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Metastatic Gastric Neuroendocrine Carcinoma

MedGen UID:
1666857
•Concept ID:
C4744983
•
Neoplastic Process

Definition

A gastric neuroendocrine carcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Pathologic differential diagnosis of metastatic carcinoma in the liver.
Park JH, Kim JH
Clin Mol Hepatol 2019 Mar;25(1):12-20. Epub 2018 Oct 5 doi: 10.3350/cmh.2018.0067. PMID: 30300991Free PMC Article
Gastroenteropancreatic Well-Differentiated Grade 3 Neuroendocrine Tumors: Review and Position Statement.
Coriat R, Walter T, Terris B, Couvelard A, Ruszniewski P
Oncologist 2016 Oct;21(10):1191-1199. Epub 2016 Jul 8 doi: 10.1634/theoncologist.2015-0476. PMID: 27401895Free PMC Article
Neuroendocrine tumors of the gallbladder: an evaluation and reassessment of management strategy.
Eltawil KM, Gustafsson BI, Kidd M, Modlin IM
J Clin Gastroenterol 2010 Nov-Dec;44(10):687-95. doi: 10.1097/MCG.0b013e3181d7a6d4. PMID: 20375728

Recent clinical studies

Etiology

Gastric medullary carcinoma: clinicopathological features and prognosis-a single-center study.
Uprak TK, Akmercan A, Coşkun M, Attaallah W
ANZ J Surg 2021 Nov;91(11):2425-2429. Epub 2021 Aug 17 doi: 10.1111/ans.17129. PMID: 34405504
Clinicopathological Features of Gastroenteropancreatic Neuroendocrine Neoplasms.
Sekerci A, Turk HM, Demir T, Seker M, Akcakaya A, Arici DS
J Coll Physicians Surg Pak 2020 Aug;30(8):863-867. doi: 10.29271/jcpsp.2020.08.863. PMID: 32893801
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Clinicopathological, treatment, and prognosis study of 43 gastric neuroendocrine carcinomas.
Liu DJ, Fu XL, Liu W, Zheng LY, Zhang JF, Huo YM, Li J, Hua R, Liu Q, Sun YW
World J Gastroenterol 2017 Jan 21;23(3):516-524. doi: 10.3748/wjg.v23.i3.516. PMID: 28210088Free PMC Article
Are There Indications for Total Pancreatectomy in 2016?
Andrén-Sandberg Å, Ansorge C, Yadav TD
Dig Surg 2016;33(4):329-34. Epub 2016 May 25 doi: 10.1159/000445018. PMID: 27215746

Diagnosis

Clinicopathological Features of Gastroenteropancreatic Neuroendocrine Neoplasms.
Sekerci A, Turk HM, Demir T, Seker M, Akcakaya A, Arici DS
J Coll Physicians Surg Pak 2020 Aug;30(8):863-867. doi: 10.29271/jcpsp.2020.08.863. PMID: 32893801
Pathologic Considerations in Gastroenteropancreatic Neuroendocrine Tumors.
Bellizzi AM
Surg Oncol Clin N Am 2020 Apr;29(2):185-208. doi: 10.1016/j.soc.2019.11.003. PMID: 32151355Free PMC Article
Pathologic differential diagnosis of metastatic carcinoma in the liver.
Park JH, Kim JH
Clin Mol Hepatol 2019 Mar;25(1):12-20. Epub 2018 Oct 5 doi: 10.3350/cmh.2018.0067. PMID: 30300991Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Therapy

PRRT in high-grade gastroenteropancreatic neuroendocrine neoplasms (WHO G3).
Sorbye H, Kong G, Grozinsky-Glasberg S
Endocr Relat Cancer 2020 Mar;27(3):R67-R77. doi: 10.1530/ERC-19-0400. PMID: 31846429
Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study.
Marabelle A, Le DT, Ascierto PA, Di Giacomo AM, De Jesus-Acosta A, Delord JP, Geva R, Gottfried M, Penel N, Hansen AR, Piha-Paul SA, Doi T, Gao B, Chung HC, Lopez-Martin J, Bang YJ, Frommer RS, Shah M, Ghori R, Joe AK, Pruitt SK, Diaz LA Jr
J Clin Oncol 2020 Jan 1;38(1):1-10. Epub 2019 Nov 4 doi: 10.1200/JCO.19.02105. PMID: 31682550Free PMC Article
Avelumab in gastric cancer.
Roviello G, D'Angelo A, Generali D, Pittacolo M, Ganzinelli M, Iezzi G, Manzini N, Sobhani N
Immunotherapy 2019 Jun;11(9):759-768. Epub 2019 May 6 doi: 10.2217/imt-2019-0011. PMID: 31060469
Are There Indications for Total Pancreatectomy in 2016?
Andrén-Sandberg Å, Ansorge C, Yadav TD
Dig Surg 2016;33(4):329-34. Epub 2016 May 25 doi: 10.1159/000445018. PMID: 27215746
Medical treatment of gastrinomas.
Auernhammer CJ, Göke B
Wien Klin Wochenschr 2007;119(19-20):609-15. doi: 10.1007/s00508-007-0877-1. PMID: 17985097

