U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Chronic graft versus host disease

MedGen UID:
167851
•Concept ID:
C0867389
•
Disease or Syndrome
Synonyms: Chronic Graft Versus Host Disease; Chronic Graft-Versus-Host Disease; Chronic Graft-Versus-Host Diseases; Disease, Chronic Graft-Versus-Host; Graft-Versus-Host Disease, Chronic; Graft-Versus-Host Diseases, Chronic
SNOMED CT: Chronic graft-versus-host disease (402356004); Chronic graft versus host disease (402356004)
 
Monarch Initiative: MONDO:0020547
Orphanet: ORPHA99921

Definition

A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, and may affect multiple organs with manifestations similar to autoimmune diseases. The onset is usually within three years of transplantation or immunologic manipulation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic graft versus host disease
Follow this link to review classifications for Chronic graft versus host disease in Orphanet.

Professional guidelines

PubMed

Novel Approaches to the Treatment of Chronic Graft-Versus-Host Disease.
Zeiser R
J Clin Oncol 2023 Apr 1;41(10):1820-1824. Epub 2023 Feb 17 doi: 10.1200/JCO.22.02256. PMID: 36800551
Management of adverse effects/toxicity of ibrutinib.
Paydas S
Crit Rev Oncol Hematol 2019 Apr;136:56-63. Epub 2019 Feb 10 doi: 10.1016/j.critrevonc.2019.02.001. PMID: 30878129
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article

Recent clinical studies

Etiology

National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report.
Kitko CL, Pidala J, Schoemans HM, Lawitschka A, Flowers ME, Cowen EW, Tkaczyk E, Farhadfar N, Jain S, Steven P, Luo ZK, Ogawa Y, Stern M, Yanik GA, Cuvelier GDE, Cheng GS, Holtan SG, Schultz KR, Martin PJ, Lee SJ, Pavletic SZ, Wolff D, Paczesny S, Blazar BR, Sarantopoulos S, Socie G, Greinix H, Cutler C
Transplant Cell Ther 2021 Jul;27(7):545-557. Epub 2021 Apr 9 doi: 10.1016/j.jtct.2021.03.033. PMID: 33839317Free PMC Article
Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets.
Zeiser R, Blazar BR
N Engl J Med 2017 Dec 28;377(26):2565-2579. doi: 10.1056/NEJMra1703472. PMID: 29281578
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article
How we treat chronic graft-versus-host disease.
Flowers ME, Martin PJ
Blood 2015 Jan 22;125(4):606-15. Epub 2014 Nov 14 doi: 10.1182/blood-2014-08-551994. PMID: 25398933Free PMC Article
Chronic graft-versus-host disease.
Horwitz ME, Sullivan KM
Blood Rev 2006 Jan;20(1):15-27. Epub 2005 Apr 7 doi: 10.1016/j.blre.2005.01.007. PMID: 16426941

Diagnosis

Chronic graft-versus-host disease. Part I: Epidemiology, pathogenesis, and clinical manifestations.
Baumrin E, Loren AW, Falk SJ, Mays JW, Cowen EW
J Am Acad Dermatol 2024 Jan;90(1):1-16. Epub 2022 Dec 23 doi: 10.1016/j.jaad.2022.12.024. PMID: 36572065Free PMC Article
Novel Approaches to the Treatment of Chronic Graft-Versus-Host Disease.
Zeiser R
J Clin Oncol 2023 Apr 1;41(10):1820-1824. Epub 2023 Feb 17 doi: 10.1200/JCO.22.02256. PMID: 36800551
Updates in chronic graft-versus-host disease.
Hamilton BK
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):648-654. doi: 10.1182/hematology.2021000301. PMID: 34889364Free PMC Article
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article
How we treat chronic graft-versus-host disease.
Flowers ME, Martin PJ
Blood 2015 Jan 22;125(4):606-15. Epub 2014 Nov 14 doi: 10.1182/blood-2014-08-551994. PMID: 25398933Free PMC Article

