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Breast Carcinoma Metastatic in the Spine

MedGen UID:
1650310
•Concept ID:
C4727105
•
Neoplastic Process

Definition

A carcinoma that arises from the breast and has spread to the spine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Carcinoma Metastatic in the Spine

Professional guidelines

PubMed

Systemic management of brain metastases in HER2+ breast cancer in 2022.
Alder L, Sammons S, Van Swearingen AED, Anders CK
Clin Adv Hematol Oncol 2022 May;20(5):325-336. PMID: 35579591
Management of metastatic spinal column neoplasms--an update.
Araujo JL, Veiga JC, Figueiredo EG, Barboza VR, Daniel JW, Panagopoulos AT
Rev Col Bras Cir 2013 Nov-Dec;40(6):508-14. doi: 10.1590/s0100-69912013000600015. PMID: 24573631
Metastatic disease in the thoracic and lumbar spine: evaluation and management.
Rose PS, Buchowski JM
J Am Acad Orthop Surg 2011 Jan;19(1):37-48. doi: 10.5435/00124635-201101000-00005. PMID: 21205766

Recent clinical studies

Etiology

Readmission-Free Survival Analysis in Metastatic Spine Tumour Surgical Patients: A Novel Concept.
Kumar N, Thomas AC, Ramos MRD, Tan JYH, Shen L, Madhu S, Lopez KG, Villanueva A, Tan JH, Vellayappan BA
Ann Surg Oncol 2021 May;28(5):2474-2482. Epub 2021 Jan 3 doi: 10.1245/s10434-020-09404-7. PMID: 33393052
The rise of metastatic bone disease in Ireland.
McCabe FJ, Jadaan DY, Jadaan MM, McCabe JP
Clin Exp Metastasis 2020 Dec;37(6):693-702. Epub 2020 Oct 24 doi: 10.1007/s10585-020-10059-7. PMID: 33099723
The surgical treatment of metastatic spine tumors within the intramedullary compartment.
Strickland BA, McCutcheon IE, Chakrabarti I, Rhines LD, Weinberg JS
J Neurosurg Spine 2018 Jan;28(1):79-87. Epub 2017 Nov 10 doi: 10.3171/2017.5.SPINE161161. PMID: 29125427
Decompression surgery for spinal metastases: a systematic review.
Bakar D, Tanenbaum JE, Phan K, Alentado VJ, Steinmetz MP, Benzel EC, Mroz TE
Neurosurg Focus 2016 Aug;41(2):E2. doi: 10.3171/2016.6.FOCUS16166. PMID: 27476844
Spine Surgery in Patients with Metastatic Breast Cancer: A Retrospective Analysis.
Telera S, Caroli F, Raus L, Pompili A, Carosi MA, Di Santo M, Sperduti I, Carapella CM, Fabi A
World Neurosurg 2016 Jun;90:133-146. Epub 2016 Feb 22 doi: 10.1016/j.wneu.2016.02.065. PMID: 26906893

Diagnosis

Triple Negative Breast Cancer and Brain Metastases.
Bansal R, Van Swearingen AED, Anders CK
Clin Breast Cancer 2023 Dec;23(8):825-831. Epub 2023 Aug 4 doi: 10.1016/j.clbc.2023.07.008. PMID: 37586926
Advances in the study of biomarkers related to bone metastasis in breast cancer.
Xu D, Tang M
Br J Radiol 2023 Oct;96(1150):20230117. Epub 2023 Jul 3 doi: 10.1259/bjr.20230117. PMID: 37393528Free PMC Article
Metastatic breast cancer to the adductor magnus: A case report and literature overview.
Bradley Jackson D, Hamdan J, Saleh R
Breast Dis 2019;38(1):35-38. doi: 10.3233/BD-180376. PMID: 30856097
Molecular Markers and Targeted Therapeutics in Metastatic Tumors of the Spine: Changing the Treatment Paradigms.
Goodwin CR, Abu-Bonsrah N, Rhines LD, Verlaan JJ, Bilsky MH, Laufer I, Boriani S, Sciubba DM, Bettegowda C
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20:S218-S223. doi: 10.1097/BRS.0000000000001833. PMID: 27488299
Metastatic disease in the thoracic and lumbar spine: evaluation and management.
Rose PS, Buchowski JM
J Am Acad Orthop Surg 2011 Jan;19(1):37-48. doi: 10.5435/00124635-201101000-00005. PMID: 21205766

