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Acinar cell carcinoma

MedGen UID:
61660
•Concept ID:
C0206685
•
Neoplastic Process
Synonyms: Acinar Carcinoma; Acinar Carcinomas; Acinar Cell Adenocarcinoma; Acinar Cell Adenocarcinomas; Acinar Cell Carcinoma; Acinar Cell Carcinomas; Acinic Cell Adenocarcinoma; Acinic Cell Adenocarcinomas; Acinic Cell Carcinoma; Acinic Cell Carcinomas; Acinic Cell Tumor; Acinic Cell Tumors; Adenocarcinoma, Acinar Cell; Adenocarcinoma, Acinic Cell; Adenocarcinomas, Acinar Cell; Adenocarcinomas, Acinic Cell; Carcinoma, Acinar; Carcinoma, Acinar Cell; Carcinoma, Acinic Cell; Carcinomas, Acinar; Carcinomas, Acinar Cell; Carcinomas, Acinic Cell; Tumor, Acinic Cell; Tumors, Acinic Cell
SNOMED CT: Acinar cell carcinoma (45410002); Acinic cell adenocarcinoma (45410002); Acinar adenocarcinoma (45410002); Acinar carcinoma (45410002)
 
Monarch Initiative: MONDO:0004965

Definition

A malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. Representative examples include the acinar cell carcinoma of the pancreas and the acinar adenocarcinoma of the prostate gland. [from NCI]

Professional guidelines

PubMed

Comprehensive review of pancreatic acinar cell carcinoma: epidemiology, diagnosis, molecular features and treatment.
Ikezawa K, Urabe M, Kai Y, Takada R, Akita H, Nagata S, Ohkawa K
Jpn J Clin Oncol 2024 Mar 9;54(3):271-281. doi: 10.1093/jjco/hyad176. PMID: 38109477Free PMC Article
A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Current diagnosis and management of unusual pancreatic tumors.
Mortenson MM, Katz MH, Tamm EP, Bhutani MS, Wang H, Evans DB, Fleming JB
Am J Surg 2008 Jul;196(1):100-13. Epub 2008 May 7 doi: 10.1016/j.amjsurg.2008.02.005. PMID: 18466869

Recent clinical studies

Etiology

Referral and treatment patterns in pancreatic acinar cell carcinoma: A regional population-level analysis.
Patel RK, Parappilly M, Sutton TL, Behrens S, Schwantes IR, Johnson AJ, Pommier RF, Sheppard BC
Am J Surg 2024 May;231:55-59. Epub 2023 Apr 18 doi: 10.1016/j.amjsurg.2023.04.010. PMID: 37087362
A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Genomic landscape and clinical features of rare subtypes of pancreatic cancer: analysis with the national database of Japan.
Sakakida T, Ishikawa T, Doi T, Morita R, Kataoka S, Miyake H, Yamaguchi K, Moriguchi M, Sogame Y, Yasuda H, Iwasaku M, Konishi H, Takayama K, Itoh Y
J Gastroenterol 2023 Jun;58(6):575-585. Epub 2023 Apr 7 doi: 10.1007/s00535-023-01986-9. PMID: 37029223Free PMC Article
Non-Ductal Tumors of the Pancreas.
Dhillon J
Monogr Clin Cytol 2020;26:92-108. Epub 2020 Sep 28 doi: 10.1159/000455737. PMID: 32987393

Diagnosis

Genomic Profiling Reveals Germline Predisposition and Homologous Recombination Deficiency in Pancreatic Acinar Cell Carcinoma.
Mandelker D, Marra A, Zheng-Lin B, Selenica P, Blanco-Heredia J, Zhu Y, Gazzo A, Wong D, Yelskaya Z, Rai V, Somar J, Ostafi S, Mehta N, Yang C, Li Y, Brown DN, da Silva EM, Pei X, Linkov I, Terraf P, Misyura M, Ceyhan-Birsoy O, Ladanyi M, Berger M, Pareja F, Stadler Z, Offit K, Riaz N, Park W, Chou J, Capanu M, Koehler M, Rosen E, O'Reilly EM, Reis-Filho JS
J Clin Oncol 2023 Nov 20;41(33):5151-5162. Epub 2023 Aug 22 doi: 10.1200/JCO.23.00561. PMID: 37607324Free PMC Article
Differential diagnosis and treatment of salivary secretory carcinoma and acinic cell carcinoma.
Pang Y, Sun L, Liu H, Ma J
Oral Oncol 2021 Aug;119:105370. Epub 2021 Jun 19 doi: 10.1016/j.oraloncology.2021.105370. PMID: 34157553
Acinar cell carcinoma of the pancreas: a clinicopathologic and cytomorphologic review.
Mustafa S, Hruban RH, Ali SZ
J Am Soc Cytopathol 2020 Nov-Dec;9(6):586-595. Epub 2020 Apr 25 doi: 10.1016/j.jasc.2020.04.005. PMID: 32461075
Nonductal Pancreatic Cancers.
Jun SY, Hong SM
Surg Pathol Clin 2016 Dec;9(4):581-593. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.005. PMID: 27926361
Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms.
Wöll S, Schlitter AM, Dhaene K, Roller M, Esposito I, Sahin U, Türeci Ö
Int J Cancer 2014 Feb 1;134(3):731-9. Epub 2013 Sep 16 doi: 10.1002/ijc.28400. PMID: 23900716

