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Colorectal Neuroendocrine Tumor

MedGen UID:
474243
•Concept ID:
C3272610
•
Neoplastic Process
Synonyms: Colorectal NET; Colorectal Well Differentiated Endocrine Tumor; Colorectal Well Differentiated Endocrine Tumor/Carcinoma; Large Intestinal Neuroendocrine Tumor

Definition

A well differentiated, low, intermediate, or high grade neoplasm with neuroendocrine differentiation that arises from the colon or rectum. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVColorectal Neuroendocrine Tumor

Professional guidelines

PubMed

Rectal neuroendocrine tumors: Current advances in management, treatment, and surveillance.
Gallo C, Rossi RE, Cavalcoli F, Barbaro F, Boškoski I, Invernizzi P, Massironi S
World J Gastroenterol 2022 Mar 21;28(11):1123-1138. doi: 10.3748/wjg.v28.i11.1123. PMID: 35431507Free PMC Article
Germline mutations in candidate predisposition genes in individuals with cutaneous melanoma and at least two independent additional primary cancers.
Pritchard AL, Johansson PA, Nathan V, Howlie M, Symmons J, Palmer JM, Hayward NK
PLoS One 2018;13(4):e0194098. Epub 2018 Apr 11 doi: 10.1371/journal.pone.0194098. PMID: 29641532Free PMC Article
Predictive and prognostic factors for treatment and survival in 305 patients with advanced gastrointestinal neuroendocrine carcinoma (WHO G3): the NORDIC NEC study.
Sorbye H, Welin S, Langer SW, Vestermark LW, Holt N, Osterlund P, Dueland S, Hofsli E, Guren MG, Ohrling K, Birkemeyer E, Thiis-Evensen E, Biagini M, Gronbaek H, Soveri LM, Olsen IH, Federspiel B, Assmus J, Janson ET, Knigge U
Ann Oncol 2013 Jan;24(1):152-60. Epub 2012 Sep 11 doi: 10.1093/annonc/mds276. PMID: 22967994

Recent clinical studies

Etiology

Correlation between Neurotransmitters (Dopamine, Epinephrine, Norepinephrine, Serotonin), Prognostic Nutritional Index, Glasgow Prognostic Score, Systemic Inflammatory Response Markers, and TNM Staging in a Cohort of Colorectal Neuroendocrine Tumor Patients.
Cîmpeanu RC, Boldeanu MV, Ahrițculesei RV, Ciobanu AE, Cristescu AM, Forțofoiu D, Siloși I, Pirici DN, Cazacu SM, Boldeanu L, Vere CC
Int J Mol Sci 2024 Jun 26;25(13) doi: 10.3390/ijms25136977. PMID: 39000088Free PMC Article
Comparing surgical and endoscopic resection approaches for colorectal neuroendocrine tumors within the diameter range of 10-20mm: an inverse probability weighting analysis based on the SEER database.
Xu J, Liang R, Cai Q, Liu Y, Ge X, Lai B, Mao S, Cao J, Wang J
Front Endocrinol (Lausanne) 2024;15:1378968. Epub 2024 Mar 27 doi: 10.3389/fendo.2024.1378968. PMID: 38601205Free PMC Article
Short-term outcomes of endoscopic resection for colorectal neuroendocrine tumors: Japanese multicenter prospective C-NET STUDY.
Ito S, Hotta K, Sekiguchi M, Takeuchi Y, Oka S, Yamamoto H, Shinmura K, Harada K, Uraoka T, Hisabe T, Sano Y, Kondo H, Horimatsu T, Kikuchi H, Kawamura T, Nagata S, Yamamoto K, Tajika M, Tsuji S, Kusaka T, Okuyama Y, Yoshida N, Moriyama T, Hasebe A, So S, Saito Y, Nakahira H, Ishikawa H, Matsuda T; C‐NET STUDY Group
Dig Endosc 2024 Aug;36(8):942-951. Epub 2024 Jan 16 doi: 10.1111/den.14728. PMID: 37986226
Characteristics of colorectal neuroendocrine tumors in patients prospectively enrolled in a Japanese multicenter study: a first report from the C-NET STUDY.
Sekiguchi M, Hotta K, Takeuchi Y, Tanaka S, Yamamoto H, Shinmura K, Harada K, Uraoka T, Hisabe T, Sano Y, Kondo H, Horimatsu T, Kikuchi H, Kawamura T, Nagata S, Yamamoto K, Tajika M, Tsuji S, Kusaka T, Okuyama Y, Yoshida N, Moriyama T, Hasebe A, So S, Kobara H, Kashida H, Miyanaga R, Kato S, Hayashi Y, Sada M, Fukuzawa M, Kato H, Takayama T, Konishi J, Matsushita HO, Narasaka T, Ohata K, Togashi K, Nakamura H, Moriichi K, Oda Y, Kanda N, Kuwai T, Terai S, Sanomura M, Kitamura S, Miyamoto H, Kiriyama S, Mizuno C, Saito Y, Sekine S, Ito S, Nakahira H, Oka S, Hayashi Y, Yoshimura K, Ishikawa H, Matsuda T; C-NET STUDY Group
J Gastroenterol 2022 Aug;57(8):547-558. Epub 2022 May 13 doi: 10.1007/s00535-022-01877-5. PMID: 35554678
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320

