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PDGFR Gene Amplification

MedGen UID:
1658759
Concept ID:
C4725011
Cell or Molecular Dysfunction
Synonyms: PDGF Receptor Gene Amplification; PDGFR Family Gene Amplification; Platelet Derived Growth Factor Receptor Gene Amplification; Platelet-Derived Growth Factor Receptor Gene Amplification

Definition

A molecular genetic abnormality indicating the presence of multiple copies of a PDGFR family gene. [from NCI]

Professional guidelines

PubMed

El-Deiry WS, Vijayvergia N, Xiu J, Scicchitano A, Lim B, Yee NS, Harvey HA, Gatalica Z, Reddy S
Cancer Biol Ther 2015;16(12):1726-37. doi: 10.1080/15384047.2015.1113356. PMID: 26553611Free PMC Article
Truffaux N, Philippe C, Paulsson J, Andreiuolo F, Guerrini-Rousseau L, Cornilleau G, Le Dret L, Richon C, Lacroix L, Puget S, Geoerger B, Vassal G, Östman A, Grill J
Neuro Oncol 2015 Jul;17(7):953-64. Epub 2014 Dec 21 doi: 10.1093/neuonc/nou330. PMID: 25534822Free PMC Article
Patwardhan PP, Surriga O, Beckman MJ, de Stanchina E, Dematteo RP, Tap WD, Schwartz GK
Clin Cancer Res 2014 Jun 15;20(12):3146-58. Epub 2014 Apr 9 doi: 10.1158/1078-0432.CCR-13-2576. PMID: 24718867Free PMC Article

Recent clinical studies

Etiology

Ohshima K, Fujiya K, Nagashima T, Ohnami S, Hatakeyama K, Urakami K, Naruoka A, Watanabe Y, Moromizato S, Shimoda Y, Ohnami S, Serizawa M, Akiyama Y, Kusuhara M, Mochizuki T, Sugino T, Shiomi A, Tsubosa Y, Uesaka K, Terashima M, Yamaguchi K
Cancer Sci 2019 Dec;110(12):3821-3833. Epub 2019 Oct 14 doi: 10.1111/cas.14202. PMID: 31553483Free PMC Article
Koschmann C, Zamler D, MacKay A, Robinson D, Wu YM, Doherty R, Marini B, Tran D, Garton H, Muraszko K, Robertson P, Leonard M, Zhao L, Bixby D, Peterson L, Camelo-Piragua S, Jones C, Mody R, Lowenstein PR, Castro MG
Oncotarget 2016 Oct 4;7(40):65696-65706. doi: 10.18632/oncotarget.11602. PMID: 27582545Free PMC Article
Bidinotto LT, Torrieri R, Mackay A, Almeida GC, Viana-Pereira M, Cruvinel-Carloni A, Spina ML, Campanella NC, Pereira de Menezes W, Clara CA, Becker AP, Jones C, Reis RM
G3 (Bethesda) 2016 Jul 7;6(7):1867-78. doi: 10.1534/g3.116.029884. PMID: 27172220Free PMC Article
Burstein MD, Tsimelzon A, Poage GM, Covington KR, Contreras A, Fuqua SA, Savage MI, Osborne CK, Hilsenbeck SG, Chang JC, Mills GB, Lau CC, Brown PH
Clin Cancer Res 2015 Apr 1;21(7):1688-98. Epub 2014 Sep 10 doi: 10.1158/1078-0432.CCR-14-0432. PMID: 25208879Free PMC Article
Harrison CJ
Hematology Am Soc Hematol Educ Program 2013;2013:118-25. doi: 10.1182/asheducation-2013.1.118. PMID: 24319172

Diagnosis

Goenka A, Song X, Tiek D, Iglesia RP, Lu M, Zeng C, Horbinski C, Zhang W, Hu B, Cheng SY
Neuro Oncol 2023 Sep 5;25(9):1592-1604. doi: 10.1093/neuonc/noad065. PMID: 36988488Free PMC Article
Bidinotto LT, Torrieri R, Mackay A, Almeida GC, Viana-Pereira M, Cruvinel-Carloni A, Spina ML, Campanella NC, Pereira de Menezes W, Clara CA, Becker AP, Jones C, Reis RM
G3 (Bethesda) 2016 Jul 7;6(7):1867-78. doi: 10.1534/g3.116.029884. PMID: 27172220Free PMC Article
Zalatimo O, Zoccoli CM, Patel A, Weston CL, Glantz M
Adv Exp Med Biol 2013;779:267-89. doi: 10.1007/978-1-4614-6176-0_12. PMID: 23288644
Yang J, Du X, Lazar AJ, Pollock R, Hunt K, Chen K, Hao X, Trent J, Zhang W
Cancer 2008 Oct 1;113(7):1532-43. doi: 10.1002/cncr.23778. PMID: 18671247Free PMC Article
Gordon H
Mayo Clin Proc 1985 Oct;60(10):697-713. doi: 10.1016/s0025-6196(12)60746-0. PMID: 2993762

