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Thyroid Gland Langerhans Cell Histiocytosis

MedGen UID:
1650468
•Concept ID:
C4744802
•
Neoplastic Process

Definition

Langerhans cell histiocytosis involving the thyroid gland focally or diffusely. It is exceedingly rare and usually occurs in patients with multifocal disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Langerhans Cell Histiocytosis

Professional guidelines

PubMed

Hormonal treatment of Hand-Schüller-Christian disease: report on a case with disappearance of the bone lesions.
FLOSI AZ, ASSIS LM, COELHO NETO AS, BLOISE W, CINTRA AB, BARROS RP
J Clin Endocrinol Metab 1959 Feb;19(2):239-47. doi: 10.1210/jcem-19-2-239. PMID: 13620751

Recent clinical studies

Etiology

The value of 18F-FDG PET/CT in Langerhans cell histiocytosis.
An R, Ma X, Wang Y
Ann Nucl Med 2024 Mar;38(3):238-245. Epub 2024 Jan 13 doi: 10.1007/s12149-023-01892-3. PMID: 38217750
Adult Langerhans cell histiocytosis with thyroid gland involvement: clinical presentation, genomic analysis, and outcome.
Cai HC, Liu T, Cai H, Duan MH, Li J, Zhou DB, Cao XX
Ann Hematol 2022 Sep;101(9):1925-1929. Epub 2022 Jul 2 doi: 10.1007/s00277-022-04894-9. PMID: 35779117
High frequency of tumours in Mulibrey nanism.
Karlberg N, Karlberg S, Karikoski R, Mikkola S, Lipsanen-Nyman M, Jalanko H
J Pathol 2009 Jun;218(2):163-71. doi: 10.1002/path.2538. PMID: 19334051
Endocrine disorders in pediatric - onset Langerhans Cell Histiocytosis.
Amato MC, Elias LL, Elias J, Santos AC, Bellucci AD, Moreira AC, De Castro M
Horm Metab Res 2006 Nov;38(11):746-51. doi: 10.1055/s-2006-955086. PMID: 17111302
Endocrinological aspects of Langerhans cell histiocytosis complicated with diabetes insipidus.
Lin KD, Lin JD, Hsu HH, Juang JH, Huang MJ, Huang HS
J Endocrinol Invest 1998 Jul-Aug;21(7):428-33. doi: 10.1007/BF03347321. PMID: 9766256

Diagnosis

Langerhans Cell Histiocytosis With Thyroid Involvement on 18 F-FDG PET/MR.
Lee H, States LJ
Clin Nucl Med 2023 Dec 1;48(12):1053-1055. Epub 2023 Sep 21 doi: 10.1097/RLU.0000000000004822. PMID: 37756470
Top Ten Oncocytic Head and Neck Lesions to Contemplate.
Bullock MJ, Jiang XS
Head Neck Pathol 2023 Mar;17(1):53-65. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01520-y. PMID: 36928735Free PMC Article
Adult Langerhans cell histiocytosis with thyroid gland involvement: clinical presentation, genomic analysis, and outcome.
Cai HC, Liu T, Cai H, Duan MH, Li J, Zhou DB, Cao XX
Ann Hematol 2022 Sep;101(9):1925-1929. Epub 2022 Jul 2 doi: 10.1007/s00277-022-04894-9. PMID: 35779117
Cytologic and histological features of rare nonepithelial and nonlymphoid tumors of the thyroid.
Rossi ED, Pantanowitz L, Hornick JL
Cancer Cytopathol 2021 Aug;129(8):583-602. Epub 2021 Jan 25 doi: 10.1002/cncy.22404. PMID: 33493367
A case report.
Liu G, Liu T, Shen C, Zhou L, Ouyang R
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2020 Jan 28;45(1):96-101. doi: 10.11817/j.issn.1672-7347.2020.180625. PMID: 32132305

