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Infiltrating bladder urothelial carcinoma

MedGen UID:
233582
•Concept ID:
C1334281
•
Neoplastic Process
Synonyms: Infiltrating Bladder Urothelial Carcinoma; infiltrating bladder urothelial carcinoma; Infiltrating Transitional Cell Carcinoma of the Urinary Bladder; infiltrating transitional cell carcinoma of the urinary bladder; Invasive Bladder Transitional Cell Carcinoma; invasive bladder transitional cell carcinoma; Invasive Bladder Urothelial Carcinoma; invasive bladder urothelial carcinoma; Invasive Transitional Cell Carcinoma of the Urinary Bladder; invasive transitional cell carcinoma of the urinary bladder
 
Monarch Initiative: MONDO:0003890

Definition

An invasive transitional cell carcinoma that arises from the urinary bladder urothelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfiltrating bladder urothelial carcinoma

Professional guidelines

PubMed

Stage T1 bladder cancer: diagnostic criteria and pitfalls.
Lopez-Beltran A, Cheng L
Pathology 2021 Jan;53(1):67-85. Epub 2020 Nov 3 doi: 10.1016/j.pathol.2020.09.014. PMID: 33153725
Glandular lesions of the urinary bladder:clinical significance and differential diagnosis.
Williamson SR, Lopez-Beltran A, Montironi R, Cheng L
Histopathology 2011 May;58(6):811-34. Epub 2010 Sep 21 doi: 10.1111/j.1365-2559.2010.03651.x. PMID: 20854477
Stage pT1 bladder carcinoma: diagnostic criteria, pitfalls and prognostic significance.
Lopez-Beltran A, Cheng L
Pathology 2003 Dec;35(6):484-91. doi: 10.1080/00313020310001619127. PMID: 14660098

Recent clinical studies

Etiology

NKG2A and PD-L1 expression panel predicts clinical benefits from adjuvant chemotherapy and PD-L1 blockade in muscle-invasive bladder cancer.
Yan S, Zeng H, Jin K, Shao F, Liu Z, Chang Y, Wang Y, Zhu Y, Wang Z, Xu L, Xu J
J Immunother Cancer 2022 May;10(5) doi: 10.1136/jitc-2022-004569. PMID: 35523436Free PMC Article
Clinical and molecular correlates of response to immune checkpoint blockade in urothelial carcinoma with liver metastasis.
Yoshida T, Ohe C, Ito K, Takada H, Saito R, Kita Y, Sano T, Tsuta K, Kinoshita H, Kitamura H, Nishiyama H, Kobayashi T; Japan Urological Oncology Group
Cancer Immunol Immunother 2022 Nov;71(11):2815-2828. Epub 2022 Apr 20 doi: 10.1007/s00262-022-03204-6. PMID: 35445305
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer.
Lindskrog SV, Prip F, Lamy P, Taber A, Groeneveld CS, Birkenkamp-Demtröder K, Jensen JB, Strandgaard T, Nordentoft I, Christensen E, Sokac M, Birkbak NJ, Maretty L, Hermann GG, Petersen AC, Weyerer V, Grimm MO, Horstmann M, Sjödahl G, Höglund M, Steiniche T, Mogensen K, de Reyniès A, Nawroth R, Jordan B, Lin X, Dragicevic D, Ward DG, Goel A, Hurst CD, Raman JD, Warrick JI, Segersten U, Sikic D, van Kessel KEM, Maurer T, Meeks JJ, DeGraff DJ, Bryan RT, Knowles MA, Simic T, Hartmann A, Zwarthoff EC, Malmström PU, Malats N, Real FX, Dyrskjøt L
Nat Commun 2021 Apr 16;12(1):2301. doi: 10.1038/s41467-021-22465-w. PMID: 33863885Free PMC Article
Molecular Subtypes of Bladder Cancer.
McConkey DJ, Choi W
Curr Oncol Rep 2018 Aug 20;20(10):77. doi: 10.1007/s11912-018-0727-5. PMID: 30128829

