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Recurrent Renal Pelvis Urothelial Carcinoma

MedGen UID:
1670555
•Concept ID:
C4725797
•
Neoplastic Process

Definition

The reemergence of renal pelvis urothelial carcinoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Renal Pelvis Urothelial Carcinoma

Professional guidelines

PubMed

European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530
Conservative nephron-sparing treatment of upper-tract tumors.
Smith P, Mandel J, Raman JD
Curr Urol Rep 2013 Apr;14(2):102-8. doi: 10.1007/s11934-013-0305-1. PMID: 23344683
Diagnosis and management of urothelial carcinoma of the bladder.
Tanaka MF, Sonpavde G
Postgrad Med 2011 May;123(3):43-55. doi: 10.3810/pgm.2011.05.2283. PMID: 21566415

Recent clinical studies

Etiology

European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2023 Update.
Rouprêt M, Seisen T, Birtle AJ, Capoun O, Compérat EM, Dominguez-Escrig JL, Gürses Andersson I, Liedberg F, Mariappan P, Hugh Mostafid A, Pradere B, van Rhijn BWG, Shariat SF, Rai BP, Soria F, Soukup V, Wood RG, Xylinas EN, Masson-Lecomte A, Gontero P
Eur Urol 2023 Jul;84(1):49-64. Epub 2023 Mar 24 doi: 10.1016/j.eururo.2023.03.013. PMID: 36967359
French AFU Cancer Committee Guidelines - Update 2022-2024: Upper urinary tract urothelial cancer (UTUC).
Neuzillet Y, Seisen T, Traxer O, Allory Y, Audenet F, Leon P, Loriot Y, Pradère B, Roumiguié M, Xylinas E, Masson-Lecomte A, Roupret M
Prog Urol 2022 Nov;32(15):1164-1194. doi: 10.1016/j.purol.2022.08.003. PMID: 36400481
European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530
Transurethral electric coagulation combined with retroperitoneal laparoscopic nephroureterectomy for upper urinary urothelial carcinoma.
Wang J, Yu S, Men C, Lin C, Zhang Z, Gao Z, Zhang Y, Wang K
Int Surg 2015 Mar;100(3):547-51. doi: 10.9738/INTSURG-D-13-00282.1. PMID: 25785342Free PMC Article
Management of ureteral and renal pelvic recurrence after cystectomy.
Braslis KG, Soloway MS
Urol Clin North Am 1994 Nov;21(4):653-9. PMID: 7974897

Diagnosis

European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2023 Update.
Rouprêt M, Seisen T, Birtle AJ, Capoun O, Compérat EM, Dominguez-Escrig JL, Gürses Andersson I, Liedberg F, Mariappan P, Hugh Mostafid A, Pradere B, van Rhijn BWG, Shariat SF, Rai BP, Soria F, Soukup V, Wood RG, Xylinas EN, Masson-Lecomte A, Gontero P
Eur Urol 2023 Jul;84(1):49-64. Epub 2023 Mar 24 doi: 10.1016/j.eururo.2023.03.013. PMID: 36967359
European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530
Non-invasive detection of urothelial cancer through the analysis of driver gene mutations and aneuploidy.
Springer SU, Chen CH, Rodriguez Pena MDC, Li L, Douville C, Wang Y, Cohen JD, Taheri D, Silliman N, Schaefer J, Ptak J, Dobbyn L, Papoli M, Kinde I, Afsari B, Tregnago AC, Bezerra SM, VandenBussche C, Fujita K, Ertoy D, Cunha IW, Yu L, Bivalacqua TJ, Grollman AP, Diaz LA, Karchin R, Danilova L, Huang CY, Shun CT, Turesky RJ, Yun BH, Rosenquist TA, Pu YS, Hruban RH, Tomasetti C, Papadopoulos N, Kinzler KW, Vogelstein B, Dickman KG, Netto GJ
Elife 2018 Mar 20;7 doi: 10.7554/eLife.32143. PMID: 29557778Free PMC Article
Management of patients with upper urinary tract transitional cell carcinoma.
Raman JD, Scherr DS
Nat Clin Pract Urol 2007 Aug;4(8):432-43. doi: 10.1038/ncpuro0875. PMID: 17673914
Ureteroscopic resection of upper-tract transitional-cell carcinoma.
Ho KL, Chow GK
J Endourol 2005 Sep;19(7):841-8. doi: 10.1089/end.2005.19.841. PMID: 16190841

