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Ependymal Pituicytoma

MedGen UID:
1654644
•Concept ID:
C4744368
•
Neoplastic Process
Synonym: Sellar ependymoma
SNOMED CT: Sellar ependymoma (788578009)

Definition

A very rare, low-grade neoplasm that arises from the posterior pituitary. It is composed of epithelioid and oncocytic cells forming sheets and fascicles. It shows histopathological features reminiscent of ependymomas, including perivascular pseudorosettes and true rosettes. There is no evidence of necrosis or increased mitotic activity. Despite the presence of ependymal histopathological features, these neoplasms probably are not related to ependymomas. Their prognosis is unknown. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpendymal Pituicytoma

Recent clinical studies

Etiology

Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain.
Hewer E, Beck J, Kellner-Weldon F, Vajtai I
Hum Pathol 2015 Jul;46(7):1045-9. Epub 2015 Mar 25 doi: 10.1016/j.humpath.2015.03.005. PMID: 25934249
Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma.
Mete O, Lopes MB, Asa SL
Am J Surg Pathol 2013 Nov;37(11):1694-9. doi: 10.1097/PAS.0b013e31829723e7. PMID: 23887161

Diagnosis

Overview of the 2022 WHO Classification of Pituitary Tumors.
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain.
Hewer E, Beck J, Kellner-Weldon F, Vajtai I
Hum Pathol 2015 Jul;46(7):1045-9. Epub 2015 Mar 25 doi: 10.1016/j.humpath.2015.03.005. PMID: 25934249
TTF-1-positive oncocytic sellar tumor with follicle formation/ependymal differentiation: non-adenomatous tumor capable of two different interpretations as a pituicytoma or a spindle cell oncocytoma.
Yoshimoto T, Takahashi-Fujigasaki J, Inoshita N, Fukuhara N, Nishioka H, Yamada S
Brain Tumor Pathol 2015 Jul;32(3):221-7. Epub 2015 Apr 18 doi: 10.1007/s10014-015-0219-3. PMID: 25893822
Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma.
Mete O, Lopes MB, Asa SL
Am J Surg Pathol 2013 Nov;37(11):1694-9. doi: 10.1097/PAS.0b013e31829723e7. PMID: 23887161
Ependymoma of the sella turcica: a variant of pituicytoma.
Scheithauer BW, Swearingen B, Whyte ET, Auluck PK, Stemmer-Rachamimov AO
Hum Pathol 2009 Mar;40(3):435-40. Epub 2008 Nov 7 doi: 10.1016/j.humpath.2008.08.013. PMID: 18992914

Prognosis

Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain.
Hewer E, Beck J, Kellner-Weldon F, Vajtai I
Hum Pathol 2015 Jul;46(7):1045-9. Epub 2015 Mar 25 doi: 10.1016/j.humpath.2015.03.005. PMID: 25934249
Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma.
Mete O, Lopes MB, Asa SL
Am J Surg Pathol 2013 Nov;37(11):1694-9. doi: 10.1097/PAS.0b013e31829723e7. PMID: 23887161

Clinical prediction guides

Suprasellar chordoid neoplasm with expression of thyroid transcription factor 1: evidence that chordoid glioma of the third ventricle and pituicytoma may form part of a spectrum of lineage-related tumors of the basal forebrain.
Hewer E, Beck J, Kellner-Weldon F, Vajtai I
Hum Pathol 2015 Jul;46(7):1045-9. Epub 2015 Mar 25 doi: 10.1016/j.humpath.2015.03.005. PMID: 25934249
TTF-1-positive oncocytic sellar tumor with follicle formation/ependymal differentiation: non-adenomatous tumor capable of two different interpretations as a pituicytoma or a spindle cell oncocytoma.
Yoshimoto T, Takahashi-Fujigasaki J, Inoshita N, Fukuhara N, Nishioka H, Yamada S
Brain Tumor Pathol 2015 Jul;32(3):221-7. Epub 2015 Apr 18 doi: 10.1007/s10014-015-0219-3. PMID: 25893822
Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma.
Mete O, Lopes MB, Asa SL
Am J Surg Pathol 2013 Nov;37(11):1694-9. doi: 10.1097/PAS.0b013e31829723e7. PMID: 23887161

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