Therapy

Systemic management of brain metastases in HER2+ breast cancer in 2022.
Alder L, Sammons S, Van Swearingen AED, Anders CK
Clin Adv Hematol Oncol 2022 May;20(5):325-336. PMID: 35579591
Properties of FDA-approved small molecule protein kinase inhibitors: A 2021 update.
Roskoski R Jr
Pharmacol Res 2021 Mar;165:105463. Epub 2021 Jan 26 doi: 10.1016/j.phrs.2021.105463. PMID: 33513356
Decompression surgery for spinal metastases: a systematic review.
Bakar D, Tanenbaum JE, Phan K, Alentado VJ, Steinmetz MP, Benzel EC, Mroz TE
Neurosurg Focus 2016 Aug;41(2):E2. doi: 10.3171/2016.6.FOCUS16166. PMID: 27476844
Association Between BMP-2 and Carcinogenicity.
Skovrlj B, Koehler SM, Anderson PA, Qureshi SA, Hecht AC, Iatridis JC, Cho SK
Spine (Phila Pa 1976) 2015 Dec;40(23):1862-71. doi: 10.1097/BRS.0000000000001126. PMID: 26274524Free PMC Article
Infusion-embolization.
Wallace S, Charnsangavej C, Carrasco CH, Bechtel W
Cancer 1984 Dec 1;54(11 Suppl):2751-65. doi: 10.1002/1097-0142(19841201)54:2+<2751::aid-cncr2820541423>3.0.co;2-5. PMID: 6093984

Prognosis

FGF2 drives osteosarcoma metastasis through activating FGFR1-4 receptor pathway-mediated ICAM-1 expression.
Huang YC, Chen WC, Yu CL, Chang TK, I-Chin Wei A, Chang TM, Liu JF, Wang SW
Biochem Pharmacol 2023 Dec;218:115853. Epub 2023 Oct 11 doi: 10.1016/j.bcp.2023.115853. PMID: 37832794
Triple Negative Breast Cancer and Brain Metastases.
Bansal R, Van Swearingen AED, Anders CK
Clin Breast Cancer 2023 Dec;23(8):825-831. Epub 2023 Aug 4 doi: 10.1016/j.clbc.2023.07.008. PMID: 37586926
Advances in the study of biomarkers related to bone metastasis in breast cancer.
Xu D, Tang M
Br J Radiol 2023 Oct;96(1150):20230117. Epub 2023 Jul 3 doi: 10.1259/bjr.20230117. PMID: 37393528Free PMC Article
Molecular Markers and Targeted Therapeutics in Metastatic Tumors of the Spine: Changing the Treatment Paradigms.
Goodwin CR, Abu-Bonsrah N, Rhines LD, Verlaan JJ, Bilsky MH, Laufer I, Boriani S, Sciubba DM, Bettegowda C
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20:S218-S223. doi: 10.1097/BRS.0000000000001833. PMID: 27488299
Metastatic disease in the thoracic and lumbar spine: evaluation and management.
Rose PS, Buchowski JM
J Am Acad Orthop Surg 2011 Jan;19(1):37-48. doi: 10.5435/00124635-201101000-00005. PMID: 21205766