Diagnosis

MARCO is a potential prognostic and immunotherapy biomarker.
Dong Q, Zhang S, Zhang H, Sun J, Lu J, Wang G, Wang X
Int Immunopharmacol 2023 Mar;116:109783. Epub 2023 Feb 9 doi: 10.1016/j.intimp.2023.109783. PMID: 36773567
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer.
Lindskrog SV, Prip F, Lamy P, Taber A, Groeneveld CS, Birkenkamp-Demtröder K, Jensen JB, Strandgaard T, Nordentoft I, Christensen E, Sokac M, Birkbak NJ, Maretty L, Hermann GG, Petersen AC, Weyerer V, Grimm MO, Horstmann M, Sjödahl G, Höglund M, Steiniche T, Mogensen K, de Reyniès A, Nawroth R, Jordan B, Lin X, Dragicevic D, Ward DG, Goel A, Hurst CD, Raman JD, Warrick JI, Segersten U, Sikic D, van Kessel KEM, Maurer T, Meeks JJ, DeGraff DJ, Bryan RT, Knowles MA, Simic T, Hartmann A, Zwarthoff EC, Malmström PU, Malats N, Real FX, Dyrskjøt L
Nat Commun 2021 Apr 16;12(1):2301. doi: 10.1038/s41467-021-22465-w. PMID: 33863885Free PMC Article
Immune-related signature predicts the prognosis and immunotherapy benefit in bladder cancer.
Wang Y, Chen L, Yu M, Fang Y, Qian K, Wang G, Ju L, Xiao Y, Wang X
Cancer Med 2020 Oct;9(20):7729-7741. Epub 2020 Aug 25 doi: 10.1002/cam4.3400. PMID: 32841548Free PMC Article
Molecular Subtypes of Bladder Cancer.
McConkey DJ, Choi W
Curr Oncol Rep 2018 Aug 20;20(10):77. doi: 10.1007/s11912-018-0727-5. PMID: 30128829

Therapy

Single-cell atlases link macrophages and CD8(+) T-cell subpopulations to disease progression and immunotherapy response in urothelial carcinoma.
Liang Y, Tan Y, Guan B, Guo B, Xia M, Li J, Shi Y, Yu Z, Zhang Q, Liu D, Yang X, Hao J, Gong Y, Shakeel M, Zhou L, Ci W, Li X
Theranostics 2022;12(18):7745-7759. Epub 2022 Nov 14 doi: 10.7150/thno.77281. PMID: 36451860Free PMC Article
Clinical and molecular correlates of response to immune checkpoint blockade in urothelial carcinoma with liver metastasis.
Yoshida T, Ohe C, Ito K, Takada H, Saito R, Kita Y, Sano T, Tsuta K, Kinoshita H, Kitamura H, Nishiyama H, Kobayashi T; Japan Urological Oncology Group
Cancer Immunol Immunother 2022 Nov;71(11):2815-2828. Epub 2022 Apr 20 doi: 10.1007/s00262-022-03204-6. PMID: 35445305
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer.
Lindskrog SV, Prip F, Lamy P, Taber A, Groeneveld CS, Birkenkamp-Demtröder K, Jensen JB, Strandgaard T, Nordentoft I, Christensen E, Sokac M, Birkbak NJ, Maretty L, Hermann GG, Petersen AC, Weyerer V, Grimm MO, Horstmann M, Sjödahl G, Höglund M, Steiniche T, Mogensen K, de Reyniès A, Nawroth R, Jordan B, Lin X, Dragicevic D, Ward DG, Goel A, Hurst CD, Raman JD, Warrick JI, Segersten U, Sikic D, van Kessel KEM, Maurer T, Meeks JJ, DeGraff DJ, Bryan RT, Knowles MA, Simic T, Hartmann A, Zwarthoff EC, Malmström PU, Malats N, Real FX, Dyrskjøt L
Nat Commun 2021 Apr 16;12(1):2301. doi: 10.1038/s41467-021-22465-w. PMID: 33863885Free PMC Article
Atezolizumab: A PD-L1-Blocking Antibody for Bladder Cancer.
Inman BA, Longo TA, Ramalingam S, Harrison MR
Clin Cancer Res 2017 Apr 15;23(8):1886-1890. Epub 2016 Nov 30 doi: 10.1158/1078-0432.CCR-16-1417. PMID: 27903674

Prognosis

MARCO is a potential prognostic and immunotherapy biomarker.
Dong Q, Zhang S, Zhang H, Sun J, Lu J, Wang G, Wang X
Int Immunopharmacol 2023 Mar;116:109783. Epub 2023 Feb 9 doi: 10.1016/j.intimp.2023.109783. PMID: 36773567
Single-cell atlases link macrophages and CD8(+) T-cell subpopulations to disease progression and immunotherapy response in urothelial carcinoma.
Liang Y, Tan Y, Guan B, Guo B, Xia M, Li J, Shi Y, Yu Z, Zhang Q, Liu D, Yang X, Hao J, Gong Y, Shakeel M, Zhou L, Ci W, Li X
Theranostics 2022;12(18):7745-7759. Epub 2022 Nov 14 doi: 10.7150/thno.77281. PMID: 36451860Free PMC Article
Prognostic and immunological role of Fam20C in pan-cancer.
Liu X, Zhan Y, Xu W, Liu X, Geng Y, Liu L, Da J, Wang J, Zhang X, Jin H, Liu Z, Guo S, Zhang B, Li Y
Biosci Rep 2021 Jan 29;41(1) doi: 10.1042/BSR20201920. PMID: 33306121Free PMC Article
A pan-cancer analysis of the oncogenic role of staphylococcal nuclease domain-containing protein 1 (SND1) in human tumors.
Cui X, Zhang X, Liu M, Zhao C, Zhang N, Ren Y, Su C, Zhang W, Sun X, He J, Gao X, Yang J
Genomics 2020 Nov;112(6):3958-3967. Epub 2020 Jul 6 doi: 10.1016/j.ygeno.2020.06.044. PMID: 32645525
Molecular Subtypes of Bladder Cancer.
McConkey DJ, Choi W
Curr Oncol Rep 2018 Aug 20;20(10):77. doi: 10.1007/s11912-018-0727-5. PMID: 30128829

