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Breast Carcinoma Metastatic in the Bone

MedGen UID:
272383
•Concept ID:
C1332623
•
Neoplastic Process
Synonym: Breast Carcinoma Metastatic to the Bone

Definition

A carcinoma that arises from the breast and has metastasized to the bone. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Carcinoma Metastatic in the Bone

Professional guidelines

PubMed

Mechanisms, Diagnosis and Treatment of Bone Metastases.
Ban J, Fock V, Aryee DNT, Kovar H
Cells 2021 Oct 29;10(11) doi: 10.3390/cells10112944. PMID: 34831167Free PMC Article
Breast Cancer with Bone Metastasis: Molecular Insights and Clinical Management.
Venetis K, Piciotti R, Sajjadi E, Invernizzi M, Morganti S, Criscitiello C, Fusco N
Cells 2021 Jun 2;10(6) doi: 10.3390/cells10061377. PMID: 34199522Free PMC Article
Bone Pain in Cancer Patients: Mechanisms and Current Treatment.
Zajączkowska R, Kocot-Kępska M, Leppert W, Wordliczek J
Int J Mol Sci 2019 Nov 30;20(23) doi: 10.3390/ijms20236047. PMID: 31801267Free PMC Article

Recent clinical studies

Etiology

Bone Metastasis of Breast Cancer.
Tahara RK, Brewer TM, Theriault RL, Ueno NT
Adv Exp Med Biol 2019;1152:105-129. doi: 10.1007/978-3-030-20301-6_7. PMID: 31456182
Bone health during endocrine therapy for cancer.
Rachner TD, Coleman R, Hadji P, Hofbauer LC
Lancet Diabetes Endocrinol 2018 Nov;6(11):901-910. Epub 2018 Mar 20 doi: 10.1016/S2213-8587(18)30047-0. PMID: 29572126
Hypoxia and Bone Metastatic Disease.
Johnson RW, Sowder ME, Giaccia AJ
Curr Osteoporos Rep 2017 Aug;15(4):231-238. doi: 10.1007/s11914-017-0378-8. PMID: 28597139Free PMC Article
What Is Breast in the Bone?
Shemanko CS, Cong Y, Forsyth A
Int J Mol Sci 2016 Oct 22;17(10) doi: 10.3390/ijms17101764. PMID: 27782069Free PMC Article
Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study.
Stopeck AT, Lipton A, Body JJ, Steger GG, Tonkin K, de Boer RH, Lichinitser M, Fujiwara Y, Yardley DA, Viniegra M, Fan M, Jiang Q, Dansey R, Jun S, Braun A
J Clin Oncol 2010 Dec 10;28(35):5132-9. Epub 2010 Nov 8 doi: 10.1200/JCO.2010.29.7101. PMID: 21060033

Diagnosis

Bone resorption and bone metastasis risk.
Mathis KM, Sturgeon KM, Winkels RM, Wiskemann J, De Souza MJ, Schmitz KH
Med Hypotheses 2018 Sep;118:36-41. Epub 2018 Jun 18 doi: 10.1016/j.mehy.2018.06.013. PMID: 30037612
Bone health during endocrine therapy for cancer.
Rachner TD, Coleman R, Hadji P, Hofbauer LC
Lancet Diabetes Endocrinol 2018 Nov;6(11):901-910. Epub 2018 Mar 20 doi: 10.1016/S2213-8587(18)30047-0. PMID: 29572126
Metaplastic breast cancer: A case report.
Surenkok S, Tahberer E, Cinkaya A, Kodaz H, Deger A
J Pak Med Assoc 2018 Mar;68(3):466-468. PMID: 29540888
What Is Breast in the Bone?
Shemanko CS, Cong Y, Forsyth A
Int J Mol Sci 2016 Oct 22;17(10) doi: 10.3390/ijms17101764. PMID: 27782069Free PMC Article
Skeletal scintigraphy.
McDougall IR
West J Med 1979 Jun;130(6):503-14. PMID: 390886Free PMC Article

