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Monoclonal Gammopathy of Renal Significance

MedGen UID:
1682637
Concept ID:
C4763555
Neoplastic Process

Definition

A condition caused by a B-cell or plasma cell clone resulting in the deposition of the secreted monoclonal immunoglobulin, without evidence for overt lymphoma or myeloma. This category includes a wide spectrum of renal pathology and include such lesions as immunoglobulin-associated amyloidosis, the monoclonal immunoglobulin deposition diseases (MIDDs; light chain deposition disease, heavy chain deposition disease, and light and heavy chain deposition disease), proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID), C3 glomerulopathy with monoclonal gammopathy, light chain proximal tubulopathy (Fanconi syndrome), and several others. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMonoclonal Gammopathy of Renal Significance

Professional guidelines

PubMed

Karam S, Haidous M, Dalle IA, Dendooven A, Moukalled N, Van Craenenbroeck A, Bazarbachi A, Sprangers B
Crit Rev Oncol Hematol 2023 Mar;183:103926. Epub 2023 Feb 2 doi: 10.1016/j.critrevonc.2023.103926. PMID: 36736510
Castillo JJ, Callander NS, Baljevic M, Sborov DW, Kumar S
Am J Hematol 2021 Jul 1;96(7):846-853. Epub 2021 Mar 25 doi: 10.1002/ajh.26155. PMID: 33709474Free PMC Article
Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D'Agati VD, Dispenzieri A, Fervenza FC, Fermand JP, Gibbs S, Gillmore JD, Herrera GA, Jaccard A, Jevremovic D, Kastritis E, Kukreti V, Kyle RA, Lachmann HJ, Larsen CP, Ludwig H, Markowitz GS, Merlini G, Mollee P, Picken MM, Rajkumar VS, Royal V, Sanders PW, Sethi S, Venner CP, Voorhees PM, Wechalekar AD, Weiss BM, Nasr SH
Nat Rev Nephrol 2019 Jan;15(1):45-59. doi: 10.1038/s41581-018-0077-4. PMID: 30510265Free PMC Article

Recent clinical studies

Etiology

Kaur J, Valisekka SS, Hameed M, Bandi PS, Varma S, Onwughalu CJ, Ibrahim H, Mongia H
Clin Lymphoma Myeloma Leuk 2023 May;23(5):e195-e212. Epub 2023 Feb 23 doi: 10.1016/j.clml.2023.02.004. PMID: 36966041
Karam S, Haidous M, Dalle IA, Dendooven A, Moukalled N, Van Craenenbroeck A, Bazarbachi A, Sprangers B
Crit Rev Oncol Hematol 2023 Mar;183:103926. Epub 2023 Feb 2 doi: 10.1016/j.critrevonc.2023.103926. PMID: 36736510
Amaador K, Peeters H, Minnema MC, Nguyen TQ, Dendooven A, Vos JMI, Croockewit AJ, van de Donk NWCJ, Jacobs JFM, Wetzels JFM, Sprangers B, Abrahams AC
Neth J Med 2019 Sep;77(7):243-254. PMID: 31582582
Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D'Agati VD, Dispenzieri A, Fervenza FC, Fermand JP, Gibbs S, Gillmore JD, Herrera GA, Jaccard A, Jevremovic D, Kastritis E, Kukreti V, Kyle RA, Lachmann HJ, Larsen CP, Ludwig H, Markowitz GS, Merlini G, Mollee P, Picken MM, Rajkumar VS, Royal V, Sanders PW, Sethi S, Venner CP, Voorhees PM, Wechalekar AD, Weiss BM, Nasr SH
Nat Rev Nephrol 2019 Jan;15(1):45-59. doi: 10.1038/s41581-018-0077-4. PMID: 30510265Free PMC Article
Bridoux F, Leung N, Hutchison CA, Touchard G, Sethi S, Fermand JP, Picken MM, Herrera GA, Kastritis E, Merlini G, Roussel M, Fervenza FC, Dispenzieri A, Kyle RA, Nasr SH; International Kidney and Monoclonal Gammopathy Research Group
Kidney Int 2015 Apr;87(4):698-711. Epub 2015 Jan 21 doi: 10.1038/ki.2014.408. PMID: 25607108

