U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Graft versus host disease(GVHD)

MedGen UID:
9082
Concept ID:
C0018133
Disease or Syndrome
Synonyms: Graft vs Host Disease; GVHD; Late acute graft versus host disease
SNOMED CT: Graft versus host disease (234646005); GVHD - Graft-versus-host disease (234646005); Graft-versus-host disease (234646005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0013730
Orphanet: ORPHA39812

Definition

A rare disease that occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen. [from ORDO]

Professional guidelines

PubMed

Malard F, Mohty M
Am J Hematol 2023 Oct;98(10):1637-1644. Epub 2023 Jul 22 doi: 10.1002/ajh.27040. PMID: 37483142
Penack O, Marchetti M, Ruutu T, Aljurf M, Bacigalupo A, Bonifazi F, Ciceri F, Cornelissen J, Malladi R, Duarte RF, Giebel S, Greinix H, Holler E, Lawitschka A, Mielke S, Mohty M, Arat M, Nagler A, Passweg J, Schoemans H, Socié G, Solano C, Vrhovac R, Zeiser R, Kröger N, Basak GW
Lancet Haematol 2020 Feb;7(2):e157-e167. doi: 10.1016/S2352-3026(19)30256-X. PMID: 32004485
Strong Rodrigues K, Oliveira-Ribeiro C, de Abreu Fiuza Gomes S, Knobler R
Am J Clin Dermatol 2018 Feb;19(1):33-50. doi: 10.1007/s40257-017-0306-9. PMID: 28656563Free PMC Article

Recent clinical studies

Etiology

Asensi Cantó P, Sanz Caballer J, Solves Alcaína P, de la Rubia Comos J, Gómez Seguí I
Transplant Cell Ther 2023 Sep;29(9):556-566. Epub 2023 Jul 6 doi: 10.1016/j.jtct.2023.07.001. PMID: 37419324
Choe H, Ferrara JLM
Expert Opin Ther Targets 2021 Sep;25(9):761-771. Epub 2021 Nov 1 doi: 10.1080/14728222.2021.1992383. PMID: 34669521Free PMC Article
Hill GR, Betts BC, Tkachev V, Kean LS, Blazar BR
Annu Rev Immunol 2021 Apr 26;39:19-49. Epub 2021 Jan 11 doi: 10.1146/annurev-immunol-102119-073227. PMID: 33428454Free PMC Article
Aladağ E, Kelkitli E, Göker H
Turk J Haematol 2020 Feb 20;37(1):1-4. Epub 2019 Sep 2 doi: 10.4274/tjh.galenos.2019.2019.0157. PMID: 31475512Free PMC Article
Kornik RI, Rustagi AS
Obstet Gynecol Clin North Am 2017 Sep;44(3):475-492. doi: 10.1016/j.ogc.2017.05.007. PMID: 28778644

Diagnosis

Baumrin E, Loren AW, Falk SJ, Mays JW, Cowen EW
J Am Acad Dermatol 2024 Jan;90(1):1-16. Epub 2022 Dec 23 doi: 10.1016/j.jaad.2022.12.024. PMID: 36572065Free PMC Article
Aladağ E, Kelkitli E, Göker H
Turk J Haematol 2020 Feb 20;37(1):1-4. Epub 2019 Sep 2 doi: 10.4274/tjh.galenos.2019.2019.0157. PMID: 31475512Free PMC Article
Ramachandran V, Kolli SS, Strowd LC
Dermatol Clin 2019 Oct;37(4):569-582. Epub 2019 Jul 10 doi: 10.1016/j.det.2019.05.014. PMID: 31466596
Moreno DF, Cid J
Med Clin (Barc) 2019 Jan 4;152(1):22-28. Epub 2018 Oct 9 doi: 10.1016/j.medcli.2018.07.012. PMID: 30309668
Schroeder MA, DiPersio JF
Dis Model Mech 2011 May;4(3):318-33. doi: 10.1242/dmm.006668. PMID: 21558065Free PMC Article

Therapy

Martinez-Cibrian N, Zeiser R, Perez-Simon JA
Blood Rev 2021 Jul;48:100792. Epub 2020 Dec 26 doi: 10.1016/j.blre.2020.100792. PMID: 33386151
Ooijevaar RE, Terveer EM, Verspaget HW, Kuijper EJ, Keller JJ
Annu Rev Med 2019 Jan 27;70:335-351. Epub 2018 Nov 7 doi: 10.1146/annurev-med-111717-122956. PMID: 30403550
Maertens JA, Girmenia C, Brüggemann RJ, Duarte RF, Kibbler CC, Ljungman P, Racil Z, Ribaud P, Slavin MA, Cornely OA, Peter Donnelly J, Cordonnier C; European Conference on Infections in Leukaemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the Immunocompromised Host Society (ICHS) and; European Conference on Infections in Leukaemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the Immunocompromised Host Society (ICHS) and the European LeukemiaNet (ELN)
J Antimicrob Chemother 2018 Dec 1;73(12):3221-3230. doi: 10.1093/jac/dky286. PMID: 30085172
Trounson A, McDonald C
Cell Stem Cell 2015 Jul 2;17(1):11-22. doi: 10.1016/j.stem.2015.06.007. PMID: 26140604
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article

