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Recurrent Digestive System Neuroendocrine Carcinoma

MedGen UID:
1652664
•Concept ID:
C4744463
•
Neoplastic Process
Synonym: Recurrent Gastrointestinal System Neuroendocrine Carcinoma

Definition

The reemergence of a neuroendocrine carcinoma in any part of the digestive system after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Digestive System Neuroendocrine Carcinoma

Professional guidelines

PubMed

Neuroendocrine Carcinoma of the Anus and Rectum: Patient Characteristics and Treatment Options.
Ueberroth BE, Liu AJ, Starr JS, Hobday TJ, Ashman JB, Mishra N, Bekaii-Saab TS, Halfdanarson TR, Sonbol MB
Clin Colorectal Cancer 2021 Jun;20(2):e139-e149. Epub 2020 Dec 17 doi: 10.1016/j.clcc.2020.12.001. PMID: 33551318
Can surgical treatment be justified for neuroendocrine carcinoma of the gallbladder?
You YH, Choi DW, Heo JS, Han IW, Choi SH, Jang KT, Han S
Medicine (Baltimore) 2019 Mar;98(11):e14886. doi: 10.1097/MD.0000000000014886. PMID: 30882701Free PMC Article
Ampullary Mixed Adenoneuroendocrine Carcinoma: Surprise Histology, Familiar Management.
Mahansaria SS, Agrawal N, Arora A, Bihari C, Appukuttan M, Chattopadhyay TK
Int J Surg Pathol 2017 Oct;25(7):585-591. Epub 2017 May 29 doi: 10.1177/1066896917712454. PMID: 28552015

Recent clinical studies

Etiology

Effectiveness of Etoposide and Cisplatin vs Irinotecan and Cisplatin Therapy for Patients With Advanced Neuroendocrine Carcinoma of the Digestive System: The TOPIC-NEC Phase 3 Randomized Clinical Trial.
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Expanding Indications for Liver Transplant: Tumor and Patient Factors.
Chu KK, Wong KH, Chok KS
Gut Liver 2021 Jan 15;15(1):19-30. doi: 10.5009/gnl19265. PMID: 32102130Free PMC Article
Long-Standing Ulcerative Colitis May Trigger a Multilineage Cancerization Field.
Fassan M, Brignola S, Sarzo G, Cappellesso R, Rugge M
Int J Surg Pathol 2018 Sep;26(6):558-560. Epub 2018 Mar 27 doi: 10.1177/1066896918764830. PMID: 29580126
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263

Diagnosis

Anal canal mixed adenoneuroendocrine carcinoma in a young patient misdiagnosed as anal abscess.
Tutino R, Battistella E, Bonariol L, Massani M
BMJ Case Rep 2021 Sep 21;14(9) doi: 10.1136/bcr-2021-244737. PMID: 34548300Free PMC Article
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Recent developments and ongoing trials in transplant oncology.
Moeckli B, Ivanics T, Claasen M, Toso C, Sapisochin G
Liver Int 2020 Oct;40(10):2326-2344. doi: 10.1111/liv.14621. PMID: 33021344
Clear cell carcinoid of the appendix: Report of two cases with literature review.
Kang GH, Lee BS, Kang DY
Pathol Int 2015 Jun;65(6):324-8. Epub 2015 Mar 24 doi: 10.1111/pin.12284. PMID: 25808197
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Therapy

Effectiveness of Etoposide and Cisplatin vs Irinotecan and Cisplatin Therapy for Patients With Advanced Neuroendocrine Carcinoma of the Digestive System: The TOPIC-NEC Phase 3 Randomized Clinical Trial.
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
A malignant cause of hypoglycaemia: a metastatic insulin-secreting pancreatic neuroendocrine carcinoma.
Sandoval MA, Pagsisihan D, Berberabe A, Palugod-Lopez EG
BMJ Case Rep 2016 Mar 18;2016 doi: 10.1136/bcr-2016-214702. PMID: 26994053Free PMC Article
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263
Poorly differentiated small-cell neuroendocrine carcinoma of the submandibular gland: a case report.
Scaduto M, Matrka L, Shah M, Wakely P Jr, Ozer E
Ear Nose Throat J 2012 Apr;91(4):E10-3. doi: 10.1177/014556131209100416. PMID: 22522359
Merkel cell tumour of the external ear. Report of a case.
Palma S, Cavazzini L, Bovo R, Padovani D, Bugli AM, Borrelli M, Martini A
Auris Nasus Larynx 2007 Jun;34(2):229-32. Epub 2006 Oct 24 doi: 10.1016/j.anl.2006.07.011. PMID: 17064866

