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Advanced Oropharyngeal Squamous Cell Carcinoma

MedGen UID:
1661808
•Concept ID:
C4725662
•
Neoplastic Process
Synonym: Advanced Squamous Cell Carcinoma of the Oropharynx

Definition

A squamous cell carcinoma of the oropharynx that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Oropharyngeal Squamous Cell Carcinoma

Professional guidelines

PubMed

Clinical Impact of CYFRA 21-1 a Marker for Treatment Failure in Patients With Oropharyngeal Cancer Treated by Radio(chemo)therapy.
Rudhart SA, Langen P, Thangavelu K, Gehrt F, Stankovic P, Wilhelm T, Stuck BA, Hoch S
Anticancer Res 2022 Jan;42(1):137-146. doi: 10.21873/anticanres.15467. PMID: 34969719
Treatment trends for advanced oropharyngeal squamous cell carcinoma in the era of human papillomavirus.
Mirza FA, Johnson CZ, Byrd JK, Albergotti WG 3rd
Head Neck 2021 Nov;43(11):3476-3492. Epub 2021 Sep 9 doi: 10.1002/hed.26860. PMID: 34499392
De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma.
Masterson L, Moualed D, Masood A, Dwivedi RC, Benson R, Sterling JC, Rhodes KM, Sudhoff H, Jani P, Goon P
Cochrane Database Syst Rev 2014 Feb 15;2014(2):CD010271. doi: 10.1002/14651858.CD010271.pub2. PMID: 24532092Free PMC Article

Recent clinical studies

Etiology

Neo-adjuvant chemotherapy and transoral robotic surgery in locoregionally advanced oropharyngeal cancer.
Costantino A, Sampieri C, De Virgilio A, Kim SH
Eur J Surg Oncol 2023 Dec;49(12):107121. Epub 2023 Oct 18 doi: 10.1016/j.ejso.2023.107121. PMID: 37879162
A predictive model for patients with local-regionally advanced oropharyngeal squamous cell carcinoma treated after cervical lymph node dissection.
Xie X, Kang M, Qu Z, Gu K
J Cancer Res Clin Oncol 2023 Dec;149(19):17241-17251. Epub 2023 Oct 7 doi: 10.1007/s00432-023-05379-6. PMID: 37804427
Catastrophic Hemorrhage After Chemoradiation for Advanced Stage Oropharyngeal Carcinoma: A Case Series.
Chou CT, Rath TJ, Johnson JT, Goyal LK
Laryngoscope 2021 May;131(5):1049-1052. Epub 2020 Oct 17 doi: 10.1002/lary.29167. PMID: 33068291
Prognostic impact of additional HPV diagnostics in 102 patients with p16-stratified advanced oropharyngeal squamous cell carcinoma.
Weiss BG, Anczykowski MZ, Küffer S, Spiegel JL, Bertlich M, Canis M, Ihler F, Kitz J, Jakob M
Eur Arch Otorhinolaryngol 2021 Jun;278(6):1983-2000. Epub 2020 Aug 20 doi: 10.1007/s00405-020-06262-7. PMID: 32814982Free PMC Article
Cetuximab induced aseptic meningitis.
Ulrich A, Weiler S, Weller M, Rordorf T, Tarnutzer AA
J Clin Neurosci 2015 Jun;22(6):1061-3. Epub 2015 Mar 11 doi: 10.1016/j.jocn.2014.11.034. PMID: 25769257

