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Recurrent Digestive System Neuroendocrine Carcinoma

MedGen UID:
1652664
•Concept ID:
C4744463
•
Neoplastic Process
Synonym: Recurrent Gastrointestinal System Neuroendocrine Carcinoma

Definition

The reemergence of a neuroendocrine carcinoma in any part of the digestive system after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Digestive System Neuroendocrine Carcinoma

Professional guidelines

PubMed

Neuroendocrine Carcinoma of the Anus and Rectum: Patient Characteristics and Treatment Options.
Ueberroth BE, Liu AJ, Starr JS, Hobday TJ, Ashman JB, Mishra N, Bekaii-Saab TS, Halfdanarson TR, Sonbol MB
Clin Colorectal Cancer 2021 Jun;20(2):e139-e149. Epub 2020 Dec 17 doi: 10.1016/j.clcc.2020.12.001. PMID: 33551318
The clinical profiles, management, and prognostic factors of biliary mixed neuroendocrine nonneuroendocrine neoplasms: A systematic review of the literature.
Wen LJ, Chen JH, Xu HJ, Yu Q, Deng Y, Liu K
Medicine (Baltimore) 2020 Dec 11;99(50):e23271. doi: 10.1097/MD.0000000000023271. PMID: 33327249Free PMC Article
Can surgical treatment be justified for neuroendocrine carcinoma of the gallbladder?
You YH, Choi DW, Heo JS, Han IW, Choi SH, Jang KT, Han S
Medicine (Baltimore) 2019 Mar;98(11):e14886. doi: 10.1097/MD.0000000000014886. PMID: 30882701Free PMC Article

Recent clinical studies

Etiology

Effectiveness of Etoposide and Cisplatin vs Irinotecan and Cisplatin Therapy for Patients With Advanced Neuroendocrine Carcinoma of the Digestive System: The TOPIC-NEC Phase 3 Randomized Clinical Trial.
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Molecular subtyping in pancreatic neuroendocrine neoplasms: New insights into clinical, pathological unmet needs and challenges.
Yan J, Yu S, Jia C, Li M, Chen J
Biochim Biophys Acta Rev Cancer 2020 Aug;1874(1):188367. Epub 2020 Apr 25 doi: 10.1016/j.bbcan.2020.188367. PMID: 32339609
Are There Indications for Total Pancreatectomy in 2016?
Andrén-Sandberg Å, Ansorge C, Yadav TD
Dig Surg 2016;33(4):329-34. Epub 2016 May 25 doi: 10.1159/000445018. PMID: 27215746
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263

Diagnosis

Adult pancreatoblastoma: Current concepts in pathology.
Omiyale AO
World J Gastroenterol 2021 Jul 14;27(26):4172-4181. doi: 10.3748/wjg.v27.i26.4172. PMID: 34326617Free PMC Article
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Neuroendocrine Carcinoma of the Anus and Rectum: Patient Characteristics and Treatment Options.
Ueberroth BE, Liu AJ, Starr JS, Hobday TJ, Ashman JB, Mishra N, Bekaii-Saab TS, Halfdanarson TR, Sonbol MB
Clin Colorectal Cancer 2021 Jun;20(2):e139-e149. Epub 2020 Dec 17 doi: 10.1016/j.clcc.2020.12.001. PMID: 33551318
Biliary tract large cell neuroendocrine carcinoma: current evidence.
Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Therapy

Effectiveness of Etoposide and Cisplatin vs Irinotecan and Cisplatin Therapy for Patients With Advanced Neuroendocrine Carcinoma of the Digestive System: The TOPIC-NEC Phase 3 Randomized Clinical Trial.
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Neuroendocrine Carcinoma of the Anus and Rectum: Patient Characteristics and Treatment Options.
Ueberroth BE, Liu AJ, Starr JS, Hobday TJ, Ashman JB, Mishra N, Bekaii-Saab TS, Halfdanarson TR, Sonbol MB
Clin Colorectal Cancer 2021 Jun;20(2):e139-e149. Epub 2020 Dec 17 doi: 10.1016/j.clcc.2020.12.001. PMID: 33551318
Are There Indications for Total Pancreatectomy in 2016?
Andrén-Sandberg Å, Ansorge C, Yadav TD
Dig Surg 2016;33(4):329-34. Epub 2016 May 25 doi: 10.1159/000445018. PMID: 27215746
Liver transplantation for hepatic tumors: a systematic review.
Ravaioli M, Ercolani G, Neri F, Cescon M, Stacchini G, Del Gaudio M, Cucchetti A, Pinna AD
World J Gastroenterol 2014 May 14;20(18):5345-52. doi: 10.3748/wjg.v20.i18.5345. PMID: 24833864Free PMC Article
Liver transplantation for malignancies.
Eghtesad B, Aucejo F
J Gastrointest Cancer 2014 Sep;45(3):353-62. doi: 10.1007/s12029-014-9590-2. PMID: 24604263

