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Chromosome Arm 1p Loss of Heterozygosity

MedGen UID:
1673975
•Concept ID:
C4763752
•
Cell or Molecular Dysfunction
Synonyms: 1p LOH; 1p Loss of Heterozygosity

Definition

A molecular abnormality that results in monoallelic loss of function mutations located within the short arm of chromosome 1 (1p). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChromosome Arm 1p Loss of Heterozygosity

Professional guidelines

PubMed

Foundations of the Diagnosis and Management of Low-Grade Gliomas.
Norman S, Juthani RG, Magge R
World Neurosurg 2022 Oct;166:306-312. doi: 10.1016/j.wneu.2022.06.068. PMID: 36192862
Diagnostic yield by supplementing prenatal metaphase karyotyping with MLPA for microdeletion syndromes and subtelomere imbalances.
Kjaergaard S, Sundberg K, Jørgensen FS, Rohde MD, Lind AM, Gerdes T, Tabor A, Kirchhoff M
Prenat Diagn 2010 Oct;30(10):995-9. doi: 10.1002/pd.2604. PMID: 20824892
The impact of genotype on outcome in oligodendroglioma: validation of the loss of chromosome arm 1p as an important factor in clinical decision making.
Kanner AA, Staugaitis SM, Castilla EA, Chernova O, Prayson RA, Vogelbaum MA, Stevens G, Peereboom D, Suh J, Lee SY, Tubbs RR, Barnett GH
J Neurosurg 2006 Apr;104(4):542-50. doi: 10.3171/jns.2006.104.4.542. PMID: 16619658

Recent clinical studies

Etiology

Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma.
McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Spencer Leal E, Faulkner CL, Palmer A, Wragg C, Jefferies S, Brandner S, Vale L, Higgins JP, Kurian KM
Cochrane Database Syst Rev 2022 Mar 2;3(3):CD013387. doi: 10.1002/14651858.CD013387.pub2. PMID: 35233774Free PMC Article
Chromosome microarray characterisation of chromosome arm 12p loss associated with complex molecular karyotype and recurrent adverse cytogenetic markers in multiple myeloma.
Hung D, Lenton D, Eslick R, Blennerhassett R, Joshi M, McCaughan G, Day S, Wright D
Genes Chromosomes Cancer 2021 Oct;60(10):668-677. Epub 2021 Jun 7 doi: 10.1002/gcc.22975. PMID: 34041820
Wilms tumor: an update.
Al-Hussain T, Ali A, Akhtar M
Adv Anat Pathol 2014 May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. PMID: 24713986
Pathology and genetics of meningiomas.
Alahmadi H, Croul SE
Semin Diagn Pathol 2011 Nov;28(4):314-24. doi: 10.1053/j.semdp.2011.01.002. PMID: 22195409
Genetic parameters of neuroblastomas.
Westermann F, Schwab M
Cancer Lett 2002 Oct 28;184(2):127-47. doi: 10.1016/s0304-3835(02)00199-4. PMID: 12127685

Diagnosis

Foundations of the Diagnosis and Management of Low-Grade Gliomas.
Norman S, Juthani RG, Magge R
World Neurosurg 2022 Oct;166:306-312. doi: 10.1016/j.wneu.2022.06.068. PMID: 36192862
Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma.
McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Spencer Leal E, Faulkner CL, Palmer A, Wragg C, Jefferies S, Brandner S, Vale L, Higgins JP, Kurian KM
Cochrane Database Syst Rev 2022 Mar 2;3(3):CD013387. doi: 10.1002/14651858.CD013387.pub2. PMID: 35233774Free PMC Article
Molecular background of oligodendroglioma: 1p/19q, IDH, TERT, CIC and FUBP1.
Cahill DP, Louis DN, Cairncross JG
CNS Oncol 2015;4(5):287-94. Epub 2015 Nov 6 doi: 10.2217/cns.15.32. PMID: 26545048Free PMC Article
Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma.
Aldape K, Burger PC, Perry A
Arch Pathol Lab Med 2007 Feb;131(2):242-51. doi: 10.5858/2007-131-242-CAOQLA. PMID: 17284109
Genetic parameters of neuroblastomas.
Westermann F, Schwab M
Cancer Lett 2002 Oct 28;184(2):127-47. doi: 10.1016/s0304-3835(02)00199-4. PMID: 12127685

