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Recurrent Pancreatic Acinar Cell Carcinoma

MedGen UID:
1653042
•Concept ID:
C4727841
•
Neoplastic Process

Definition

The reemergence of pancreatic acinar cell carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Pancreatic Acinar Cell Carcinoma

Professional guidelines

PubMed

Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment.
Ikezawa K, Urabe M, Kai Y, Takada R, Akita H, Nagata S, Ohkawa K
Jpn J Clin Oncol 2024 Mar 9;54(3):271-281. doi: 10.1093/jjco/hyad176. PMID: 38109477Free PMC Article
Acinar cell carcinoma of the pancreas: new genetic and treatment insights into a rare malignancy.
Lowery MA, Klimstra DS, Shia J, Yu KH, Allen PJ, Brennan MF, O'Reilly EM
Oncologist 2011;16(12):1714-20. Epub 2011 Oct 31 doi: 10.1634/theoncologist.2011-0231. PMID: 22042785Free PMC Article

Recent clinical studies

Etiology

Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap.
Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM
Mod Pathol 2023 Mar;36(3):100065. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100065. PMID: 36788102
Clinical outcomes of patients with resectable pancreatic acinar cell carcinoma.
Seo S, Yoo C, Kim KP, Ryoo BY, Chang HM, Hong SM, Lee JH, Song KB, Hwang DW, Kim KH, Hwang S, Kim SC
J Dig Dis 2017 Aug;18(8):480-486. doi: 10.1111/1751-2980.12505. PMID: 28671770
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article
Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review.
Butturini G, Pisano M, Scarpa A, D'Onofrio M, Auriemma A, Bassi C
Langenbecks Arch Surg 2011 Mar;396(3):363-9. Epub 2010 Aug 28 doi: 10.1007/s00423-010-0706-2. PMID: 20803029
Pancreatic acinar cell carcinoma: a multi-institutional study.
Matos JM, Schmidt CM, Turrini O, Agaram NP, Niedergethmann M, Saeger HD, Merchant N, Johnson CS, Lillemoe KD, Grützmann R
J Gastrointest Surg 2009 Aug;13(8):1495-502. Epub 2009 Jun 3 doi: 10.1007/s11605-009-0938-z. PMID: 19495891

Diagnosis

Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment.
Ikezawa K, Urabe M, Kai Y, Takada R, Akita H, Nagata S, Ohkawa K
Jpn J Clin Oncol 2024 Mar 9;54(3):271-281. doi: 10.1093/jjco/hyad176. PMID: 38109477Free PMC Article
Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap.
Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM
Mod Pathol 2023 Mar;36(3):100065. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100065. PMID: 36788102
Acinar cell carcinoma with PRKAR1A and PTEN alterations and paraneoplastic panniculitis.
Yang Z, Zarate Rodriguez JG, Beck H, Byrnes K, Trikalinos NA, Hammill CW
BMJ Case Rep 2022 Dec 22;15(12) doi: 10.1136/bcr-2022-251400. PMID: 36549753Free PMC Article
Adult pancreatoblastoma: Current concepts in pathology.
Omiyale AO
World J Gastroenterol 2021 Jul 14;27(26):4172-4181. doi: 10.3748/wjg.v27.i26.4172. PMID: 34326617Free PMC Article
Intraductal Tubulopapillary Neoplasm of the Pancreas and Bile Duct: A Review.
Kuan LL, Dennison AR, Garcea G
Pancreas 2020 Apr;49(4):498-502. doi: 10.1097/MPA.0000000000001518. PMID: 32282762

