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Chronic graft versus host disease

MedGen UID:
167851
Concept ID:
C0867389
Disease or Syndrome
Synonyms: Chronic Graft Versus Host Disease; Chronic Graft-Versus-Host Disease; Chronic Graft-Versus-Host Diseases; Disease, Chronic Graft-Versus-Host; Graft-Versus-Host Disease, Chronic; Graft-Versus-Host Diseases, Chronic
SNOMED CT: Chronic graft-versus-host disease (402356004); Chronic graft versus host disease (402356004)
 
Monarch Initiative: MONDO:0020547
Orphanet: ORPHA99921

Definition

A syndrome of immunologically mediated tissue damage that may occur following an allogeneic transplant, and may affect multiple organs with manifestations similar to autoimmune diseases. The onset is usually within three years of transplantation or immunologic manipulation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVChronic graft versus host disease
Follow this link to review classifications for Chronic graft versus host disease in Orphanet.

Professional guidelines

PubMed

Malard F, Mohty M
Am J Hematol 2023 Oct;98(10):1637-1644. Epub 2023 Jul 22 doi: 10.1002/ajh.27040. PMID: 37483142
Zeiser R
J Clin Oncol 2023 Apr 1;41(10):1820-1824. Epub 2023 Feb 17 doi: 10.1200/JCO.22.02256. PMID: 36800551
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article

Recent clinical studies

Etiology

Kitko CL, Pidala J, Schoemans HM, Lawitschka A, Flowers ME, Cowen EW, Tkaczyk E, Farhadfar N, Jain S, Steven P, Luo ZK, Ogawa Y, Stern M, Yanik GA, Cuvelier GDE, Cheng GS, Holtan SG, Schultz KR, Martin PJ, Lee SJ, Pavletic SZ, Wolff D, Paczesny S, Blazar BR, Sarantopoulos S, Socie G, Greinix H, Cutler C
Transplant Cell Ther 2021 Jul;27(7):545-557. Epub 2021 Apr 9 doi: 10.1016/j.jtct.2021.03.033. PMID: 33839317Free PMC Article
Zeiser R, Blazar BR
N Engl J Med 2017 Dec 28;377(26):2565-2579. doi: 10.1056/NEJMra1703472. PMID: 29281578
Lee SJ, Wolff D, Kitko C, Koreth J, Inamoto Y, Jagasia M, Pidala J, Olivieri A, Martin PJ, Przepiorka D, Pusic I, Dignan F, Mitchell SA, Lawitschka A, Jacobsohn D, Hall AM, Flowers ME, Schultz KR, Vogelsang G, Pavletic S
Biol Blood Marrow Transplant 2015 Jun;21(6):984-99. Epub 2015 Mar 19 doi: 10.1016/j.bbmt.2015.02.025. PMID: 25796139Free PMC Article
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article
Flowers ME, Martin PJ
Blood 2015 Jan 22;125(4):606-15. Epub 2014 Nov 14 doi: 10.1182/blood-2014-08-551994. PMID: 25398933Free PMC Article

Diagnosis

Baumrin E, Loren AW, Falk SJ, Mays JW, Cowen EW
J Am Acad Dermatol 2024 Jan;90(1):1-16. Epub 2022 Dec 23 doi: 10.1016/j.jaad.2022.12.024. PMID: 36572065Free PMC Article
Zeiser R
J Clin Oncol 2023 Apr 1;41(10):1820-1824. Epub 2023 Feb 17 doi: 10.1200/JCO.22.02256. PMID: 36800551
Hamilton BK
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):648-654. doi: 10.1182/hematology.2021000301. PMID: 34889364Free PMC Article
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article
Flowers ME, Martin PJ
Blood 2015 Jan 22;125(4):606-15. Epub 2014 Nov 14 doi: 10.1182/blood-2014-08-551994. PMID: 25398933Free PMC Article

Therapy

Malard F, Mohty M
Am J Hematol 2023 Oct;98(10):1637-1644. Epub 2023 Jul 22 doi: 10.1002/ajh.27040. PMID: 37483142
Zeiser R
J Clin Oncol 2023 Apr 1;41(10):1820-1824. Epub 2023 Feb 17 doi: 10.1200/JCO.22.02256. PMID: 36800551
Hamilton BK
Hematology Am Soc Hematol Educ Program 2021 Dec 10;2021(1):648-654. doi: 10.1182/hematology.2021000301. PMID: 34889364Free PMC Article
Cutler C, Lee SJ, Arai S, Rotta M, Zoghi B, Lazaryan A, Ramakrishnan A, DeFilipp Z, Salhotra A, Chai-Ho W, Mehta R, Wang T, Arora M, Pusic I, Saad A, Shah NN, Abhyankar S, Bachier C, Galvin J, Im A, Langston A, Liesveld J, Juckett M, Logan A, Schachter L, Alavi A, Howard D, Waksal HW, Ryan J, Eiznhamer D, Aggarwal SK, Ieyoub J, Schueller O, Green L, Yang Z, Krenz H, Jagasia M, Blazar BR, Pavletic S
Blood 2021 Dec 2;138(22):2278-2289. doi: 10.1182/blood.2021012021. PMID: 34265047Free PMC Article
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article