Therapy

Prognostic value of 1p deletion for multiple myeloma: a meta-analysis.
Ouyang J, Gou X, Ma Y, Huang Q, Jiang T
Int J Lab Hematol 2014 Oct;36(5):555-65. Epub 2014 Jan 27 doi: 10.1111/ijlh.12189. PMID: 24460694
iTRAQ-based quantitative proteomic analysis for identification of oligodendroglioma biomarkers related with loss of heterozygosity on chromosomal arm 1p.
Yang LS, Xu XE, Liu XP, Jin H, Chen ZQ, Liu XH, Wang Y, Huang FP, Shi Q
J Proteomics 2012 Dec 21;77:480-91. Epub 2012 Oct 4 doi: 10.1016/j.jprot.2012.09.028. PMID: 23041135
Genetic parameters of neuroblastomas.
Westermann F, Schwab M
Cancer Lett 2002 Oct 28;184(2):127-47. doi: 10.1016/s0304-3835(02)00199-4. PMID: 12127685
Loss of heterozygosity on chromosome 1 in human hepatoblastoma.
Kraus JA, Albrecht S, Wiestler OD, von Schweinitz D, Pietsch T
Int J Cancer 1996 Aug 7;67(4):467-71. doi: 10.1002/(SICI)1097-0215(19960807)67:4<467::AID-IJC1>3.0.CO;2-Q. PMID: 8759602
Neuroblastoma: the result of multistep transformation?
Tonini GP
Stem Cells 1993 Jul;11(4):276-82. doi: 10.1002/stem.5530110404. PMID: 8401251

Prognosis

Foundations of the Diagnosis and Management of Low-Grade Gliomas.
Norman S, Juthani RG, Magge R
World Neurosurg 2022 Oct;166:306-312. doi: 10.1016/j.wneu.2022.06.068. PMID: 36192862
Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma.
McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Spencer Leal E, Faulkner CL, Palmer A, Wragg C, Jefferies S, Brandner S, Vale L, Higgins JP, Kurian KM
Cochrane Database Syst Rev 2022 Mar 2;3(3):CD013387. doi: 10.1002/14651858.CD013387.pub2. PMID: 35233774Free PMC Article
Wilms tumor: an update.
Al-Hussain T, Ali A, Akhtar M
Adv Anat Pathol 2014 May;21(3):166-73. doi: 10.1097/PAP.0000000000000017. PMID: 24713986
Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma.
Aldape K, Burger PC, Perry A
Arch Pathol Lab Med 2007 Feb;131(2):242-51. doi: 10.5858/2007-131-242-CAOQLA. PMID: 17284109
Genetic parameters of neuroblastomas.
Westermann F, Schwab M
Cancer Lett 2002 Oct 28;184(2):127-47. doi: 10.1016/s0304-3835(02)00199-4. PMID: 12127685

Clinical prediction guides

Evaluation of the Oncomine Comprehensive Assay v3 panel for the detection of 1p/19q codeletion in oligodendroglial tumours.
Ali RH, Alateeqi M, Jama H, Alrumaidhi N, Alqallaf A, Mohammed EM, Almurshed M, Bahzad S
J Clin Pathol 2023 Feb;76(2):103-110. Epub 2021 Sep 6 doi: 10.1136/jclinpath-2021-207876. PMID: 34489310
Utility of targeted next-generation sequencing assay to detect 1p/19q co-deletion in formalin-fixed paraffin-embedded glioma specimens.
Pallavajjala A, Haley L, Stinnett V, Adams E, Pallavajjala R, Huang J, Morsberger L, Hardy M, Long P, Gocke CD, Eshleman JR, Rodriguez FJ, Zou YS
Hum Pathol 2022 Aug;126:63-76. Epub 2022 May 10 doi: 10.1016/j.humpath.2022.05.001. PMID: 35561840
Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma.
McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Spencer Leal E, Faulkner CL, Palmer A, Wragg C, Jefferies S, Brandner S, Vale L, Higgins JP, Kurian KM
Cochrane Database Syst Rev 2022 Mar 2;3(3):CD013387. doi: 10.1002/14651858.CD013387.pub2. PMID: 35233774Free PMC Article
Genetic parameters of neuroblastomas.
Westermann F, Schwab M
Cancer Lett 2002 Oct 28;184(2):127-47. doi: 10.1016/s0304-3835(02)00199-4. PMID: 12127685
Clinical categories of neuroblastoma are associated with different patterns of loss of heterozygosity on chromosome arm 1p.
Mora J, Cheung NK, Kushner BH, LaQuaglia MP, Kramer K, Fazzari M, Heller G, Chen L, Gerald WL
J Mol Diagn 2000 Feb;2(1):37-46. doi: 10.1016/S1525-1578(10)60613-7. PMID: 11272900Free PMC Article

Recent systematic reviews

Diagnostic test accuracy and cost-effectiveness of tests for codeletion of chromosomal arms 1p and 19q in people with glioma.
McAleenan A, Jones HE, Kernohan A, Robinson T, Schmidt L, Dawson S, Kelly C, Spencer Leal E, Faulkner CL, Palmer A, Wragg C, Jefferies S, Brandner S, Vale L, Higgins JP, Kurian KM
Cochrane Database Syst Rev 2022 Mar 2;3(3):CD013387. doi: 10.1002/14651858.CD013387.pub2. PMID: 35233774Free PMC Article

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