Prognosis

Gastric medullary carcinoma: clinicopathological features and prognosis-a single-center study.
Uprak TK, Akmercan A, Coşkun M, Attaallah W
ANZ J Surg 2021 Nov;91(11):2425-2429. Epub 2021 Aug 17 doi: 10.1111/ans.17129. PMID: 34405504
PRRT in high-grade gastroenteropancreatic neuroendocrine neoplasms (WHO G3).
Sorbye H, Kong G, Grozinsky-Glasberg S
Endocr Relat Cancer 2020 Mar;27(3):R67-R77. doi: 10.1530/ERC-19-0400. PMID: 31846429
Avelumab in gastric cancer.
Roviello G, D'Angelo A, Generali D, Pittacolo M, Ganzinelli M, Iezzi G, Manzini N, Sobhani N
Immunotherapy 2019 Jun;11(9):759-768. Epub 2019 May 6 doi: 10.2217/imt-2019-0011. PMID: 31060469
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Clinical prediction guides

Prognostic Values of MLNn and MLNr for Gastric Cancer Patients Receiving Chemoradiotherapy and Lesser Curvature Resection.
Wang L
Clin Lab 2022 Sep 1;68(9) doi: 10.7754/Clin.Lab.2021.211103. PMID: 36125156
Gastric medullary carcinoma: clinicopathological features and prognosis-a single-center study.
Uprak TK, Akmercan A, Coşkun M, Attaallah W
ANZ J Surg 2021 Nov;91(11):2425-2429. Epub 2021 Aug 17 doi: 10.1111/ans.17129. PMID: 34405504
Neuroendocrine carcinoma of the gastric stump: A case report and literature review.
Ma FH, Xue LY, Chen YT, Xie YB, Zhong YX, Xu Q, Tian YT
World J Gastroenterol 2018 Jan 28;24(4):543-548. doi: 10.3748/wjg.v24.i4.543. PMID: 29398875Free PMC Article
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Neuroendocrine carcinoma of the stomach: morphologic and immunohistochemical characteristics and prognosis.
Ishida M, Sekine S, Fukagawa T, Ohashi M, Morita S, Taniguchi H, Katai H, Tsuda H, Kushima R
Am J Surg Pathol 2013 Jul;37(7):949-59. doi: 10.1097/PAS.0b013e31828ff59d. PMID: 23759931

Recent systematic reviews

Neuroendocrine neoplasms of gastrointestinal tract and secondary primary synchronous tumors: A systematic review of case reports. Casualty or causality?
Parra-Medina R, Moreno-Lucero P, Jimenez-Moreno J, Parra-Morales AM, Romero-Rojas A
PLoS One 2019;14(5):e0216647. Epub 2019 May 14 doi: 10.1371/journal.pone.0216647. PMID: 31086397Free PMC Article
External Beam Radiotherapy in the Treatment of Gastroenteropancreatic Neuroendocrine Tumours: A Systematic Review.
Chan DL, Thompson R, Lam M, Pavlakis N, Hallet J, Law C, Singh S, Myrehaug S
Clin Oncol (R Coll Radiol) 2018 Jul;30(7):400-408. Epub 2018 Mar 31 doi: 10.1016/j.clon.2018.03.006. PMID: 29615284
Duodenal intussusception due to a giant neuroendocrine carcinoma in a patient with Peutz-Jeghers syndrome: case report and systematic review.
Chen XD, Yu YY, Yang L, Rui YY, Zhou ZG
Eur J Gastroenterol Hepatol 2012 Jun;24(6):722-6. doi: 10.1097/MEG.0b013e328351c1df. PMID: 22356785

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