Therapy

Chronic graft-versus-host disease. Part I: Epidemiology, pathogenesis, and clinical manifestations.
Baumrin E, Loren AW, Falk SJ, Mays JW, Cowen EW
J Am Acad Dermatol 2024 Jan;90(1):1-16. Epub 2022 Dec 23 doi: 10.1016/j.jaad.2022.12.024. PMID: 36572065Free PMC Article
Novel Approaches to the Treatment of Chronic Graft-Versus-Host Disease.
Zeiser R
J Clin Oncol 2023 Apr 1;41(10):1820-1824. Epub 2023 Feb 17 doi: 10.1200/JCO.22.02256. PMID: 36800551
Updates in chronic graft-versus-host disease.
Hamilton BK
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):648-654. doi: 10.1182/hematology.2021000301. PMID: 34889364Free PMC Article
Belumosudil for chronic graft-versus-host disease after 2 or more prior lines of therapy: the ROCKstar Study.
Cutler C, Lee SJ, Arai S, Rotta M, Zoghi B, Lazaryan A, Ramakrishnan A, DeFilipp Z, Salhotra A, Chai-Ho W, Mehta R, Wang T, Arora M, Pusic I, Saad A, Shah NN, Abhyankar S, Bachier C, Galvin J, Im A, Langston A, Liesveld J, Juckett M, Logan A, Schachter L, Alavi A, Howard D, Waksal HW, Ryan J, Eiznhamer D, Aggarwal SK, Ieyoub J, Schueller O, Green L, Yang Z, Krenz H, Jagasia M, Blazar BR, Pavletic S
Blood 2021 Dec 2;138(22):2278-2289. doi: 10.1182/blood.2021012021. PMID: 34265047Free PMC Article
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article

Prognosis

Posttransplant cyclophosphamide is associated with increased cytomegalovirus infection: a CIBMTR analysis.
Goldsmith SR, Abid MB, Auletta JJ, Bashey A, Beitinjaneh A, Castillo P, Chemaly RF, Chen M, Ciurea S, Dandoy CE, Díaz MÁ, Fuchs E, Ganguly S, Kanakry CG, Kanakry JA, Kim S, Komanduri KV, Krem MM, Lazarus HM, Liu H, Ljungman P, Masiarz R, Mulroney C, Nathan S, Nishihori T, Page KM, Perales MA, Taplitz R, Romee R, Riches M
Blood 2021 Jun 10;137(23):3291-3305. doi: 10.1182/blood.2020009362. PMID: 33657221Free PMC Article
Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets.
Zeiser R, Blazar BR
N Engl J Med 2017 Dec 28;377(26):2565-2579. doi: 10.1056/NEJMra1703472. PMID: 29281578
Graft-versus-host disease management.
Mistrik M, Bojtarova E, Sopko L, Masakova L, Roziakova L, Martinka J, Batorova A
Bratisl Lek Listy 2016;117(7):388-96. doi: 10.4149/bll_2016_077. PMID: 27546540
How we treat chronic graft-versus-host disease.
Flowers ME, Martin PJ
Blood 2015 Jan 22;125(4):606-15. Epub 2014 Nov 14 doi: 10.1182/blood-2014-08-551994. PMID: 25398933Free PMC Article
Chronic graft-versus-host disease (GVHD) in children.
Baird K, Cooke K, Schultz KR
Pediatr Clin North Am 2010 Feb;57(1):297-322. doi: 10.1016/j.pcl.2009.11.003. PMID: 20307722Free PMC Article