Diagnosis

Treatment trends for advanced oropharyngeal squamous cell carcinoma in the era of human papillomavirus.
Mirza FA, Johnson CZ, Byrd JK, Albergotti WG 3rd
Head Neck 2021 Nov;43(11):3476-3492. Epub 2021 Sep 9 doi: 10.1002/hed.26860. PMID: 34499392
Catastrophic Hemorrhage After Chemoradiation for Advanced Stage Oropharyngeal Carcinoma: A Case Series.
Chou CT, Rath TJ, Johnson JT, Goyal LK
Laryngoscope 2021 May;131(5):1049-1052. Epub 2020 Oct 17 doi: 10.1002/lary.29167. PMID: 33068291
Prognostic impact of additional HPV diagnostics in 102 patients with p16-stratified advanced oropharyngeal squamous cell carcinoma.
Weiss BG, Anczykowski MZ, Küffer S, Spiegel JL, Bertlich M, Canis M, Ihler F, Kitz J, Jakob M
Eur Arch Otorhinolaryngol 2021 Jun;278(6):1983-2000. Epub 2020 Aug 20 doi: 10.1007/s00405-020-06262-7. PMID: 32814982Free PMC Article
Comparative effectiveness of primary radiotherapy versus surgery in elderly patients with locally advanced oropharyngeal squamous cell carcinoma.
Sher DJ, Yan J, Day A, Sumer BD, Pham NL, Khan S, Zhu H
Oral Oncol 2019 Jan;88:18-26. Epub 2018 Nov 16 doi: 10.1016/j.oraloncology.2018.11.004. PMID: 30616791
Cetuximab induced aseptic meningitis.
Ulrich A, Weiler S, Weller M, Rordorf T, Tarnutzer AA
J Clin Neurosci 2015 Jun;22(6):1061-3. Epub 2015 Mar 11 doi: 10.1016/j.jocn.2014.11.034. PMID: 25769257

Therapy

Neo-adjuvant chemotherapy and transoral robotic surgery in locoregionally advanced oropharyngeal cancer.
Costantino A, Sampieri C, De Virgilio A, Kim SH
Eur J Surg Oncol 2023 Dec;49(12):107121. Epub 2023 Oct 18 doi: 10.1016/j.ejso.2023.107121. PMID: 37879162
Catastrophic Hemorrhage After Chemoradiation for Advanced Stage Oropharyngeal Carcinoma: A Case Series.
Chou CT, Rath TJ, Johnson JT, Goyal LK
Laryngoscope 2021 May;131(5):1049-1052. Epub 2020 Oct 17 doi: 10.1002/lary.29167. PMID: 33068291
Cetuximab induced aseptic meningitis.
Ulrich A, Weiler S, Weller M, Rordorf T, Tarnutzer AA
J Clin Neurosci 2015 Jun;22(6):1061-3. Epub 2015 Mar 11 doi: 10.1016/j.jocn.2014.11.034. PMID: 25769257
Submandibular gland-sparing radiation therapy for locally advanced oropharyngeal squamous cell carcinoma: patterns of failure and xerostomia outcomes.
Gensheimer MF, Liao JJ, Garden AS, Laramore GE, Parvathaneni U
Radiat Oncol 2014 Nov 26;9:255. doi: 10.1186/s13014-014-0255-x. PMID: 25424729Free PMC Article
Use of a trypsin, Peru balsam, and castor oil spray on the oral mucosa: case report and review of the literature.
Noble TA, Carr DS, Gonzalez MF
Pharmacotherapy 1989;9(6):386-8. doi: 10.1002/j.1875-9114.1989.tb04154.x. PMID: 2694114

