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Acinar cell carcinoma

MedGen UID:
61660
•Concept ID:
C0206685
•
Neoplastic Process
Synonyms: Acinar Carcinoma; Acinar Carcinomas; Acinar Cell Adenocarcinoma; Acinar Cell Adenocarcinomas; Acinar Cell Carcinoma; Acinar Cell Carcinomas; Acinic Cell Adenocarcinoma; Acinic Cell Adenocarcinomas; Acinic Cell Carcinoma; Acinic Cell Carcinomas; Acinic Cell Tumor; Acinic Cell Tumors; Adenocarcinoma, Acinar Cell; Adenocarcinoma, Acinic Cell; Adenocarcinomas, Acinar Cell; Adenocarcinomas, Acinic Cell; Carcinoma, Acinar; Carcinoma, Acinar Cell; Carcinoma, Acinic Cell; Carcinomas, Acinar; Carcinomas, Acinar Cell; Carcinomas, Acinic Cell; Tumor, Acinic Cell; Tumors, Acinic Cell
SNOMED CT: Acinar cell carcinoma (45410002); Acinic cell adenocarcinoma (45410002); Acinar adenocarcinoma (45410002); Acinar carcinoma (45410002)
 
Monarch Initiative: MONDO:0004965

Definition

A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland. [from NCI]

Professional guidelines

PubMed

Prognostic Assessment and Risk Stratification in Patients With Postoperative Major Salivary Acinar Cell Carcinoma.
Zhang D, Wei Y, Chai Y, Qi F, Dong M
Otolaryngol Head Neck Surg 2023 May;168(5):1119-1129. Epub 2023 Jan 22 doi: 10.1002/ohn.195. PMID: 36939406
Artificial intelligence using deep learning analysis of endoscopic ultrasonography images for the differential diagnosis of pancreatic masses.
Kuwahara T, Hara K, Mizuno N, Haba S, Okuno N, Kuraishi Y, Fumihara D, Yanaidani T, Ishikawa S, Yasuda T, Yamada M, Onishi S, Yamada K, Tanaka T, Tajika M, Niwa Y, Yamaguchi R, Shimizu Y
Endoscopy 2023 Feb;55(2):140-149. Epub 2022 Jun 10 doi: 10.1055/a-1873-7920. PMID: 35688454
Current diagnosis and management of unusual pancreatic tumors.
Mortenson MM, Katz MH, Tamm EP, Bhutani MS, Wang H, Evans DB, Fleming JB
Am J Surg 2008 Jul;196(1):100-13. Epub 2008 May 7 doi: 10.1016/j.amjsurg.2008.02.005. PMID: 18466869

Recent clinical studies

Etiology

Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Metastatic Acinar Cell Carcinoma of the Pancreas: A Retrospective Cohort Study on Systemic Chemotherapy and Review of the Literature.
Busch E, Werft W, Bougatf N, Hackert T, Jäger D, Springfeld C, Berger AK
Pancreas 2021 Mar 1;50(3):300-305. doi: 10.1097/MPA.0000000000001765. PMID: 33835959
Non-Ductal Tumors of the Pancreas.
Dhillon J
Monogr Clin Cytol 2020;26:92-108. Epub 2020 Sep 28 doi: 10.1159/000455737. PMID: 32987393
Pancreatic Neoplasms With Acinar Differentiation: A Review of Pathologic and Molecular Features.
Thompson ED, Wood LD
Arch Pathol Lab Med 2020 Jul 1;144(7):808-815. doi: 10.5858/arpa.2019-0472-RA. PMID: 31869246
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article

Diagnosis

Acinic cell carcinoma of the parotid gland: from pathogenesis to management: a literature review.
Cavaliere M, De Luca P, Scarpa A, Savignano L, Cassandro C, Cassandro E, Iemma M
Eur Arch Otorhinolaryngol 2020 Oct;277(10):2673-2679. Epub 2020 May 4 doi: 10.1007/s00405-020-05998-6. PMID: 32367151
RAS in pancreatic cancer.
Lanfredini S, Thapa A, O'Neill E
Biochem Soc Trans 2019 Aug 30;47(4):961-972. Epub 2019 Jul 24 doi: 10.1042/BST20170521. PMID: 31341034
Imaging mimics of pancreatic ductal adenocarcinoma.
Gandhi NS, Feldman MK, Le O, Morris-Stiff G
Abdom Radiol (NY) 2018 Feb;43(2):273-284. doi: 10.1007/s00261-017-1330-1. PMID: 29038855
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms.
Wöll S, Schlitter AM, Dhaene K, Roller M, Esposito I, Sahin U, Türeci Ö
Int J Cancer 2014 Feb 1;134(3):731-9. Epub 2013 Sep 16 doi: 10.1002/ijc.28400. PMID: 23900716

