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Aggressive Non-Hodgkin Lymphoma

MedGen UID:
272299
•Concept ID:
C1332225
•
Neoplastic Process
Synonym: Aggressive Non-Hodgkin's Lymphoma

Definition

A non-Hodgkin lymphoma with an aggressive clinical course. Representative examples include Burkitt lymphoma, mantle cell lymphoma, and angioimmunoblastic T-cell lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAggressive Non-Hodgkin Lymphoma

Professional guidelines

PubMed

Diagnosis, treatment, and outcome of primary CNS lymphoma-a single-center experience.
Wismann J, Sommer-Sørensen RH, Kofoed MS, Halle B, Pedersen CB, Schulz MK, Grønhøj MH, Larsen TS, Møller MB, Poulsen FR
Acta Neurochir (Wien) 2022 May;164(5):1365-1373. Epub 2022 Mar 7 doi: 10.1007/s00701-022-05170-5. PMID: 35257217
Diffuse large B-cell lymphoma: 2019 update on diagnosis, risk stratification, and treatment.
Liu Y, Barta SK
Am J Hematol 2019 May;94(5):604-616. doi: 10.1002/ajh.25460. PMID: 30859597
FDG-PET/CT based response-adapted treatment.
de Geus-Oei LF, Vriens D, Arens AI, Hutchings M, Oyen WJ
Cancer Imaging 2012 Sep 28;12(2):324-35. doi: 10.1102/1470-7330.2012.9006. PMID: 23023063Free PMC Article

Recent clinical studies

Therapy

An open-label, single-arm phase 2 trial of valemetostat for relapsed or refractory adult T-cell leukemia/lymphoma.
Izutsu K, Makita S, Nosaka K, Yoshimitsu M, Utsunomiya A, Kusumoto S, Morishima S, Tsukasaki K, Kawamata T, Ono T, Rai S, Katsuya H, Ishikawa J, Yamada H, Kato K, Tachibana M, Kakurai Y, Adachi N, Tobinai K, Yonekura K, Ishitsuka K
Blood 2023 Mar 9;141(10):1159-1168. doi: 10.1182/blood.2022016862. PMID: 36150143Free PMC Article
Nivolumab Combined With Brentuximab Vedotin for Relapsed/Refractory Primary Mediastinal Large B-Cell Lymphoma: Efficacy and Safety From the Phase II CheckMate 436 Study.
Zinzani PL, Santoro A, Gritti G, Brice P, Barr PM, Kuruvilla J, Cunningham D, Kline J, Johnson NA, Mehta-Shah N, Manley T, Francis S, Sharma M, Moskowitz AJ
J Clin Oncol 2019 Nov 20;37(33):3081-3089. Epub 2019 Aug 9 doi: 10.1200/JCO.19.01492. PMID: 31398081Free PMC Article
The response to lymphodepletion impacts PFS in patients with aggressive non-Hodgkin lymphoma treated with CD19 CAR T cells.
Hirayama AV, Gauthier J, Hay KA, Voutsinas JM, Wu Q, Gooley T, Li D, Cherian S, Chen X, Pender BS, Hawkins RM, Vakil A, Steinmetz RN, Acharya UH, Cassaday RD, Chapuis AG, Dhawale TM, Hendrie PC, Kiem HP, Lynch RC, Ramos J, Shadman M, Till BG, Riddell SR, Maloney DG, Turtle CJ
Blood 2019 Apr 25;133(17):1876-1887. Epub 2019 Feb 19 doi: 10.1182/blood-2018-11-887067. PMID: 30782611Free PMC Article
Pretransplant FDG-PET in aggressive non-Hodgkin lymphoma: systematic review and meta-analysis.
Adams HJ, Kwee TC
Eur J Haematol 2017 Apr;98(4):337-347. Epub 2017 Jan 23 doi: 10.1111/ejh.12837. PMID: 27943422
Transformed follicular non-Hodgkin lymphoma.
Casulo C, Burack WR, Friedberg JW
Blood 2015 Jan 1;125(1):40-7. Epub 2014 Dec 11 doi: 10.1182/blood-2014-04-516815. PMID: 25499449

Prognosis

An open-label, single-arm phase 2 trial of valemetostat for relapsed or refractory adult T-cell leukemia/lymphoma.
Izutsu K, Makita S, Nosaka K, Yoshimitsu M, Utsunomiya A, Kusumoto S, Morishima S, Tsukasaki K, Kawamata T, Ono T, Rai S, Katsuya H, Ishikawa J, Yamada H, Kato K, Tachibana M, Kakurai Y, Adachi N, Tobinai K, Yonekura K, Ishitsuka K
Blood 2023 Mar 9;141(10):1159-1168. doi: 10.1182/blood.2022016862. PMID: 36150143Free PMC Article
Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
HIV-associated Burkitt lymphoma.
Atallah-Yunes SA, Murphy DJ, Noy A
Lancet Haematol 2020 Aug;7(8):e594-e600. doi: 10.1016/S2352-3026(20)30126-5. PMID: 32735838
Diffuse large B-cell lymphoma: 2019 update on diagnosis, risk stratification, and treatment.
Liu Y, Barta SK
Am J Hematol 2019 May;94(5):604-616. doi: 10.1002/ajh.25460. PMID: 30859597
The response to lymphodepletion impacts PFS in patients with aggressive non-Hodgkin lymphoma treated with CD19 CAR T cells.
Hirayama AV, Gauthier J, Hay KA, Voutsinas JM, Wu Q, Gooley T, Li D, Cherian S, Chen X, Pender BS, Hawkins RM, Vakil A, Steinmetz RN, Acharya UH, Cassaday RD, Chapuis AG, Dhawale TM, Hendrie PC, Kiem HP, Lynch RC, Ramos J, Shadman M, Till BG, Riddell SR, Maloney DG, Turtle CJ
Blood 2019 Apr 25;133(17):1876-1887. Epub 2019 Feb 19 doi: 10.1182/blood-2018-11-887067. PMID: 30782611Free PMC Article

