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Maternally Derived Graft Versus Host Disease

MedGen UID:
1657488
•Concept ID:
C4745068
•
Disease or Syndrome
Synonym: Maternally Derived GVHD

Definition

Graft versus host disease (GVHD) that occurs in an infant as the result of engraftment of maternal lymphocytes, resulting from in utero maternal-fetal cellular trafficking. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMaternally Derived Graft Versus Host Disease

Professional guidelines

PubMed

Adoptive Immunotherapy with Cord Blood for the Treatment of Refractory Acute Myelogenous Leukemia: Feasibility, Safety, and Preliminary Outcomes.
Gergis U, Frenet EM, Shore T, Mayer S, Phillips A, Hsu JM, Roboz G, Ritchie E, Scandura J, Lee S, Desai P, Samuel M, Ball J, Blanco A, Romeo C, Albano MS, Dobrila L, Scaradavou A, van Besien K
Biol Blood Marrow Transplant 2019 Mar;25(3):466-473. Epub 2018 Nov 9 doi: 10.1016/j.bbmt.2018.11.002. PMID: 30414955
Fetal membrane cells for treatment of steroid-refractory acute graft-versus-host disease.
Ringdén O, Erkers T, Nava S, Uzunel M, Iwarsson E, Conrad R, Westgren M, Mattsson J, Kaipe H
Stem Cells 2013 Mar;31(3):592-601. doi: 10.1002/stem.1314. PMID: 23307526
Applying embryo-derived immune tolerance to the treatment of immune disorders.
Barnea ER
Ann N Y Acad Sci 2007 Sep;1110:602-18. doi: 10.1196/annals.1423.064. PMID: 17911476

Recent clinical studies

Etiology

Haploidentical Stem Cell Transplantation After TCR-αβ(+) and CD19(+) Cells Depletion In Children With Congenital Non-Malignant Disease.
Giardino S, Bagnasco F, Falco M, Miano M, Pierri F, Risso M, Terranova P, Di Martino D, Massaccesi E, Ricci M, Chianucci B, Dell'Orso G, Sabatini F, Podestà M, Lanino E, Faraci M
Transplant Cell Ther 2022 Jul;28(7):394.e1-394.e9. Epub 2022 Apr 8 doi: 10.1016/j.jtct.2022.04.002. PMID: 35405368
A Phase I Study to Evaluate Two Doses of Wharton's Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease.
Soder RP, Dawn B, Weiss ML, Dunavin N, Weir S, Mitchell J, Li M, Shune L, Singh AK, Ganguly S, Morrison M, Abdelhakim H, Godwin AK, Abhyankar S, McGuirk J
Stem Cell Rev Rep 2020 Oct;16(5):979-991. doi: 10.1007/s12015-020-10015-8. PMID: 32740891Free PMC Article
Long-Term Follow-Up of a Pilot Study Using Placenta-Derived Decidua Stromal Cells for Severe Acute Graft-versus-Host Disease.
Sadeghi B, Remberger M, Gustafsson B, Winiarski J, Moretti G, Khoein B, Klingspor L, Westgren M, Mattsson J, Ringdén O
Biol Blood Marrow Transplant 2019 Oct;25(10):1965-1969. Epub 2019 Jun 4 doi: 10.1016/j.bbmt.2019.05.034. PMID: 31173898
Microchimerism and the pathogenesis of systemic sclerosis.
Nelson JL
Curr Opin Rheumatol 1998 Nov;10(6):564-71. doi: 10.1097/00002281-199811000-00010. PMID: 9812217
Transfusion-associated graft-versus-host disease.
Rappeport JM
Yale J Biol Med 1990 Sep-Oct;63(5):445-54. PMID: 2293503Free PMC Article

