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Colon Neuroendocrine Tumor G2

MedGen UID:
1685155
•Concept ID:
C5205254
•
Neoplastic Process
Synonym: Colon NET G2

Definition

A well differentiated, intermediate grade neoplasm with neuroendocrine differentiation that arises from the colon. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColon Neuroendocrine Tumor G2

Professional guidelines

PubMed

Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre.
Bazarbashi S, Aseafan M, Elgazzar T, Alkhayat M, Alghabban A, Abdelgawad MI, Alshamsan B, Alshibany A, Elhassan T, Aljubran A, Alzahrani A, Alhindi H, Raef H
BMC Endocr Disord 2023 Apr 7;23(1):74. doi: 10.1186/s12902-023-01326-1. PMID: 37029347Free PMC Article
Gastroenteropancreatic Well-Differentiated Grade 3 Neuroendocrine Tumors: Review and Position Statement.
Coriat R, Walter T, Terris B, Couvelard A, Ruszniewski P
Oncologist 2016 Oct;21(10):1191-1199. Epub 2016 Jul 8 doi: 10.1634/theoncologist.2015-0476. PMID: 27401895Free PMC Article
PBISe, a novel selenium-containing drug for the treatment of malignant melanoma.
Madhunapantula SV, Desai D, Sharma A, Huh SJ, Amin S, Robertson GP
Mol Cancer Ther 2008 May;7(5):1297-308. doi: 10.1158/1535-7163.MCT-07-2267. PMID: 18483317

Recent clinical studies

Etiology

Site-specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany.
Grundmann N, Voigtländer S, Hakimhashemi A, Pape UF, Meyer M, Müller-Nordhorn J
Cancer Med 2023 Oct;12(19):19949-19958. Epub 2023 Sep 22 doi: 10.1002/cam4.6510. PMID: 37737059Free PMC Article
Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre.
Bazarbashi S, Aseafan M, Elgazzar T, Alkhayat M, Alghabban A, Abdelgawad MI, Alshamsan B, Alshibany A, Elhassan T, Aljubran A, Alzahrani A, Alhindi H, Raef H
BMC Endocr Disord 2023 Apr 7;23(1):74. doi: 10.1186/s12902-023-01326-1. PMID: 37029347Free PMC Article
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320
Lymphocytic toxicity in patients after peptide-receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE and 90Y-DOTATOC.
Sierra ML, Agazzi A, Bodei L, Pacifici M, Aricò D, De Cicco C, Quarna J, Sansovini M, De Simone M, Paganelli G
Cancer Biother Radiopharm 2009 Dec;24(6):659-65. doi: 10.1089/cbr.2009.0641. PMID: 20025545
2-(4-Aminophenyl)benzothiazoles: novel agents with selective profiles of in vitro anti-tumour activity.
Bradshaw TD, Wrigley S, Shi DF, Schultz RJ, Paull KD, Stevens MF
Br J Cancer 1998 Mar;77(5):745-52. doi: 10.1038/bjc.1998.122. PMID: 9514053Free PMC Article

Diagnosis

Site-specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany.
Grundmann N, Voigtländer S, Hakimhashemi A, Pape UF, Meyer M, Müller-Nordhorn J
Cancer Med 2023 Oct;12(19):19949-19958. Epub 2023 Sep 22 doi: 10.1002/cam4.6510. PMID: 37737059Free PMC Article
Development of novel prediction models for nodal and distant metastasis in G1 and G2 colorectal neuroendocrine tumors.
Wang Z, Liu Q
Int J Colorectal Dis 2023 Feb 13;38(1):37. doi: 10.1007/s00384-023-04331-x. PMID: 36781493
Gastroenteropancreatic Well-Differentiated Grade 3 Neuroendocrine Tumors: Review and Position Statement.
Coriat R, Walter T, Terris B, Couvelard A, Ruszniewski P
Oncologist 2016 Oct;21(10):1191-1199. Epub 2016 Jul 8 doi: 10.1634/theoncologist.2015-0476. PMID: 27401895Free PMC Article
Novel DNA damage checkpoints mediating cell death induced by the NEDD8-activating enzyme inhibitor MLN4924.
Blank JL, Liu XJ, Cosmopoulos K, Bouck DC, Garcia K, Bernard H, Tayber O, Hather G, Liu R, Narayanan U, Milhollen MA, Lightcap ES
Cancer Res 2013 Jan 1;73(1):225-34. Epub 2012 Oct 24 doi: 10.1158/0008-5472.CAN-12-1729. PMID: 23100467
2-(4-Aminophenyl)benzothiazoles: novel agents with selective profiles of in vitro anti-tumour activity.
Bradshaw TD, Wrigley S, Shi DF, Schultz RJ, Paull KD, Stevens MF
Br J Cancer 1998 Mar;77(5):745-52. doi: 10.1038/bjc.1998.122. PMID: 9514053Free PMC Article