Therapy

Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update.
Eisen A, Somerfield MR, Accordino MK, Blanchette PS, Clemons MJ, Dhesy-Thind S, Dillmon MS, D'Oronzo S, Fletcher GG, Frank ES, Hallmeyer S, Makhoul I, Moy B, Thawer A, Wu JY, Van Poznak CH
J Clin Oncol 2022 Mar 1;40(7):787-800. Epub 2022 Jan 18 doi: 10.1200/JCO.21.02647. PMID: 35041467
Bone-modifying Agents (BMAs) in Breast Cancer.
Shapiro CL
Clin Breast Cancer 2021 Oct;21(5):e618-e630. Epub 2021 Apr 26 doi: 10.1016/j.clbc.2021.04.009. PMID: 34045175
Bone health during endocrine therapy for cancer.
Rachner TD, Coleman R, Hadji P, Hofbauer LC
Lancet Diabetes Endocrinol 2018 Nov;6(11):901-910. Epub 2018 Mar 20 doi: 10.1016/S2213-8587(18)30047-0. PMID: 29572126
Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study.
Stopeck AT, Lipton A, Body JJ, Steger GG, Tonkin K, de Boer RH, Lichinitser M, Fujiwara Y, Yardley DA, Viniegra M, Fan M, Jiang Q, Dansey R, Jun S, Braun A
J Clin Oncol 2010 Dec 10;28(35):5132-9. Epub 2010 Nov 8 doi: 10.1200/JCO.2010.29.7101. PMID: 21060033
Bisphosphonates: mechanism of action and role in clinical practice.
Drake MT, Clarke BL, Khosla S
Mayo Clin Proc 2008 Sep;83(9):1032-45. doi: 10.4065/83.9.1032. PMID: 18775204Free PMC Article

Prognosis

Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis.
Yip RKH, Rimes JS, Capaldo BD, Vaillant F, Mouchemore KA, Pal B, Chen Y, Surgenor E, Murphy AJ, Anderson RL, Smyth GK, Lindeman GJ, Hawkins ED, Visvader JE
Nat Commun 2021 Nov 26;12(1):6920. doi: 10.1038/s41467-021-26556-6. PMID: 34836954Free PMC Article
Correlative Biomarker Analysis of Intrinsic Subtypes and Efficacy Across the MONALEESA Phase III Studies.
Prat A, Chaudhury A, Solovieff N, Paré L, Martinez D, Chic N, Martínez-Sáez O, Brasó-Maristany F, Lteif A, Taran T, Babbar N, Su F
J Clin Oncol 2021 May 1;39(13):1458-1467. Epub 2021 Mar 26 doi: 10.1200/JCO.20.02977. PMID: 33769862Free PMC Article
ER(+)/HER2(+) Breast Cancer Has Different Metastatic Patterns and Better Survival Than ER(-)/HER2(+) Breast Cancer.
Arciero CA, Guo Y, Jiang R, Behera M, O'Regan R, Peng L, Li X
Clin Breast Cancer 2019 Aug;19(4):236-245. Epub 2019 Feb 14 doi: 10.1016/j.clbc.2019.02.001. PMID: 30846407
Metaplastic breast cancer: A case report.
Surenkok S, Tahberer E, Cinkaya A, Kodaz H, Deger A
J Pak Med Assoc 2018 Mar;68(3):466-468. PMID: 29540888
Metastatic behavior of breast cancer subtypes.
Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO, Gelmon K
J Clin Oncol 2010 Jul 10;28(20):3271-7. Epub 2010 May 24 doi: 10.1200/JCO.2009.25.9820. PMID: 20498394

