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Recurrent Aplastic Anemia

MedGen UID:
1661033
•Concept ID:
C4727148
•
Disease or Syndrome

Definition

The reemergence of aplastic anemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Aplastic Anemia

Professional guidelines

PubMed

Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment.
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article
Updates on the pathophysiology and treatment of aplastic anemia: a comprehensive review.
Boddu PC, Kadia TM
Expert Rev Hematol 2017 May;10(5):433-448. Epub 2017 Apr 28 doi: 10.1080/17474086.2017.1313700. PMID: 28452257
Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review.
Devalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C
Eur J Haematol 2015 Sep;95(3):190-8. Epub 2015 Mar 26 doi: 10.1111/ejh.12543. PMID: 25753400

Recent clinical studies

Etiology

Molecular pathogenesis of acquired aplastic anemia.
Boddu PC, Kadia TM
Eur J Haematol 2019 Feb;102(2):103-110. Epub 2018 Dec 18 doi: 10.1111/ejh.13182. PMID: 30380171
Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment.
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article
Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review.
Devalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C
Eur J Haematol 2015 Sep;95(3):190-8. Epub 2015 Mar 26 doi: 10.1111/ejh.12543. PMID: 25753400
Eltrombopag in aplastic anemia.
Desmond R, Townsley DM, Dunbar C, Young NS
Semin Hematol 2015 Jan;52(1):31-7. Epub 2014 Oct 31 doi: 10.1053/j.seminhematol.2014.10.002. PMID: 25578417Free PMC Article
Temozolomide-related hematologic toxicity.
Scaringi C, De Sanctis V, Minniti G, Enrici RM
Onkologie 2013;36(7-8):444-9. Epub 2013 Jul 8 doi: 10.1159/000353752. PMID: 23921765

Diagnosis

Molecular pathogenesis of acquired aplastic anemia.
Boddu PC, Kadia TM
Eur J Haematol 2019 Feb;102(2):103-110. Epub 2018 Dec 18 doi: 10.1111/ejh.13182. PMID: 30380171
Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment.
Georges GE, Doney K, Storb R
Blood Adv 2018 Aug 14;2(15):2020-2028. doi: 10.1182/bloodadvances.2018021162. PMID: 30108110Free PMC Article
Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review.
Devalet B, Mullier F, Chatelain B, Dogné JM, Chatelain C
Eur J Haematol 2015 Sep;95(3):190-8. Epub 2015 Mar 26 doi: 10.1111/ejh.12543. PMID: 25753400
Temozolomide-related hematologic toxicity.
Scaringi C, De Sanctis V, Minniti G, Enrici RM
Onkologie 2013;36(7-8):444-9. Epub 2013 Jul 8 doi: 10.1159/000353752. PMID: 23921765
Acquired aplastic anemia.
Young NS
Ann Intern Med 2002 Apr 2;136(7):534-46. doi: 10.7326/0003-4819-136-7-200204020-00011. PMID: 11926789

Therapy

Traditional Chinese medicine for treating aplastic anemia.
Guan J, Zhao Y, Wang T, Fu R
J Pharm Pharm Sci 2023;26:11863. Epub 2023 Nov 13 doi: 10.3389/jpps.2023.11863. PMID: 38022904Free PMC Article
Clonal hematopoiesis: Pre-cancer PLUS.
Silver AJ, Jaiswal S
Adv Cancer Res 2019;141:85-128. Epub 2019 Jan 14 doi: 10.1016/bs.acr.2018.12.003. PMID: 30691686
Eltrombopag in aplastic anemia.
Desmond R, Townsley DM, Dunbar C, Young NS
Semin Hematol 2015 Jan;52(1):31-7. Epub 2014 Oct 31 doi: 10.1053/j.seminhematol.2014.10.002. PMID: 25578417Free PMC Article
Temozolomide-related hematologic toxicity.
Scaringi C, De Sanctis V, Minniti G, Enrici RM
Onkologie 2013;36(7-8):444-9. Epub 2013 Jul 8 doi: 10.1159/000353752. PMID: 23921765
Acquired aplastic anemia.
Young NS
Ann Intern Med 2002 Apr 2;136(7):534-46. doi: 10.7326/0003-4819-136-7-200204020-00011. PMID: 11926789

