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Chromosome Arm 1p Loss of Heterozygosity

MedGen UID:
1673975
Concept ID:
C4763752
Cell or Molecular Dysfunction
Synonyms: 1p LOH; 1p Loss of Heterozygosity

Definition

A molecular abnormality that results in monoallelic loss of function mutations located within the short arm of chromosome 1 (1p). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChromosome Arm 1p Loss of Heterozygosity

Professional guidelines

PubMed

Norman S, Juthani RG, Magge R
World Neurosurg 2022 Oct;166:306-312. doi: 10.1016/j.wneu.2022.06.068. PMID: 36192862
Kjaergaard S, Sundberg K, Jørgensen FS, Rohde MD, Lind AM, Gerdes T, Tabor A, Kirchhoff M
Prenat Diagn 2010 Oct;30(10):995-9. doi: 10.1002/pd.2604. PMID: 20824892
Kanner AA, Staugaitis SM, Castilla EA, Chernova O, Prayson RA, Vogelbaum MA, Stevens G, Peereboom D, Suh J, Lee SY, Tubbs RR, Barnett GH
J Neurosurg 2006 Apr;104(4):542-50. doi: 10.3171/jns.2006.104.4.542. PMID: 16619658

Recent clinical studies

Etiology

Lourenço N, Hélias-Rodzewicz Z, Bachet JB, Brahimi-Adouane S, Jardin F, Tran van Nhieu J, Peschaud F, Martin E, Beauchet A, Chibon F, Emile JF
Mol Cancer 2014 Nov 6;13:246. doi: 10.1186/1476-4598-13-246. PMID: 25373456Free PMC Article
Al-Hussain T, Ali A, Akhtar M
Adv Anat Pathol 2014 May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. PMID: 24713986
Alahmadi H, Croul SE
Semin Diagn Pathol 2011 Nov;28(4):314-24. doi: 10.1053/j.semdp.2011.01.002. PMID: 22195409
Dacic S, Sasatomi E, Swalsky PA, Kim DW, Finkelstein SD, Yousem SA
Arch Pathol Lab Med 2004 Aug;128(8):880-4. doi: 10.5858/2004-128-880-LOHPOS. PMID: 15270615
Westermann F, Schwab M
Cancer Lett 2002 Oct 28;184(2):127-47. doi: 10.1016/s0304-3835(02)00199-4. PMID: 12127685

Diagnosis

Norman S, Juthani RG, Magge R
World Neurosurg 2022 Oct;166:306-312. doi: 10.1016/j.wneu.2022.06.068. PMID: 36192862
Cahill DP, Louis DN, Cairncross JG
CNS Oncol 2015;4(5):287-94. Epub 2015 Nov 6 doi: 10.2217/cns.15.32. PMID: 26545048Free PMC Article
Aldape K, Burger PC, Perry A
Arch Pathol Lab Med 2007 Feb;131(2):242-51. doi: 10.5858/2007-131-242-CAOQLA. PMID: 17284109
Westermann F, Schwab M
Cancer Lett 2002 Oct 28;184(2):127-47. doi: 10.1016/s0304-3835(02)00199-4. PMID: 12127685
Mora J, Cheung NK, Kushner BH, LaQuaglia MP, Kramer K, Fazzari M, Heller G, Chen L, Gerald WL
J Mol Diagn 2000 Feb;2(1):37-46. doi: 10.1016/S1525-1578(10)60613-7. PMID: 11272900Free PMC Article

Therapy

Yang LS, Xu XE, Liu XP, Jin H, Chen ZQ, Liu XH, Wang Y, Huang FP, Shi Q
J Proteomics 2012 Dec 21;77:480-91. Epub 2012 Oct 4 doi: 10.1016/j.jprot.2012.09.028. PMID: 23041135
Westermann F, Schwab M
Cancer Lett 2002 Oct 28;184(2):127-47. doi: 10.1016/s0304-3835(02)00199-4. PMID: 12127685
Hogarty MD, Maris JM, White PS, Guo C, Brodeur GM
Med Pediatr Oncol 2001 Jan;36(1):52-5. doi: 10.1002/1096-911X(20010101)36:1<52::AID-MPO1014>3.0.CO;2-8. PMID: 11464906
Kraus JA, Albrecht S, Wiestler OD, von Schweinitz D, Pietsch T
Int J Cancer 1996 Aug 7;67(4):467-71. doi: 10.1002/(SICI)1097-0215(19960807)67:4<467::AID-IJC1>3.0.CO;2-Q. PMID: 8759602
Tonini GP
Stem Cells 1993 Jul;11(4):276-82. doi: 10.1002/stem.5530110404. PMID: 8401251

Prognosis

Norman S, Juthani RG, Magge R
World Neurosurg 2022 Oct;166:306-312. doi: 10.1016/j.wneu.2022.06.068. PMID: 36192862
Al-Hussain T, Ali A, Akhtar M
Adv Anat Pathol 2014 May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. PMID: 24713986
Aldape K, Burger PC, Perry A
Arch Pathol Lab Med 2007 Feb;131(2):242-51. doi: 10.5858/2007-131-242-CAOQLA. PMID: 17284109
Westermann F, Schwab M
Cancer Lett 2002 Oct 28;184(2):127-47. doi: 10.1016/s0304-3835(02)00199-4. PMID: 12127685
Mora J, Cheung NK, Kushner BH, LaQuaglia MP, Kramer K, Fazzari M, Heller G, Chen L, Gerald WL
J Mol Diagn 2000 Feb;2(1):37-46. doi: 10.1016/S1525-1578(10)60613-7. PMID: 11272900Free PMC Article

Clinical prediction guides

McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Spencer Leal E, Faulkner CL, Palmer A, Wragg C, Jefferies S, Brandner S, Vale L, Higgins JP, Kurian KM
Cochrane Database Syst Rev 2022 Mar 2;3(3):CD013387. doi: 10.1002/14651858.CD013387.pub2. PMID: 35233774Free PMC Article
Häusler T, Stang A, Anastassiou G, Jöckel KH, Mrzyk S, Horsthemke B, Lohmann DR, Zeschnigk M
Int J Cancer 2005 Oct 10;116(6):909-13. doi: 10.1002/ijc.21086. PMID: 15849744
Westermann F, Schwab M
Cancer Lett 2002 Oct 28;184(2):127-47. doi: 10.1016/s0304-3835(02)00199-4. PMID: 12127685
Mora J, Cheung NK, Kushner BH, LaQuaglia MP, Kramer K, Fazzari M, Heller G, Chen L, Gerald WL
J Mol Diagn 2000 Feb;2(1):37-46. doi: 10.1016/S1525-1578(10)60613-7. PMID: 11272900Free PMC Article
Gibas Z, Weil S, Chen ST, McCue PA
Genes Chromosomes Cancer 1994 Mar;9(3):216-20. doi: 10.1002/gcc.2870090310. PMID: 7515664

Recent systematic reviews

McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Spencer Leal E, Faulkner CL, Palmer A, Wragg C, Jefferies S, Brandner S, Vale L, Higgins JP, Kurian KM
Cochrane Database Syst Rev 2022 Mar 2;3(3):CD013387. doi: 10.1002/14651858.CD013387.pub2. PMID: 35233774Free PMC Article

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