Clinical prediction guides

A vertebral skeletal stem cell lineage driving metastasis.
Sun J, Hu L, Bok S, Yallowitz AR, Cung M, McCormick J, Zheng LJ, Debnath S, Niu Y, Tan AY, Lalani S, Morse KW, Shinn D, Pajak A, Hammad M, Suhardi VJ, Li Z, Li N, Wang L, Zou W, Mittal V, Bostrom MPG, Xu R, Iyer S, Greenblatt MB
Nature 2023 Sep;621(7979):602-609. Epub 2023 Sep 13 doi: 10.1038/s41586-023-06519-1. PMID: 37704733
Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG).
Biganzoli L, Battisti NML, Wildiers H, McCartney A, Colloca G, Kunkler IH, Cardoso MJ, Cheung KL, de Glas NA, Trimboli RM, Korc-Grodzicki B, Soto-Perez-de-Celis E, Ponti A, Tsang J, Marotti L, Benn K, Aapro MS, Brain EGC
Lancet Oncol 2021 Jul;22(7):e327-e340. Epub 2021 May 14 doi: 10.1016/S1470-2045(20)30741-5. PMID: 34000244
Randomized Trial Comparing Resection of Primary Tumor with No Surgery in Stage IV Breast Cancer at Presentation: Protocol MF07-01.
Soran A, Ozmen V, Ozbas S, Karanlik H, Muslumanoglu M, Igci A, Canturk Z, Utkan Z, Ozaslan C, Evrensel T, Uras C, Aksaz E, Soyder A, Ugurlu U, Col C, Cabioglu N, Bozkurt B, Uzunkoy A, Koksal N, Gulluoglu BM, Unal B, Atalay C, Yıldırım E, Erdem E, Salimoglu S, Sezer A, Koyuncu A, Gurleyik G, Alagol H, Ulufi N, Berberoglu U, Dulger M, Cengiz O, Sezgin E, Johnson R
Ann Surg Oncol 2018 Oct;25(11):3141-3149. Epub 2018 May 17 doi: 10.1245/s10434-018-6494-6. PMID: 29777404
Effect of Longer-Interval vs Standard Dosing of Zoledronic Acid on Skeletal Events in Patients With Bone Metastases: A Randomized Clinical Trial.
Himelstein AL, Foster JC, Khatcheressian JL, Roberts JD, Seisler DK, Novotny PJ, Qin R, Go RS, Grubbs SS, O'Connor T, Velasco MR Jr, Weckstein D, O'Mara A, Loprinzi CL, Shapiro CL
JAMA 2017 Jan 3;317(1):48-58. doi: 10.1001/jama.2016.19425. PMID: 28030702Free PMC Article
The endocrine influence on the bone microenvironment in early breast cancer.
Wilson C, Brown H, Holen I
Endocr Relat Cancer 2016 Dec;23(12):R567-R576. Epub 2016 Sep 29 doi: 10.1530/ERC-16-0238. PMID: 27687494

Recent systematic reviews

Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update.
Eisen A, Somerfield MR, Accordino MK, Blanchette PS, Clemons MJ, Dhesy-Thind S, Dillmon MS, D'Oronzo S, Fletcher GG, Frank ES, Hallmeyer S, Makhoul I, Moy B, Thawer A, Wu JY, Van Poznak CH
J Clin Oncol 2022 Mar 1;40(7):787-800. Epub 2022 Jan 18 doi: 10.1200/JCO.21.02647. PMID: 35041467
Management of Male Breast Cancer: ASCO Guideline.
Hassett MJ, Somerfield MR, Baker ER, Cardoso F, Kansal KJ, Kwait DC, Plichta JK, Ricker C, Roshal A, Ruddy KJ, Safer JD, Van Poznak C, Yung RL, Giordano SH
J Clin Oncol 2020 Jun 1;38(16):1849-1863. Epub 2020 Feb 14 doi: 10.1200/JCO.19.03120. PMID: 32058842
Bisphosphonates and other bone agents for breast cancer.
O'Carrigan B, Wong MH, Willson ML, Stockler MR, Pavlakis N, Goodwin A
Cochrane Database Syst Rev 2017 Oct 30;10(10):CD003474. doi: 10.1002/14651858.CD003474.pub4. PMID: 29082518Free PMC Article
Breast cancer (metastatic).
Stebbing J, Ngan S
BMJ Clin Evid 2010 Sep 8;2010 PMID: 21418674Free PMC Article
Breast cancer (metastatic).
Stebbing J, Slater S, Slevin M
BMJ Clin Evid 2007 Feb 1;2007 PMID: 19454050Free PMC Article

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