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Chronic graft versus host disease

MedGen UID:
167851
•Concept ID:
C0867389
•
Disease or Syndrome
Synonyms: Chronic Graft Versus Host Disease; chronic graft versus host disease; Chronic graft-versus-host disease; Chronic GVHD; chronic GVHD; graft versus host disease, chronic; GVHD, chronic
SNOMED CT: Chronic graft-versus-host disease (402356004); Chronic graft versus host disease (402356004)
 
Monarch Initiative: MONDO:0020547
Orphanet: ORPHA99921

Definition

A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, and may affect multiple organs with manifestations similar to autoimmune diseases. The onset is usually within three years of transplantation or immunologic manipulation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic graft versus host disease
Follow this link to review classifications for Chronic graft versus host disease in Orphanet.

Professional guidelines

PubMed

Management of adverse effects/toxicity of ibrutinib.
Paydas S
Crit Rev Oncol Hematol 2019 Apr;136:56-63. Epub 2019 Feb 10 doi: 10.1016/j.critrevonc.2019.02.001. PMID: 30878129
Diagnosis and treatment of bronchiolitis obliterans syndrome accessible universally.
Hakim A, Cooke KR, Pavletic SZ, Khalid M, Williams KM, Hashmi SK
Bone Marrow Transplant 2019 Mar;54(3):383-392. Epub 2018 Jul 23 doi: 10.1038/s41409-018-0266-6. PMID: 30038355
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article

Recent clinical studies

Etiology

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report.
Kitko CL, Pidala J, Schoemans HM, Lawitschka A, Flowers ME, Cowen EW, Tkaczyk E, Farhadfar N, Jain S, Steven P, Luo ZK, Ogawa Y, Stern M, Yanik GA, Cuvelier GDE, Cheng GS, Holtan SG, Schultz KR, Martin PJ, Lee SJ, Pavletic SZ, Wolff D, Paczesny S, Blazar BR, Sarantopoulos S, Socie G, Greinix H, Cutler C
Transplant Cell Ther 2021 Jul;27(7):545-557. Epub 2021 Apr 9 doi: 10.1016/j.jtct.2021.03.033. PMID: 33839317Free PMC Article
Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets.
Zeiser R, Blazar BR
N Engl J Med 2017 Dec 28;377(26):2565-2579. doi: 10.1056/NEJMra1703472. PMID: 29281578
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article
How we treat chronic graft-versus-host disease.
Flowers ME, Martin PJ
Blood 2015 Jan 22;125(4):606-15. Epub 2014 Nov 14 doi: 10.1182/blood-2014-08-551994. PMID: 25398933Free PMC Article
Graft-versus-host disease.
Parkman R
Annu Rev Med 1991;42:189-97. doi: 10.1146/annurev.me.42.020191.001201. PMID: 2035965

Diagnosis

Updates in chronic graft-versus-host disease.
Hamilton BK
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):648-654. doi: 10.1182/hematology.2021000301. PMID: 34889364Free PMC Article
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report.
Kitko CL, Pidala J, Schoemans HM, Lawitschka A, Flowers ME, Cowen EW, Tkaczyk E, Farhadfar N, Jain S, Steven P, Luo ZK, Ogawa Y, Stern M, Yanik GA, Cuvelier GDE, Cheng GS, Holtan SG, Schultz KR, Martin PJ, Lee SJ, Pavletic SZ, Wolff D, Paczesny S, Blazar BR, Sarantopoulos S, Socie G, Greinix H, Cutler C
Transplant Cell Ther 2021 Jul;27(7):545-557. Epub 2021 Apr 9 doi: 10.1016/j.jtct.2021.03.033. PMID: 33839317Free PMC Article
How I treat acquired aplastic anemia.
Bacigalupo A
Blood 2017 Mar 16;129(11):1428-1436. Epub 2017 Jan 17 doi: 10.1182/blood-2016-08-693481. PMID: 28096088
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article
How we treat chronic graft-versus-host disease.
Flowers ME, Martin PJ
Blood 2015 Jan 22;125(4):606-15. Epub 2014 Nov 14 doi: 10.1182/blood-2014-08-551994. PMID: 25398933Free PMC Article

