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Placental choriocarcinoma

MedGen UID:
167782
•Concept ID:
C0855173
•
Neoplastic Process
Synonyms: Choriocarcinoma of placenta; Choriocarcinoma of Placenta; choriocarcinoma of placenta; Choriocarcinoma of the Placenta; choriocarcinoma of the placenta; Placenta Choriocarcinoma; placenta choriocarcinoma; placenta choriocarcinoma (disease); Placental Choriocarcinoma; placental choriocarcinoma
SNOMED CT: Choriocarcinoma of placenta (448401007)
 
Monarch Initiative: MONDO:0006374

Definition

Choriocarcinoma that develops in the placenta. It is the rarest form of gestational choriocarcinoma. Metastases to the mother and infant may occur. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlacental choriocarcinoma

Professional guidelines

PubMed

Advances in diagnostics and management of gestational trophoblastic disease.
Lukinovic N, Malovrh EP, Takac I, Sobocan M, Knez J
Radiol Oncol 2022 Dec 1;56(4):430-439. Epub 2022 Oct 27 doi: 10.2478/raon-2022-0038. PMID: 36286620Free PMC Article
Surgery including fertility-sparing treatment of GTD.
Ngu SF, Ngan HYS
Best Pract Res Clin Obstet Gynaecol 2021 Jul;74:97-108. Epub 2020 Oct 10 doi: 10.1016/j.bpobgyn.2020.10.005. PMID: 33127305Free PMC Article
Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole.
Lurain JR
Am J Obstet Gynecol 2010 Dec;203(6):531-9. Epub 2010 Aug 21 doi: 10.1016/j.ajog.2010.06.073. PMID: 20728069

Recent clinical studies

Etiology

Regulation of uterus and placenta remodeling under high estradiol levels in gestational diabetes mellitus models†.
Kang DH, Kim MJ, Mohamed EA, Kim DS, Jeong JS, Kim SY, Kang HG, Lee GS, Hong EJ, Ahn C, Jung EM, An BS, Kim SC
Biol Reprod 2023 Aug 10;109(2):215-226. doi: 10.1093/biolre/ioad059. PMID: 37255320
The heat shock protein 60 promotes progesterone synthesis in mitochondria of JEG-3 cells.
Monreal-Flores J, Espinosa-García MT, García-Regalado A, Arechavaleta-Velasco F, Martínez F
Reprod Biol 2017 Jun;17(2):154-161. Epub 2017 Apr 20 doi: 10.1016/j.repbio.2017.04.001. PMID: 28434777
Perfluorinated chemicals: differential toxicity, inhibition of aromatase activity and alteration of cellular lipids in human placental cells.
Gorrochategui E, Pérez-Albaladejo E, Casas J, Lacorte S, Porte C
Toxicol Appl Pharmacol 2014 Jun 1;277(2):124-30. Epub 2014 Mar 26 doi: 10.1016/j.taap.2014.03.012. PMID: 24680846
Transporter-mediated release: a superfusion study on human embryonic kidney cells stably expressing the human serotonin transporter.
Scholze P, Zwach J, Kattinger A, Pifl C, Singer EA, Sitte HH
J Pharmacol Exp Ther 2000 Jun;293(3):870-8. PMID: 10869387
The appetite suppressant d-fenfluramine induces apoptosis in human serotonergic cells.
Bengel D, Isaacs KR, Heils A, Lesch KP, Murphy DL
Neuroreport 1998 Sep 14;9(13):2989-93. doi: 10.1097/00001756-199809140-00013. PMID: 9804303

Diagnosis

Human placental cell and tissue uptake of doxorubicin and its liposomal formulations.
Soininen SK, Repo JK, Karttunen V, Auriola S, Vähäkangas KH, Ruponen M
Toxicol Lett 2015 Dec 3;239(2):108-14. Epub 2015 Sep 14 doi: 10.1016/j.toxlet.2015.09.011. PMID: 26383631
Gestational choriocarcinoma transmission following multiorgan donation.
Braun-Parvez L, Charlin E, Caillard S, Ducloux D, Wolf P, Rolle F, Golfier F, Flicoteaux H, Bergerat JP, Moulin B
Am J Transplant 2010 Nov;10(11):2541-6. doi: 10.1111/j.1600-6143.2010.03275.x. PMID: 20977645
CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo.
Berryman M, Bruno J, Price J, Edwards JC
J Biol Chem 2004 Aug 13;279(33):34794-801. Epub 2004 Jun 7 doi: 10.1074/jbc.M402835200. PMID: 15184393
Multidimensional gas chromatography-mass spectrometry for tracer studies of fatty acid metabolism via stable isotopes in cultured human trophoblast cells.
Muth A, Mosandl A, Bursen A, Marschalek R, Sewell AC, Böhles H
J Chromatogr B Analyt Technol Biomed Life Sci 2003 Jul 5;791(1-2):235-44. doi: 10.1016/s1570-0232(03)00220-4. PMID: 12798183
Relative sensitivity to inhibition by cimetidine and clonidine differentiates between the two types of Na(+)-H+ exchangers in cultured cells.
Ramamoorthy S, Tiruppathi C, Nair CN, Mahesh VB, Leibach FH, Ganapathy V
Biochem J 1991 Dec 1;280 ( Pt 2)(Pt 2):317-22. doi: 10.1042/bj2800317. PMID: 1660711Free PMC Article

