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NTRK1 Gene Amplification

MedGen UID:
1661118
Concept ID:
C4727000
Cell or Molecular Dysfunction
Synonyms: MTC Gene Amplification; Neurotrophic Receptor Tyrosine Kinase 1 Gene Amplification; Neurotrophic Tyrosine Kinase, Receptor, Type 1 Gene Amplification; NTRK1 Amplification; p140-TrkA Gene Amplification; TRK Amplification; TRK Gene Amplification; Trk-A Gene Amplification; TRK1 Gene Amplification; TRKA Amplification; TRKA Gene Amplification

Definition

A molecular genetic abnormality indicating the presence of multiple copies of the NTRK1 gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNTRK1 Gene Amplification

Professional guidelines

PubMed

Tauziède-Espariat A, Beccaria K, Dangouloff-Ros V, Sievers P, Meurgey A, Pissaloux D, Appay R, Saffroy R, Grill J, Mariet C, Bourdeaut F, Hasty L, Métais A, Chrétien F, Blauwblomme T, Puget S, Boddaert N, Varlet P; RENOCLIP-LOC
Brain Pathol 2023 Sep;33(5):e13182. Epub 2023 Jun 22 doi: 10.1111/bpa.13182. PMID: 37349135Free PMC Article
Chu YH, Barbee J, Yang SR, Chang JC, Liang P, Mullaney K, Chan R, Salazar P, Benayed R, Offin M, Drilon A, Ladanyi M, Nafa K, Arcila ME
J Mol Diagn 2022 Jun;24(6):642-654. Epub 2022 Apr 14 doi: 10.1016/j.jmoldx.2022.03.006. PMID: 35430374Free PMC Article
Pu X, Zhu L, Li F, Zheng J, Wu H, Fu Y, Chen J, Qi L
Pathol Res Pract 2020 Sep;216(9):153116. Epub 2020 Jul 11 doi: 10.1016/j.prp.2020.153116. PMID: 32825971

Recent clinical studies

Etiology

Tauziède-Espariat A, Beccaria K, Dangouloff-Ros V, Sievers P, Meurgey A, Pissaloux D, Appay R, Saffroy R, Grill J, Mariet C, Bourdeaut F, Hasty L, Métais A, Chrétien F, Blauwblomme T, Puget S, Boddaert N, Varlet P; RENOCLIP-LOC
Brain Pathol 2023 Sep;33(5):e13182. Epub 2023 Jun 22 doi: 10.1111/bpa.13182. PMID: 37349135Free PMC Article
Girard N, Basse C, Schrock A, Ramkissoon S, Killian K, Ross JS
Oncologist 2022 Nov 3;27(11):919-929. doi: 10.1093/oncolo/oyac115. PMID: 35749302Free PMC Article
Chen Y, Shi YZ, Feng XH, Wang XT, He XL, Zhao M
Diagn Pathol 2021 Jul 13;16(1):63. doi: 10.1186/s13000-021-01123-1. PMID: 34256767Free PMC Article
Meng X, Fang E, Zhao X, Feng J
Cancer Med 2020 Jun;9(11):3800-3815. Epub 2020 Mar 26 doi: 10.1002/cam4.3022. PMID: 32216054Free PMC Article
Wang L, Busam KJ, Benayed R, Cimera R, Wang J, Denley R, Rao M, Aryeequaye R, Mullaney K, Cao L, Ladanyi M, Hameed M
J Mol Diagn 2017 May;19(3):387-396. doi: 10.1016/j.jmoldx.2016.11.005. PMID: 28433076Free PMC Article

Diagnosis

Radhakrishnan S, Martin CA, Vij M, Raju LP, Gowripriya G, Jana K, Rammohan A, Jothimani D, Kaliamoorthy I, Veldore VH, Rela M
Int J Surg Pathol 2023 Aug;31(5):839-845. Epub 2022 Dec 7 doi: 10.1177/10668969221142043. PMID: 36476133
Gianno F, Giovannoni I, Cafferata B, Diomedi-Camassei F, Minasi S, Barresi S, Buttarelli FR, Alesi V, Cardoni A, Antonelli M, Puggioni C, Colafati GS, Carai A, Vinci M, Mastronuzzi A, Miele E, Alaggio R, Giangaspero F, Rossi S
Pathologica 2022 Dec;114(6):422-435. doi: 10.32074/1591-951X-830. PMID: 36534421Free PMC Article
Chu YH, Barbee J, Yang SR, Chang JC, Liang P, Mullaney K, Chan R, Salazar P, Benayed R, Offin M, Drilon A, Ladanyi M, Nafa K, Arcila ME
J Mol Diagn 2022 Jun;24(6):642-654. Epub 2022 Apr 14 doi: 10.1016/j.jmoldx.2022.03.006. PMID: 35430374Free PMC Article
Pareja F, Weigelt B, Reis-Filho JS
Mod Pathol 2021 Jan;34(Suppl 1):38-47. Epub 2020 Oct 6 doi: 10.1038/s41379-020-00693-7. PMID: 33024304Free PMC Article
Cremolini C, Pietrantonio F
Tumori 2016 Dec 1;102(6):541-547. Epub 2016 Sep 20 doi: 10.5301/tj.5000551. PMID: 27647226

