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Recurrent Pancreatic Neuroendocrine Carcinoma

MedGen UID:
857326
•Concept ID:
C3897732
•
Neoplastic Process

Definition

The reemergence of pancreatic neuroendocrine carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Pancreatic Neuroendocrine Carcinoma

Professional guidelines

PubMed

Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Clinicopathological, treatment, and prognosis study of 43 gastric neuroendocrine carcinomas.
Liu DJ, Fu XL, Liu W, Zheng LY, Zhang JF, Huo YM, Li J, Hua R, Liu Q, Sun YW
World J Gastroenterol 2017 Jan 21;23(3):516-524. doi: 10.3748/wjg.v23.i3.516. PMID: 28210088Free PMC Article
Surgical management of pancreatic neuroendocrine tumors.
Kimura W, Tezuka K, Hirai I
Surg Today 2011 Oct;41(10):1332-43. Epub 2011 Sep 16 doi: 10.1007/s00595-011-4547-6. PMID: 21922354

Recent clinical studies

Etiology

Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap.
Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM
Mod Pathol 2023 Mar;36(3):100065. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100065. PMID: 36788102
Effectiveness of Etoposide and Cisplatin vs Irinotecan and Cisplatin Therapy for Patients With Advanced Neuroendocrine Carcinoma of the Digestive System: The TOPIC-NEC Phase 3 Randomized Clinical Trial.
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Everolimus.
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
Incidence and Prognosis of Primary Gastrinomas in the Hepatobiliary Tract.
Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025Free PMC Article

Diagnosis

Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap.
Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM
Mod Pathol 2023 Mar;36(3):100065. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100065. PMID: 36788102
Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies.
Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Incidence and Prognosis of Primary Gastrinomas in the Hepatobiliary Tract.
Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025Free PMC Article
Value of surgery in patients with negative imaging and sporadic Zollinger-Ellison syndrome.
Norton JA, Fraker DL, Alexander HR, Jensen RT
Ann Surg 2012 Sep;256(3):509-17. doi: 10.1097/SLA.0b013e318265f08d. PMID: 22868363Free PMC Article
Gastrinoma--morphological aspects.
Klöppel G, Anlauf M
Wien Klin Wochenschr 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1. PMID: 17985091

Therapy

Effectiveness of Etoposide and Cisplatin vs Irinotecan and Cisplatin Therapy for Patients With Advanced Neuroendocrine Carcinoma of the Digestive System: The TOPIC-NEC Phase 3 Randomized Clinical Trial.
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Germline genetic variability in pancreatic cancer risk and prognosis.
Gentiluomo M, Canzian F, Nicolini A, Gemignani F, Landi S, Campa D
Semin Cancer Biol 2022 Feb;79:105-131. Epub 2020 Aug 18 doi: 10.1016/j.semcancer.2020.08.003. PMID: 32818625
Incidence and Prognosis of Primary Gastrinomas in the Hepatobiliary Tract.
Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025Free PMC Article
Are There Indications for Total Pancreatectomy in 2016?
Andrén-Sandberg Å, Ansorge C, Yadav TD
Dig Surg 2016;33(4):329-34. Epub 2016 May 25 doi: 10.1159/000445018. PMID: 27215746
Value of surgery in patients with negative imaging and sporadic Zollinger-Ellison syndrome.
Norton JA, Fraker DL, Alexander HR, Jensen RT
Ann Surg 2012 Sep;256(3):509-17. doi: 10.1097/SLA.0b013e318265f08d. PMID: 22868363Free PMC Article