Therapy

TTK inhibitor OSU13 promotes immunotherapy responses by activating tumor STING.
Bharti V, Kumar A, Wang Y, Roychowdhury N, de Lima Bellan D, Kassaye BB, Watkins R, Capece M, Chung CG, Hilinski G, Vilgelm AE
JCI Insight 2024 Jun 20;9(15) doi: 10.1172/jci.insight.177523. PMID: 38900577Free PMC Article
Lactobacillus rhamnosus GG cell-free supernatant as a novel anti-cancer adjuvant.
Salemi R, Vivarelli S, Ricci D, Scillato M, Santagati M, Gattuso G, Falzone L, Libra M
J Transl Med 2023 Mar 14;21(1):195. doi: 10.1186/s12967-023-04036-3. PMID: 36918929Free PMC Article
Clinicopathologic characteristics and prognosis of gastroenteropancreatic neuroendocrine neoplasms: a multicenter study in South China.
Fang C, Wang W, Zhang Y, Feng X, Sun J, Zeng Y, Chen Y, Li Y, Chen M, Zhou Z, Chen J
Chin J Cancer 2017 Jun 21;36(1):51. doi: 10.1186/s40880-017-0218-3. PMID: 28637502Free PMC Article
Clinical Usefulness of Somatostatin Receptor Scintigraphy in Japanese Patients with Gastroenteropancreatic Neuroendocrine Tumors.
Hasegawa S, Kobayashi N, Tokuhisa M, Goto A, Takano S, Takada Y, Kaneta T, Mori R, Matsuyama R, Endo I, Yamanaka S, Nakajima A, Inoue T, Ichikawa Y
Digestion 2017;96(1):13-20. Epub 2017 Jun 14 doi: 10.1159/000470838. PMID: 28609761
Gold(I) biscarbene complexes derived from vascular-disrupting combretastatin A-4 address different targets and show antimetastatic potential.
Muenzner JK, Biersack B, Kalie H, Andronache IC, Kaps L, Schuppan D, Sasse F, Schobert R
ChemMedChem 2014 Jun;9(6):1195-204. Epub 2014 Mar 19 doi: 10.1002/cmdc.201400049. PMID: 24648184

Prognosis

Characteristics and treatment results of patients with gastroenteropancreatic neuroendocrine tumors in a tertiary care centre.
Bazarbashi S, Aseafan M, Elgazzar T, Alkhayat M, Alghabban A, Abdelgawad MI, Alshamsan B, Alshibany A, Elhassan T, Aljubran A, Alzahrani A, Alhindi H, Raef H
BMC Endocr Disord 2023 Apr 7;23(1):74. doi: 10.1186/s12902-023-01326-1. PMID: 37029347Free PMC Article
Development of novel prediction models for nodal and distant metastasis in G1 and G2 colorectal neuroendocrine tumors.
Wang Z, Liu Q
Int J Colorectal Dis 2023 Feb 13;38(1):37. doi: 10.1007/s00384-023-04331-x. PMID: 36781493
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320
Clinicopathologic characteristics and prognosis of gastroenteropancreatic neuroendocrine neoplasms: a multicenter study in South China.
Fang C, Wang W, Zhang Y, Feng X, Sun J, Zeng Y, Chen Y, Li Y, Chen M, Zhou Z, Chen J
Chin J Cancer 2017 Jun 21;36(1):51. doi: 10.1186/s40880-017-0218-3. PMID: 28637502Free PMC Article
Gastroenteropancreatic Well-Differentiated Grade 3 Neuroendocrine Tumors: Review and Position Statement.
Coriat R, Walter T, Terris B, Couvelard A, Ruszniewski P
Oncologist 2016 Oct;21(10):1191-1199. Epub 2016 Jul 8 doi: 10.1634/theoncologist.2015-0476. PMID: 27401895Free PMC Article

Clinical prediction guides

TTK inhibitor OSU13 promotes immunotherapy responses by activating tumor STING.
Bharti V, Kumar A, Wang Y, Roychowdhury N, de Lima Bellan D, Kassaye BB, Watkins R, Capece M, Chung CG, Hilinski G, Vilgelm AE
JCI Insight 2024 Jun 20;9(15) doi: 10.1172/jci.insight.177523. PMID: 38900577Free PMC Article
Development of novel prediction models for nodal and distant metastasis in G1 and G2 colorectal neuroendocrine tumors.
Wang Z, Liu Q
Int J Colorectal Dis 2023 Feb 13;38(1):37. doi: 10.1007/s00384-023-04331-x. PMID: 36781493
Biodistribution of (18)F-AlF-NOTA-octreotide in Different Organs and Characterization of Uptake in Neuroendocrine Neoplasms.
Hou J, Long T, Yang N, Chen D, Zeng S, Zheng K, Liao G, Hu S
Mol Imaging Biol 2021 Dec;23(6):827-835. Epub 2021 Jul 6 doi: 10.1007/s11307-021-01628-7. PMID: 34231107
Oncologic outcome of mixed adenoneuroendocrine carcinoma (MANEC): A single center case series.
Dulskas A, Pilvelis A
Eur J Surg Oncol 2020 Jan;46(1):105-107. Epub 2019 Aug 2 doi: 10.1016/j.ejso.2019.08.002. PMID: 31444026
2-(4-Aminophenyl)benzothiazoles: novel agents with selective profiles of in vitro anti-tumour activity.
Bradshaw TD, Wrigley S, Shi DF, Schultz RJ, Paull KD, Stevens MF
Br J Cancer 1998 Mar;77(5):745-52. doi: 10.1038/bjc.1998.122. PMID: 9514053Free PMC Article

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