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Abnormal circulating pyrimidine concentration

MedGen UID:
1684685
•Concept ID:
C5139038
•
Finding
Synonym: Abnormality of pyrimidine metabolism
 
HPO: HP:0004353

Definition

Any deviation from the normal concentration of a pyrimidine in the blood circulation. [from HPO]

Recent clinical studies

Etiology

Promotion of tumor progression induced by continuous low-dose administration of antineoplastic agent gemcitabine or gemcitabine combined with cisplatin.
Chen Y, Liu H, Zheng Q, Li H, You H, Feng Y, Feng W
Life Sci 2022 Oct 1;306:120826. Epub 2022 Jul 21 doi: 10.1016/j.lfs.2022.120826. PMID: 35870618
Development and validation of a multiplex UHPLC-MS/MS assay with stable isotopic internal standards for the monitoring of the plasma concentrations of the antiretroviral drugs bictegravir, cabotegravir, doravirine, and rilpivirine in people living with HIV.
Courlet P, Alves Saldanha S, Cavassini M, Marzolini C, Choong E, Csajka C, Günthard HF, André P, Buclin T, Desfontaine V, Decosterd LA
J Mass Spectrom 2020 Jun;55(6):e4506. Epub 2020 Mar 11 doi: 10.1002/jms.4506. PMID: 32160389Free PMC Article
Results of a phase I/II multi-center investigation of udenafil in adolescents after fontan palliation.
Goldberg DJ, Zak V, Goldstein BH, Chen S, Hamstra MS, Radojewski EA, Maunsell E, Mital S, Menon SC, Schumacher KR, Payne RM, Stylianou M, Kaltman JR, deVries TM, Yeager JL, Paridon SM; Pediatric Heart Network Investigators
Am Heart J 2017 Jun;188:42-52. Epub 2017 Mar 6 doi: 10.1016/j.ahj.2017.02.030. PMID: 28577680Free PMC Article
Coronary flow reserve is reduced in young men with IDDM.
Pitkänen OP, Nuutila P, Raitakari OT, Rönnemaa T, Koskinen PJ, Iida H, Lehtimäki TJ, Laine HK, Takala T, Viikari JS, Knuuti J
Diabetes 1998 Feb;47(2):248-54. doi: 10.2337/diab.47.2.248. PMID: 9519721
Pharmacology of antineoplastic agents in pregnancy.
Wiebe VJ, Sipila PE
Crit Rev Oncol Hematol 1994 Apr;16(2):75-112. doi: 10.1016/1040-8428(94)90043-4. PMID: 8068213

Diagnosis

Development and validation of a multiplex UHPLC-MS/MS assay with stable isotopic internal standards for the monitoring of the plasma concentrations of the antiretroviral drugs bictegravir, cabotegravir, doravirine, and rilpivirine in people living with HIV.
Courlet P, Alves Saldanha S, Cavassini M, Marzolini C, Choong E, Csajka C, Günthard HF, André P, Buclin T, Desfontaine V, Decosterd LA
J Mass Spectrom 2020 Jun;55(6):e4506. Epub 2020 Mar 11 doi: 10.1002/jms.4506. PMID: 32160389Free PMC Article
Changes in coronary sinus pH during dipyridamole stress in patients with hypertrophic cardiomyopathy.
Elliott PM, Rosano GM, Gill JS, Poole-Wilson PA, Kaski JC, McKenna WJ
Heart 1996 Feb;75(2):179-83. doi: 10.1136/hrt.75.2.179. PMID: 8673758Free PMC Article
Assessment of anatomic and physiological severity of single-vessel coronary artery lesions by dipyridamole echocardiography. Comparison with positron emission tomography and quantitative arteriography.
Picano E, Parodi O, Lattanzi F, Sambuceti G, Andrade MJ, Marzullo P, Giorgetti A, Salvadori P, Marzilli M, Distante A
Circulation 1994 Feb;89(2):753-61. doi: 10.1161/01.cir.89.2.753. PMID: 8313564
Noninvasive detection of coronary artery disease by myocardial imaging with thallium-201--the significance of pharmacologic interventions.
Narita M, Kurihara T, Usami M
Jpn Circ J 1981 Jan;45(1):127-40. doi: 10.1253/jcj.45.127. PMID: 6779029
Reappearance of beriberi heart disease in Japan. A study of 23 cases.
Kawai C, Wakabayashi A, Matsumura T, Yui Y
Am J Med 1980 Sep;69(3):383-6. doi: 10.1016/0002-9343(80)90008-x. PMID: 7416185

