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Grade 3 Bronchopulmonary Dysplasia, AE

MedGen UID:
1662513
•Concept ID:
C4743911
•
Finding
Synonyms: Grade 3 BPD, AE; Grade 3 Bronchopulmonary Dysplasia, Adverse Event

Definition

An adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND need for greater than 30% oxygen or positive pressure at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks'' gestation; need for greater than 30% oxygen or positive pressure by 56 days postnatal age in infants born greater than 32 weeks'' gestation; need for greater than 30% oxygen and/or positive pressure at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 3 Bronchopulmonary Dysplasia, AE

Professional guidelines

PubMed

Corticosteroids for the prevention and treatment of bronchopulmonary dysplasia: an overview of systematic reviews.
van de Loo M, van Kaam A, Offringa M, Doyle LW, Cooper C, Onland W
Cochrane Database Syst Rev 2024 Apr 10;4(4):CD013271. doi: 10.1002/14651858.CD013271.pub2. PMID: 38597338Free PMC Article
Animal derived surfactant extract versus protein free synthetic surfactant for the prevention and treatment of respiratory distress syndrome.
Ardell S, Pfister RH, Soll R
Cochrane Database Syst Rev 2015 Aug 24;8(8):CD000144. doi: 10.1002/14651858.CD000144.pub3. PMID: 26301526Free PMC Article
Bronchodilators for the prevention and treatment of chronic lung disease in preterm infants.
Ng GY, da S, Ohlsson A
Cochrane Database Syst Rev 2001;(3):CD003214. doi: 10.1002/14651858.CD003214. PMID: 11687053

Recent clinical studies

Etiology

Palivizumab for preventing severe respiratory syncytial virus (RSV) infection in children.
Garegnani L, Styrmisdóttir L, Roson Rodriguez P, Escobar Liquitay CM, Esteban I, Franco JV
Cochrane Database Syst Rev 2021 Nov 16;11(11):CD013757. doi: 10.1002/14651858.CD013757.pub2. PMID: 34783356Free PMC Article
Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants.
Subramaniam P, Ho JJ, Davis PG
Cochrane Database Syst Rev 2021 Oct 18;10(10):CD001243. doi: 10.1002/14651858.CD001243.pub4. PMID: 34661278Free PMC Article
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
17-OHPC to Prevent Recurrent Preterm Birth in Singleton Gestations (PROLONG Study): A Multicenter, International, Randomized Double-Blind Trial.
Blackwell SC, Gyamfi-Bannerman C, Biggio JR Jr, Chauhan SP, Hughes BL, Louis JM, Manuck TA, Miller HS, Das AF, Saade GR, Nielsen P, Baker J, Yuzko OM, Reznichenko GI, Reznichenko NY, Pekarev O, Tatarova N, Gudeman J, Birch R, Jozwiakowski MJ, Duncan M, Williams L, Krop J
Am J Perinatol 2020 Jan;37(2):127-136. Epub 2019 Oct 25 doi: 10.1055/s-0039-3400227. PMID: 31652479
Inhaled Corticosteroids for Bronchopulmonary Dysplasia: A Meta-analysis.
Shinwell ES, Portnov I, Meerpohl JJ, Karen T, Bassler D
Pediatrics 2016 Dec;138(6) doi: 10.1542/peds.2016-2511. PMID: 27940717