Clinical prediction guides

FGF2 drives osteosarcoma metastasis through activating FGFR1-4 receptor pathway-mediated ICAM-1 expression.
Huang YC, Chen WC, Yu CL, Chang TK, I-Chin Wei A, Chang TM, Liu JF, Wang SW
Biochem Pharmacol 2023 Dec;218:115853. Epub 2023 Oct 11 doi: 10.1016/j.bcp.2023.115853. PMID: 37832794
A vertebral skeletal stem cell lineage driving metastasis.
Sun J, Hu L, Bok S, Yallowitz AR, Cung M, McCormick J, Zheng LJ, Debnath S, Niu Y, Tan AY, Lalani S, Morse KW, Shinn D, Pajak A, Hammad M, Suhardi VJ, Li Z, Li N, Wang L, Zou W, Mittal V, Bostrom MPG, Xu R, Iyer S, Greenblatt MB
Nature 2023 Sep;621(7979):602-609. Epub 2023 Sep 13 doi: 10.1038/s41586-023-06519-1. PMID: 37704733Free PMC Article
Identification of Bone Metastatic and Prognostic Alternative Splicing Signatures in Prostate Adenocarcinoma.
Zhu J, Zhang J, Hu P, Fan M, Song D, Yin H, Yan P, Xian S, Li Z, Guo J, Long C, Xu R, Huang R, Meng T, Zhang J, Huang Z
Biochem Genet 2023 Dec;61(6):2242-2259. Epub 2023 Apr 3 doi: 10.1007/s10528-023-10367-z. PMID: 37010714Free PMC Article
Readmission-Free Survival Analysis in Metastatic Spine Tumour Surgical Patients: A Novel Concept.
Kumar N, Thomas AC, Ramos MRD, Tan JYH, Shen L, Madhu S, Lopez KG, Villanueva A, Tan JH, Vellayappan BA
Ann Surg Oncol 2021 May;28(5):2474-2482. Epub 2021 Jan 3 doi: 10.1245/s10434-020-09404-7. PMID: 33393052
Molecular Markers and Targeted Therapeutics in Metastatic Tumors of the Spine: Changing the Treatment Paradigms.
Goodwin CR, Abu-Bonsrah N, Rhines LD, Verlaan JJ, Bilsky MH, Laufer I, Boriani S, Sciubba DM, Bettegowda C
Spine (Phila Pa 1976) 2016 Oct 15;41 Suppl 20:S218-S223. doi: 10.1097/BRS.0000000000001833. PMID: 27488299

Recent systematic reviews

The Role of Cytokines in the Metastasis of Solid Tumors to the Spine: Systematic Review.
Łabędź W, Przybyla A, Zimna A, Dąbrowski M, Kubaszewski Ł
Int J Mol Sci 2023 Feb 14;24(4) doi: 10.3390/ijms24043785. PMID: 36835198Free PMC Article
Leptomeningeal Metastases of the Spine: A Systematic Review.
Palmisciano P, Sagoo NS, Kharbat AF, Kenfack YJ, Bin Alamer O, Scalia G, Umana GE, Aoun SG, Haider AS
Anticancer Res 2022 Feb;42(2):619-628. doi: 10.21873/anticanres.15519. PMID: 35093859
Contemporary spinal oncology treatment paradigms and outcomes for metastatic tumors to the spine: A systematic review of breast, prostate, renal, and lung metastases.
Yao A, Sarkiss CA, Ladner TR, Jenkins AL 3rd
J Clin Neurosci 2017 Jul;41:11-23. Epub 2017 Apr 24 doi: 10.1016/j.jocn.2017.04.004. PMID: 28462790
Decompression surgery for spinal metastases: a systematic review.
Bakar D, Tanenbaum JE, Phan K, Alentado VJ, Steinmetz MP, Benzel EC, Mroz TE
Neurosurg Focus 2016 Aug;41(2):E2. doi: 10.3171/2016.6.FOCUS16166. PMID: 27476844
Association Between BMP-2 and Carcinogenicity.
Skovrlj B, Koehler SM, Anderson PA, Qureshi SA, Hecht AC, Iatridis JC, Cho SK
Spine (Phila Pa 1976) 2015 Dec;40(23):1862-71. doi: 10.1097/BRS.0000000000001126. PMID: 26274524Free PMC Article

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