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Placental choriocarcinoma

MedGen UID:
167782
•Concept ID:
C0855173
•
Neoplastic Process
Synonyms: Choriocarcinoma of placenta; Choriocarcinoma of Placenta; choriocarcinoma of placenta; Choriocarcinoma of the Placenta; choriocarcinoma of the placenta; Placenta Choriocarcinoma; placenta choriocarcinoma; placenta choriocarcinoma (disease); Placental Choriocarcinoma; placental choriocarcinoma
SNOMED CT: Choriocarcinoma of placenta (448401007)
 
Monarch Initiative: MONDO:0006374

Definition

Choriocarcinoma that develops in the placenta. It is the rarest form of gestational choriocarcinoma. Metastases to the mother and infant may occur. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlacental choriocarcinoma

Professional guidelines

PubMed

Advances in diagnostics and management of gestational trophoblastic disease.
Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620Free PMC Article
Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Recent clinical studies

Etiology

Regulation of uterus and placenta remodeling under high estradiol levels in gestational diabetes mellitus models†.
Kang DH, Kim MJ, Mohamed EA, Kim DS, Jeong JS, Kim SY, Kang HG, Lee GS, Hong EJ, Ahn C, Jung EM, An BS, Kim SC
Biol Reprod 2023 Aug 10;109(2):215-226. doi: 10.1093/biolre/ioad059. PMID: 37255320
Xanthines down-regulate the drug transporter ABCG2 and reverse multidrug resistance.
Ding R, Shi J, Pabon K, Scotto KW
Mol Pharmacol 2012 Mar;81(3):328-37. Epub 2011 Nov 23 doi: 10.1124/mol.111.075556. PMID: 22113078Free PMC Article
Expression of melatoninergic receptors in human placental choriocarcinoma cell lines.
Lanoix D, Ouellette R, Vaillancourt C
Hum Reprod 2006 Aug;21(8):1981-9. Epub 2006 Apr 21 doi: 10.1093/humrep/del120. PMID: 16632463
Hypoxia activates the human placental vascular endothelial growth factor system in vitro and in vivo: up-regulation of vascular endothelial growth factor in clinically relevant hypoxic ischemia in birth asphyxia.
Trollmann R, Amann K, Schoof E, Beinder E, Wenzel D, Rascher W, Dötsch J
Am J Obstet Gynecol 2003 Feb;188(2):517-23. doi: 10.1067/mob.2003.138. PMID: 12592265
Characterization of the expression of the retinoid-related, testis-associated receptor (RTR) in trophoblasts.
Mehta DV, Kim YS, Dixon D, Jetten AM
Placenta 2002 Apr;23(4):281-7. doi: 10.1053/plac.2001.0779. PMID: 11969338

Diagnosis

Coumestrol induces mitochondrial dysfunction by stimulating ROS production and calcium ion influx into mitochondria in human placental choriocarcinoma cells.
Lim W, Yang C, Jeong M, Bazer FW, Song G
Mol Hum Reprod 2017 Nov 1;23(11):786-802. doi: 10.1093/molehr/gax052. PMID: 29040664
Human placental cell and tissue uptake of doxorubicin and its liposomal formulations.
Soininen SK, Repo JK, Karttunen V, Auriola S, Vähäkangas KH, Ruponen M
Toxicol Lett 2015 Dec 3;239(2):108-14. Epub 2015 Sep 14 doi: 10.1016/j.toxlet.2015.09.011. PMID: 26383631
The expression of the imprinted gene pleckstrin homology-like domain family A member 2 in placental tissues of preeclampsia and its effects on the proliferation, migration and invasion of trophoblast cells JEG-3.
Jin F, Qiao C, Luan N, Shang T
Clin Exp Pharmacol Physiol 2015 Nov;42(11):1142-51. doi: 10.1111/1440-1681.12468. PMID: 26218012
Incidental finding of placental choriocarcinoma after an uncomplicated term pregnancy: a case report with review of the literature.
Ganapathi KA, Paczos T, George MD, Goodloe S, Balos LL, Chen F
Int J Gynecol Pathol 2010 Sep;29(5):476-8. doi: 10.1097/PGP.0b013e3181d81cc2. PMID: 20736774
Placental ceruloplasmin homolog is regulated by iron and copper and is implicated in iron metabolism.
Danzeisen R, Fosset C, Chariana Z, Page K, David S, McArdle HJ
Am J Physiol Cell Physiol 2002 Mar;282(3):C472-8. doi: 10.1152/ajpcell.00019.2001. PMID: 11832331