Therapy

Luteolin Inhibits Proliferation and Induces Apoptosis of Human Placental Choriocarcinoma Cells by Blocking the PI3K/AKT Pathway and Regulating Sterol Regulatory Element Binding Protein Activity.
Lim W, Yang C, Bazer FW, Song G
Biol Reprod 2016 Oct;95(4):82. Epub 2016 Aug 31 doi: 10.1095/biolreprod.116.141556. PMID: 27580988
Human placental cell and tissue uptake of doxorubicin and its liposomal formulations.
Soininen SK, Repo JK, Karttunen V, Auriola S, Vähäkangas KH, Ruponen M
Toxicol Lett 2015 Dec 3;239(2):108-14. Epub 2015 Sep 14 doi: 10.1016/j.toxlet.2015.09.011. PMID: 26383631
A monoclonal antibody against leptin.
Mahmoudian J, Jeddi-Tehrani M, Bayat AA, Mahmoudi AR, Vojgani Y, Tavangar B, Hadavi R, Zarei S
Hybridoma (Larchmt) 2012 Oct;31(5):372-7. doi: 10.1089/hyb.2012.0045. PMID: 23098305
Gestational choriocarcinoma transmission following multiorgan donation.
Braun-Parvez L, Charlin E, Caillard S, Ducloux D, Wolf P, Rolle F, Golfier F, Flicoteaux H, Bergerat JP, Moulin B
Am J Transplant 2010 Nov;10(11):2541-6. doi: 10.1111/j.1600-6143.2010.03275.x. PMID: 20977645
Selective impairment of taurine transport by cyclosporin A in a human placental cell line.
Ramamoorthy S, Leibach FH, Mahesh VB, Ganapathy V
Pediatr Res 1992 Jul;32(1):125-7. doi: 10.1203/00006450-199207000-00024. PMID: 1378960

Prognosis

Glucocorticoid receptor-mediated insulin-like growth factor-I transcriptional regulation in BeWo trophoblast cells before and after syncytialisation.
He B, Zhang N, Jia Y, Sun Q, Zhao R
Steroids 2016 Nov;115:26-33. Epub 2016 Aug 5 doi: 10.1016/j.steroids.2016.08.004. PMID: 27500692
Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.
Rajan DP, Huang W, Dutta B, Devoe LD, Leibach FH, Ganapathy V, Prasad PD
Biochem Biophys Res Commun 1999 Sep 7;262(3):762-8. doi: 10.1006/bbrc.1999.1272. PMID: 10471399
Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1).
Kekuda R, Prasad PD, Fei YJ, Leibach FH, Ganapathy V
Biochem Biophys Res Commun 1996 Dec 13;229(2):553-8. doi: 10.1006/bbrc.1996.1842. PMID: 8954936
Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line.
Kekuda R, Prasad PD, Fei YJ, Torres-Zamorano V, Sinha S, Yang-Feng TL, Leibach FH, Ganapathy V
J Biol Chem 1996 Aug 2;271(31):18657-61. doi: 10.1074/jbc.271.31.18657. PMID: 8702519
PACAP-38 positively regulates glycoprotein hormone alpha-gene expression in placental cells.
Desai BJ, Burrin JM
Mol Cell Endocrinol 1994 Feb;99(1):31-7. doi: 10.1016/0303-7207(94)90143-0. PMID: 7514549

Clinical prediction guides

Let-7i-Induced Atg4B Suppression Is Essential for Autophagy of Placental Trophoblast in Preeclampsia.
Xu Y, Huang X, Xie J, Chen Y, Fu J, Wang L
J Cell Physiol 2017 Sep;232(9):2581-2589. Epub 2017 Apr 10 doi: 10.1002/jcp.25661. PMID: 27770612
Gestational choriocarcinoma transmission following multiorgan donation.
Braun-Parvez L, Charlin E, Caillard S, Ducloux D, Wolf P, Rolle F, Golfier F, Flicoteaux H, Bergerat JP, Moulin B
Am J Transplant 2010 Nov;10(11):2541-6. doi: 10.1111/j.1600-6143.2010.03275.x. PMID: 20977645
Human placental sodium-dependent vitamin C transporter (SVCT2): molecular cloning and transport function.
Rajan DP, Huang W, Dutta B, Devoe LD, Leibach FH, Ganapathy V, Prasad PD
Biochem Biophys Res Commun 1999 Sep 7;262(3):762-8. doi: 10.1006/bbrc.1999.1272. PMID: 10471399
The appetite suppressant d-fenfluramine induces apoptosis in human serotonergic cells.
Bengel D, Isaacs KR, Heils A, Lesch KP, Murphy DL
Neuroreport 1998 Sep 14;9(13):2989-93. doi: 10.1097/00001756-199809140-00013. PMID: 9804303
Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1).
Kekuda R, Prasad PD, Fei YJ, Leibach FH, Ganapathy V
Biochem Biophys Res Commun 1996 Dec 13;229(2):553-8. doi: 10.1006/bbrc.1996.1842. PMID: 8954936

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