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Refractory Adrenal Gland Pheochromocytoma

MedGen UID:
1673295
•Concept ID:
C4764217
•
Neoplastic Process

Definition

A pheochromocytoma that does not respond to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Adrenal Gland Pheochromocytoma

Professional guidelines

PubMed

The diagnosis and management of pheochromocytoma and paraganglioma during pregnancy.
Clifton-Bligh RJ
Rev Endocr Metab Disord 2023 Feb;24(1):49-56. Epub 2023 Jan 13 doi: 10.1007/s11154-022-09773-2. PMID: 36637675Free PMC Article
Recent advances in the management of pheochromocytoma and paraganglioma.
Tanabe A, Naruse M
Hypertens Res 2020 Nov;43(11):1141-1151. Epub 2020 Aug 11 doi: 10.1038/s41440-020-0531-0. PMID: 32778780
Pathophysiology and Acute Management of Tachyarrhythmias in Pheochromocytoma: JACC Review Topic of the Week.
Nazari MA, Rosenblum JS, Haigney MC, Rosing DR, Pacak K
J Am Coll Cardiol 2020 Jul 28;76(4):451-464. doi: 10.1016/j.jacc.2020.04.080. PMID: 32703516Free PMC Article

Recent clinical studies

Etiology

Takotsubo syndrome and pheochromocytoma: an insidious combination.
Maffè S, Dellavesa P, Paffoni P, Bergamasco L, Arrondini M, Valentini S, Facchini E, Prenna E, Baduena L, Careri G, Franchetti Pardo N, Parravicini U
Monaldi Arch Chest Dis 2021 Mar 9;91(3) doi: 10.4081/monaldi.2021.1711. PMID: 33691391
A phase I clinical trial for [(131)I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma: a study protocol.
Inaki A, Yoshimura K, Murayama T, Imai Y, Kuribayashi Y, Higuchi T, Jinguji M, Shiga T, Kinuya S
J Med Invest 2017;64(3.4):205-209. doi: 10.2152/jmi.64.205. PMID: 28954983
Life-threatening events in patients with pheochromocytoma.
Riester A, Weismann D, Quinkler M, Lichtenauer UD, Sommerey S, Halbritter R, Penning R, Spitzweg C, Schopohl J, Beuschlein F, Reincke M
Eur J Endocrinol 2015 Dec;173(6):757-64. Epub 2015 Sep 7 doi: 10.1530/EJE-15-0483. PMID: 26346138
Phaeochromocytoma: state-of-the-art.
Donckier JE, Michel L
Acta Chir Belg 2010 Mar-Apr;110(2):140-8. doi: 10.1080/00015458.2010.11680587. PMID: 20514823
Colorectal manifestations of endocrine disease.
Sharma S, Longo WE, Baniadam B, Vernava AM 3rd
Dis Colon Rectum 1995 Mar;38(3):318-23. doi: 10.1007/BF02055611. PMID: 7882801

Diagnosis

The diagnosis and management of pheochromocytoma and paraganglioma during pregnancy.
Clifton-Bligh RJ
Rev Endocr Metab Disord 2023 Feb;24(1):49-56. Epub 2023 Jan 13 doi: 10.1007/s11154-022-09773-2. PMID: 36637675Free PMC Article
Takotsubo syndrome and pheochromocytoma: an insidious combination.
Maffè S, Dellavesa P, Paffoni P, Bergamasco L, Arrondini M, Valentini S, Facchini E, Prenna E, Baduena L, Careri G, Franchetti Pardo N, Parravicini U
Monaldi Arch Chest Dis 2021 Mar 9;91(3) doi: 10.4081/monaldi.2021.1711. PMID: 33691391
Recent advances in the management of pheochromocytoma and paraganglioma.
Tanabe A, Naruse M
Hypertens Res 2020 Nov;43(11):1141-1151. Epub 2020 Aug 11 doi: 10.1038/s41440-020-0531-0. PMID: 32778780
Metastatic pheochromocytoma and paraganglioma.
Angelousi A, Kassi E, Zografos G, Kaltsas G
Eur J Clin Invest 2015 Sep;45(9):986-97. doi: 10.1111/eci.12495. PMID: 26183460
Phaeochromocytoma: state-of-the-art.
Donckier JE, Michel L
Acta Chir Belg 2010 Mar-Apr;110(2):140-8. doi: 10.1080/00015458.2010.11680587. PMID: 20514823

Therapy

Pheochromocytoma crisis with refractory Acute Respiratory Distress Syndrome (ARDS), Takotsubo syndrome, emergency adrenalectomy, and need for Extracorporeal Membrane Oxygenation (ECMO) in a previously undiagnosed and asymptomatic patient, due to the use of metoclopramide.
Xie Y, Zhang A, Qi M, Xiong B, Zhang S, Zhou J, Cao Y
BMC Endocr Disord 2023 Jul 10;23(1):145. doi: 10.1186/s12902-023-01404-4. PMID: 37430225Free PMC Article
An open-label, single-arm, multi-center, phase II clinical trial of single-dose [(131)I]meta-iodobenzylguanidine therapy for patients with refractory pheochromocytoma and paraganglioma.
Inaki A, Shiga T, Tsushima Y, Jinguji M, Wakabayashi H, Kayano D, Akatani N, Yamase T, Kunita Y, Watanabe S, Hiromasa T, Mori H, Hirata K, Watanabe S, Higuchi T, Tomonaga H, Kinuya S
Ann Nucl Med 2022 Mar;36(3):267-278. Epub 2021 Dec 6 doi: 10.1007/s12149-021-01699-0. PMID: 34870794Free PMC Article
A phase I clinical trial for [(131)I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma.
Wakabayashi H, Inaki A, Yoshimura K, Murayama T, Imai Y, Higuchi T, Jinguji M, Shiga T, Kinuya S
Sci Rep 2019 May 20;9(1):7625. doi: 10.1038/s41598-019-43880-6. PMID: 31110198Free PMC Article
A phase I clinical trial for [(131)I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma: a study protocol.
Inaki A, Yoshimura K, Murayama T, Imai Y, Kuribayashi Y, Higuchi T, Jinguji M, Shiga T, Kinuya S
J Med Invest 2017;64(3.4):205-209. doi: 10.2152/jmi.64.205. PMID: 28954983
Imipramine-provoked paradoxical pheochromocytoma crisis: a case of cardiogenic shock.
Ferguson KL
Am J Emerg Med 1994 Mar;12(2):190-2. doi: 10.1016/0735-6757(94)90245-3. PMID: 8161395