Clinical prediction guides

MARCO is a potential prognostic and immunotherapy biomarker.
Dong Q, Zhang S, Zhang H, Sun J, Lu J, Wang G, Wang X
Int Immunopharmacol 2023 Mar;116:109783. Epub 2023 Feb 9 doi: 10.1016/j.intimp.2023.109783. PMID: 36773567
Single-cell atlases link macrophages and CD8(+) T-cell subpopulations to disease progression and immunotherapy response in urothelial carcinoma.
Liang Y, Tan Y, Guan B, Guo B, Xia M, Li J, Shi Y, Yu Z, Zhang Q, Liu D, Yang X, Hao J, Gong Y, Shakeel M, Zhou L, Ci W, Li X
Theranostics 2022;12(18):7745-7759. Epub 2022 Nov 14 doi: 10.7150/thno.77281. PMID: 36451860Free PMC Article
Clinical and molecular correlates of response to immune checkpoint blockade in urothelial carcinoma with liver metastasis.
Yoshida T, Ohe C, Ito K, Takada H, Saito R, Kita Y, Sano T, Tsuta K, Kinoshita H, Kitamura H, Nishiyama H, Kobayashi T; Japan Urological Oncology Group
Cancer Immunol Immunother 2022 Nov;71(11):2815-2828. Epub 2022 Apr 20 doi: 10.1007/s00262-022-03204-6. PMID: 35445305
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures.
Zhang X, Wang Y, A G, Qu C, Chen J
Front Immunol 2021;12:721030. Epub 2021 Aug 31 doi: 10.3389/fimmu.2021.721030. PMID: 34531868Free PMC Article
A pan-cancer analysis of the oncogenic role of staphylococcal nuclease domain-containing protein 1 (SND1) in human tumors.
Cui X, Zhang X, Liu M, Zhao C, Zhang N, Ren Y, Su C, Zhang W, Sun X, He J, Gao X, Yang J
Genomics 2020 Nov;112(6):3958-3967. Epub 2020 Jul 6 doi: 10.1016/j.ygeno.2020.06.044. PMID: 32645525

Recent systematic reviews

French AFU Cancer Committee Guidelines - Update 2022-2024: Non-muscle-invasive bladder cancer (NMIBC).
Neuzillet Y, Pradère B, Xylinas E, Allory Y, Audenet F, Loriot Y, Masson-Lecomte A, Roumiguié M, Seisen T, Traxer O, Leon P, Roupret M
Prog Urol 2022 Nov;32(15):1102-1140. doi: 10.1016/j.purol.2022.08.006. PMID: 36400479
Catalog of prognostic tissue-based biomarkers in patients treated with neoadjuvant systemic therapy for urothelial carcinoma of the bladder: a systematic review.
Laukhtina E, Pradere B, Mori K, Schuettfort VM, Quhal F, Mostafaei H, Sari Motlangh R, Katayama S, Grossmann NC, Moschini M, Enikeev D, Shariat SF; European Association of Urology—Young Academic Urologists (EAU-YAU): Urothelial carcinoma working group
Urol Oncol 2021 Mar;39(3):180-190. Epub 2021 Jan 8 doi: 10.1016/j.urolonc.2020.12.019. PMID: 33423937
Prognostic value of T1 substaging on oncological outcomes in patients with non-muscle-invasive bladder urothelial carcinoma: a systematic literature review and meta-analysis.
Kardoust Parizi M, Enikeev D, Glybochko PV, Seebacher V, Janisch F, Fajkovic H, Chłosta PL, Shariat SF
World J Urol 2020 Jun;38(6):1437-1449. Epub 2019 Sep 6 doi: 10.1007/s00345-019-02936-y. PMID: 31493109Free PMC Article

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