Therapy

Poisoning by abnormally high blood phenobarbital concentration treated with extracorporeal therapy.
Kohara S, Kamijo Y, Seki S, Hasegawa E
Am J Emerg Med 2023 Oct;72:221.e5-221.e7. Epub 2023 Aug 22 doi: 10.1016/j.ajem.2023.08.034. PMID: 37635049
Promotion of tumor progression induced by continuous low-dose administration of antineoplastic agent gemcitabine or gemcitabine combined with cisplatin.
Chen Y, Liu H, Zheng Q, Li H, You H, Feng Y, Feng W
Life Sci 2022 Oct 1;306:120826. Epub 2022 Jul 21 doi: 10.1016/j.lfs.2022.120826. PMID: 35870618
Development and validation of a multiplex UHPLC-MS/MS assay with stable isotopic internal standards for the monitoring of the plasma concentrations of the antiretroviral drugs bictegravir, cabotegravir, doravirine, and rilpivirine in people living with HIV.
Courlet P, Alves Saldanha S, Cavassini M, Marzolini C, Choong E, Csajka C, Günthard HF, André P, Buclin T, Desfontaine V, Decosterd LA
J Mass Spectrom 2020 Jun;55(6):e4506. Epub 2020 Mar 11 doi: 10.1002/jms.4506. PMID: 32160389Free PMC Article
The effects of sildenafil on human sperm function in healthy volunteers.
Purvis K, Muirhead GJ, Harness JA
Br J Clin Pharmacol 2002;53 Suppl 1(Suppl 1):53S-60S. doi: 10.1046/j.0306-5251.2001.00033.x. PMID: 11879260Free PMC Article
Pharmacology of antineoplastic agents in pregnancy.
Wiebe VJ, Sipila PE
Crit Rev Oncol Hematol 1994 Apr;16(2):75-112. doi: 10.1016/1040-8428(94)90043-4. PMID: 8068213

Prognosis

Development and validation of a multiplex UHPLC-MS/MS assay with stable isotopic internal standards for the monitoring of the plasma concentrations of the antiretroviral drugs bictegravir, cabotegravir, doravirine, and rilpivirine in people living with HIV.
Courlet P, Alves Saldanha S, Cavassini M, Marzolini C, Choong E, Csajka C, Günthard HF, André P, Buclin T, Desfontaine V, Decosterd LA
J Mass Spectrom 2020 Jun;55(6):e4506. Epub 2020 Mar 11 doi: 10.1002/jms.4506. PMID: 32160389Free PMC Article
Results of a phase I/II multi-center investigation of udenafil in adolescents after fontan palliation.
Goldberg DJ, Zak V, Goldstein BH, Chen S, Hamstra MS, Radojewski EA, Maunsell E, Mital S, Menon SC, Schumacher KR, Payne RM, Stylianou M, Kaltman JR, deVries TM, Yeager JL, Paridon SM; Pediatric Heart Network Investigators
Am Heart J 2017 Jun;188:42-52. Epub 2017 Mar 6 doi: 10.1016/j.ahj.2017.02.030. PMID: 28577680Free PMC Article
Changes in coronary sinus pH during dipyridamole stress in patients with hypertrophic cardiomyopathy.
Elliott PM, Rosano GM, Gill JS, Poole-Wilson PA, Kaski JC, McKenna WJ
Heart 1996 Feb;75(2):179-83. doi: 10.1136/hrt.75.2.179. PMID: 8673758Free PMC Article

Clinical prediction guides

Promotion of tumor progression induced by continuous low-dose administration of antineoplastic agent gemcitabine or gemcitabine combined with cisplatin.
Chen Y, Liu H, Zheng Q, Li H, You H, Feng Y, Feng W
Life Sci 2022 Oct 1;306:120826. Epub 2022 Jul 21 doi: 10.1016/j.lfs.2022.120826. PMID: 35870618
Non-invasive assessment of coronary flow reserve and ADMA levels: a case-control study of early rheumatoid arthritis patients.
Turiel M, Atzeni F, Tomasoni L, de Portu S, Delfino L, Bodini BD, Longhi M, Sitia S, Bianchi M, Ferrario P, Doria A, De Gennaro Colonna V, Sarzi-Puttini P
Rheumatology (Oxford) 2009 Jul;48(7):834-9. Epub 2009 May 22 doi: 10.1093/rheumatology/kep082. PMID: 19465588
Phenotype-dependent and -independent actions of rosuvastatin on atherogenic lipoprotein subfractions in hyperlipidaemia.
Caslake MJ, Stewart G, Day SP, Daly E, McTaggart F, Chapman MJ, Durrington P, Laggner P, Mackness M, Pears J, Packard CJ
Atherosclerosis 2003 Dec;171(2):245-53. doi: 10.1016/j.atherosclerosis.2003.08.025. PMID: 14644393
Coronary flow reserve is impaired in young men with familial hypercholesterolemia.
Pitkänen OP, Raitakari OT, Niinikoski H, Nuutila P, Iida H, Voipio-Pulkki LM, Härkönen R, Wegelius U, Rönnemaa T, Viikari J, Knuuti J
J Am Coll Cardiol 1996 Dec;28(7):1705-11. doi: 10.1016/S0735-1097(96)00376-2. PMID: 8962555
Assessment of anatomic and physiological severity of single-vessel coronary artery lesions by dipyridamole echocardiography. Comparison with positron emission tomography and quantitative arteriography.
Picano E, Parodi O, Lattanzi F, Sambuceti G, Andrade MJ, Marzullo P, Giorgetti A, Salvadori P, Marzilli M, Distante A
Circulation 1994 Feb;89(2):753-61. doi: 10.1161/01.cir.89.2.753. PMID: 8313564

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