Prognosis

An open-label, single-arm, multi-center, phase II clinical trial of single-dose [(131)I]meta-iodobenzylguanidine therapy for patients with refractory pheochromocytoma and paraganglioma.
Inaki A, Shiga T, Tsushima Y, Jinguji M, Wakabayashi H, Kayano D, Akatani N, Yamase T, Kunita Y, Watanabe S, Hiromasa T, Mori H, Hirata K, Watanabe S, Higuchi T, Tomonaga H, Kinuya S
Ann Nucl Med 2022 Mar;36(3):267-278. Epub 2021 Dec 6 doi: 10.1007/s12149-021-01699-0. PMID: 34870794Free PMC Article
Sustained response to brigatinib in a patient with refractory metastatic pheochromocytoma harboring R1192P anaplastic lymphoma kinase mutation: a case report from the Austrian Group Medical Tumor Therapy next-generation sequencing registry and discussion of the literature.
Heregger R, Huemer F, Hutarew G, Hecht S, Cheveresan L, Kotzot D, Schamschula E, Rinnerthaler G, Melchardt T, Weiss L, Greil R
ESMO Open 2021 Aug;6(4):100233. Epub 2021 Aug 7 doi: 10.1016/j.esmoop.2021.100233. PMID: 34371380Free PMC Article
A phase I clinical trial for [(131)I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma.
Wakabayashi H, Inaki A, Yoshimura K, Murayama T, Imai Y, Higuchi T, Jinguji M, Shiga T, Kinuya S
Sci Rep 2019 May 20;9(1):7625. doi: 10.1038/s41598-019-43880-6. PMID: 31110198Free PMC Article
A phase I clinical trial for [(131)I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma: a study protocol.
Inaki A, Yoshimura K, Murayama T, Imai Y, Kuribayashi Y, Higuchi T, Jinguji M, Shiga T, Kinuya S
J Med Invest 2017;64(3.4):205-209. doi: 10.2152/jmi.64.205. PMID: 28954983
Metastatic pheochromocytoma and paraganglioma.
Angelousi A, Kassi E, Zografos G, Kaltsas G
Eur J Clin Invest 2015 Sep;45(9):986-97. doi: 10.1111/eci.12495. PMID: 26183460

Clinical prediction guides

An open-label, single-arm, multi-center, phase II clinical trial of single-dose [(131)I]meta-iodobenzylguanidine therapy for patients with refractory pheochromocytoma and paraganglioma.
Inaki A, Shiga T, Tsushima Y, Jinguji M, Wakabayashi H, Kayano D, Akatani N, Yamase T, Kunita Y, Watanabe S, Hiromasa T, Mori H, Hirata K, Watanabe S, Higuchi T, Tomonaga H, Kinuya S
Ann Nucl Med 2022 Mar;36(3):267-278. Epub 2021 Dec 6 doi: 10.1007/s12149-021-01699-0. PMID: 34870794Free PMC Article
Sustained response to brigatinib in a patient with refractory metastatic pheochromocytoma harboring R1192P anaplastic lymphoma kinase mutation: a case report from the Austrian Group Medical Tumor Therapy next-generation sequencing registry and discussion of the literature.
Heregger R, Huemer F, Hutarew G, Hecht S, Cheveresan L, Kotzot D, Schamschula E, Rinnerthaler G, Melchardt T, Weiss L, Greil R
ESMO Open 2021 Aug;6(4):100233. Epub 2021 Aug 7 doi: 10.1016/j.esmoop.2021.100233. PMID: 34371380Free PMC Article
Recent advances in the management of pheochromocytoma and paraganglioma.
Tanabe A, Naruse M
Hypertens Res 2020 Nov;43(11):1141-1151. Epub 2020 Aug 11 doi: 10.1038/s41440-020-0531-0. PMID: 32778780
A phase I clinical trial for [(131)I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma.
Wakabayashi H, Inaki A, Yoshimura K, Murayama T, Imai Y, Higuchi T, Jinguji M, Shiga T, Kinuya S
Sci Rep 2019 May 20;9(1):7625. doi: 10.1038/s41598-019-43880-6. PMID: 31110198Free PMC Article
Metastatic pheochromocytoma and paraganglioma.
Angelousi A, Kassi E, Zografos G, Kaltsas G
Eur J Clin Invest 2015 Sep;45(9):986-97. doi: 10.1111/eci.12495. PMID: 26183460

Recent systematic reviews

Extracorporeal life support for phaeochromocytoma-induced cardiogenic shock: a systematic review.
Matteucci M, Kowalewski M, Fina D, Jiritano F, Meani P, Raffa GM, Aldobayyan I, Beghi C, Maessen J, Lorusso R
Perfusion 2020 May;35(1_suppl):20-28. doi: 10.1177/0267659120908413. PMID: 32397890

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