Diagnosis

Haploidentical Stem Cell Transplantation After TCR-αβ(+) and CD19(+) Cells Depletion In Children With Congenital Non-Malignant Disease.
Giardino S, Bagnasco F, Falco M, Miano M, Pierri F, Risso M, Terranova P, Di Martino D, Massaccesi E, Ricci M, Chianucci B, Dell'Orso G, Sabatini F, Podestà M, Lanino E, Faraci M
Transplant Cell Ther 2022 Jul;28(7):394.e1-394.e9. Epub 2022 Apr 8 doi: 10.1016/j.jtct.2022.04.002. PMID: 35405368
Intrathecal Infusion of Haploidentical Nondonor Lymphocytes for Central Nervous System Leukemic Relapse After Haploidentical Hematopoietic Stem Cell Transplantation.
Mayumi A, Sawada A, Ioi A, Higuchi K, Shimizu M, Sato M, Yasui M, Inoue M
J Pediatr Hematol Oncol 2018 Mar;40(2):e129-e132. doi: 10.1097/MPH.0000000000000937. PMID: 28816796
Naturally acquired microchimerism: implications for transplantation outcome and novel methodologies for detection.
Eikmans M, van Halteren AG, van Besien K, van Rood JJ, Drabbels JJ, Claas FH
Chimerism 2014;5(2):24-39. doi: 10.4161/chim.28908. PMID: 24762743Free PMC Article
Foreign cells in polymyositis: could stem cell transplantation and pregnancy-derived chimerism lead to the same disease?
Stevens AM
Curr Rheumatol Rep 2003 Dec;5(6):437-44. doi: 10.1007/s11926-003-0054-0. PMID: 14609488
Transfusion-associated graft-versus-host disease.
Rappeport JM
Yale J Biol Med 1990 Sep-Oct;63(5):445-54. PMID: 2293503Free PMC Article

Therapy

Microbiota dynamics in a randomized trial of gut decontamination during allogeneic hematopoietic cell transplantation.
Severyn CJ, Siranosian BA, Kong ST, Moreno A, Li MM, Chen N, Duncan CN, Margossian SP, Lehmann LE, Sun S, Andermann TM, Birbrayer O, Silverstein S, Reynolds CG, Kim S, Banaei N, Ritz J, Fodor AA, London WB, Bhatt AS, Whangbo JS
JCI Insight 2022 Apr 8;7(7) doi: 10.1172/jci.insight.154344. PMID: 35239511Free PMC Article
A Phase I Study to Evaluate Two Doses of Wharton's Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease.
Soder RP, Dawn B, Weiss ML, Dunavin N, Weir S, Mitchell J, Li M, Shune L, Singh AK, Ganguly S, Morrison M, Abdelhakim H, Godwin AK, Abhyankar S, McGuirk J
Stem Cell Rev Rep 2020 Oct;16(5):979-991. doi: 10.1007/s12015-020-10015-8. PMID: 32740891Free PMC Article
Long-Term Follow-Up of a Pilot Study Using Placenta-Derived Decidua Stromal Cells for Severe Acute Graft-versus-Host Disease.
Sadeghi B, Remberger M, Gustafsson B, Winiarski J, Moretti G, Khoein B, Klingspor L, Westgren M, Mattsson J, Ringdén O
Biol Blood Marrow Transplant 2019 Oct;25(10):1965-1969. Epub 2019 Jun 4 doi: 10.1016/j.bbmt.2019.05.034. PMID: 31173898
Endothelial microparticles delivering microRNA-155 into T lymphocytes are involved in the initiation of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.
Zhang R, Wang X, Hong M, Luo T, Zhao M, Shen H, Fang J, Li X, Zang S, Chen P, Nie D, Zheng P, Wu Q, Xia L
Oncotarget 2017 Apr 4;8(14):23360-23375. doi: 10.18632/oncotarget.15579. PMID: 28423578Free PMC Article
Graft rejection and hyperacute graft-versus-host disease in stem cell transplantation from non-inherited maternal-antigen-complementary HLA-mismatched siblings.
Okumura H, Yamaguchi M, Kotani T, Sugimori N, Sugimori C, Ozaki J, Kondo Y, Yamazaki H, Chuhjo T, Takami A, Ueda M, Ohtake S, Nakao S
Eur J Haematol 2007 Feb;78(2):157-60. doi: 10.1111/j.1600-0609.2006.00797.x. PMID: 17313562