Therapy

Kim EE, Park CK, Kim SK, Phi JH, Paek SH, Choi JY, Kang HJ, Lee JH, Won JK, Yun H, Park SH
Acta Neuropathol Commun 2024 Jul 16;12(1):118. doi: 10.1186/s40478-024-01798-9. PMID: 39014476Free PMC Article
Pu X, Zhu L, Li F, Zheng J, Wu H, Fu Y, Chen J, Qi L
Pathol Res Pract 2020 Sep;216(9):153116. Epub 2020 Jul 11 doi: 10.1016/j.prp.2020.153116. PMID: 32825971
Vranic S, Palazzo J, Sanati S, Florento E, Contreras E, Xiu J, Swensen J, Gatalica Z
Clin Breast Cancer 2019 Apr;19(2):131-136. Epub 2018 Sep 5 doi: 10.1016/j.clbc.2018.09.001. PMID: 30268765
Dey N, Krie A, Klein J, Williams K, McMillan A, Elsey R, Sun Y, Williams C, De P, Leyland-Jones B
Int J Mol Sci 2017 Jun 7;18(6) doi: 10.3390/ijms18061218. PMID: 28590426Free PMC Article
Suh JH, Johnson A, Albacker L, Wang K, Chmielecki J, Frampton G, Gay L, Elvin JA, Vergilio JA, Ali S, Miller VA, Stephens PJ, Ross JS
Oncologist 2016 Jun;21(6):684-91. Epub 2016 May 5 doi: 10.1634/theoncologist.2016-0030. PMID: 27151654Free PMC Article

Prognosis

Zito Marino F, Buono S, Montella M, Giannatiempo R, Messina F, Casaretta G, Arpino G, Vita G, Fiorentino F, Insabato L, Sgambato A, Orditura M, Franco R, Accardo M
J Pathol Clin Res 2023 Sep;9(5):367-377. Epub 2023 May 4 doi: 10.1002/cjp2.324. PMID: 37143440Free PMC Article
Pu X, Zhu L, Li F, Zheng J, Wu H, Fu Y, Chen J, Qi L
Pathol Res Pract 2020 Sep;216(9):153116. Epub 2020 Jul 11 doi: 10.1016/j.prp.2020.153116. PMID: 32825971
Youssef G, Gillett C, Rampling D, Chagtai T, Virasami A, Barton J, Edwards D, Sebire N, Anderson J, Montano X
Hum Pathol 2019 Apr;86:182-192. Epub 2018 Dec 27 doi: 10.1016/j.humpath.2018.12.003. PMID: 30594749
Vranic S, Palazzo J, Sanati S, Florento E, Contreras E, Xiu J, Swensen J, Gatalica Z
Clin Breast Cancer 2019 Apr;19(2):131-136. Epub 2018 Sep 5 doi: 10.1016/j.clbc.2018.09.001. PMID: 30268765
Cremolini C, Pietrantonio F
Tumori 2016 Dec 1;102(6):541-547. Epub 2016 Sep 20 doi: 10.5301/tj.5000551. PMID: 27647226

Clinical prediction guides

Yamamoto H, Arai H, Oikawa R, Umemoto K, Takeda H, Mizukami T, Kubota Y, Doi A, Horie Y, Ogura T, Izawa N, Moore JA, Sokol ES, Sunakawa Y
Target Oncol 2024 May;19(3):459-471. Epub 2024 Apr 13 doi: 10.1007/s11523-024-01052-1. PMID: 38613733
Zito Marino F, Buono S, Montella M, Giannatiempo R, Messina F, Casaretta G, Arpino G, Vita G, Fiorentino F, Insabato L, Sgambato A, Orditura M, Franco R, Accardo M
J Pathol Clin Res 2023 Sep;9(5):367-377. Epub 2023 May 4 doi: 10.1002/cjp2.324. PMID: 37143440Free PMC Article
Pu X, Zhu L, Li F, Zheng J, Wu H, Fu Y, Chen J, Qi L
Pathol Res Pract 2020 Sep;216(9):153116. Epub 2020 Jul 11 doi: 10.1016/j.prp.2020.153116. PMID: 32825971
Vranic S, Palazzo J, Sanati S, Florento E, Contreras E, Xiu J, Swensen J, Gatalica Z
Clin Breast Cancer 2019 Apr;19(2):131-136. Epub 2018 Sep 5 doi: 10.1016/j.clbc.2018.09.001. PMID: 30268765
Cremolini C, Pietrantonio F
Tumori 2016 Dec 1;102(6):541-547. Epub 2016 Sep 20 doi: 10.5301/tj.5000551. PMID: 27647226

Supplemental Content

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    Practice guidelines

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