Prognosis

Wolff D, Radojcic V, Lafyatis R, Cinar R, Rosenstein RK, Cowen EW, Cheng GS, Sheshadri A, Bergeron A, Williams KM, Todd JL, Teshima T, Cuvelier GDE, Holler E, McCurdy SR, Jenq RR, Hanash AM, Jacobsohn D, Santomasso BD, Jain S, Ogawa Y, Steven P, Luo ZK, Dietrich-Ntoukas T, Saban D, Bilic E, Penack O, Griffith LM, Cowden M, Martin PJ, Greinix HT, Sarantopoulos S, Socie G, Blazar BR, Pidala J, Kitko CL, Couriel DR, Cutler C, Schultz KR, Pavletic SZ, Lee SJ, Paczesny S
Transplant Cell Ther 2021 Oct;27(10):817-835. Epub 2021 Jun 10 doi: 10.1016/j.jtct.2021.06.001. PMID: 34217703Free PMC Article
Goldsmith SR, Abid MB, Auletta JJ, Bashey A, Beitinjaneh A, Castillo P, Chemaly RF, Chen M, Ciurea S, Dandoy CE, Díaz MÁ, Fuchs E, Ganguly S, Kanakry CG, Kanakry JA, Kim S, Komanduri KV, Krem MM, Lazarus HM, Liu H, Ljungman P, Masiarz R, Mulroney C, Nathan S, Nishihori T, Page KM, Perales MA, Taplitz R, Romee R, Riches M
Blood 2021 Jun 10;137(23):3291-3305. doi: 10.1182/blood.2020009362. PMID: 33657221Free PMC Article
Cordeiro A, Bezerra ED, Hirayama AV, Hill JA, Wu QV, Voutsinas J, Sorror ML, Turtle CJ, Maloney DG, Bar M
Biol Blood Marrow Transplant 2020 Jan;26(1):26-33. Epub 2019 Aug 13 doi: 10.1016/j.bbmt.2019.08.003. PMID: 31419568Free PMC Article
Flowers ME, Martin PJ
Blood 2015 Jan 22;125(4):606-15. Epub 2014 Nov 14 doi: 10.1182/blood-2014-08-551994. PMID: 25398933Free PMC Article
Sunul H, Erguven N
Transfus Apher Sci 2013 Oct;49(2):331-3. Epub 2013 Jul 23 doi: 10.1016/j.transci.2013.07.001. PMID: 23890576

Clinical prediction guides

DeFilipp Z, Kim HT, Yang Z, Noonan J, Blazar BR, Lee SJ, Pavletic SZ, Cutler C
Blood Adv 2022 Dec 27;6(24):6263-6270. doi: 10.1182/bloodadvances.2022008095. PMID: 36083121Free PMC Article
Hidalgo Calleja C, Martín Hidalgo D, Román Curto C, Vázquez López L, Pérez López E, Cabrero Calvo M, Martín López AÁ, Caballero Barrigón MD, Lopez-Corral L
Adv Rheumatol 2022 Aug 23;62(1):33. doi: 10.1186/s42358-022-00262-3. PMID: 35999577
Elhage A, Sligar C, Cuthbertson P, Watson D, Sluyter R
Biosci Rep 2022 Sep 30;42(9) doi: 10.1042/BSR20211986. PMID: 35993192Free PMC Article
Crossland RE, Perutelli F, Bogunia-Kubik K, Mooney N, Milutin Gašperov N, Pučić-Baković M, Greinix H, Weber D, Holler E, Pulanić D, Wolff D, Dickinson AM, Inngjerdingen M, Grce M
Front Immunol 2020;11:602547. Epub 2020 Dec 23 doi: 10.3389/fimmu.2020.602547. PMID: 33424849Free PMC Article
Aguilar PR, Michelson AP, Isakow W
Transplantation 2016 Feb;100(2):272-83. doi: 10.1097/TP.0000000000000892. PMID: 26335918

Recent systematic reviews

Hidalgo Calleja C, Sánchez González MD, Medina Luezas J, López Corral L
Reumatol Clin (Engl Ed) 2023 May;19(5):235-243. Epub 2023 Apr 20 doi: 10.1016/j.reumae.2023.04.001. PMID: 37087381
Appeldoorn TYJ, Munnink THO, Morsink LM, Hooge MNL, Touw DJ
Clin Pharmacokinet 2023 Apr;62(4):559-571. Epub 2023 Mar 31 doi: 10.1007/s40262-023-01225-7. PMID: 37000342Free PMC Article
Zhu J, Navarini AA, Halter JP, Mueller SM
J Eur Acad Dermatol Venereol 2023 Jul;37(7):1276-1283. Epub 2023 Apr 5 doi: 10.1111/jdv.19057. PMID: 36950958
Fan S, Huo WX, Yang Y, Shen MZ, Mo XD
Front Immunol 2022;13:954268. Epub 2022 Aug 4 doi: 10.3389/fimmu.2022.954268. PMID: 35990629Free PMC Article
Arnold DD, Yalamanoglu A, Boyman O
Front Immunol 2022;13:888392. Epub 2022 Jul 6 doi: 10.3389/fimmu.2022.888392. PMID: 35874710Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...