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Thyroid Gland Anaplastic Carcinoma, Osteoclastic Variant

MedGen UID:
1657279
•Concept ID:
C4745369
•
Neoplastic Process

Definition

An extremely rare morphologic variant of anaplastic carcinoma of the thyroid gland, characterized by the presence of large numbers of non-neoplastic, osteoclast-like giant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Anaplastic Carcinoma, Osteoclastic Variant

Recent clinical studies

Diagnosis

A unique case of anaplastic thyroid carcinoma comprising of two distinct patterns osteoclastic variant and squamous cell carcinoma in separate lobe imitating collision tumor: A case report.
Gupta RK, John A, Ravina M, Arora RD
Diagn Cytopathol 2023 Mar;51(3):E89-E93. Epub 2022 Dec 1 doi: 10.1002/dc.25085. PMID: 36458378
A case of osteoclastic variant of anaplastic thyroid carcinoma: Diagnostic and prognostic marker studies by cytology.
Bantumilli S, Zhu LC, Sakthivel M, Dodd L
Diagn Cytopathol 2022 Dec;50(12):E357-E360. Epub 2022 Aug 5 doi: 10.1002/dc.25028. PMID: 35929756
An exceptionally rare case of metastatic osteoclast-like giant cell-rich variant of anaplastic thyroid carcinoma: A diagnostic challenge.
Saini T, Dey P
Cytopathology 2022 May;33(3):380-383. Epub 2022 Feb 6 doi: 10.1111/cyt.13104. PMID: 35094433
Early undifferentiated pancreatic carcinoma with osteoclastlike giant cells: direct evidence for ductal evolution.
Bergmann F, Esposito I, Michalski CW, Herpel E, Friess H, Schirmacher P
Am J Surg Pathol 2007 Dec;31(12):1919-25. doi: 10.1097/PAS.0b013e318067bca8. PMID: 18043049
Cytology of anaplastic giant cell carcinoma of the thyroid with osteoclast-like giant cells--a case report.
Mehdi G, Ansari HA, Siddiqui SA
Diagn Cytopathol 2007 Feb;35(2):111-2. doi: 10.1002/dc.20595. PMID: 17230568

Therapy

Osteoclastome-like giant cell thyroid carcinoma controlled by intensive radiation and adriamycin, in a patient with meningioma and multiple myeloma treated by radiation and cytoxan.
Vizel-Schwartz M
J Surg Oncol 1981;17(1):57-61. doi: 10.1002/jso.2930170110. PMID: 7230831

Prognosis

A case of osteoclastic variant of anaplastic thyroid carcinoma: Diagnostic and prognostic marker studies by cytology.
Bantumilli S, Zhu LC, Sakthivel M, Dodd L
Diagn Cytopathol 2022 Dec;50(12):E357-E360. Epub 2022 Aug 5 doi: 10.1002/dc.25028. PMID: 35929756
Osteoclastic variant of anaplastic thyroid carcinoma: An insight into a rarest of rare entity.
Mathur P, Rana C, Gupta V, Ramakant P, Singh K, Mishra AK, Babu S
Diagn Cytopathol 2022 Aug;50(8):E210-E213. Epub 2022 Mar 16 doi: 10.1002/dc.24953. PMID: 35293694

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