Diagnosis

Can Red Blood Cell and Platelet Transfusions Have a Pathogenic Role in Bronchopulmonary Dysplasia?
Bahr TM, Snow GL, Christensen TR, Davenport P, Henry E, Tweddell SM, Ilstrup SJ, Yoder BA, Ohls RK, Sola-Visner MC, Christensen RD
J Pediatr 2024 Feb;265:113836. Epub 2023 Nov 20 doi: 10.1016/j.jpeds.2023.113836. PMID: 37992802
Early (< 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.
Doyle LW, Cheong JL, Hay S, Manley BJ, Halliday HL
Cochrane Database Syst Rev 2021 Oct 21;10(10):CD001146. doi: 10.1002/14651858.CD001146.pub6. PMID: 34674229Free PMC Article
The future of Cochrane Neonatal.
Soll RF, Ovelman C, McGuire W
Early Hum Dev 2020 Nov;150:105191. Epub 2020 Sep 12 doi: 10.1016/j.earlhumdev.2020.105191. PMID: 33036834
Physiology and Predictors of Impaired Gas Exchange in Infants with Bronchopulmonary Dysplasia.
Svedenkrans J, Stoecklin B, Jones JG, Doherty DA, Pillow JJ
Am J Respir Crit Care Med 2019 Aug 15;200(4):471-480. doi: 10.1164/rccm.201810-2037OC. PMID: 30789787
Inhaled versus systemic corticosteroids for preventing bronchopulmonary dysplasia in ventilated very low birth weight preterm neonates.
Shah SS, Ohlsson A, Halliday HL, Shah VS
Cochrane Database Syst Rev 2017 Oct 17;10(10):CD002058. doi: 10.1002/14651858.CD002058.pub3. PMID: 29041034Free PMC Article

Therapy

Palivizumab for preventing severe respiratory syncytial virus (RSV) infection in children.
Garegnani L, Styrmisdóttir L, Roson Rodriguez P, Escobar Liquitay CM, Esteban I, Franco JV
Cochrane Database Syst Rev 2021 Nov 16;11(11):CD013757. doi: 10.1002/14651858.CD013757.pub2. PMID: 34783356Free PMC Article
Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants.
Subramaniam P, Ho JJ, Davis PG
Cochrane Database Syst Rev 2021 Oct 18;10(10):CD001243. doi: 10.1002/14651858.CD001243.pub4. PMID: 34661278Free PMC Article
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
17-OHPC to Prevent Recurrent Preterm Birth in Singleton Gestations (PROLONG Study): A Multicenter, International, Randomized Double-Blind Trial.
Blackwell SC, Gyamfi-Bannerman C, Biggio JR Jr, Chauhan SP, Hughes BL, Louis JM, Manuck TA, Miller HS, Das AF, Saade GR, Nielsen P, Baker J, Yuzko OM, Reznichenko GI, Reznichenko NY, Pekarev O, Tatarova N, Gudeman J, Birch R, Jozwiakowski MJ, Duncan M, Williams L, Krop J
Am J Perinatol 2020 Jan;37(2):127-136. Epub 2019 Oct 25 doi: 10.1055/s-0039-3400227. PMID: 31652479
Inhaled Corticosteroids for Bronchopulmonary Dysplasia: A Meta-analysis.
Shinwell ES, Portnov I, Meerpohl JJ, Karen T, Bassler D
Pediatrics 2016 Dec;138(6) doi: 10.1542/peds.2016-2511. PMID: 27940717

Prognosis

Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Physiology and Predictors of Impaired Gas Exchange in Infants with Bronchopulmonary Dysplasia.
Svedenkrans J, Stoecklin B, Jones JG, Doherty DA, Pillow JJ
Am J Respir Crit Care Med 2019 Aug 15;200(4):471-480. doi: 10.1164/rccm.201810-2037OC. PMID: 30789787
High versus standard dose caffeine for apnoea: a systematic review.
Vliegenthart R, Miedema M, Hutten GJ, van Kaam AH, Onland W
Arch Dis Child Fetal Neonatal Ed 2018 Nov;103(6):F523-F529. Epub 2018 Feb 7 doi: 10.1136/archdischild-2017-313556. PMID: 29437799
Inhaled nitric oxide for respiratory failure in preterm infants.
Barrington KJ, Finer N, Pennaforte T
Cochrane Database Syst Rev 2017 Jan 3;1(1):CD000509. doi: 10.1002/14651858.CD000509.pub5. PMID: 28045472Free PMC Article
Inhaled Corticosteroids for Bronchopulmonary Dysplasia: A Meta-analysis.
Shinwell ES, Portnov I, Meerpohl JJ, Karen T, Bassler D
Pediatrics 2016 Dec;138(6) doi: 10.1542/peds.2016-2511. PMID: 27940717

