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Bronchopulmonary Dysplasia, AE

MedGen UID:
1652354
Concept ID:
C4722188
Finding
Synonyms: BPD, AE; Bronchopulmonary Dysplasia, Adverse Event

Definition

An adverse event in a newborn characterized by a lung disorder associated with pulmonary maldevelopment, scarring, and/or inflammation that develops in preterm neonates. The condition is defined based on treatment with supplemental oxygen for at least 28 days adjusted for the degree of prematurity. [from NCI]

Professional guidelines

PubMed

Schulzke SM, Stoecklin B
Paediatr Anaesth 2022 Feb;32(2):363-371. Epub 2021 Dec 15 doi: 10.1111/pan.14369. PMID: 34878697Free PMC Article
Duijts L, van Meel ER, Moschino L, Baraldi E, Barnhoorn M, Bramer WM, Bolton CE, Boyd J, Buchvald F, Del Cerro MJ, Colin AA, Ersu R, Greenough A, Gremmen C, Halvorsen T, Kamphuis J, Kotecha S, Rooney-Otero K, Schulzke S, Wilson A, Rigau D, Morgan RL, Tonia T, Roehr CC, Pijnenburg MW
Eur Respir J 2020 Jan;55(1) Epub 2020 Jan 2 doi: 10.1183/13993003.00788-2019. PMID: 31558663
Hwang JS, Rehan VK
Lung 2018 Apr;196(2):129-138. Epub 2018 Jan 27 doi: 10.1007/s00408-018-0084-z. PMID: 29374791Free PMC Article

Recent clinical studies

Etiology

Omar SA, Abdul-Hafez A, Ibrahim S, Pillai N, Abdulmageed M, Thiruvenkataramani RP, Mohamed T, Madhukar BV, Uhal BD
Cells 2022 Apr 9;11(8) doi: 10.3390/cells11081275. PMID: 35455954Free PMC Article
Subramaniam P, Ho JJ, Davis PG
Cochrane Database Syst Rev 2021 Oct 18;10(10):CD001243. doi: 10.1002/14651858.CD001243.pub4. PMID: 34661278Free PMC Article
Doyle LW
Neonatology 2021;118(2):244-251. Epub 2021 May 11 doi: 10.1159/000515950. PMID: 33975319
Hwang JS, Rehan VK
Lung 2018 Apr;196(2):129-138. Epub 2018 Jan 27 doi: 10.1007/s00408-018-0084-z. PMID: 29374791Free PMC Article
Gyamfi-Bannerman C, Thom EA, Blackwell SC, Tita AT, Reddy UM, Saade GR, Rouse DJ, McKenna DS, Clark EA, Thorp JM Jr, Chien EK, Peaceman AM, Gibbs RS, Swamy GK, Norton ME, Casey BM, Caritis SN, Tolosa JE, Sorokin Y, VanDorsten JP, Jain L; NICHD Maternal–Fetal Medicine Units Network
N Engl J Med 2016 Apr 7;374(14):1311-20. Epub 2016 Feb 4 doi: 10.1056/NEJMoa1516783. PMID: 26842679Free PMC Article