Clinical prediction guides

Ibrutinib for First-Line Treatment of Chronic Graft-Versus-Host Disease: Results From the Randomized Phase III iNTEGRATE Study.
Miklos DB, Abu Zaid M, Cooney JP, Albring JC, Flowers M, Skarbnik AP, Yakoub-Agha I, Ko BS, Bruno B, Waller EK, Yared J, Sohn SK, Bulabois CE, Teshima T, Jacobsohn D, Greinix H, Mokatrin A, Lee Y, Wahlstrom JT, Styles L, Socie G
J Clin Oncol 2023 Apr 1;41(10):1876-1887. Epub 2023 Jan 6 doi: 10.1200/JCO.22.00509. PMID: 36608310Free PMC Article
Clinical response to belumosudil in bronchiolitis obliterans syndrome: a combined analysis from 2 prospective trials.
DeFilipp Z, Kim HT, Yang Z, Noonan J, Blazar BR, Lee SJ, Pavletic SZ, Cutler C
Blood Adv 2022 Dec 27;6(24):6263-6270. doi: 10.1182/bloodadvances.2022008095. PMID: 36083121Free PMC Article
Belumosudil for chronic graft-versus-host disease after 2 or more prior lines of therapy: the ROCKstar Study.
Cutler C, Lee SJ, Arai S, Rotta M, Zoghi B, Lazaryan A, Ramakrishnan A, DeFilipp Z, Salhotra A, Chai-Ho W, Mehta R, Wang T, Arora M, Pusic I, Saad A, Shah NN, Abhyankar S, Bachier C, Galvin J, Im A, Langston A, Liesveld J, Juckett M, Logan A, Schachter L, Alavi A, Howard D, Waksal HW, Ryan J, Eiznhamer D, Aggarwal SK, Ieyoub J, Schueller O, Green L, Yang Z, Krenz H, Jagasia M, Blazar BR, Pavletic S
Blood 2021 Dec 2;138(22):2278-2289. doi: 10.1182/blood.2021012021. PMID: 34265047Free PMC Article
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report.
Kitko CL, Pidala J, Schoemans HM, Lawitschka A, Flowers ME, Cowen EW, Tkaczyk E, Farhadfar N, Jain S, Steven P, Luo ZK, Ogawa Y, Stern M, Yanik GA, Cuvelier GDE, Cheng GS, Holtan SG, Schultz KR, Martin PJ, Lee SJ, Pavletic SZ, Wolff D, Paczesny S, Blazar BR, Sarantopoulos S, Socie G, Greinix H, Cutler C
Transplant Cell Ther 2021 Jul;27(7):545-557. Epub 2021 Apr 9 doi: 10.1016/j.jtct.2021.03.033. PMID: 33839317Free PMC Article
Obliterative Bronchiolitis.
Aguilar PR, Michelson AP, Isakow W
Transplantation 2016 Feb;100(2):272-83. doi: 10.1097/TP.0000000000000892. PMID: 26335918

Recent systematic reviews

Efficacy and Safety of Ibrutinib for Chronic Graft-Versus-Host Disease: A Systematic Review.
Santosa D, Rizky D, Tandarto K, Kartiyani I, Yunarvika V, Ardini DNE, Setiawan B, Pangarsa EA, Suharti C
Asian Pac J Cancer Prev 2023 Dec 1;24(12):4025-4033. doi: 10.31557/APJCP.2023.24.12.4025. PMID: 38156834Free PMC Article
Chronic graft-versus-recipient disease: Systematic review of joint and fascial involvement.
Hidalgo Calleja C, Sánchez González MD, Medina Luezas J, López Corral L
Reumatol Clin (Engl Ed) 2023 May;19(5):235-243. Epub 2023 Apr 20 doi: 10.1016/j.reumae.2023.04.001. PMID: 37087381
Efficacy and safety of ruxolitinib in steroid-refractory graft-versus-host disease: A meta-analysis.
Fan S, Huo WX, Yang Y, Shen MZ, Mo XD
Front Immunol 2022;13:954268. Epub 2022 Aug 4 doi: 10.3389/fimmu.2022.954268. PMID: 35990629Free PMC Article
Chronic graft-versus-host disease presenting as acute polymyositis: A case series and systematic review.
Shahzad M, Chaudhary SG, Basit A, Thellman C, Rodriguez L, Abhyankar SH, McGuirk JP, Mushtaq MU
Transpl Immunol 2022 Feb;70:101520. Epub 2021 Dec 22 doi: 10.1016/j.trim.2021.101520. PMID: 34952168
Guidelines for Cervical Cancer Screening in Immunosuppressed Women Without HIV Infection.
Moscicki AB, Flowers L, Huchko MJ, Long ME, MacLaughlin KL, Murphy J, Spiryda LB, Gold MA
J Low Genit Tract Dis 2019 Apr;23(2):87-101. doi: 10.1097/LGT.0000000000000468. PMID: 30907775

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...