Therapy

Luteolin Inhibits Proliferation and Induces Apoptosis of Human Placental Choriocarcinoma Cells by Blocking the PI3K/AKT Pathway and Regulating Sterol Regulatory Element Binding Protein Activity.
Lim W, Yang C, Bazer FW, Song G
Biol Reprod 2016 Oct;95(4):82. Epub 2016 Aug 31 doi: 10.1095/biolreprod.116.141556. PMID: 27580988
Human placental cell and tissue uptake of doxorubicin and its liposomal formulations.
Soininen SK, Repo JK, Karttunen V, Auriola S, Vähäkangas KH, Ruponen M
Toxicol Lett 2015 Dec 3;239(2):108-14. Epub 2015 Sep 14 doi: 10.1016/j.toxlet.2015.09.011. PMID: 26383631
A monoclonal antibody against leptin.
Mahmoudian J, Jeddi-Tehrani M, Bayat AA, Mahmoudi AR, Vojgani Y, Tavangar B, Hadavi R, Zarei S
Hybridoma (Larchmt) 2012 Oct;31(5):372-7. doi: 10.1089/hyb.2012.0045. PMID: 23098305
Interactions between riluzole and ABCG2/BCRP transporter.
Milane A, Vautier S, Chacun H, Meininger V, Bensimon G, Farinotti R, Fernandez C
Neurosci Lett 2009 Mar 6;452(1):12-6. Epub 2009 Jan 6 doi: 10.1016/j.neulet.2008.12.061. PMID: 19146924
Dickkopf-1 induced apoptosis in human placental choriocarcinoma is independent of canonical Wnt signaling.
Peng S, Miao C, Li J, Fan X, Cao Y, Duan E
Biochem Biophys Res Commun 2006 Nov 24;350(3):641-7. Epub 2006 Sep 27 doi: 10.1016/j.bbrc.2006.09.087. PMID: 17026960

Prognosis

Glucocorticoid receptor-mediated insulin-like growth factor-I transcriptional regulation in BeWo trophoblast cells before and after syncytialisation.
He B, Zhang N, Jia Y, Sun Q, Zhao R
Steroids 2016 Nov;115:26-33. Epub 2016 Aug 5 doi: 10.1016/j.steroids.2016.08.004. PMID: 27500692
In vitro placental model optimization for nanoparticle transport studies.
Cartwright L, Poulsen MS, Nielsen HM, Pojana G, Knudsen LE, Saunders M, Rytting E
Int J Nanomedicine 2012;7:497-510. Epub 2012 Jan 31 doi: 10.2147/IJN.S26601. PMID: 22334780Free PMC Article
Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.
Rajan DP, Huang W, Dutta B, Devoe LD, Leibach FH, Ganapathy V, Prasad PD
Biochem Biophys Res Commun 1999 Sep 7;262(3):762-8. doi: 10.1006/bbrc.1999.1272. PMID: 10471399
Differential distribution and metabolism of arachidonic acid and docosahexaenoic acid by human placental choriocarcinoma (BeWo) cells.
Crabtree JT, Gordon MJ, Campbell FM, Dutta-Roy AK
Mol Cell Biochem 1998 Aug;185(1-2):191-8. doi: 10.1023/a:1006852230337. PMID: 9746226
Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line.
Kekuda R, Prasad PD, Fei YJ, Torres-Zamorano V, Sinha S, Yang-Feng TL, Leibach FH, Ganapathy V
J Biol Chem 1996 Aug 2;271(31):18657-61. doi: 10.1074/jbc.271.31.18657. PMID: 8702519

Clinical prediction guides

Platelet-derived growth factor-AA promotes placental choriocarcinoma JAR cell proliferation via primary cilia.
Sheu SY, Wang CY, Cheng HL, Tsai PY
Taiwan J Obstet Gynecol 2022 Mar;61(2):299-305. doi: 10.1016/j.tjog.2022.02.018. PMID: 35361391
Impact of Axis of GHRH and GHRH Receptor on Cell Viability and Apoptosis of the Placental Choriocarcinoma Cell Line.
Liu AX, Zhang D, Zhu YM, Gao HJ, Jiang JY, Hu XL, Lv PP, Leung PC, Huang HF
Curr Mol Med 2016;16(3):299-311. doi: 10.2174/1566524016666160225154040. PMID: 26917260
Altered folate metabolism modifies cell proliferation and progesterone secretion in human placental choriocarcinoma JEG-3 cells.
Moussa C, Ross N, Jolette P, MacFarlane AJ
Br J Nutr 2015 Sep 28;114(6):844-52. Epub 2015 Aug 24 doi: 10.1017/S0007114515002688. PMID: 26299783
Divalent metal transporter 1 expression and regulation in human placenta.
Li YQ, Bai B, Cao XX, Zhang YH, Yan H, Zheng QQ, Zhuang GH
Biol Trace Elem Res 2012 Apr;146(1):6-12. Epub 2011 Sep 27 doi: 10.1007/s12011-011-9214-7. PMID: 21947861
Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta.
Dutta-Roy AK
Am J Clin Nutr 2000 Jan;71(1 Suppl):315S-22S. doi: 10.1093/ajcn/71.1.315s. PMID: 10617989

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