;40(23):1862-71. doi: 10.1097/BRS.0000000000001126. PMID: 26274524Free PMC Article

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