Prognosis

Adoptive immunotherapy with CB following chemotherapy for patients with refractory myeloid malignancy: chimerism and response.
Chaekal OK, Scaradavou A, Masson Frenet E, Albano MS, Cushing M, Desai P, Dobrila L, Gergis U, Guarneri D, Hsu JM, Lee S, Mayer SA, Phillips AA, Orfali N, Ritchie EK, Roboz GJ, Romeo C, Samuel MS, Shore T, van Besien K
Blood Adv 2020 Oct 27;4(20):5146-5156. doi: 10.1182/bloodadvances.2020002805. PMID: 33091124Free PMC Article
Long-Term Follow-Up of a Pilot Study Using Placenta-Derived Decidua Stromal Cells for Severe Acute Graft-versus-Host Disease.
Sadeghi B, Remberger M, Gustafsson B, Winiarski J, Moretti G, Khoein B, Klingspor L, Westgren M, Mattsson J, Ringdén O
Biol Blood Marrow Transplant 2019 Oct;25(10):1965-1969. Epub 2019 Jun 4 doi: 10.1016/j.bbmt.2019.05.034. PMID: 31173898
Intrathecal Infusion of Haploidentical Nondonor Lymphocytes for Central Nervous System Leukemic Relapse After Haploidentical Hematopoietic Stem Cell Transplantation.
Mayumi A, Sawada A, Ioi A, Higuchi K, Shimizu M, Sato M, Yasui M, Inoue M
J Pediatr Hematol Oncol 2018 Mar;40(2):e129-e132. doi: 10.1097/MPH.0000000000000937. PMID: 28816796
Graft rejection and hyperacute graft-versus-host disease in stem cell transplantation from non-inherited maternal-antigen-complementary HLA-mismatched siblings.
Okumura H, Yamaguchi M, Kotani T, Sugimori N, Sugimori C, Ozaki J, Kondo Y, Yamazaki H, Chuhjo T, Takami A, Ueda M, Ohtake S, Nakao S
Eur J Haematol 2007 Feb;78(2):157-60. doi: 10.1111/j.1600-0609.2006.00797.x. PMID: 17313562
Foreign cells in polymyositis: could stem cell transplantation and pregnancy-derived chimerism lead to the same disease?
Stevens AM
Curr Rheumatol Rep 2003 Dec;5(6):437-44. doi: 10.1007/s11926-003-0054-0. PMID: 14609488

Clinical prediction guides

Haploidentical Stem Cell Transplantation After TCR-αβ(+) and CD19(+) Cells Depletion In Children With Congenital Non-Malignant Disease.
Giardino S, Bagnasco F, Falco M, Miano M, Pierri F, Risso M, Terranova P, Di Martino D, Massaccesi E, Ricci M, Chianucci B, Dell'Orso G, Sabatini F, Podestà M, Lanino E, Faraci M
Transplant Cell Ther 2022 Jul;28(7):394.e1-394.e9. Epub 2022 Apr 8 doi: 10.1016/j.jtct.2022.04.002. PMID: 35405368
A Phase I Study to Evaluate Two Doses of Wharton's Jelly-Derived Mesenchymal Stromal Cells for the Treatment of De Novo High-Risk or Steroid-Refractory Acute Graft Versus Host Disease.
Soder RP, Dawn B, Weiss ML, Dunavin N, Weir S, Mitchell J, Li M, Shune L, Singh AK, Ganguly S, Morrison M, Abdelhakim H, Godwin AK, Abhyankar S, McGuirk J
Stem Cell Rev Rep 2020 Oct;16(5):979-991. doi: 10.1007/s12015-020-10015-8. PMID: 32740891Free PMC Article
Endothelial microparticles delivering microRNA-155 into T lymphocytes are involved in the initiation of acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation.
Zhang R, Wang X, Hong M, Luo T, Zhao M, Shen H, Fang J, Li X, Zang S, Chen P, Nie D, Zheng P, Wu Q, Xia L
Oncotarget 2017 Apr 4;8(14):23360-23375. doi: 10.18632/oncotarget.15579. PMID: 28423578Free PMC Article
Microchimerism in human health and disease.
Nelson JL
Autoimmunity 2003 Feb;36(1):5-9. doi: 10.1080/0891693031000067304. PMID: 12765465
Microchimerism and human autoimmune diseases.
Nelson JL
Lupus 2002;11(10):651-4. doi: 10.1191/0961203302lu271oa. PMID: 12413060

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