Prognosis

Potent molecular-targeted therapies for gastro-entero-pancreatic neuroendocrine carcinoma.
Ooki A, Osumi H, Fukuda K, Yamaguchi K
Cancer Metastasis Rev 2023 Sep;42(3):1021-1054. Epub 2023 Jul 8 doi: 10.1007/s10555-023-10121-2. PMID: 37422534Free PMC Article
Molecular radionuclide imaging of pancreatic neoplasms.
Panda A, Garg I, Johnson GB, Truty MJ, Halfdanarson TR, Goenka AH
Lancet Gastroenterol Hepatol 2019 Jul;4(7):559-570. doi: 10.1016/S2468-1253(19)30081-0. PMID: 31169124
Incidence and Prognosis of Primary Gastrinomas in the Hepatobiliary Tract.
Norton JA, Foster DS, Blumgart LH, Poultsides GA, Visser BC, Fraker DL, Alexander HR, Jensen RT
JAMA Surg 2018 Mar 1;153(3):e175083. doi: 10.1001/jamasurg.2017.5083. PMID: 29365025Free PMC Article
Value of surgery in patients with negative imaging and sporadic Zollinger-Ellison syndrome.
Norton JA, Fraker DL, Alexander HR, Jensen RT
Ann Surg 2012 Sep;256(3):509-17. doi: 10.1097/SLA.0b013e318265f08d. PMID: 22868363Free PMC Article
Gastrinoma--morphological aspects.
Klöppel G, Anlauf M
Wien Klin Wochenschr 2007;119(19-20):579-84. doi: 10.1007/s00508-007-0885-1. PMID: 17985091

Clinical prediction guides

Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap.
Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM
Mod Pathol 2023 Mar;36(3):100065. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100065. PMID: 36788102
Germline genetic variability in pancreatic cancer risk and prognosis.
Gentiluomo M, Canzian F, Nicolini A, Gemignani F, Landi S, Campa D
Semin Cancer Biol 2022 Feb;79:105-131. Epub 2020 Aug 18 doi: 10.1016/j.semcancer.2020.08.003. PMID: 32818625
Multimodality Imaging of Abdominopelvic Tumors with Venous Invasion.
LeGout JD, Bailey RE, Bolan CW, Bowman AW, Chen F, Cernigliaro JG, Alexander LF
Radiographics 2020 Nov-Dec;40(7):2098-2116. Epub 2020 Oct 16 doi: 10.1148/rg.2020200047. PMID: 33064623
Molecular subtyping in pancreatic neuroendocrine neoplasms: New insights into clinical, pathological unmet needs and challenges.
Yan J, Yu S, Jia C, Li M, Chen J
Biochim Biophys Acta Rev Cancer 2020 Aug;1874(1):188367. Epub 2020 Apr 25 doi: 10.1016/j.bbcan.2020.188367. PMID: 32339609
Paraneoplastic manifestations in children.
de Graaf JH, Tamminga RY, Kamps WA
Eur J Pediatr 1994 Nov;153(11):784-91. doi: 10.1007/BF01972883. PMID: 7843190

Recent systematic reviews

Neuroendocrine carcinoma of the minor papilla with pancreas divisum: a case report and review of the literature.
Saito K, Matsuo Y, Denda Y, Nonoyama K, Murase H, Kato T, Hayashi Y, Imafuji H, Morimoto M, Ogawa R, Takahashi H, Takiguchi S
J Med Case Rep 2023 Mar 28;17(1):127. doi: 10.1186/s13256-023-03828-x. PMID: 36973791Free PMC Article
Predictors of disease recurrence after curative surgery for nonfunctioning pancreatic neuroendocrine neoplasms (NF-PanNENs): a systematic review and meta-analysis.
Andreasi V, Ricci C, Partelli S, Guarneri G, Ingaldi C, Muffatti F, Crippa S, Casadei R, Falconi M
J Endocrinol Invest 2022 Apr;45(4):705-718. Epub 2021 Nov 13 doi: 10.1007/s40618-021-01705-2. PMID: 34773595
Clinicopathological data and treatment modalities for pancreatic vipomas: a systematic review.
Schizas D, Mastoraki A, Bagias G, Patras R, Moris D, Lazaridis II, Arkadopoulos N, Felekouras E
J BUON 2019 Mar-Apr;24(2):415-423. PMID: 31127985
External Beam Radiotherapy in the Treatment of Gastroenteropancreatic Neuroendocrine Tumours: A Systematic Review.
Chan DL, Thompson R, Lam M, Pavlakis N, Hallet J, Law C, Singh S, Myrehaug S
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):400-408. Epub 2018 Mar 31 doi: 10.1016/j.clon.2018.03.006. PMID: 29615284
Liver transplantation for hepatic metastases of neuroendocrine pancreatic tumors: a survival-based analysis.
Máthé Z, Tagkalos E, Paul A, Molmenti EP, Kóbori L, Fouzas I, Beckebaum S, Sotiropoulos GC
Transplantation 2011 Mar 15;91(5):575-82. doi: 10.1097/TP.0b013e3182081312. PMID: 21200365

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