Diagnosis

Karam S, Haidous M, Dalle IA, Dendooven A, Moukalled N, Van Craenenbroeck A, Bazarbachi A, Sprangers B
Crit Rev Oncol Hematol 2023 Mar;183:103926. Epub 2023 Feb 2 doi: 10.1016/j.critrevonc.2023.103926. PMID: 36736510
Leung N, Bridoux F, Nasr SH
N Engl J Med 2021 May 20;384(20):1931-1941. doi: 10.1056/NEJMra1810907. PMID: 34010532
Amaador K, Peeters H, Minnema MC, Nguyen TQ, Dendooven A, Vos JMI, Croockewit AJ, van de Donk NWCJ, Jacobs JFM, Wetzels JFM, Sprangers B, Abrahams AC
Neth J Med 2019 Sep;77(7):243-254. PMID: 31582582
Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D'Agati VD, Dispenzieri A, Fervenza FC, Fermand JP, Gibbs S, Gillmore JD, Herrera GA, Jaccard A, Jevremovic D, Kastritis E, Kukreti V, Kyle RA, Lachmann HJ, Larsen CP, Ludwig H, Markowitz GS, Merlini G, Mollee P, Picken MM, Rajkumar VS, Royal V, Sanders PW, Sethi S, Venner CP, Voorhees PM, Wechalekar AD, Weiss BM, Nasr SH
Nat Rev Nephrol 2019 Jan;15(1):45-59. doi: 10.1038/s41581-018-0077-4. PMID: 30510265Free PMC Article
Bridoux F, Leung N, Hutchison CA, Touchard G, Sethi S, Fermand JP, Picken MM, Herrera GA, Kastritis E, Merlini G, Roussel M, Fervenza FC, Dispenzieri A, Kyle RA, Nasr SH; International Kidney and Monoclonal Gammopathy Research Group
Kidney Int 2015 Apr;87(4):698-711. Epub 2015 Jan 21 doi: 10.1038/ki.2014.408. PMID: 25607108

Therapy

Lim MA, Bloom RD
Curr Opin Organ Transplant 2023 Feb 1;28(1):55-63. Epub 2022 Dec 9 doi: 10.1097/MOT.0000000000001039. PMID: 36579685
Oganesyan A, Gregory A, Malard F, Ghahramanyan N, Mohty M, Kazandjian D, Mekinian A, Hakobyan Y
Front Immunol 2022;13:1045002. Epub 2022 Nov 23 doi: 10.3389/fimmu.2022.1045002. PMID: 36505449Free PMC Article
Gozzetti A, Guarnieri A, Zamagni E, Zakharova E, Coriu D, Bittrich M, Pika T, Tovar N, Schutz N, Ciofini S, Peña C, Rocchi S, Rassner M, Avivi I, Waszczuk-Gajda A, Chhabra S, Usnarska-Zubkiewicz L, González-Calle V, Mateos MV, Bocchia M, Bigi F, Füllgraf H, Bhasin-Chhabra B, Gentile M, Davila J, Vesole DH, Cavo M, Thapa B, Crusoe E, Einsele H, Legiec W, Charliński G, Jurczyszyn A
Am J Hematol 2022 Jul;97(7):877-884. Epub 2022 Apr 20 doi: 10.1002/ajh.26566. PMID: 35389534Free PMC Article
Cao Q, Qi H, Yao L, Liu Q
Panminerva Med 2020 Mar;62(1):38-53. Epub 2019 Mar 4 doi: 10.23736/S0031-0808.19.03609-7. PMID: 30848114
Caravaca-Fontán F, Gutiérrez E, Delgado Lillo R, Praga M
Nefrologia 2017 Sep-Oct;37(5):465-477. doi: 10.1016/j.nefro.2017.03.012. PMID: 28946960