Therapy

Metastatic Acinar Cell Carcinoma of the Pancreas: A Retrospective Cohort Study on Systemic Chemotherapy and Review of the Literature.
Busch E, Werft W, Bougatf N, Hackert T, Jäger D, Springfeld C, Berger AK
Pancreas 2021 Mar 1;50(3):300-305. doi: 10.1097/MPA.0000000000001765. PMID: 33835959
Acinic cell carcinoma of the parotid gland: from pathogenesis to management: a literature review.
Cavaliere M, De Luca P, Scarpa A, Savignano L, Cassandro C, Cassandro E, Iemma M
Eur Arch Otorhinolaryngol 2020 Oct;277(10):2673-2679. Epub 2020 May 4 doi: 10.1007/s00405-020-05998-6. PMID: 32367151
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Acinar cell carcinoma of the pancreas: a rare disease with different diagnostic and therapeutic implications than ductal adenocarcinoma.
Kruger S, Haas M, Burger PJ, Ormanns S, Modest DP, Westphalen CB, Kleespies A, Angele MK, Hartwig W, Bruns CJ, Kirchner T, Werner J, Heinemann V, Boeck S
J Cancer Res Clin Oncol 2016 Dec;142(12):2585-2591. Epub 2016 Sep 14 doi: 10.1007/s00432-016-2264-7. PMID: 27629876
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article

Prognosis

Comparative profiling of single-cell transcriptome reveals heterogeneity of tumor microenvironment between solid and acinar lung adenocarcinoma.
Li D, Yu H, Hu J, Li S, Yan Y, Li S, Sun L, Jiang G, Hou L, Zhang L, Zhang P
J Transl Med 2022 Sep 23;20(1):423. doi: 10.1186/s12967-022-03620-3. PMID: 36138435Free PMC Article
A systematic review of secretory carcinoma of the salivary gland: where are we?
Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Pancreatic Panniculitis and Polyarthritis.
Zundler S, Strobel D, Manger B, Neurath MF, Wildner D
Curr Rheumatol Rep 2017 Aug 26;19(10):62. doi: 10.1007/s11926-017-0690-4. PMID: 28844095
Salivary acinic cell carcinoma: reappraisal and update.
Vander Poorten V, Triantafyllou A, Thompson LD, Bishop J, Hauben E, Hunt J, Skalova A, Stenman G, Takes RP, Gnepp DR, Hellquist H, Wenig B, Bell D, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2016 Nov;273(11):3511-3531. Epub 2015 Dec 19 doi: 10.1007/s00405-015-3855-7. PMID: 26685679

Clinical prediction guides

Pancreatic Neoplasms With Acinar Differentiation: A Review of Pathologic and Molecular Features.
Thompson ED, Wood LD
Arch Pathol Lab Med 2020 Jul 1;144(7):808-815. doi: 10.5858/arpa.2019-0472-RA. PMID: 31869246
Primary Pulmonary Acinic Cell Carcinoma: A Clinicopathological Study of 6 Cases and Literature Review.
Nie L, Zhou C, Wu H, Zhou Q, Meng F
Int J Surg Pathol 2019 Sep;27(6):584-592. Epub 2019 Mar 21 doi: 10.1177/1066896919836499. PMID: 30898020
Pancreatic acinar cell carcinoma-case report and literature review.
Xing-Mao Z, Hong-Juan Z, Qing L, Qiang H
BMC Cancer 2018 Nov 8;18(1):1083. doi: 10.1186/s12885-018-5008-z. PMID: 30409114Free PMC Article
High-grade prostatic intraepithelial neoplasia, PIN-like carcinoma, ductal carcinoma, and intraductal carcinoma of the prostate.
Zhou M
Mod Pathol 2018 Jan;31(S1):S71-79. doi: 10.1038/modpathol.2017.138. PMID: 29297491
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article

Recent systematic reviews

DOG1 as an Immunohistochemical Marker of Acinic Cell Carcinoma: A Systematic Review and Meta-Analysis.
Fiorentino V, Straccia P, Tralongo P, Musarra T, Pierconti F, Martini M, Fadda G, Rossi ED, Larocca LM
Int J Mol Sci 2022 Aug 26;23(17) doi: 10.3390/ijms23179711. PMID: 36077107Free PMC Article
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review.
Kirschnick LB, Silveira FM, Schuch LF, Fonseca FP, Martins MAT, Lopes MA, Santos-Silva AR, Carrard VC, Dos Santos JN, Vargas PA, Wagner VP, Martins MD
J Oral Pathol Med 2021 Sep;50(8):741-749. Epub 2021 Feb 18 doi: 10.1111/jop.13159. PMID: 33455041
A systematic review of secretory carcinoma of the salivary gland: where are we?
Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686
Systematic Review and Case Series Report of Acinar Cell Carcinoma of the Pancreas.
Glazer ES, Neill KG, Frakes JM, Coppola D, Hodul PJ, Hoffe SE, Pimiento JM, Springett GM, Malafa MP
Cancer Control 2016 Oct;23(4):446-454. doi: 10.1177/107327481602300417. PMID: 27842335

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