Diagnosis

Hansen ML, Pellicer A, Hyttel-Sørensen S, Ergenekon E, Szczapa T, Hagmann C, Naulaers G, Mintzer J, Fumagalli M, Dimitriou G, Dempsey E, Tkaczyk J, Cheng G, Fredly S, Heuchan AM, Pichler G, Fuchs H, Nesargi S, Hahn GH, Piris-Borregas S, Širc J, Alsina-Casanova M, Stocker M, Ozkan H, Sarafidis K, Hopper AO, Karen T, Rzepecka-Weglarz B, Oguz SS, Arruza L, Memisoglu AC, Del Rio Florentino R, Baserga M, Maton P, Truttmann AC, de Las Cuevas I, Agergaard P, Zafra P, Bender L, Lauterbach R, Lecart C, de Buyst J, El-Khuffash A, Curley A, Vaccarello OO, Miletin J, Papathoma E, Vesoulis Z, Vento G, Cornette L, Lopez LS, Yasa B, Klamer A, Agosti M, Baud O, Mastretta E, Cetinkaya M, McCall K, Zeng S, Hatzidaki E, Bargiel A, Marciniak S, Gao X, Huijia L, Chalak L, Yang L, Rao SA, Xu X, Gonzalez BL, Wilinska M, Yin Z, Sadowska-Krawczenko I, Serrano-Viñuales I, Krolak-Olejnik B, Ybarra MM, Morales-Betancourt C, Korček P, Teresa-Palacio M, Mosca F, Hergenhan A, Koksal N, Tsoni K, Kadri MM, Knöpfli C, Rafinska-Wazny E, Akin MS, Nordvik T, Peng Z, Kersin SG, Thewissen L, Alarcon A, Healy D, Urlesberger B, Baş M, Baumgartner J, Skylogianni E, Karadyova V, Valverde E, Bergon-Sendin E, Kucera J, Pisoni S, Wang L, Smits A, Sanchez-Salmador R, Rasmussen MI, Olsen MH, Jensen AK, Gluud C, Jakobsen JC, Greisen G
N Engl J Med 2023 Apr 20;388(16):1501-1511. doi: 10.1056/NEJMoa2207554. PMID: 37075142
Sung JH, Kim JH, Kim Y, Choi YS, Hong S, Choi SJ, Kim JS, Roh CR, Oh SY
Am J Obstet Gynecol MFM 2023 Apr;5(4):100886. Epub 2023 Feb 4 doi: 10.1016/j.ajogmf.2023.100886. PMID: 36746334
Franz AR, Engel C, Bassler D, Rüdiger M, Thome UH, Maier RF, Krägeloh-Mann I, Kron M, Essers J, Bührer C, Rellensmann G, Rossi R, Bittrich HJ, Roll C, Höhn T, Ehrhardt H, Avenarius S, Körner HT, Stein A, Buxmann H, Vochem M, Poets CF; ETTNO Investigators
JAMA 2020 Aug 11;324(6):560-570. doi: 10.1001/jama.2020.10690. PMID: 32780138Free PMC Article
Almadhoob A, Ohlsson A
Cochrane Database Syst Rev 2020 Jan 27;1(1):CD010333. doi: 10.1002/14651858.CD010333.pub3. PMID: 31986231Free PMC Article
Abman SH, Hansmann G, Archer SL, Ivy DD, Adatia I, Chung WK, Hanna BD, Rosenzweig EB, Raj JU, Cornfield D, Stenmark KR, Steinhorn R, Thébaud B, Fineman JR, Kuehne T, Feinstein JA, Friedberg MK, Earing M, Barst RJ, Keller RL, Kinsella JP, Mullen M, Deterding R, Kulik T, Mallory G, Humpl T, Wessel DL; American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular Surgery and Anesthesia; and the American Thoracic Society
Circulation 2015 Nov 24;132(21):2037-99. Epub 2015 Nov 3 doi: 10.1161/CIR.0000000000000329. PMID: 26534956

Therapy

Jensen EA, Watterberg KL
Neoreviews 2023 Nov 1;24(11):e691-e703. doi: 10.1542/neo.24-11-e691. PMID: 37907402
Chen X, Han D, Wang X, Huang X, Huang Z, Liu Y, Zhong J, Walther FJ, Yang C, Wagenaar GTM
Respir Res 2023 Feb 2;24(1):39. doi: 10.1186/s12931-023-02342-4. PMID: 36732726Free PMC Article
Subramaniam P, Ho JJ, Davis PG
Cochrane Database Syst Rev 2021 Oct 18;10(10):CD001243. doi: 10.1002/14651858.CD001243.pub4. PMID: 34661278Free PMC Article
Doyle LW
Neonatology 2021;118(2):244-251. Epub 2021 May 11 doi: 10.1159/000515950. PMID: 33975319
Hwang JS, Rehan VK
Lung 2018 Apr;196(2):129-138. Epub 2018 Jan 27 doi: 10.1007/s00408-018-0084-z. PMID: 29374791Free PMC Article

Prognosis

Watterberg KL, Walsh MC, Li L, Chawla S, D'Angio CT, Goldberg RN, Hintz SR, Laughon MM, Yoder BA, Kennedy KA, McDavid GE, Backstrom-Lacy C, Das A, Crawford MM, Keszler M, Sokol GM, Poindexter BB, Ambalavanan N, Hibbs AM, Truog WE, Schmidt B, Wyckoff MH, Khan AM, Garg M, Chess PR, Reynolds AM, Moallem M, Bell EF, Meyer LR, Patel RM, Van Meurs KP, Cotten CM, McGowan EC, Hines AC, Merhar S, Peralta-Carcelen M, Wilson-Costello DE, Kilbride HW, DeMauro SB, Heyne RJ, Mosquera RA, Natarajan G, Purdy IB, Lowe JR, Maitre NL, Harmon HM, Hogden LA, Adams-Chapman I, Winter S, Malcolm WF, Higgins RD; Eunice Kennedy Shriver NICHD Neonatal Research Network
N Engl J Med 2022 Mar 24;386(12):1121-1131. doi: 10.1056/NEJMoa2114897. PMID: 35320643Free PMC Article
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Juul SE, Comstock BA, Wadhawan R, Mayock DE, Courtney SE, Robinson T, Ahmad KA, Bendel-Stenzel E, Baserga M, LaGamma EF, Downey LC, Rao R, Fahim N, Lampland A, Frantz ID III, Khan JY, Weiss M, Gilmore MM, Ohls RK, Srinivasan N, Perez JE, McKay V, Vu PT, Lowe J, Kuban K, O'Shea TM, Hartman AL, Heagerty PJ; PENUT Trial Consortium
N Engl J Med 2020 Jan 16;382(3):233-243. doi: 10.1056/NEJMoa1907423. PMID: 31940698Free PMC Article
Onland W, Cools F, Kroon A, Rademaker K, Merkus MP, Dijk PH, van Straaten HL, Te Pas AB, Mohns T, Bruneel E, van Heijst AF, Kramer BW, Debeer A, Zonnenberg I, Marechal Y, Blom H, Plaskie K, Offringa M, van Kaam AH; STOP-BPD Study Group
JAMA 2019 Jan 29;321(4):354-363. doi: 10.1001/jama.2018.21443. PMID: 30694322Free PMC Article
Hwang JS, Rehan VK
Lung 2018 Apr;196(2):129-138. Epub 2018 Jan 27 doi: 10.1007/s00408-018-0084-z. PMID: 29374791Free PMC Article

