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Metastatic Bladder Giant Cell Urothelial Carcinoma

MedGen UID:
1679881
•Concept ID:
C4763841
•
Neoplastic Process
Synonyms: Metastatic Giant Cell Bladder Urothelial Carcinoma; Metastatic Giant Cell Urothelial Carcinoma of the Bladder; Metastatic Infiltrating Bladder Urothelial Carcinoma with Giant Cells; Metastatic Invasive Bladder Urothelial Carcinoma with Giant Cells

Definition

Bladder giant cell urothelial carcinoma that has spread to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Bladder Giant Cell Urothelial Carcinoma

Recent clinical studies

Etiology

Clinicopathological characteristics of ypT0N0 urothelial carcinoma following neoadjuvant chemotherapy and cystectomy.
Magers MJ, Kaimakliotis HZ, Barboza MP, Bandali E, Adra N, Koch MO, Cheng L
J Clin Pathol 2019 Aug;72(8):550-553. Epub 2019 Jun 4 doi: 10.1136/jclinpath-2019-205742. PMID: 31164444
Value of uroplakin III in distinguishing variants of primary bladder urothelial carcinoma from malignancy metastatic to the urinary bladder.
Klopfer K, Delahunt B, Adamson M, Samaratunga H
Anticancer Res 2014 Nov;34(11):6779-84. PMID: 25368291
The spectrum of histopathologic findings in vesical diverticulum: implications for pathogenesis and staging.
Idrees MT, Alexander RE, Kum JB, Cheng L
Hum Pathol 2013 Jul;44(7):1223-32. Epub 2013 Jan 31 doi: 10.1016/j.humpath.2012.11.005. PMID: 23375647
Large cell neuroendocrine carcinoma of the urinary bladder with lymphoepithelioma-like features.
Dundr P, Pesl M, Povýsil C, Vítková I, Dvorácek J
Pathol Res Pract 2003;199(8):559-63. doi: 10.1078/0344-0338-00462. PMID: 14533941

Diagnosis

Value of uroplakin III in distinguishing variants of primary bladder urothelial carcinoma from malignancy metastatic to the urinary bladder.
Klopfer K, Delahunt B, Adamson M, Samaratunga H
Anticancer Res 2014 Nov;34(11):6779-84. PMID: 25368291
Is GATA3 expression maintained in regional metastases?: a study of paired primary and metastatic urothelial carcinomas.
Zhao L, Antic T, Witten D, Paner GP, Taxy JB, Husain A, Gwin K, Mirza MK, Lingen MW, Tretiakova MS
Am J Surg Pathol 2013 Dec;37(12):1876-81. doi: 10.1097/PAS.0b013e31829e2525. PMID: 24121175
Polyomavirus (BK)-associated pleomorphic giant cell carcinoma of the urinary bladder: a case report.
Alexiev BA, Papadimitriou JC, Chai TC, Ramos E, Staats PN, Drachenberg CB
Pathol Res Pract 2013 Apr;209(4):255-9. Epub 2013 Mar 6 doi: 10.1016/j.prp.2013.01.008. PMID: 23481349
Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics.
Shanks JH, Iczkowski KA
Histopathology 2009 Jun;54(7):885-900. Epub 2008 Oct 30 doi: 10.1111/j.1365-2559.2008.03167.x. PMID: 19178589
Large cell neuroendocrine carcinoma of the urinary bladder with lymphoepithelioma-like features.
Dundr P, Pesl M, Povýsil C, Vítková I, Dvorácek J
Pathol Res Pract 2003;199(8):559-63. doi: 10.1078/0344-0338-00462. PMID: 14533941

Therapy

Clinicopathological characteristics of ypT0N0 urothelial carcinoma following neoadjuvant chemotherapy and cystectomy.
Magers MJ, Kaimakliotis HZ, Barboza MP, Bandali E, Adra N, Koch MO, Cheng L
J Clin Pathol 2019 Aug;72(8):550-553. Epub 2019 Jun 4 doi: 10.1136/jclinpath-2019-205742. PMID: 31164444
Polyomavirus (BK)-associated pleomorphic giant cell carcinoma of the urinary bladder: a case report.
Alexiev BA, Papadimitriou JC, Chai TC, Ramos E, Staats PN, Drachenberg CB
Pathol Res Pract 2013 Apr;209(4):255-9. Epub 2013 Mar 6 doi: 10.1016/j.prp.2013.01.008. PMID: 23481349
Epithelioid cell granulomas in urine cytology smears: Same cause, different implications.
Arora SK, Gupta N, Nijhawan R, Mandal AK
Diagn Cytopathol 2010 Oct;38(10):765-7. doi: 10.1002/dc.21327. PMID: 20187110
Large cell neuroendocrine carcinoma of the urinary bladder with lymphoepithelioma-like features.
Dundr P, Pesl M, Povýsil C, Vítková I, Dvorácek J
Pathol Res Pract 2003;199(8):559-63. doi: 10.1078/0344-0338-00462. PMID: 14533941

Prognosis

Clinicopathological characteristics of ypT0N0 urothelial carcinoma following neoadjuvant chemotherapy and cystectomy.
Magers MJ, Kaimakliotis HZ, Barboza MP, Bandali E, Adra N, Koch MO, Cheng L
J Clin Pathol 2019 Aug;72(8):550-553. Epub 2019 Jun 4 doi: 10.1136/jclinpath-2019-205742. PMID: 31164444
Polyomavirus (BK)-associated pleomorphic giant cell carcinoma of the urinary bladder: a case report.
Alexiev BA, Papadimitriou JC, Chai TC, Ramos E, Staats PN, Drachenberg CB
Pathol Res Pract 2013 Apr;209(4):255-9. Epub 2013 Mar 6 doi: 10.1016/j.prp.2013.01.008. PMID: 23481349
Pleomorphic giant cell carcinoma of the urinary bladder.
Lopez-Beltran A, Blanca A, Montironi R, Cheng L, Regueiro JC
Hum Pathol 2009 Oct;40(10):1461-6. Epub 2009 May 20 doi: 10.1016/j.humpath.2009.02.016. PMID: 19467692
Divergent differentiation in urothelial carcinoma and other bladder cancer subtypes with selected mimics.
Shanks JH, Iczkowski KA
Histopathology 2009 Jun;54(7):885-900. Epub 2008 Oct 30 doi: 10.1111/j.1365-2559.2008.03167.x. PMID: 19178589
Squamous cell carcinoma of the bladder: a clinicopathologic analysis of 45 cases.
Lagwinski N, Thomas A, Stephenson AJ, Campbell S, Hoschar AP, El-Gabry E, Dreicer R, Hansel DE
Am J Surg Pathol 2007 Dec;31(12):1777-87. doi: 10.1097/PAS.0b013e31805c9cd9. PMID: 18043032

Clinical prediction guides

Polyomavirus (BK)-associated pleomorphic giant cell carcinoma of the urinary bladder: a case report.
Alexiev BA, Papadimitriou JC, Chai TC, Ramos E, Staats PN, Drachenberg CB
Pathol Res Pract 2013 Apr;209(4):255-9. Epub 2013 Mar 6 doi: 10.1016/j.prp.2013.01.008. PMID: 23481349

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