Therapy

Novel Approaches to the Treatment of Chronic Graft-Versus-Host Disease.
Zeiser R
J Clin Oncol 2023 Apr 1;41(10):1820-1824. Epub 2023 Feb 17 doi: 10.1200/JCO.22.02256. PMID: 36800551
Updates in chronic graft-versus-host disease.
Hamilton BK
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):648-654. doi: 10.1182/hematology.2021000301. PMID: 34889364Free PMC Article
Belumosudil for chronic graft-versus-host disease after 2 or more prior lines of therapy: the ROCKstar Study.
Cutler C, Lee SJ, Arai S, Rotta M, Zoghi B, Lazaryan A, Ramakrishnan A, DeFilipp Z, Salhotra A, Chai-Ho W, Mehta R, Wang T, Arora M, Pusic I, Saad A, Shah NN, Abhyankar S, Bachier C, Galvin J, Im A, Langston A, Liesveld J, Juckett M, Logan A, Schachter L, Alavi A, Howard D, Waksal HW, Ryan J, Eiznhamer D, Aggarwal SK, Ieyoub J, Schueller O, Green L, Yang Z, Krenz H, Jagasia M, Blazar BR, Pavletic S
Blood 2021 Dec 2;138(22):2278-2289. doi: 10.1182/blood.2021012021. PMID: 34265047Free PMC Article
Bruton Tyrosine Kinase Inhibitors: Present and Future.
Burger JA
Cancer J 2019 Nov/Dec;25(6):386-393. doi: 10.1097/PPO.0000000000000412. PMID: 31764119Free PMC Article
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article

Prognosis

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report.
Wolff D, Radojcic V, Lafyatis R, Cinar R, Rosenstein RK, Cowen EW, Cheng GS, Sheshadri A, Bergeron A, Williams KM, Todd JL, Teshima T, Cuvelier GDE, Holler E, McCurdy SR, Jenq RR, Hanash AM, Jacobsohn D, Santomasso BD, Jain S, Ogawa Y, Steven P, Luo ZK, Dietrich-Ntoukas T, Saban D, Bilic E, Penack O, Griffith LM, Cowden M, Martin PJ, Greinix HT, Sarantopoulos S, Socie G, Blazar BR, Pidala J, Kitko CL, Couriel DR, Cutler C, Schultz KR, Pavletic SZ, Lee SJ, Paczesny S
Transplant Cell Ther 2021 Oct;27(10):817-835. Epub 2021 Jun 10 doi: 10.1016/j.jtct.2021.06.001. PMID: 34217703Free PMC Article
Posttransplant cyclophosphamide is associated with increased cytomegalovirus infection: a CIBMTR analysis.
Goldsmith SR, Abid MB, Auletta JJ, Bashey A, Beitinjaneh A, Castillo P, Chemaly RF, Chen M, Ciurea S, Dandoy CE, Díaz MÁ, Fuchs E, Ganguly S, Kanakry CG, Kanakry JA, Kim S, Komanduri KV, Krem MM, Lazarus HM, Liu H, Ljungman P, Masiarz R, Mulroney C, Nathan S, Nishihori T, Page KM, Perales MA, Taplitz R, Romee R, Riches M
Blood 2021 Jun 10;137(23):3291-3305. doi: 10.1182/blood.2020009362. PMID: 33657221Free PMC Article
Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets.
Zeiser R, Blazar BR
N Engl J Med 2017 Dec 28;377(26):2565-2579. doi: 10.1056/NEJMra1703472. PMID: 29281578
Graft-versus-host disease management.
Mistrik M, Bojtarova E, Sopko L, Masakova L, Roziakova L, Martinka J, Batorova A
Bratisl Lek Listy 2016;117(7):388-96. doi: 10.4149/bll_2016_077. PMID: 27546540
How we treat chronic graft-versus-host disease.
Flowers ME, Martin PJ
Blood 2015 Jan 22;125(4):606-15. Epub 2014 Nov 14 doi: 10.1182/blood-2014-08-551994. PMID: 25398933Free PMC Article