Diagnosis

Deep learning model with pathological knowledge for detection of colorectal neuroendocrine tumor.
Zheng K, Duan J, Wang R, Chen H, He H, Zheng X, Zhao Z, Jing B, Zhang Y, Liu S, Xie D, Lin Y, Sun Y, Zhang N, Cai M
Cell Rep Med 2024 Oct 15;5(10):101785. doi: 10.1016/j.xcrm.2024.101785. PMID: 39413732Free PMC Article
Correlation between Neurotransmitters (Dopamine, Epinephrine, Norepinephrine, Serotonin), Prognostic Nutritional Index, Glasgow Prognostic Score, Systemic Inflammatory Response Markers, and TNM Staging in a Cohort of Colorectal Neuroendocrine Tumor Patients.
Cîmpeanu RC, Boldeanu MV, Ahrițculesei RV, Ciobanu AE, Cristescu AM, Forțofoiu D, Siloși I, Pirici DN, Cazacu SM, Boldeanu L, Vere CC
Int J Mol Sci 2024 Jun 26;25(13) doi: 10.3390/ijms25136977. PMID: 39000088Free PMC Article
Comparing surgical and endoscopic resection approaches for colorectal neuroendocrine tumors within the diameter range of 10-20mm: an inverse probability weighting analysis based on the SEER database.
Xu J, Liang R, Cai Q, Liu Y, Ge X, Lai B, Mao S, Cao J, Wang J
Front Endocrinol (Lausanne) 2024;15:1378968. Epub 2024 Mar 27 doi: 10.3389/fendo.2024.1378968. PMID: 38601205Free PMC Article
Characteristics of colorectal neuroendocrine tumors in patients prospectively enrolled in a Japanese multicenter study: a first report from the C-NET STUDY.
Sekiguchi M, Hotta K, Takeuchi Y, Tanaka S, Yamamoto H, Shinmura K, Harada K, Uraoka T, Hisabe T, Sano Y, Kondo H, Horimatsu T, Kikuchi H, Kawamura T, Nagata S, Yamamoto K, Tajika M, Tsuji S, Kusaka T, Okuyama Y, Yoshida N, Moriyama T, Hasebe A, So S, Kobara H, Kashida H, Miyanaga R, Kato S, Hayashi Y, Sada M, Fukuzawa M, Kato H, Takayama T, Konishi J, Matsushita HO, Narasaka T, Ohata K, Togashi K, Nakamura H, Moriichi K, Oda Y, Kanda N, Kuwai T, Terai S, Sanomura M, Kitamura S, Miyamoto H, Kiriyama S, Mizuno C, Saito Y, Sekine S, Ito S, Nakahira H, Oka S, Hayashi Y, Yoshimura K, Ishikawa H, Matsuda T; C-NET STUDY Group
J Gastroenterol 2022 Aug;57(8):547-558. Epub 2022 May 13 doi: 10.1007/s00535-022-01877-5. PMID: 35554678
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320

Therapy

Characteristics of colorectal neuroendocrine tumors in patients prospectively enrolled in a Japanese multicenter study: a first report from the C-NET STUDY.
Sekiguchi M, Hotta K, Takeuchi Y, Tanaka S, Yamamoto H, Shinmura K, Harada K, Uraoka T, Hisabe T, Sano Y, Kondo H, Horimatsu T, Kikuchi H, Kawamura T, Nagata S, Yamamoto K, Tajika M, Tsuji S, Kusaka T, Okuyama Y, Yoshida N, Moriyama T, Hasebe A, So S, Kobara H, Kashida H, Miyanaga R, Kato S, Hayashi Y, Sada M, Fukuzawa M, Kato H, Takayama T, Konishi J, Matsushita HO, Narasaka T, Ohata K, Togashi K, Nakamura H, Moriichi K, Oda Y, Kanda N, Kuwai T, Terai S, Sanomura M, Kitamura S, Miyamoto H, Kiriyama S, Mizuno C, Saito Y, Sekine S, Ito S, Nakahira H, Oka S, Hayashi Y, Yoshimura K, Ishikawa H, Matsuda T; C-NET STUDY Group
J Gastroenterol 2022 Aug;57(8):547-558. Epub 2022 May 13 doi: 10.1007/s00535-022-01877-5. PMID: 35554678