Therapy

BRAF gene mutations in synchronous papillary thyroid carcinoma and Langerhans cell histiocytosis co-existing in the thyroid gland: a case report and literature review.
A Al Hamad M, Albisher HM, Al Saeed WR, Almumtin AT, Allabbad FM, A Shawarby M
BMC Cancer 2019 Feb 22;19(1):170. doi: 10.1186/s12885-019-5372-3. PMID: 30795755Free PMC Article
A rare cause of goiter: Langerhans cell histiocytosis of the thyroid.
Xia CX, Li R, Wang ZH, Lv FJ, Tang XQ, Li QF, Zhang SH
Endocr J 2012;59(1):47-54. Epub 2011 Oct 21 doi: 10.1507/endocrj.ej11-0243. PMID: 22019948
Thyroid involvement in Langerhans cell histiocytosis: a report of two cases and review of the literature.
Yağci B, Kandemir N, Yazici N, Yalçin B, Varan A, Akyüz C, Büyükpamukçu M
Eur J Pediatr 2007 Sep;166(9):901-4. Epub 2007 Apr 19 doi: 10.1007/s00431-007-0487-y. PMID: 17443347
Langerhans' cell histiocytosis involving the pituitary, thyroid, lung, and liver.
Sampathkumar S, Younger C, Cramer H, Chalasani N, Skierczynski PA
Endocr Pract 2002 May-Jun;8(3):217-21. doi: 10.4158/EP.8.3.217. PMID: 12113636
Endocrinological aspects of Langerhans cell histiocytosis complicated with diabetes insipidus.
Lin KD, Lin JD, Hsu HH, Juang JH, Huang MJ, Huang HS
J Endocrinol Invest 1998 Jul-Aug;21(7):428-33. doi: 10.1007/BF03347321. PMID: 9766256

Prognosis

Immunohistochemical Biomarkers in Diagnosis of Hematolymphoid Neoplasms of Endocrine Organs.
Kuzu I, Dogan A
Endocr Pathol 2018 Jun;29(2):176-188. doi: 10.1007/s12022-018-9533-8. PMID: 29855797Free PMC Article
Hypopituitarism and goitre as endocrine manifestation of Langerhans cell histiocytosis (LCH). Case Report.
Skowronska-Jozwiak E, Sporny S, Szymanska-Duda J, Baranska D, Lewinski A
Neuro Endocrinol Lett 2016 Jul;37(3):174-178. PMID: 27618599
A rare cause of goiter: Langerhans cell histiocytosis of the thyroid.
Xia CX, Li R, Wang ZH, Lv FJ, Tang XQ, Li QF, Zhang SH
Endocr J 2012;59(1):47-54. Epub 2011 Oct 21 doi: 10.1507/endocrj.ej11-0243. PMID: 22019948
Pituitary tumours: inflammatory and granulomatous expansive lesions of the pituitary.
Carpinteri R, Patelli I, Casanueva FF, Giustina A
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):639-50. doi: 10.1016/j.beem.2009.05.009. PMID: 19945028
Thyroid involvement in Langerhans cell histiocytosis: a report of two cases and review of the literature.
Yağci B, Kandemir N, Yazici N, Yalçin B, Varan A, Akyüz C, Büyükpamukçu M
Eur J Pediatr 2007 Sep;166(9):901-4. Epub 2007 Apr 19 doi: 10.1007/s00431-007-0487-y. PMID: 17443347

Clinical prediction guides

A rare imaging presentation with multisystemic clinicopathological features of Langerhans cell histiocytosis: Case report and literature review.
Li X, Wang Y, Liu Q, Zeng Q, Fu H, He J, Schmidt-Wolf IGH, Sharma A, Liao F
Medicine (Baltimore) 2023 Sep 1;102(35):e34881. doi: 10.1097/MD.0000000000034881. PMID: 37657004Free PMC Article
(18)F-fluorodeoxyglucose positron emission tomography-computed tomography in the management of adult multisystem Langerhans cell histiocytosis.
Obert J, Vercellino L, Van Der Gucht A, de Margerie-Mellon C, Bugnet E, Chevret S, Lorillon G, Tazi A
Eur J Nucl Med Mol Imaging 2017 Apr;44(4):598-610. Epub 2016 Sep 20 doi: 10.1007/s00259-016-3521-3. PMID: 27645693
Hypopituitarism and goitre as endocrine manifestation of Langerhans cell histiocytosis (LCH). Case Report.
Skowronska-Jozwiak E, Sporny S, Szymanska-Duda J, Baranska D, Lewinski A
Neuro Endocrinol Lett 2016 Jul;37(3):174-178. PMID: 27618599
Langerhans Cell Histiocytosis: Diagnosis on Thyroid Aspirate and Review of the Literature.
Saqi A, Kuker AP, Ebner SA, Ausiello J, Jobanputra V, Bhagat G, Giorgadze TA
Head Neck Pathol 2015 Dec;9(4):496-502. Epub 2015 Jan 18 doi: 10.1007/s12105-015-0608-2. PMID: 25596951Free PMC Article
Pituitary tumours: inflammatory and granulomatous expansive lesions of the pituitary.
Carpinteri R, Patelli I, Casanueva FF, Giustina A
Best Pract Res Clin Endocrinol Metab 2009 Oct;23(5):639-50. doi: 10.1016/j.beem.2009.05.009. PMID: 19945028

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