Prognosis

Gozzetti A, Guarnieri A, Zamagni E, Zakharova E, Coriu D, Bittrich M, Pika T, Tovar N, Schutz N, Ciofini S, Peña C, Rocchi S, Rassner M, Avivi I, Waszczuk-Gajda A, Chhabra S, Usnarska-Zubkiewicz L, González-Calle V, Mateos MV, Bocchia M, Bigi F, Füllgraf H, Bhasin-Chhabra B, Gentile M, Davila J, Vesole DH, Cavo M, Thapa B, Crusoe E, Einsele H, Legiec W, Charliński G, Jurczyszyn A
Am J Hematol 2022 Jul;97(7):877-884. Epub 2022 Apr 20 doi: 10.1002/ajh.26566. PMID: 35389534Free PMC Article
Bridoux F, Javaugue V, Nasr SH, Leung N
Nephrol Dial Transplant 2021 Jan 25;36(2):208-215. doi: 10.1093/ndt/gfz176. PMID: 33494099
Klomjit N, Leung N, Fervenza F, Sethi S, Zand L
J Am Soc Nephrol 2020 Oct;31(10):2400-2411. Epub 2020 Aug 3 doi: 10.1681/ASN.2020010054. PMID: 32747354Free PMC Article
Cao Q, Qi H, Yao L, Liu Q
Panminerva Med 2020 Mar;62(1):38-53. Epub 2019 Mar 4 doi: 10.23736/S0031-0808.19.03609-7. PMID: 30848114
Caravaca-Fontán F, Gutiérrez E, Delgado Lillo R, Praga M
Nefrologia 2017 Sep-Oct;37(5):465-477. doi: 10.1016/j.nefro.2017.03.012. PMID: 28946960

Clinical prediction guides

Javaugue V, Valeri AM, Jaffer Sathick I, Said SM, Erdogan Damgard S, Murray DL, Klobucher T, Andeen NK, Sethi S, Fervenza FC, Leung N, Nasr SH
Kidney Int 2022 Aug;102(2):382-394. Epub 2022 May 2 doi: 10.1016/j.kint.2022.03.030. PMID: 35513122
Gozzetti A, Guarnieri A, Zamagni E, Zakharova E, Coriu D, Bittrich M, Pika T, Tovar N, Schutz N, Ciofini S, Peña C, Rocchi S, Rassner M, Avivi I, Waszczuk-Gajda A, Chhabra S, Usnarska-Zubkiewicz L, González-Calle V, Mateos MV, Bocchia M, Bigi F, Füllgraf H, Bhasin-Chhabra B, Gentile M, Davila J, Vesole DH, Cavo M, Thapa B, Crusoe E, Einsele H, Legiec W, Charliński G, Jurczyszyn A
Am J Hematol 2022 Jul;97(7):877-884. Epub 2022 Apr 20 doi: 10.1002/ajh.26566. PMID: 35389534Free PMC Article
Tewari R, Chatterjee T, Mendonca S, Dogra M, Pramanik SK, Yanamandra U
Saudi J Kidney Dis Transpl 2021 Mar-Apr;32(2):298-306. doi: 10.4103/1319-2442.335440. PMID: 35017322
Kastritis E, Theodorakakou F, Roussou M, Psimenou E, Gakiopoulou C, Marinaki S, Gatou A, Fotiou D, Migkou M, Kanellias N, Eleutherakis-Papaiakovou E, Malandrakis P, Dialoupi I, Ntanasis-Stathopoulos I, Kostopoulos IV, Terpos E, Gavriatopoulou M, Dimopoulos MA
Br J Haematol 2021 Apr;193(1):113-118. Epub 2020 Aug 23 doi: 10.1111/bjh.17052. PMID: 32829529
Klomjit N, Leung N, Fervenza F, Sethi S, Zand L
J Am Soc Nephrol 2020 Oct;31(10):2400-2411. Epub 2020 Aug 3 doi: 10.1681/ASN.2020010054. PMID: 32747354Free PMC Article

Recent systematic reviews

Du J, Hu Z
BMC Nephrol 2024 Jan 16;25(1):22. doi: 10.1186/s12882-024-03458-5. PMID: 38229028Free PMC Article

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