Therapy

Exceptional Response of Pancreatic Acinar Cell Carcinoma and Bile Duct Cancer to Platinum-Based Chemotherapy in a Family With a Germline BRCA2 Variant.
Sunami T, Yamada A, Kondo T, Kanai M, Nagai K, Uchida Y, Yokode M, Matsumori T, Uza N, Murakami H, Yamada T, Muto M
Pancreas 2022 Oct 1;51(9):1258-1262. doi: 10.1097/MPA.0000000000002150. PMID: 37078954
Clinical outcomes of patients with resectable pancreatic acinar cell carcinoma.
Seo S, Yoo C, Kim KP, Ryoo BY, Chang HM, Hong SM, Lee JH, Song KB, Hwang DW, Kim KH, Hwang S, Kim SC
J Dig Dis 2017 Aug;18(8):480-486. doi: 10.1111/1751-2980.12505. PMID: 28671770
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article
Acinar cell carcinoma of the pancreas: new genetic and treatment insights into a rare malignancy.
Lowery MA, Klimstra DS, Shia J, Yu KH, Allen PJ, Brennan MF, O'Reilly EM
Oncologist 2011;16(12):1714-20. Epub 2011 Oct 31 doi: 10.1634/theoncologist.2011-0231. PMID: 22042785Free PMC Article
Pancreatic acinar cell carcinoma: a multi-institutional study.
Matos JM, Schmidt CM, Turrini O, Agaram NP, Niedergethmann M, Saeger HD, Merchant N, Johnson CS, Lillemoe KD, Grützmann R
J Gastrointest Surg 2009 Aug;13(8):1495-502. Epub 2009 Jun 3 doi: 10.1007/s11605-009-0938-z. PMID: 19495891

Prognosis

Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment.
Ikezawa K, Urabe M, Kai Y, Takada R, Akita H, Nagata S, Ohkawa K
Jpn J Clin Oncol 2024 Mar 9;54(3):271-281. doi: 10.1093/jjco/hyad176. PMID: 38109477Free PMC Article
Intraductal Tubulopapillary Neoplasm of the Pancreas and Bile Duct: A Review.
Kuan LL, Dennison AR, Garcea G
Pancreas 2020 Apr;49(4):498-502. doi: 10.1097/MPA.0000000000001518. PMID: 32282762
Clinical outcomes of patients with resectable pancreatic acinar cell carcinoma.
Seo S, Yoo C, Kim KP, Ryoo BY, Chang HM, Hong SM, Lee JH, Song KB, Hwang DW, Kim KH, Hwang S, Kim SC
J Dig Dis 2017 Aug;18(8):480-486. doi: 10.1111/1751-2980.12505. PMID: 28671770
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article
Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review.
Butturini G, Pisano M, Scarpa A, D'Onofrio M, Auriemma A, Bassi C
Langenbecks Arch Surg 2011 Mar;396(3):363-9. Epub 2010 Aug 28 doi: 10.1007/s00423-010-0706-2. PMID: 20803029

Clinical prediction guides

Integrated Genomic and Clinicopathologic Approach Distinguishes Pancreatic Grade 3 Neuroendocrine Tumor From Neuroendocrine Carcinoma and Identifies a Subset With Molecular Overlap.
Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM
Mod Pathol 2023 Mar;36(3):100065. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100065. PMID: 36788102
Pancreatic acinar cell carcinoma with a ductal adenocarcinoma component: a case report and analysis of the histogenesis of the tumor.
Kimura T, Tabata S, Togawa T, Onchi H, Iida A, Sato Y, Goi T
World J Surg Oncol 2020 Sep 5;18(1):238. doi: 10.1186/s12957-020-02014-3. PMID: 32891173Free PMC Article
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article
Acinar cell carcinoma of the pancreas: new genetic and treatment insights into a rare malignancy.
Lowery MA, Klimstra DS, Shia J, Yu KH, Allen PJ, Brennan MF, O'Reilly EM
Oncologist 2011;16(12):1714-20. Epub 2011 Oct 31 doi: 10.1634/theoncologist.2011-0231. PMID: 22042785Free PMC Article
Prevalence and prognostic significance of acinar cell differentiation in pancreatic endocrine tumors.
Yantiss RK, Chang HK, Farraye FA, Compton CC, Odze RD
Am J Surg Pathol 2002 Jul;26(7):893-901. doi: 10.1097/00000478-200207000-00007. PMID: 12131156

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