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Focal cortical dysplasia type III

MedGen UID:
1671041
•Concept ID:
C4732825
•
Congenital Abnormality
HPO: HP:0032054

Definition

A type of focal cortical dysplasia that is characterized by cortical lamination abnormalities associated with a principal lesion, usually adjacent to or affecting the same cortical area/lobe. [from HPO]

Professional guidelines

PubMed

Surgical treatment of pediatric focal cortical dysplasia: Clinical spectrum and surgical outcome.
Kwon HE, Eom S, Kang HC, Lee JS, Kim SH, Kim DS, Kim HD
Neurology 2016 Aug 30;87(9):945-51. Epub 2016 Jul 27 doi: 10.1212/WNL.0000000000003042. PMID: 27466475
Neuropathological work-up of focal cortical dysplasias using the new ILAE consensus classification system - practical guideline article invited by the Euro-CNS Research Committee.
Blümcke I, Mühlebner A
Clin Neuropathol 2011 Jul-Aug;30(4):164-77. doi: 10.5414/np300398. PMID: 21726501
Surgical treatment of drug-resistant nocturnal frontal lobe epilepsy.
Nobili L, Francione S, Mai R, Cardinale F, Castana L, Tassi L, Sartori I, Didato G, Citterio A, Colombo N, Galli C, Lo Russo G, Cossu M
Brain 2007 Feb;130(Pt 2):561-73. Epub 2006 Nov 22 doi: 10.1093/brain/awl322. PMID: 17124189

Recent clinical studies

Etiology

Somatic variants in diverse genes leads to a spectrum of focal cortical malformations.
Lai D, Gade M, Yang E, Koh HY, Lu J, Walley NM, Buckley AF, Sands TT, Akman CI, Mikati MA, McKhann GM, Goldman JE, Canoll P, Alexander AL, Park KL, Von Allmen GK, Rodziyevska O, Bhattacharjee MB, Lidov HGW, Vogel H, Grant GA, Porter BE, Poduri AH, Crino PB, Heinzen EL
Brain 2022 Aug 27;145(8):2704-2720. doi: 10.1093/brain/awac117. PMID: 35441233Free PMC Article

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