Therapy

Primary chemoablation of low-grade upper tract urothelial carcinoma using UGN-101, a mitomycin-containing reverse thermal gel (OLYMPUS): an open-label, single-arm, phase 3 trial.
Kleinmann N, Matin SF, Pierorazio PM, Gore JL, Shabsigh A, Hu B, Chamie K, Godoy G, Hubosky S, Rivera M, O'Donnell M, Quek M, Raman JD, Knoedler JJ, Scherr D, Stern J, Weight C, Weizer A, Woods M, Kaimakliotis H, Smith AB, Linehan J, Coleman J, Humphreys MR, Pak R, Lifshitz D, Verni M, Adibi M, Amin MB, Seltzer E, Klein I, Konorty M, Strauss-Ayali D, Hakim G, Schoenberg M, Lerner SP
Lancet Oncol 2020 Jun;21(6):776-785. Epub 2020 Apr 29 doi: 10.1016/S1470-2045(20)30147-9. PMID: 32631491
Conservative nephron-sparing treatment of upper-tract tumors.
Smith P, Mandel J, Raman JD
Curr Urol Rep 2013 Apr;14(2):102-8. doi: 10.1007/s11934-013-0305-1. PMID: 23344683
Oncologic outcomes obtained after laparoscopic, robotic and/or single port nephroureterectomy for upper urinary tract tumours.
Ribal MJ, Huguet J, Alcaraz A
World J Urol 2013 Feb;31(1):93-107. Epub 2012 Oct 25 doi: 10.1007/s00345-012-0968-0. PMID: 23097034
Ureteroscopic resection of upper-tract transitional-cell carcinoma.
Ho KL, Chow GK
J Endourol 2005 Sep;19(7):841-8. doi: 10.1089/end.2005.19.841. PMID: 16190841
Cyclophosphamide is contraindicated in patients with a history of transitional cell carcinoma.
Volkmer BG, Seidl-Schlick EM, Bach D, Romics I, Kleinschmidt K
Clin Rheumatol 2005 Aug;24(4):319-23. Epub 2004 Dec 1 doi: 10.1007/s10067-004-1032-2. PMID: 16034647

Prognosis

European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2023 Update.
Rouprêt M, Seisen T, Birtle AJ, Capoun O, Compérat EM, Dominguez-Escrig JL, Gürses Andersson I, Liedberg F, Mariappan P, Hugh Mostafid A, Pradere B, van Rhijn BWG, Shariat SF, Rai BP, Soria F, Soukup V, Wood RG, Xylinas EN, Masson-Lecomte A, Gontero P
Eur Urol 2023 Jul;84(1):49-64. Epub 2023 Mar 24 doi: 10.1016/j.eururo.2023.03.013. PMID: 36967359
European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Rouprêt M, Babjuk M, Burger M, Capoun O, Cohen D, Compérat EM, Cowan NC, Dominguez-Escrig JL, Gontero P, Hugh Mostafid A, Palou J, Peyronnet B, Seisen T, Soukup V, Sylvester RJ, Rhijn BWGV, Zigeuner R, Shariat SF
Eur Urol 2021 Jan;79(1):62-79. Epub 2020 Jun 24 doi: 10.1016/j.eururo.2020.05.042. PMID: 32593530
Risk factors for intravesical recurrence after nephroureterectomy in patients with upper urinary tract urothelial carcinoma.
Yamashita R, Watanabe R, Ito I, Shinsaka H, Nakamura M, Matsuzaki M, Niwakawa M
Int Urol Nephrol 2017 Mar;49(3):425-430. Epub 2017 Jan 11 doi: 10.1007/s11255-017-1510-5. PMID: 28078533
Transurethral electric coagulation combined with retroperitoneal laparoscopic nephroureterectomy for upper urinary urothelial carcinoma.
Wang J, Yu S, Men C, Lin C, Zhang Z, Gao Z, Zhang Y, Wang K
Int Surg 2015 Mar;100(3):547-51. doi: 10.9738/INTSURG-D-13-00282.1. PMID: 25785342Free PMC Article
Management of patients with upper urinary tract transitional cell carcinoma.
Raman JD, Scherr DS
Nat Clin Pract Urol 2007 Aug;4(8):432-43. doi: 10.1038/ncpuro0875. PMID: 17673914