Prognosis

Goldsmith SR, Abid MB, Auletta JJ, Bashey A, Beitinjaneh A, Castillo P, Chemaly RF, Chen M, Ciurea S, Dandoy CE, Díaz MÁ, Fuchs E, Ganguly S, Kanakry CG, Kanakry JA, Kim S, Komanduri KV, Krem MM, Lazarus HM, Liu H, Ljungman P, Masiarz R, Mulroney C, Nathan S, Nishihori T, Page KM, Perales MA, Taplitz R, Romee R, Riches M
Blood 2021 Jun 10;137(23):3291-3305. doi: 10.1182/blood.2020009362. PMID: 33657221Free PMC Article
Zeiser R, Blazar BR
N Engl J Med 2017 Dec 28;377(26):2565-2579. doi: 10.1056/NEJMra1703472. PMID: 29281578
Mistrik M, Bojtarova E, Sopko L, Masakova L, Roziakova L, Martinka J, Batorova A
Bratisl Lek Listy 2016;117(7):388-96. doi: 10.4149/bll_2016_077. PMID: 27546540
Flowers ME, Martin PJ
Blood 2015 Jan 22;125(4):606-15. Epub 2014 Nov 14 doi: 10.1182/blood-2014-08-551994. PMID: 25398933Free PMC Article
Baird K, Cooke K, Schultz KR
Pediatr Clin North Am 2010 Feb;57(1):297-322. doi: 10.1016/j.pcl.2009.11.003. PMID: 20307722Free PMC Article

Clinical prediction guides

Miklos DB, Abu Zaid M, Cooney JP, Albring JC, Flowers M, Skarbnik AP, Yakoub-Agha I, Ko BS, Bruno B, Waller EK, Yared J, Sohn SK, Bulabois CE, Teshima T, Jacobsohn D, Greinix H, Mokatrin A, Lee Y, Wahlstrom JT, Styles L, Socie G
J Clin Oncol 2023 Apr 1;41(10):1876-1887. Epub 2023 Jan 6 doi: 10.1200/JCO.22.00509. PMID: 36608310Free PMC Article
DeFilipp Z, Kim HT, Yang Z, Noonan J, Blazar BR, Lee SJ, Pavletic SZ, Cutler C
Blood Adv 2022 Dec 27;6(24):6263-6270. doi: 10.1182/bloodadvances.2022008095. PMID: 36083121Free PMC Article
Cutler C, Lee SJ, Arai S, Rotta M, Zoghi B, Lazaryan A, Ramakrishnan A, DeFilipp Z, Salhotra A, Chai-Ho W, Mehta R, Wang T, Arora M, Pusic I, Saad A, Shah NN, Abhyankar S, Bachier C, Galvin J, Im A, Langston A, Liesveld J, Juckett M, Logan A, Schachter L, Alavi A, Howard D, Waksal HW, Ryan J, Eiznhamer D, Aggarwal SK, Ieyoub J, Schueller O, Green L, Yang Z, Krenz H, Jagasia M, Blazar BR, Pavletic S
Blood 2021 Dec 2;138(22):2278-2289. doi: 10.1182/blood.2021012021. PMID: 34265047Free PMC Article
Kitko CL, Pidala J, Schoemans HM, Lawitschka A, Flowers ME, Cowen EW, Tkaczyk E, Farhadfar N, Jain S, Steven P, Luo ZK, Ogawa Y, Stern M, Yanik GA, Cuvelier GDE, Cheng GS, Holtan SG, Schultz KR, Martin PJ, Lee SJ, Pavletic SZ, Wolff D, Paczesny S, Blazar BR, Sarantopoulos S, Socie G, Greinix H, Cutler C
Transplant Cell Ther 2021 Jul;27(7):545-557. Epub 2021 Apr 9 doi: 10.1016/j.jtct.2021.03.033. PMID: 33839317Free PMC Article
Aguilar PR, Michelson AP, Isakow W
Transplantation 2016 Feb;100(2):272-83. doi: 10.1097/TP.0000000000000892. PMID: 26335918

Recent systematic reviews

Baccelli F, Gottardi F, Muratore E, Leardini D, Grasso AG, Gori D, Belotti T, Prete A, Masetti R
Bone Marrow Transplant 2024 Jun;59(6):765-776. Epub 2024 Feb 24 doi: 10.1038/s41409-024-02252-z. PMID: 38402346Free PMC Article
Santosa D, Rizky D, Tandarto K, Kartiyani I, Yunarvika V, Ardini DNE, Setiawan B, Pangarsa EA, Suharti C
Asian Pac J Cancer Prev 2023 Dec 1;24(12):4025-4033. doi: 10.31557/APJCP.2023.24.12.4025. PMID: 38156834Free PMC Article
Hidalgo Calleja C, Sánchez González MD, Medina Luezas J, López Corral L
Reumatol Clin (Engl Ed) 2023 May;19(5):235-243. Epub 2023 Apr 20 doi: 10.1016/j.reumae.2023.04.001. PMID: 37087381
Fan S, Huo WX, Yang Y, Shen MZ, Mo XD
Front Immunol 2022;13:954268. Epub 2022 Aug 4 doi: 10.3389/fimmu.2022.954268. PMID: 35990629Free PMC Article
Moscicki AB, Flowers L, Huchko MJ, Long ME, MacLaughlin KL, Murphy J, Spiryda LB, Gold MA
J Low Genit Tract Dis 2019 Apr;23(2):87-101. doi: 10.1097/LGT.0000000000000468. PMID: 30907775

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