Clinical prediction guides

Corticosteroids for the prevention and treatment of bronchopulmonary dysplasia: an overview of systematic reviews.
van de Loo M, van Kaam A, Offringa M, Doyle LW, Cooper C, Onland W
Cochrane Database Syst Rev 2024 Apr 10;4(4):CD013271. doi: 10.1002/14651858.CD013271.pub2. PMID: 38597338Free PMC Article
Can Red Blood Cell and Platelet Transfusions Have a Pathogenic Role in Bronchopulmonary Dysplasia?
Bahr TM, Snow GL, Christensen TR, Davenport P, Henry E, Tweddell SM, Ilstrup SJ, Yoder BA, Ohls RK, Sola-Visner MC, Christensen RD
J Pediatr 2024 Feb;265:113836. Epub 2023 Nov 20 doi: 10.1016/j.jpeds.2023.113836. PMID: 37992802
Systemic corticosteroids for the prevention of bronchopulmonary dysplasia, a network meta-analysis.
Hay S, Ovelman C, Zupancic JA, Doyle LW, Onland W, Konstantinidis M, Shah PS, Soll R
Cochrane Database Syst Rev 2023 Aug 31;8(8):CD013730. doi: 10.1002/14651858.CD013730.pub2. PMID: 37650547Free PMC Article
Physiology and Predictors of Impaired Gas Exchange in Infants with Bronchopulmonary Dysplasia.
Svedenkrans J, Stoecklin B, Jones JG, Doherty DA, Pillow JJ
Am J Respir Crit Care Med 2019 Aug 15;200(4):471-480. doi: 10.1164/rccm.201810-2037OC. PMID: 30789787
Retinopathy of Prematurity: Therapeutic Strategies Based on Pathophysiology.
Cayabyab R, Ramanathan R
Neonatology 2016;109(4):369-76. Epub 2016 Jun 3 doi: 10.1159/000444901. PMID: 27251645

Recent systematic reviews

Late (≥ 7 days) inhaled corticosteroids to reduce bronchopulmonary dysplasia in preterm infants.
Onland W, Offringa M, van Kaam A
Cochrane Database Syst Rev 2022 Dec 15;12(12):CD002311. doi: 10.1002/14651858.CD002311.pub5. PMID: 36521169Free PMC Article
Palivizumab for preventing severe respiratory syncytial virus (RSV) infection in children.
Garegnani L, Styrmisdóttir L, Roson Rodriguez P, Escobar Liquitay CM, Esteban I, Franco JV
Cochrane Database Syst Rev 2021 Nov 16;11(11):CD013757. doi: 10.1002/14651858.CD013757.pub2. PMID: 34783356Free PMC Article
Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants.
Subramaniam P, Ho JJ, Davis PG
Cochrane Database Syst Rev 2021 Oct 18;10(10):CD001243. doi: 10.1002/14651858.CD001243.pub4. PMID: 34661278Free PMC Article
Continuous positive airway pressure (CPAP) for respiratory distress in preterm infants.
Ho JJ, Subramaniam P, Davis PG
Cochrane Database Syst Rev 2020 Oct 15;10(10):CD002271. doi: 10.1002/14651858.CD002271.pub3. PMID: 33058208Free PMC Article
Inhaled nitric oxide for respiratory failure in preterm infants.
Barrington KJ, Finer N, Pennaforte T
Cochrane Database Syst Rev 2017 Jan 3;1(1):CD000509. doi: 10.1002/14651858.CD000509.pub5. PMID: 28045472Free PMC Article

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