Prognosis

Acquired aplastic anemia following SARS-CoV-2 vaccination.
Röth A, Bertram S, Schroeder T, Haverkamp T, Voigt S, Holtkamp C, Klump H, Wörmann B, Reinhardt HC, Alashkar F
Eur J Haematol 2022 Aug;109(2):186-194. Epub 2022 Jun 1 doi: 10.1111/ejh.13788. PMID: 35592930Free PMC Article
Anti-thymocyte globulin in haematology: Recent developments.
Siddiqui S, Cox J, Herzig R, Palaniyandi S, Hildebrandt GC, Munker R
Indian J Med Res 2019 Sep;150(3):221-227. doi: 10.4103/ijmr.IJMR_752_19. PMID: 31719292Free PMC Article
Management of aplastic anemia after failure of frontline immunosuppression.
Pierri F, Dufour C
Expert Rev Hematol 2019 Oct;12(10):809-819. Epub 2019 Jul 24 doi: 10.1080/17474086.2019.1645003. PMID: 31311355
Updates on the pathophysiology and treatment of aplastic anemia: a comprehensive review.
Boddu PC, Kadia TM
Expert Rev Hematol 2017 May;10(5):433-448. Epub 2017 Apr 28 doi: 10.1080/17474086.2017.1313700. PMID: 28452257
Temozolomide-related hematologic toxicity.
Scaringi C, De Sanctis V, Minniti G, Enrici RM
Onkologie 2013;36(7-8):444-9. Epub 2013 Jul 8 doi: 10.1159/000353752. PMID: 23921765

Clinical prediction guides

Alemtuzumab in relapsed immune severe aplastic anemia: Long-term results of a phase II study.
Aggarwal N, Manley AL, Shalhoub R, Durrani J, Rios O, Lotter J, Patel BA, Wu CO, Young NS, Groarke EM
Am J Hematol 2023 Jun;98(6):932-939. Epub 2023 Apr 6 doi: 10.1002/ajh.26924. PMID: 37021397Free PMC Article
Haploidentical bone marrow transplantation in patients with relapsed or refractory severe aplastic anaemia in the USA (BMT CTN 1502): a multicentre, single-arm, phase 2 trial.
DeZern AE, Eapen M, Wu J, Talano JA, Solh M, Dávila Saldaña BJ, Karanes C, Horwitz ME, Mallhi K, Arai S, Farhadfar N, Hexner E, Westervelt P, Antin JH, Deeg HJ, Leifer E, Brodsky RA, Logan BR, Horowitz MM, Jones RJ, Pulsipher MA
Lancet Haematol 2022 Sep;9(9):e660-e669. Epub 2022 Jul 27 doi: 10.1016/S2352-3026(22)00206-X. PMID: 35907408Free PMC Article
Acquired aplastic anemia following SARS-CoV-2 vaccination.
Röth A, Bertram S, Schroeder T, Haverkamp T, Voigt S, Holtkamp C, Klump H, Wörmann B, Reinhardt HC, Alashkar F
Eur J Haematol 2022 Aug;109(2):186-194. Epub 2022 Jun 1 doi: 10.1111/ejh.13788. PMID: 35592930Free PMC Article
Niraparib plus bevacizumab versus niraparib alone for platinum-sensitive recurrent ovarian cancer (NSGO-AVANOVA2/ENGOT-ov24): a randomised, phase 2, superiority trial.
Mirza MR, Åvall Lundqvist E, Birrer MJ, dePont Christensen R, Nyvang GB, Malander S, Anttila M, Werner TL, Lund B, Lindahl G, Hietanen S, Peen U, Dimoula M, Roed H, Ør Knudsen A, Staff S, Krog Vistisen A, Bjørge L, Mäenpää JU; AVANOVA investigators
Lancet Oncol 2019 Oct;20(10):1409-1419. Epub 2019 Aug 29 doi: 10.1016/S1470-2045(19)30515-7. PMID: 31474354
Clonal hematopoiesis: Pre-cancer PLUS.
Silver AJ, Jaiswal S
Adv Cancer Res 2019;141:85-128. Epub 2019 Jan 14 doi: 10.1016/bs.acr.2018.12.003. PMID: 30691686

Recent systematic reviews

Oral cancer and oral potentially malignant disorders in patients with Fanconi anemia - A systematic review.
Santana NCM, de Sena ACVP, Rocha PADS, de Arruda JAA, Torres-Pereira CC, Abreu LG, Fournier BPJ, Warnakulasuriya S, Silva TA
Oral Oncol 2024 Mar;150:106699. Epub 2024 Feb 3 doi: 10.1016/j.oraloncology.2024.106699. PMID: 38309198
Long-term effects of hematopoietic growth factors in aplastic anemia patients treated with immunosuppression: Meta-analysis of randomized controlled trials.
Wang A, Su D, Luo J, Fu Y, Li Q, Chen S
Medicine (Baltimore) 2022 Oct 21;101(42):e31103. doi: 10.1097/MD.0000000000031103. PMID: 36281138Free PMC Article
Pharmacological interventions for painful sickle cell vaso-occlusive crises in adults.
Cooper TE, Hambleton IR, Ballas SK, Johnston BA, Wiffen PJ
Cochrane Database Syst Rev 2019 Nov 14;2019(11) doi: 10.1002/14651858.CD012187.pub2. PMID: 31742673Free PMC Article
Eculizumab for treating patients with paroxysmal nocturnal hemoglobinuria.
Martí-Carvajal AJ, Anand V, Cardona AF, Solà I
Cochrane Database Syst Rev 2014 Oct 30;(10):CD010340. doi: 10.1002/14651858.CD010340.pub2. PMID: 25356860

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