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Refractory Hepatosplenic T-Cell Lymphoma

MedGen UID:
1669474
•Concept ID:
C4727065
•
Neoplastic Process

Definition

Hepatosplenic T-cell lymphoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Hepatosplenic T-Cell Lymphoma

Professional guidelines

PubMed

Clinical features and treatment outcomes of 14 patients with hepatosplenic γ δ T-cell lymphoma.
Wang Q, Jiang Y, Zhu Q, Duan Y, Chen X, Xu T, Jin Z, Li C, Wu D, Huang H
J Cancer Res Clin Oncol 2021 Nov;147(11):3441-3445. Epub 2021 Apr 15 doi: 10.1007/s00432-021-03587-6. PMID: 33856526
Adjunctive treatment to antitumor necrosis factor in pediatric patients with refractory Crohn's disease.
Absah I, Stephens M
Curr Opin Pediatr 2013 Oct;25(5):624-8. doi: 10.1097/MOP.0b013e328364df22. PMID: 23995433
Coeliac disease and (extra)intestinal T-cell lymphomas: definition, diagnosis and treatment.
Meijer JW, Mulder CJ, Goerres MG, Boot H, Schweizer JJ
Scand J Gastroenterol Suppl 2004;(241):78-84. doi: 10.1080/00855920410014605. PMID: 15696854

Recent clinical studies

Therapy

Clinical features and treatment outcomes of 14 patients with hepatosplenic γ δ T-cell lymphoma.
Wang Q, Jiang Y, Zhu Q, Duan Y, Chen X, Xu T, Jin Z, Li C, Wu D, Huang H
J Cancer Res Clin Oncol 2021 Nov;147(11):3441-3445. Epub 2021 Apr 15 doi: 10.1007/s00432-021-03587-6. PMID: 33856526
Challenges and new prospects in hepatosplenic γδ T-cell lymphoma.
Calvaruso M, Gulino A, Buffa S, Guarnotta C, Franco G, Cacciatore M, Bonura MG, Franco V, Florena AM
Leuk Lymphoma 2014 Nov;55(11):2457-65. Epub 2014 Mar 10 doi: 10.3109/10428194.2014.889821. PMID: 24506469
Peripheral T-cell lymphoma in children and adolescents: a single-institution experience.
Al Mahmoud R, Weitzman S, Schechter T, Ngan B, Abdelhaleem M, Alexander S
J Pediatr Hematol Oncol 2012 Nov;34(8):611-6. doi: 10.1097/MPH.0b013e3182707592. PMID: 23042011
Hepatosplenic T-cell lymphoma in a young man with Crohn's disease: case report and literature review.
Ochenrider MG, Patterson DJ, Aboulafia DM
Clin Lymphoma Myeloma Leuk 2010 Apr;10(2):144-8. doi: 10.3816/CLML.2010.n.021. PMID: 20371449
Infliximab therapy for pediatric Crohn's disease.
Veres G, Baldassano RN, Mamula P
Expert Opin Biol Ther 2007 Dec;7(12):1869-80. doi: 10.1517/14712598.7.12.1869. PMID: 18034652

Prognosis

Refractory hepatosplenic T-cell lymphoma was successfully treated with salvage allogeneic hematopoietic stem cell transplantation combined with enhanced myeloablative preconditioning.
Huang W, Xue S, Zhang Y, Liu F, Tian M, Wang Y, Li F, Lu Y, Wang J
Ann Hematol 2023 Jan;102(1):175-180. Epub 2022 Nov 10 doi: 10.1007/s00277-022-05017-0. PMID: 36355191
Hepatosplenic T-cell lymphoma: a rare but challenging entity.
Pro B, Allen P, Behdad A
Blood 2020 Oct 29;136(18):2018-2026. doi: 10.1182/blood.2019004118. PMID: 32756940Free PMC Article
Challenges and new prospects in hepatosplenic γδ T-cell lymphoma.
Calvaruso M, Gulino A, Buffa S, Guarnotta C, Franco G, Cacciatore M, Bonura MG, Franco V, Florena AM
Leuk Lymphoma 2014 Nov;55(11):2457-65. Epub 2014 Mar 10 doi: 10.3109/10428194.2014.889821. PMID: 24506469
Allogeneic transplantation in T-cell lymphomas.
Schmitz N, Wu HS, Glass B
Semin Hematol 2014 Jan;51(1):67-72. Epub 2013 Nov 28 doi: 10.1053/j.seminhematol.2013.11.010. PMID: 24468318
Peripheral T-cell lymphoma in children and adolescents: a single-institution experience.
Al Mahmoud R, Weitzman S, Schechter T, Ngan B, Abdelhaleem M, Alexander S
J Pediatr Hematol Oncol 2012 Nov;34(8):611-6. doi: 10.1097/MPH.0b013e3182707592. PMID: 23042011

Clinical prediction guides

Coexistent hairy cell leukaemia and hepatosplenic T-cell lymphoma: a case report.
Gasljevic G, Kloboves-Prevodnik V, Gazic B, Vovk M
Diagn Pathol 2014 Mar 12;9:58. doi: 10.1186/1746-1596-9-58. PMID: 24621139Free PMC Article
Infliximab therapy in children and adolescents with inflammatory bowel disease.
Veres G, Baldassano RN, Mamula P
Drugs 2007;67(12):1703-23. doi: 10.2165/00003495-200767120-00005. PMID: 17683171
High-dose chemotherapy and autologous stem cell transplantation for peripheral T-cell lymphoma: complete response at transplant predicts survival.
Kim MK, Kim S, Lee SS, Sym SJ, Lee DH, Jang S, Park CJ, Chi HS, Huh J, Suh C
Ann Hematol 2007 Jun;86(6):435-42. Epub 2007 Jan 26 doi: 10.1007/s00277-007-0254-1. PMID: 17256144
Hepatosplenic gamma-delta T-cell malignant lymphoma: report of the first case in childhood, including molecular minimal residual disease follow-up.
Garcia-Sanchez F, Menárguez J, Cristobal E, Cantalejo A, Gil J, Algara P, Vicario JL
Br J Haematol 1995 Aug;90(4):943-6. doi: 10.1111/j.1365-2141.1995.tb05221.x. PMID: 7669677

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