Clinical prediction guides

Primary chemoablation of low-grade upper tract urothelial carcinoma using UGN-101, a mitomycin-containing reverse thermal gel (OLYMPUS): an open-label, single-arm, phase 3 trial.
Kleinmann N, Matin SF, Pierorazio PM, Gore JL, Shabsigh A, Hu B, Chamie K, Godoy G, Hubosky S, Rivera M, O'Donnell M, Quek M, Raman JD, Knoedler JJ, Scherr D, Stern J, Weight C, Weizer A, Woods M, Kaimakliotis H, Smith AB, Linehan J, Coleman J, Humphreys MR, Pak R, Lifshitz D, Verni M, Adibi M, Amin MB, Seltzer E, Klein I, Konorty M, Strauss-Ayali D, Hakim G, Schoenberg M, Lerner SP
Lancet Oncol 2020 Jun;21(6):776-785. Epub 2020 Apr 29 doi: 10.1016/S1470-2045(20)30147-9. PMID: 32631491
Risk factors for intravesical recurrence after nephroureterectomy in patients with upper urinary tract urothelial carcinoma.
Yamashita R, Watanabe R, Ito I, Shinsaka H, Nakamura M, Matsuzaki M, Niwakawa M
Int Urol Nephrol 2017 Mar;49(3):425-430. Epub 2017 Jan 11 doi: 10.1007/s11255-017-1510-5. PMID: 28078533
Management of patients with upper urinary tract transitional cell carcinoma.
Raman JD, Scherr DS
Nat Clin Pract Urol 2007 Aug;4(8):432-43. doi: 10.1038/ncpuro0875. PMID: 17673914
Cyclophosphamide is contraindicated in patients with a history of transitional cell carcinoma.
Volkmer BG, Seidl-Schlick EM, Bach D, Romics I, Kleinschmidt K
Clin Rheumatol 2005 Aug;24(4):319-23. Epub 2004 Dec 1 doi: 10.1007/s10067-004-1032-2. PMID: 16034647
Total nephroureterectomy with ureteral intussusception and transurethral ureteral detachment and pull-through.
Clayman RV, Garske GL, Lange PH
Urology 1983 May;21(5):482-6. doi: 10.1016/0090-4295(83)90046-8. PMID: 6857887

Recent systematic reviews

Adjuvant Radiotherapy for Upper Tract Urothelial Carcinoma: Systematic Review and Meta-Analysis.
Zalay O, Yan M, Sigurdson S, Malone S, Vera-Badillo FE, Mahmud A
Curr Oncol 2022 Dec 20;30(1):19-36. doi: 10.3390/curroncol30010002. PMID: 36661651Free PMC Article
Systematic Review on the Fate of the Remnant Urothelium after Radical Cystectomy.
Gakis G, Black PC, Bochner BH, Boorjian SA, Stenzl A, Thalmann GN, Kassouf W
Eur Urol 2017 Apr;71(4):545-557. Epub 2016 Oct 6 doi: 10.1016/j.eururo.2016.09.035. PMID: 27720534Free PMC Article
Prognostic factors and predictive tools for upper tract urothelial carcinoma: a systematic review.
Mbeutcha A, Rouprêt M, Kamat AM, Karakiewicz PI, Lawrentschuk N, Novara G, Raman JD, Seitz C, Xylinas E, Shariat SF
World J Urol 2017 Mar;35(3):337-353. Epub 2016 Apr 21 doi: 10.1007/s00345-016-1826-2. PMID: 27101100
Oncologic Outcomes of Kidney-sparing Surgery Versus Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the EAU Non-muscle Invasive Bladder Cancer Guidelines Panel.
Seisen T, Peyronnet B, Dominguez-Escrig JL, Bruins HM, Yuan CY, Babjuk M, Böhle A, Burger M, Compérat EM, Cowan NC, Kaasinen E, Palou J, van Rhijn BW, Sylvester RJ, Zigeuner R, Shariat SF, Rouprêt M
Eur Urol 2016 Dec;70(6):1052-1068. Epub 2016 Jul 28 doi: 10.1016/j.eururo.2016.07.014. PMID: 27477528
A Systematic Review and Meta-analysis of Clinicopathologic Factors Linked to Intravesical Recurrence After Radical Nephroureterectomy to Treat Upper Tract Urothelial Carcinoma.
Seisen T, Granger B, Colin P, Léon P, Utard G, Renard-Penna R, Compérat E, Mozer P, Cussenot O, Shariat SF, Rouprêt M
Eur Urol 2015 Jun;67(6):1122-1133. Epub 2014 Dec 6 doi: 10.1016/j.eururo.2014.11.035. PMID: 25488681

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