Prognosis

Deep learning model with pathological knowledge for detection of colorectal neuroendocrine tumor.
Zheng K, Duan J, Wang R, Chen H, He H, Zheng X, Zhao Z, Jing B, Zhang Y, Liu S, Xie D, Lin Y, Sun Y, Zhang N, Cai M
Cell Rep Med 2024 Oct 15;5(10):101785. doi: 10.1016/j.xcrm.2024.101785. PMID: 39413732Free PMC Article
Correlation between Neurotransmitters (Dopamine, Epinephrine, Norepinephrine, Serotonin), Prognostic Nutritional Index, Glasgow Prognostic Score, Systemic Inflammatory Response Markers, and TNM Staging in a Cohort of Colorectal Neuroendocrine Tumor Patients.
Cîmpeanu RC, Boldeanu MV, Ahrițculesei RV, Ciobanu AE, Cristescu AM, Forțofoiu D, Siloși I, Pirici DN, Cazacu SM, Boldeanu L, Vere CC
Int J Mol Sci 2024 Jun 26;25(13) doi: 10.3390/ijms25136977. PMID: 39000088Free PMC Article
Comparing surgical and endoscopic resection approaches for colorectal neuroendocrine tumors within the diameter range of 10-20mm: an inverse probability weighting analysis based on the SEER database.
Xu J, Liang R, Cai Q, Liu Y, Ge X, Lai B, Mao S, Cao J, Wang J
Front Endocrinol (Lausanne) 2024;15:1378968. Epub 2024 Mar 27 doi: 10.3389/fendo.2024.1378968. PMID: 38601205Free PMC Article
Surgical treatment of extra-appendiceal colorectal neuroendocrine tumors.
Maryański J, Cyran-Chlebicka A, Szczepankiewicz B, Cebulski W, Słodkowski M, Wroński M
Pol Przegl Chir 2018 May 16;90(3):7-12. doi: 10.5604/01.3001.0011.8164. PMID: 30015320
Neuroendocrine tumors of the colon and rectum: prognostic relevance and comparative performance of current staging systems.
Chagpar R, Chiang YJ, Xing Y, Cormier JN, Feig BW, Rashid A, Chang GJ, You YN
Ann Surg Oncol 2013 Apr;20(4):1170-8. Epub 2012 Dec 1 doi: 10.1245/s10434-012-2746-z. PMID: 23212760

Clinical prediction guides

Correlation between Neurotransmitters (Dopamine, Epinephrine, Norepinephrine, Serotonin), Prognostic Nutritional Index, Glasgow Prognostic Score, Systemic Inflammatory Response Markers, and TNM Staging in a Cohort of Colorectal Neuroendocrine Tumor Patients.
Cîmpeanu RC, Boldeanu MV, Ahrițculesei RV, Ciobanu AE, Cristescu AM, Forțofoiu D, Siloși I, Pirici DN, Cazacu SM, Boldeanu L, Vere CC
Int J Mol Sci 2024 Jun 26;25(13) doi: 10.3390/ijms25136977. PMID: 39000088Free PMC Article
Comparing surgical and endoscopic resection approaches for colorectal neuroendocrine tumors within the diameter range of 10-20mm: an inverse probability weighting analysis based on the SEER database.
Xu J, Liang R, Cai Q, Liu Y, Ge X, Lai B, Mao S, Cao J, Wang J
Front Endocrinol (Lausanne) 2024;15:1378968. Epub 2024 Mar 27 doi: 10.3389/fendo.2024.1378968. PMID: 38601205Free PMC Article
Neuroendocrine tumors of the colon and rectum: prognostic relevance and comparative performance of current staging systems.
Chagpar R, Chiang YJ, Xing Y, Cormier JN, Feig BW, Rashid A, Chang GJ, You YN
Ann Surg Oncol 2013 Apr;20(4):1170-8. Epub 2012 Dec 1 doi: 10.1245/s10434-012-2746-z. PMID: 23212760

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