Clinical prediction guides

Ibrutinib for First-Line Treatment of Chronic Graft-Versus-Host Disease: Results From the Randomized Phase III iNTEGRATE Study.
Miklos DB, Abu Zaid M, Cooney JP, Albring JC, Flowers M, Skarbnik AP, Yakoub-Agha I, Ko BS, Bruno B, Waller EK, Yared J, Sohn SK, Bulabois CE, Teshima T, Jacobsohn D, Greinix H, Mokatrin A, Lee Y, Wahlstrom JT, Styles L, Socie G
J Clin Oncol 2023 Apr 1;41(10):1876-1887. Epub 2023 Jan 6 doi: 10.1200/JCO.22.00509. PMID: 36608310Free PMC Article
SGK1, a Critical Regulator of Immune Modulation and Fibrosis and a Potential Therapeutic Target in Chronic Graft-Versus-Host Disease.
Lu RQ, Zhang YY, Zhao HQ, Guo RQ, Jiang ZX, Guo R
Front Immunol 2022;13:822303. Epub 2022 Feb 10 doi: 10.3389/fimmu.2022.822303. PMID: 35222400Free PMC Article
Belumosudil for chronic graft-versus-host disease after 2 or more prior lines of therapy: the ROCKstar Study.
Cutler C, Lee SJ, Arai S, Rotta M, Zoghi B, Lazaryan A, Ramakrishnan A, DeFilipp Z, Salhotra A, Chai-Ho W, Mehta R, Wang T, Arora M, Pusic I, Saad A, Shah NN, Abhyankar S, Bachier C, Galvin J, Im A, Langston A, Liesveld J, Juckett M, Logan A, Schachter L, Alavi A, Howard D, Waksal HW, Ryan J, Eiznhamer D, Aggarwal SK, Ieyoub J, Schueller O, Green L, Yang Z, Krenz H, Jagasia M, Blazar BR, Pavletic S
Blood 2021 Dec 2;138(22):2278-2289. doi: 10.1182/blood.2021012021. PMID: 34265047Free PMC Article
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report.
Kitko CL, Pidala J, Schoemans HM, Lawitschka A, Flowers ME, Cowen EW, Tkaczyk E, Farhadfar N, Jain S, Steven P, Luo ZK, Ogawa Y, Stern M, Yanik GA, Cuvelier GDE, Cheng GS, Holtan SG, Schultz KR, Martin PJ, Lee SJ, Pavletic SZ, Wolff D, Paczesny S, Blazar BR, Sarantopoulos S, Socie G, Greinix H, Cutler C
Transplant Cell Ther 2021 Jul;27(7):545-557. Epub 2021 Apr 9 doi: 10.1016/j.jtct.2021.03.033. PMID: 33839317Free PMC Article
Steroid Refractory Chronic Graft-Versus-Host Disease: Cost-Effectiveness Analysis.
Yalniz FF, Murad MH, Lee SJ, Pavletic SZ, Khera N, Shah ND, Hashmi SK
Biol Blood Marrow Transplant 2018 Sep;24(9):1920-1927. Epub 2018 Mar 14 doi: 10.1016/j.bbmt.2018.03.008. PMID: 29550629Free PMC Article

Recent systematic reviews

Chronic graft-versus-recipient disease: Systematic review of joint and fascial involvement.
Hidalgo Calleja C, Sánchez González MD, Medina Luezas J, López Corral L
Reumatol Clin (Engl Ed) 2023 May;19(5):235-243. Epub 2023 Apr 20 doi: 10.1016/j.reumae.2023.04.001. PMID: 37087381
Efficacy and safety of ruxolitinib in steroid-refractory graft-versus-host disease: A meta-analysis.
Fan S, Huo WX, Yang Y, Shen MZ, Mo XD
Front Immunol 2022;13:954268. Epub 2022 Aug 4 doi: 10.3389/fimmu.2022.954268. PMID: 35990629Free PMC Article
Chronic graft-versus-host disease presenting as acute polymyositis: A case series and systematic review.
Shahzad M, Chaudhary SG, Basit A, Thellman C, Rodriguez L, Abhyankar SH, McGuirk JP, Mushtaq MU
Transpl Immunol 2022 Feb;70:101520. Epub 2021 Dec 22 doi: 10.1016/j.trim.2021.101520. PMID: 34952168
Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection.
Moscicki AB, Flowers L, Huchko MJ, Long ME, MacLaughlin KL, Murphy J, Spiryda LB, Gold MA
J Low Genit Tract Dis 2019 Apr;23(2):87-101. doi: 10.1097/LGT.0000000000000468. PMID: 30907775
Efficacy of rituximab in the setting of steroid-refractory chronic graft-versus-host disease: a systematic review and meta-analysis.
Kharfan-Dabaja MA, Mhaskar AR, Djulbegovic B, Cutler C, Mohty M, Kumar A
Biol Blood Marrow Transplant 2009 Sep;15(9):1005-13. Epub 2009 Jun 10 doi: 10.1016/j.bbmt.2009.04.003. PMID: 19660713

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