Clinical prediction guides

Metabolic PET/CT analysis of aggressive Non-Hodgkin lymphoma prior to Axicabtagene Ciloleucel CAR-T infusion: predictors of progressive disease, survival, and toxicity.
Breen WG, Young JR, Hathcock MA, Kowalchuk RO, Thorpe MP, Bansal R, Khurana A, Bennani NN, Paludo J, Bisneto JV, Wang Y, Ansell SM, Peterson JL, Johnston PB, Lester SC, Lin Y
Blood Cancer J 2023 Aug 18;13(1):127. doi: 10.1038/s41408-023-00895-7. PMID: 37591834Free PMC Article
Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Modified EPOCH for high-risk non-Hodgkin lymphoma in sub-Saharan Africa.
Zuze T, Ellis GK, Kasonkanji E, Kaimila B, Nyasosela R, Nyirenda R, Tomoka T, Mulenga M, Chikasema M, Tewete B, Mtangwanika A, Chiyoyola S, Chimzimu F, Kampani C, Mhango W, Nicholas S, Randall C, Montgomery ND, Fedoriw G, Westmoreland KD, Painschab MS, Gopal S
Cancer Med 2020 Jan;9(1):77-83. Epub 2019 Nov 9 doi: 10.1002/cam4.2631. PMID: 31705618Free PMC Article
Pretransplant FDG-PET in aggressive non-Hodgkin lymphoma: systematic review and meta-analysis.
Adams HJ, Kwee TC
Eur J Haematol 2017 Apr;98(4):337-347. Epub 2017 Jan 23 doi: 10.1111/ejh.12837. PMID: 27943422
An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era.
Zhou Z, Sehn LH, Rademaker AW, Gordon LI, Lacasce AS, Crosby-Thompson A, Vanderplas A, Zelenetz AD, Abel GA, Rodriguez MA, Nademanee A, Kaminski MS, Czuczman MS, Millenson M, Niland J, Gascoyne RD, Connors JM, Friedberg JW, Winter JN
Blood 2014 Feb 6;123(6):837-42. Epub 2013 Nov 21 doi: 10.1182/blood-2013-09-524108. PMID: 24264230Free PMC Article

Recent systematic reviews

Long non-coding RNA as a novel biomarker and therapeutic target in aggressive B-cell non-Hodgkin lymphoma: A systematic review.
Khanmohammadi S, Fallahtafti P
J Cell Mol Med 2023 Jul;27(14):1928-1946. Epub 2023 May 29 doi: 10.1111/jcmm.17795. PMID: 37246627Free PMC Article
Safety and efficacy of dual PI3K-δ, γ inhibitor, duvelisib in patients with relapsed or refractory lymphoid neoplasms: A systematic review and meta-analysis of prospective clinical trials.
Wang Z, Zhou H, Xu J, Wang J, Niu T
Front Immunol 2022;13:1070660. Epub 2023 Jan 4 doi: 10.3389/fimmu.2022.1070660. PMID: 36685572Free PMC Article
Systematic literature review of health-related quality of life among aggressive non-Hodgkin lymphoma survivors.
Lin VW, Blaylock B, Epstein J, Purdum A
Curr Med Res Opin 2018 Aug;34(8):1529-1535. Epub 2018 May 18 doi: 10.1080/03007995.2018.1474091. PMID: 29741105
Pretransplant FDG-PET in aggressive non-Hodgkin lymphoma: systematic review and meta-analysis.
Adams HJ, Kwee TC
Eur J Haematol 2017 Apr;98(4):337-347. Epub 2017 Jan 23 doi: 10.1111/ejh.12837. PMID: 27943422
Changes in the influence of lymphoma- and HIV-specific factors on outcomes in AIDS-related non-Hodgkin lymphoma.
Barta SK, Samuel MS, Xue X, Wang D, Lee JY, Mounier N, Ribera JM, Spina M, Tirelli U, Weiss R, Galicier L, Boue F, Little RF, Dunleavy K, Wilson WH, Wyen C, Remick SC, Kaplan LD, Ratner L, Noy A, Sparano JA
Ann Oncol 2015 May;26(5):958-966. Epub 2015 Jan 28 doi: 10.1093/annonc/mdv036. PMID: 25632071Free PMC Article

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