U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Recurrent Dedifferentiated Liposarcoma

MedGen UID:
1662508
•Concept ID:
C4725858
•
Neoplastic Process

Definition

The reemergence of dedifferentiated liposarcoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Dedifferentiated Liposarcoma

Professional guidelines

PubMed

Histology-tailored multidisciplinary management of primary retroperitoneal sarcomas.
Bonvalot S, Roland C, Raut C, Le Péchoux C, Tzanis D, Frezza AM, Gronchi A
Eur J Surg Oncol 2023 Jun;49(6):1061-1067. Epub 2022 May 16 doi: 10.1016/j.ejso.2022.05.010. PMID: 35599138
Liposarcoma: Multimodality Management and Future Targeted Therapies.
Crago AM, Dickson MA
Surg Oncol Clin N Am 2016 Oct;25(4):761-73. Epub 2016 Jul 30 doi: 10.1016/j.soc.2016.05.007. PMID: 27591497Free PMC Article
Management of Truncal Sarcoma.
Mullinax JE, Gonzalez RJ
Surg Clin North Am 2016 Oct;96(5):1003-13. doi: 10.1016/j.suc.2016.06.005. PMID: 27542639

Recent clinical studies

Etiology

The combination of gemcitabine and docetaxel arrests a doxorubicin-resistant dedifferentiated liposarcoma in a patient-derived orthotopic xenograft model.
Miyake K, Higuchi T, Oshiro H, Zhang Z, Sugisawa N, Park JH, Razmjooei S, Katsuya Y, Barangi M, Li Y, Nelson SD, Murakami T, Homma Y, Hiroshima Y, Matsuyama R, Bouvet M, Chawla SP, Singh SR, Endo I, Hoffman RM
Biomed Pharmacother 2019 Sep;117:109093. Epub 2019 Jun 11 doi: 10.1016/j.biopha.2019.109093. PMID: 31200257
Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.
Keung EZ, Lazar AJ, Torres KE, Wang WL, Cormier JN, Ashleigh Guadagnolo B, Bishop AJ, Lin H, Hunt KK, Bird J, Lewis VO, Patel SR, Wargo JA, Somaiah N, Roland CL
BMC Cancer 2018 Sep 24;18(1):913. doi: 10.1186/s12885-018-4829-0. PMID: 30249211Free PMC Article

Diagnosis

Recurrent dedifferentiated liposarcoma of the spermatic cord simulating malignant fibrous histiocytoma: an immunohistochemical and ultrastructural study.
Chan YF, Yuen MY, Ma LT, Li MK
Pathology 1987 Jan;19(1):99-102. doi: 10.3109/00313028709065147. PMID: 3035471

Therapy

The combination of gemcitabine and docetaxel arrests a doxorubicin-resistant dedifferentiated liposarcoma in a patient-derived orthotopic xenograft model.
Miyake K, Higuchi T, Oshiro H, Zhang Z, Sugisawa N, Park JH, Razmjooei S, Katsuya Y, Barangi M, Li Y, Nelson SD, Murakami T, Homma Y, Hiroshima Y, Matsuyama R, Bouvet M, Chawla SP, Singh SR, Endo I, Hoffman RM
Biomed Pharmacother 2019 Sep;117:109093. Epub 2019 Jun 11 doi: 10.1016/j.biopha.2019.109093. PMID: 31200257
Phase II study of neoadjuvant checkpoint blockade in patients with surgically resectable undifferentiated pleomorphic sarcoma and dedifferentiated liposarcoma.
Keung EZ, Lazar AJ, Torres KE, Wang WL, Cormier JN, Ashleigh Guadagnolo B, Bishop AJ, Lin H, Hunt KK, Bird J, Lewis VO, Patel SR, Wargo JA, Somaiah N, Roland CL
BMC Cancer 2018 Sep 24;18(1):913. doi: 10.1186/s12885-018-4829-0. PMID: 30249211Free PMC Article

Prognosis

Recurrent Dedifferentiated Liposarcoma Arising from the Small Bowel Mesentery: A Case Report.
Panagiotopoulos N, Kyriakides C, Weerakkody RA, Ahma R, Buchanan G, Lowdell C, Jiao LR
J Gastrointest Cancer 2012 Sep;43 Suppl 1:S175-7. doi: 10.1007/s12029-011-9357-y. PMID: 22207349
Recurrent dedifferentiated liposarcoma of mediastinum involving lung and pleura.
Coulibaly B, Bouvier C, Payan MJ, Thomas P
Interact Cardiovasc Thorac Surg 2009 Oct;9(4):741-2. Epub 2009 Jul 9 doi: 10.1510/icvts.2009.209494. PMID: 19589790

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...