Clinical prediction guides

Gould JF, Makrides M, Gibson RA, Sullivan TR, McPhee AJ, Anderson PJ, Best KP, Sharp M, Cheong JLY, Opie GF, Travadi J, Bednarz JM, Davis PG, Simmer K, Doyle LW, Collins CT
N Engl J Med 2022 Oct 27;387(17):1579-1588. doi: 10.1056/NEJMoa2206868. PMID: 36300974
Gilfillan M, Bhandari V
Am J Physiol Lung Cell Mol Physiol 2022 Jun 1;322(6):L804-L821. Epub 2022 Apr 19 doi: 10.1152/ajplung.00452.2021. PMID: 35437999
Franz AR, Engel C, Bassler D, Rüdiger M, Thome UH, Maier RF, Krägeloh-Mann I, Kron M, Essers J, Bührer C, Rellensmann G, Rossi R, Bittrich HJ, Roll C, Höhn T, Ehrhardt H, Avenarius S, Körner HT, Stein A, Buxmann H, Vochem M, Poets CF; ETTNO Investigators
JAMA 2020 Aug 11;324(6):560-570. doi: 10.1001/jama.2020.10690. PMID: 32780138Free PMC Article
Juul SE, Comstock BA, Wadhawan R, Mayock DE, Courtney SE, Robinson T, Ahmad KA, Bendel-Stenzel E, Baserga M, LaGamma EF, Downey LC, Rao R, Fahim N, Lampland A, Frantz ID III, Khan JY, Weiss M, Gilmore MM, Ohls RK, Srinivasan N, Perez JE, McKay V, Vu PT, Lowe J, Kuban K, O'Shea TM, Hartman AL, Heagerty PJ; PENUT Trial Consortium
N Engl J Med 2020 Jan 16;382(3):233-243. doi: 10.1056/NEJMoa1907423. PMID: 31940698Free PMC Article
Norman JE, Marlow N, Messow CM, Shennan A, Bennett PR, Thornton S, Robson SC, McConnachie A, Petrou S, Sebire NJ, Lavender T, Whyte S, Norrie J; OPPTIMUM study group
Lancet 2016 May 21;387(10033):2106-2116. Epub 2016 Feb 24 doi: 10.1016/S0140-6736(16)00350-0. PMID: 26921136Free PMC Article

Recent systematic reviews

Garegnani L, Styrmisdóttir L, Roson Rodriguez P, Escobar Liquitay CM, Esteban I, Franco JV
Cochrane Database Syst Rev 2021 Nov 16;11(11):CD013757. doi: 10.1002/14651858.CD013757.pub2. PMID: 34783356Free PMC Article
Doyle LW, Cheong JL, Hay S, Manley BJ, Halliday HL
Cochrane Database Syst Rev 2021 Nov 11;11(11):CD001145. doi: 10.1002/14651858.CD001145.pub5. PMID: 34758507Free PMC Article
Subramaniam P, Ho JJ, Davis PG
Cochrane Database Syst Rev 2021 Oct 18;10(10):CD001243. doi: 10.1002/14651858.CD001243.pub4. PMID: 34661278Free PMC Article
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Duijts L, van Meel ER, Moschino L, Baraldi E, Barnhoorn M, Bramer WM, Bolton CE, Boyd J, Buchvald F, Del Cerro MJ, Colin AA, Ersu R, Greenough A, Gremmen C, Halvorsen T, Kamphuis J, Kotecha S, Rooney-Otero K, Schulzke S, Wilson A, Rigau D, Morgan RL, Tonia T, Roehr CC, Pijnenburg MW
Eur Respir J 2020 Jan;55(1) Epub 2020 Jan 2 doi: 10.1183/13993003.00788-2019. PMID: 31558663

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