Therapy

A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Genomic landscape and clinical features of rare subtypes of pancreatic cancer: analysis with the national database of Japan.
Sakakida T, Ishikawa T, Doi T, Morita R, Kataoka S, Miyake H, Yamaguchi K, Moriguchi M, Sogame Y, Yasuda H, Iwasaku M, Konishi H, Takayama K, Itoh Y
J Gastroenterol 2023 Jun;58(6):575-585. Epub 2023 Apr 7 doi: 10.1007/s00535-023-01986-9. PMID: 37029223Free PMC Article
Metastatic Acinar Cell Carcinoma of the Pancreas: A Retrospective Cohort Study on Systemic Chemotherapy and Review of the Literature.
Busch E, Werft W, Bougatf N, Hackert T, Jäger D, Springfeld C, Berger AK
Pancreas 2021 Mar 1;50(3):300-305. doi: 10.1097/MPA.0000000000001765. PMID: 33835959
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article

Prognosis

A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review.
Kirschnick LB, Silveira FM, Schuch LF, Fonseca FP, Martins MAT, Lopes MA, Santos-Silva AR, Carrard VC, Dos Santos JN, Vargas PA, Wagner VP, Martins MD
J Oral Pathol Med 2021 Sep;50(8):741-749. Epub 2021 Feb 18 doi: 10.1111/jop.13159. PMID: 33455041
Heterotopic acinic cell carcinoma and its clinical implications.
Starek I, Salzman R, Skalova A
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Mar;165(1):13-18. Epub 2020 Nov 12 doi: 10.5507/bp.2020.047. PMID: 33177745
Pancreatic Panniculitis and Polyarthritis.
Zundler S, Strobel D, Manger B, Neurath MF, Wildner D
Curr Rheumatol Rep 2017 Aug 26;19(10):62. doi: 10.1007/s11926-017-0690-4. PMID: 28844095
Salivary acinic cell carcinoma: reappraisal and update.
Vander Poorten V, Triantafyllou A, Thompson LD, Bishop J, Hauben E, Hunt J, Skalova A, Stenman G, Takes RP, Gnepp DR, Hellquist H, Wenig B, Bell D, Rinaldo A, Ferlito A
Eur Arch Otorhinolaryngol 2016 Nov;273(11):3511-3531. Epub 2015 Dec 19 doi: 10.1007/s00405-015-3855-7. PMID: 26685679

Clinical prediction guides

Cytomorphologic, immunophenotypical and molecular features of pancreatic acinar cell carcinoma.
Sun T, Gilani S, Jain D, Cai G
Diagn Cytopathol 2023 Nov;51(11):674-683. Epub 2023 Jul 19 doi: 10.1002/dc.25196. PMID: 37469257
Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Microsatellite instability in pancreatic and ampullary carcinomas: histology, molecular pathology, and clinical implications.
Luchini C, Scarpa A
Hum Pathol 2023 Feb;132:176-182. Epub 2022 Jun 14 doi: 10.1016/j.humpath.2022.06.009. PMID: 35714836
Primary Pulmonary Acinic Cell Carcinoma: A Clinicopathological Study of 6 Cases and Literature Review.
Nie L, Zhou C, Wu H, Zhou Q, Meng F
Int J Surg Pathol 2019 Sep;27(6):584-592. Epub 2019 Mar 21 doi: 10.1177/1066896919836499. PMID: 30898020
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article

Recent systematic reviews

DOG1 as an Immunohistochemical Marker of Acinic Cell Carcinoma: A Systematic Review and Meta-Analysis.
Fiorentino V, Straccia P, Tralongo P, Musarra T, Pierconti F, Martini M, Fadda G, Rossi ED, Larocca LM
Int J Mol Sci 2022 Aug 26;23(17) doi: 10.3390/ijms23179711. PMID: 36077107Free PMC Article
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Clinicopathological analysis of oral and maxillofacial acinic cell carcinoma: A systematic review.
Kirschnick LB, Silveira FM, Schuch LF, Fonseca FP, Martins MAT, Lopes MA, Santos-Silva AR, Carrard VC, Dos Santos JN, Vargas PA, Wagner VP, Martins MD
J Oral Pathol Med 2021 Sep;50(8):741-749. Epub 2021 Feb 18 doi: 10.1111/jop.13159. PMID: 33455041
A systematic review of secretory carcinoma of the salivary gland: where are we?
Alves LDB, de Melo AC, Farinha TA, de Lima Araujo LH, Thiago LS, Dias FL, Antunes HS, Amaral Eisenberg AL, Santos Thuler LC, Cohen Goldemberg D
Oral Surg Oral Med Oral Pathol Oral Radiol 2021 Oct;132(4):e143-e152. Epub 2020 May 31 doi: 10.1016/j.oooo.2020.04.007. PMID: 32493686
Systematic Review and Case Series Report of Acinar Cell Carcinoma of the Pancreas.
Glazer ES, Neill KG, Frakes JM, Coppola D, Hodul PJ, Hoffe SE, Pimiento JM, Springett GM, Malafa MP
Cancer Control 2016 Oct;23(4):446-454. doi: 10.1177/107327481602300417. PMID: 27842335

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