Prognosis

Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Neuroendocrine Carcinoma of the Anus and Rectum: Patient Characteristics and Treatment Options.
Ueberroth BE, Liu AJ, Starr JS, Hobday TJ, Ashman JB, Mishra N, Bekaii-Saab TS, Halfdanarson TR, Sonbol MB
Clin Colorectal Cancer 2021 Jun;20(2):e139-e149. Epub 2020 Dec 17 doi: 10.1016/j.clcc.2020.12.001. PMID: 33551318
Biliary tract large cell neuroendocrine carcinoma: current evidence.
Raiker R, Chauhan A, Hasanein H, Burkeen G, Horn M, Veedu J, Vela C, Arnold S, Kolesar J, Anthony L, Evers BM, Cavnar M
Orphanet J Rare Dis 2019 Nov 21;14(1):266. doi: 10.1186/s13023-019-1230-2. PMID: 31752927Free PMC Article
Neuroendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review.
Zhang L, Wan D, Bao L, Chen Q, Xie H, Xu S, Lin S
Medicine (Baltimore) 2018 Jul;97(29):e11487. doi: 10.1097/MD.0000000000011487. PMID: 30024526Free PMC Article
Anal neoplasms.
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Clinical prediction guides

Childhood neuroendocrine tumors of the digestive system: A single center experience.
Kartal İ
Medicine (Baltimore) 2022 Feb 11;101(6):e28795. doi: 10.1097/MD.0000000000028795. PMID: 35147110Free PMC Article
Neuroendocrine carcinoma and mixed neuroendocrine‒non-neuroendocrine neoplasm of the stomach: a clinicopathological and exome sequencing study.
Ishida S, Akita M, Fujikura K, Komatsu M, Sawada R, Matsumoto H, Saegusa J, Itoh T, Kakeji Y, Zen Y
Hum Pathol 2021 Apr;110:1-10. Epub 2021 Jan 21 doi: 10.1016/j.humpath.2020.12.008. PMID: 33359239
Expanding Indications for Liver Transplant: Tumor and Patient Factors.
Chu KK, Wong KH, Chok KS
Gut Liver 2021 Jan 15;15(1):19-30. doi: 10.5009/gnl19265. PMID: 32102130Free PMC Article
Molecular subtyping in pancreatic neuroendocrine neoplasms: New insights into clinical, pathological unmet needs and challenges.
Yan J, Yu S, Jia C, Li M, Chen J
Biochim Biophys Acta Rev Cancer 2020 Aug;1874(1):188367. Epub 2020 Apr 25 doi: 10.1016/j.bbcan.2020.188367. PMID: 32339609
Neuroendocrine carcinoma in the extrahepatic biliary tract: A case report and literature review.
Zhang L, Wan D, Bao L, Chen Q, Xie H, Xu S, Lin S
Medicine (Baltimore) 2018 Jul;97(29):e11487. doi: 10.1097/MD.0000000000011487. PMID: 30024526Free PMC Article

Recent systematic reviews

Neuroendocrine carcinoma of the minor papilla with pancreas divisum: a case report and review of the literature.
Saito K, Matsuo Y, Denda Y, Nonoyama K, Murase H, Kato T, Hayashi Y, Imafuji H, Morimoto M, Ogawa R, Takahashi H, Takiguchi S
J Med Case Rep 2023 Mar 28;17(1):127. doi: 10.1186/s13256-023-03828-x. PMID: 36973791Free PMC Article
Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
The clinical profiles, management, and prognostic factors of biliary mixed neuroendocrine nonneuroendocrine neoplasms: A systematic review of the literature.
Wen LJ, Chen JH, Xu HJ, Yu Q, Deng Y, Liu K
Medicine (Baltimore) 2020 Dec 11;99(50):e23271. doi: 10.1097/MD.0000000000023271. PMID: 33327249Free PMC Article
Clinicopathological data and treatment modalities for pancreatic vipomas: a systematic review.
Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, Felekouras E
J BUON 2019 Mar-Apr;24(2):415-423. PMID: 31127985
Liver transplantation for hepatic tumors: a systematic review.
Ravaioli M, Ercolani G, Neri F, Cescon M, Stacchini G, Del Gaudio M, Cucchetti A, Pinna AD
World J Gastroenterol 2014 May 14;20(18):5345-52. doi: 10.3748/wjg.v20.i18.5345. PMID: 24833864Free PMC Article

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