Therapy

Cardona AF, Jaramillo-Velásquez D, Ruiz-Patiño A, Polo C, Jiménez E, Hakim F, Gómez D, Ramón JF, Cifuentes H, Mejía JA, Salguero F, Ordoñez C, Muñoz Á, Bermúdez S, Useche N, Pineda D, Ricaurte L, Zatarain-Barrón ZL, Rodríguez J, Avila J, Rojas L, Jaller E, Sotelo C, Garcia-Robledo JE, Santoyo N, Rolfo C, Rosell R, Arrieta O
J Neurooncol 2021 Sep;154(3):353-364. Epub 2021 Sep 9 doi: 10.1007/s11060-021-03834-3. PMID: 34498213
Berghoff AS, Birner P, Streubel B, Kenner L, Preusser M
APMIS 2014 Sep;122(9):867-72. Epub 2014 Apr 3 doi: 10.1111/apm.12249. PMID: 24750504
Waller CF
Recent Results Cancer Res 2010;184:3-20. doi: 10.1007/978-3-642-01222-8_1. PMID: 20072827
Maleddu A, Pantaleo MA, Nannini M, Di Battista M, Saponara M, Lolli C, Biasco G
Oncol Rep 2009 Jun;21(6):1359-66. doi: 10.3892/or_00000361. PMID: 19424610
Gambacorti-Passerini CB, Gunby RH, Piazza R, Galietta A, Rostagno R, Scapozza L
Lancet Oncol 2003 Feb;4(2):75-85. doi: 10.1016/s1470-2045(03)00979-3. PMID: 12573349

Prognosis

Carlotto BS, Trevisan P, Provenzi VO, Soares FP, Rosa RFM, Varella-Garcia M, Zen PRG
Neuromolecular Med 2023 Sep;25(3):441-450. Epub 2023 Aug 23 doi: 10.1007/s12017-023-08749-y. PMID: 37610648Free PMC Article
Goenka A, Song X, Tiek D, Iglesia RP, Lu M, Zeng C, Horbinski C, Zhang W, Hu B, Cheng SY
Neuro Oncol 2023 Sep 5;25(9):1592-1604. doi: 10.1093/neuonc/noad065. PMID: 36988488Free PMC Article
Burstein MD, Tsimelzon A, Poage GM, Covington KR, Contreras A, Fuqua SA, Savage MI, Osborne CK, Hilsenbeck SG, Chang JC, Mills GB, Lau CC, Brown PH
Clin Cancer Res 2015 Apr 1;21(7):1688-98. Epub 2014 Sep 10 doi: 10.1158/1078-0432.CCR-14-0432. PMID: 25208879Free PMC Article
Westermark B
Ups J Med Sci 2014 Nov;119(4):298-305. Epub 2014 Oct 24 doi: 10.3109/03009734.2014.970304. PMID: 25342206Free PMC Article
Yang J, Du X, Lazar AJ, Pollock R, Hunt K, Chen K, Hao X, Trent J, Zhang W
Cancer 2008 Oct 1;113(7):1532-43. doi: 10.1002/cncr.23778. PMID: 18671247Free PMC Article

Clinical prediction guides

Carlotto BS, Trevisan P, Provenzi VO, Soares FP, Rosa RFM, Varella-Garcia M, Zen PRG
Neuromolecular Med 2023 Sep;25(3):441-450. Epub 2023 Aug 23 doi: 10.1007/s12017-023-08749-y. PMID: 37610648Free PMC Article
Ohshima K, Fujiya K, Nagashima T, Ohnami S, Hatakeyama K, Urakami K, Naruoka A, Watanabe Y, Moromizato S, Shimoda Y, Ohnami S, Serizawa M, Akiyama Y, Kusuhara M, Mochizuki T, Sugino T, Shiomi A, Tsubosa Y, Uesaka K, Terashima M, Yamaguchi K
Cancer Sci 2019 Dec;110(12):3821-3833. Epub 2019 Oct 14 doi: 10.1111/cas.14202. PMID: 31553483Free PMC Article
Bidinotto LT, Torrieri R, Mackay A, Almeida GC, Viana-Pereira M, Cruvinel-Carloni A, Spina ML, Campanella NC, Pereira de Menezes W, Clara CA, Becker AP, Jones C, Reis RM
G3 (Bethesda) 2016 Jul 7;6(7):1867-78. doi: 10.1534/g3.116.029884. PMID: 27172220Free PMC Article
Zalatimo O, Zoccoli CM, Patel A, Weston CL, Glantz M
Adv Exp Med Biol 2013;779:267-89. doi: 10.1007/978-1-4614-6176-0_12. PMID: 23288644
Biscuola M, Van de Vijver K, Castilla MÁ, Romero-Pérez L, López-García MÁ, Díaz-Martín J, Matias-Guiu X, Oliva E, Palacios Calvo J
Hum Pathol 2013 May;44(5):852-9. Epub 2012 Nov 28 doi: 10.1016/j.humpath.2012.07.027. PMID: 23199529

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