Prognosis

A predictive model for patients with local-regionally advanced oropharyngeal squamous cell carcinoma treated after cervical lymph node dissection.
Xie X, Kang M, Qu Z, Gu K
J Cancer Res Clin Oncol 2023 Dec;149(19):17241-17251. Epub 2023 Oct 7 doi: 10.1007/s00432-023-05379-6. PMID: 37804427
Prognostic value of FOXP3+ regulatory T cells for patients with locally advanced oropharyngeal squamous cell carcinoma.
Hur JY, Ku BM, Park S, Jung HA, Lee SH, Ahn MJ
PLoS One 2022;17(10):e0274830. Epub 2022 Oct 6 doi: 10.1371/journal.pone.0274830. PMID: 36201479Free PMC Article
Prognostic impact of additional HPV diagnostics in 102 patients with p16-stratified advanced oropharyngeal squamous cell carcinoma.
Weiss BG, Anczykowski MZ, Küffer S, Spiegel JL, Bertlich M, Canis M, Ihler F, Kitz J, Jakob M
Eur Arch Otorhinolaryngol 2021 Jun;278(6):1983-2000. Epub 2020 Aug 20 doi: 10.1007/s00405-020-06262-7. PMID: 32814982Free PMC Article
Radiotherapy alone as a possible de-intensified treatment for human papillomavirus-related locally advanced oropharyngeal squamous cell carcinoma.
Yamamoto Y, Takemoto N, Michiba T, Seo Y, Isohashi F, Otani K, Suzuki M, Fujii T, Yoshii T, Mitani K, Yasui T, Cho H, Tomita Y, Morii E, Teshima T, Ogawa K, Inohara H
Int J Clin Oncol 2019 Jun;24(6):640-648. Epub 2019 Jan 29 doi: 10.1007/s10147-019-01394-1. PMID: 30694402
De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma.
Masterson L, Moualed D, Masood A, Dwivedi RC, Benson R, Sterling JC, Rhodes KM, Sudhoff H, Jani P, Goon P
Cochrane Database Syst Rev 2014 Feb 15;2014(2):CD010271. doi: 10.1002/14651858.CD010271.pub2. PMID: 24532092Free PMC Article

Clinical prediction guides

A predictive model for patients with local-regionally advanced oropharyngeal squamous cell carcinoma treated after cervical lymph node dissection.
Xie X, Kang M, Qu Z, Gu K
J Cancer Res Clin Oncol 2023 Dec;149(19):17241-17251. Epub 2023 Oct 7 doi: 10.1007/s00432-023-05379-6. PMID: 37804427
Prognostic value of FOXP3+ regulatory T cells for patients with locally advanced oropharyngeal squamous cell carcinoma.
Hur JY, Ku BM, Park S, Jung HA, Lee SH, Ahn MJ
PLoS One 2022;17(10):e0274830. Epub 2022 Oct 6 doi: 10.1371/journal.pone.0274830. PMID: 36201479Free PMC Article
Prognostic impact of additional HPV diagnostics in 102 patients with p16-stratified advanced oropharyngeal squamous cell carcinoma.
Weiss BG, Anczykowski MZ, Küffer S, Spiegel JL, Bertlich M, Canis M, Ihler F, Kitz J, Jakob M
Eur Arch Otorhinolaryngol 2021 Jun;278(6):1983-2000. Epub 2020 Aug 20 doi: 10.1007/s00405-020-06262-7. PMID: 32814982Free PMC Article
Comparative effectiveness of primary radiotherapy versus surgery in elderly patients with locally advanced oropharyngeal squamous cell carcinoma.
Sher DJ, Yan J, Day A, Sumer BD, Pham NL, Khan S, Zhu H
Oral Oncol 2019 Jan;88:18-26. Epub 2018 Nov 16 doi: 10.1016/j.oraloncology.2018.11.004. PMID: 30616791
Exploration for an Algorithm for Deintensification to Exclude the Retropharyngeal Site From Advanced Oropharyngeal Squamous Cell Carcinoma Treatment.
Spector ME, Chinn SB, Bellile E, Gallagher KK, Kang SY, Moyer JS, Prince ME, Wolf GT, Bradford CR, McHugh JB, Carey TE, Worden FP, Eisbruch A, Ibrahim M, Chepeha DB
JAMA Otolaryngol Head Neck Surg 2016 Apr;142(4):313-8. doi: 10.1001/jamaoto.2015.3602. PMID: 26892642Free PMC Article

Recent systematic reviews

De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma: a systematic review and meta-analysis of current clinical trials.
Masterson L, Moualed D, Liu ZW, Howard JE, Dwivedi RC, Tysome JR, Benson R, Sterling JC, Sudhoff H, Jani P, Goon PK
Eur J Cancer 2014 Oct;50(15):2636-48. Epub 2014 Aug 1 doi: 10.1016/j.ejca.2014.07.001. PMID: 25091798

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