Prognosis

Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Expanding Indications for Liver Transplant: Tumor and Patient Factors.
Chu KK, Wong KH, Chok KS
Gut Liver 2021 Jan 15;15(1):19-30. doi: 10.5009/gnl19265. PMID: 32102130Free PMC Article
Multiple gastrointestinal metastases of Merkel cell carcinoma.
Poškus E, Platkevičius G, Simanskaitė V, Rimkevičiūtė E, Petrulionis M, Strupas K
Medicina (Kaunas) 2016;52(5):321-324. Epub 2016 Sep 20 doi: 10.1016/j.medici.2016.09.001. PMID: 27707579
Mixed adenoneuroendocrine carcinoma of the gastric stump following Billroth II gastrectomy: case report and review of the literature.
Cazzo E, de Saito HP
Sao Paulo Med J 2016 Jan-Feb;134(1):84-7. Epub 2015 Apr 14 doi: 10.1590/1516-3180.2013.9080911. PMID: 25885489Free PMC Article
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Clinical prediction guides

Expanding Indications for Liver Transplant: Tumor and Patient Factors.
Chu KK, Wong KH, Chok KS
Gut Liver 2021 Jan 15;15(1):19-30. doi: 10.5009/gnl19265. PMID: 32102130Free PMC Article
Clear cell carcinoid of the appendix: Report of two cases with literature review.
Kang GH, Lee BS, Kang DY
Pathol Int 2015 Jun;65(6):324-8. Epub 2015 Mar 24 doi: 10.1111/pin.12284. PMID: 25808197
Cytopathologic evaluation of the in situ margin in patients undergoing hepatectomy.
Jones NB, Wakely PE Jr, Klemanski DL, Al-Saif O, Young G, Frankel WL, Martin EW, Bloomston M
Cancer Cytopathol 2012 Dec 25;120(6):410-5. Epub 2012 May 17 doi: 10.1002/cncy.21204. PMID: 22605571
A malignant nonfunctioning pancreatic endocrine tumor with a unique pattern of intraductal growth.
Inagaki M, Watanabe K, Yoshikawa D, Suzuki S, Ishizaki A, Matsumoto K, Haneda M, Tokusashi Y, Miyokawa N, Sato S, Kasai S
J Hepatobiliary Pancreat Surg 2007;14(3):318-23. Epub 2007 May 29 doi: 10.1007/s00534-006-1140-2. PMID: 17520210
Somatostatin-producing pancreatic endocrine carcinoma presented as relapsing cholangitis -- a case report.
Marakis G, Ballas K, Rafailidis S, Alatsakis M, Patsiaoura K, Sakadamis A
Pancreatology 2005;5(2-3):295-9. Epub 2005 Apr 21 doi: 10.1159/000085286. PMID: 15849491

Recent systematic reviews

Neuroendocrine carcinoma of the minor papilla with pancreas divisum: a case report and review of the literature.
Saito K, Matsuo Y, Denda Y, Nonoyama K, Murase H, Kato T, Hayashi Y, Imafuji H, Morimoto M, Ogawa R, Takahashi H, Takiguchi S
J Med Case Rep 2023 Mar 28;17(1):127. doi: 10.1186/s13256-023-03828-x. PMID: 36973791Free PMC Article
Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
The clinical profiles, management, and prognostic factors of biliary mixed neuroendocrine nonneuroendocrine neoplasms: A systematic review of the literature.
Wen LJ, Chen JH, Xu HJ, Yu Q, Deng Y, Liu K
Medicine (Baltimore) 2020 Dec 11;99(50):e23271. doi: 10.1097/MD.0000000000023271. PMID: 33327249Free PMC Article
Clinicopathological data and treatment modalities for pancreatic vipomas: a systematic review.
Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, Felekouras E
J BUON 2019 Mar-Apr;24(2):415-423. PMID: 31127985
Liver transplantation for hepatic tumors: a systematic review.
Ravaioli M, Ercolani G, Neri F, Cescon M, Stacchini G, Del Gaudio M, Cucchetti A, Pinna AD
World J Gastroenterol 2014 May 14;20(18):5345-52. doi: 10.3748/wjg.v20.i18.5345. PMID: 24833864Free PMC Article

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