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Resectable Pancreatic Acinar Cell Carcinoma

MedGen UID:
1668056
•Concept ID:
C4745159
•
Neoplastic Process

Definition

Pancreatic acinar cell carcinoma that is amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResectable Pancreatic Acinar Cell Carcinoma

Professional guidelines

PubMed

A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Acinar cell carcinoma of the pancreas: new genetic and treatment insights into a rare malignancy.
Lowery MA, Klimstra DS, Shia J, Yu KH, Allen PJ, Brennan MF, O'Reilly EM
Oncologist 2011;16(12):1714-20. Epub 2011 Oct 31 doi: 10.1634/theoncologist.2011-0231. PMID: 22042785Free PMC Article

Recent clinical studies

Etiology

DNA Methylation Profiling Enables Accurate Classification of Nonductal Primary Pancreatic Neoplasms.
Verschuur AVD, Hackeng WM, Westerbeke F, Benhamida JK, Basturk O, Selenica P, Raicu GM, Molenaar IQ, van Santvoort HC, Daamen LA, Klimstra DS, Yachida S, Luchini C, Singhi AD, Geisenberger C, Brosens LAA
Clin Gastroenterol Hepatol 2024 Jun;22(6):1245-1254.e10. Epub 2024 Feb 20 doi: 10.1016/j.cgh.2024.02.007. PMID: 38382726
Single-cell RNA sequencing highlights epithelial and microenvironmental heterogeneity in malignant progression of pancreatic ductal adenocarcinoma.
Li J, Wei T, Ma K, Zhang J, Lu J, Zhao J, Huang J, Zeng T, Xie Y, Liang Y, Li X, Zhang Q, Liang T
Cancer Lett 2024 Mar 1;584:216607. Epub 2024 Jan 20 doi: 10.1016/j.canlet.2024.216607. PMID: 38246225
A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Clinical outcomes of patients with resectable pancreatic acinar cell carcinoma.
Seo S, Yoo C, Kim KP, Ryoo BY, Chang HM, Hong SM, Lee JH, Song KB, Hwang DW, Kim KH, Hwang S, Kim SC
J Dig Dis 2017 Aug;18(8):480-486. doi: 10.1111/1751-2980.12505. PMID: 28671770
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article

Diagnosis

Intraductal and cystic pancreatic neoplasia.
Hermanová M
Cesk Patol 2024;60(2):81-89. PMID: 39138010
Adult pancreatoblastoma: Current concepts in pathology.
Omiyale AO
World J Gastroenterol 2021 Jul 14;27(26):4172-4181. doi: 10.3748/wjg.v27.i26.4172. PMID: 34326617Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids.
Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, Nostro C, Wang R, Muthuswamy LB, Crawford HC, Arrowsmith C, Kalloger SE, Renouf DJ, Connor AA, Cleary S, Schaeffer DF, Roehrl M, Tsao MS, Gallinger S, Keller G, Muthuswamy SK
Nat Med 2015 Nov;21(11):1364-71. Epub 2015 Oct 26 doi: 10.1038/nm.3973. PMID: 26501191Free PMC Article
Pancreatoblastoma.
Saif MW
JOP 2007 Jan 9;8(1):55-63. PMID: 17228135

Therapy

DNA Methylation Profiling Enables Accurate Classification of Nonductal Primary Pancreatic Neoplasms.
Verschuur AVD, Hackeng WM, Westerbeke F, Benhamida JK, Basturk O, Selenica P, Raicu GM, Molenaar IQ, van Santvoort HC, Daamen LA, Klimstra DS, Yachida S, Luchini C, Singhi AD, Geisenberger C, Brosens LAA
Clin Gastroenterol Hepatol 2024 Jun;22(6):1245-1254.e10. Epub 2024 Feb 20 doi: 10.1016/j.cgh.2024.02.007. PMID: 38382726
A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis.
Neuhöfer P, Roake CM, Kim SJ, Lu RJ, West RB, Charville GW, Artandi SE
Nature 2021 Sep;597(7878):715-719. Epub 2021 Sep 15 doi: 10.1038/s41586-021-03916-2. PMID: 34526722Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article

Prognosis

Intraductal and cystic pancreatic neoplasia.
Hermanová M
Cesk Patol 2024;60(2):81-89. PMID: 39138010
Single-cell RNA sequencing highlights epithelial and microenvironmental heterogeneity in malignant progression of pancreatic ductal adenocarcinoma.
Li J, Wei T, Ma K, Zhang J, Lu J, Zhao J, Huang J, Zeng T, Xie Y, Liang Y, Li X, Zhang Q, Liang T
Cancer Lett 2024 Mar 1;584:216607. Epub 2024 Jan 20 doi: 10.1016/j.canlet.2024.216607. PMID: 38246225
A Simple Overview of Pancreatic Cancer Treatment for Clinical Oncologists.
Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Pancreatoblastoma.
Saif MW
JOP 2007 Jan 9;8(1):55-63. PMID: 17228135

Clinical prediction guides

DNA Methylation Profiling Enables Accurate Classification of Nonductal Primary Pancreatic Neoplasms.
Verschuur AVD, Hackeng WM, Westerbeke F, Benhamida JK, Basturk O, Selenica P, Raicu GM, Molenaar IQ, van Santvoort HC, Daamen LA, Klimstra DS, Yachida S, Luchini C, Singhi AD, Geisenberger C, Brosens LAA
Clin Gastroenterol Hepatol 2024 Jun;22(6):1245-1254.e10. Epub 2024 Feb 20 doi: 10.1016/j.cgh.2024.02.007. PMID: 38382726
Single-cell RNA sequencing highlights epithelial and microenvironmental heterogeneity in malignant progression of pancreatic ductal adenocarcinoma.
Li J, Wei T, Ma K, Zhang J, Lu J, Zhao J, Huang J, Zeng T, Xie Y, Liang Y, Li X, Zhang Q, Liang T
Cancer Lett 2024 Mar 1;584:216607. Epub 2024 Jan 20 doi: 10.1016/j.canlet.2024.216607. PMID: 38246225
Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice.
Perusina Lanfranca M, Zhang Y, Girgis A, Kasselman S, Lazarus J, Kryczek I, Delrosario L, Rhim A, Koneva L, Sartor M, Sun L, Halbrook C, Nathan H, Shi J, Crawford HC, Pasca di Magliano M, Zou W, Frankel TL
Gastroenterology 2020 Apr;158(5):1417-1432.e11. Epub 2019 Dec 14 doi: 10.1053/j.gastro.2019.12.010. PMID: 31843590Free PMC Article
Pancreatic acinar cell carcinoma-case report and literature review.
Xing-Mao Z, Hong-Juan Z, Qing L, Qiang H
BMC Cancer 2018 Nov 8;18(1):1083. doi: 10.1186/s12885-018-5008-z. PMID: 30409114Free PMC Article
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature.
Wang Y, Wang S, Zhou X, Zhou H, Cui Y, Li Q, Zhang L
World J Surg Oncol 2016 Jun 28;14(1):172. doi: 10.1186/s12957-016-0919-0. PMID: 27352960Free PMC Article

Recent systematic reviews

Systematic Review and Case Series Report of Acinar Cell Carcinoma of the Pancreas.
Glazer ES, Neill KG, Frakes JM, Coppola D, Hodul PJ, Hoffe SE, Pimiento JM, Springett GM, Malafa MP
Cancer Control 2016 Oct;23(4):446-454. doi: 10.1177/107327481602300417. PMID: 27842335

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