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Abnormal circulating C-reactive protein concentration

MedGen UID:
1686782
•Concept ID:
C5139346
•
Finding
Synonym: Abnormal C-reactive protein level
 
HPO: HP:0032436

Definition

Any deviation from the normal concentration of C-reactive protein in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating C-reactive protein concentration

Conditions with this feature

Immune dysregulation, autoimmunity, and autoinflammation
MedGen UID:
1847968
•Concept ID:
C5848750
•
Disease or Syndrome
Immune dysregulation, autoimmunity, and autoinflammation (IDAA) is an immunologic disorder characterized by anemia and thrombocytopenia associated with circulating autoantibodies, positive Coombs test, and increased levels of proinflammatory cytokines due to constitutive activation of immune-related signaling pathways (Tao et al., 2023).
See: Condition Record
Immune dysregulation, autoimmunity, and autoinflammation

Professional guidelines

PubMed

Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment.
Yang K, Deng HB, Man AWC, Song E, Zhang J, Luo C, Cheung BMY, Yuen KY, Jensen PS, Irmukhamedov A, Elie AGIM, Vanhoutte PM, Xu A, De Mey JGR, Wang Y
ESC Heart Fail 2017 Nov;4(4):563-575. Epub 2017 Jun 27 doi: 10.1002/ehf2.12183. PMID: 29154418Free PMC Article
Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement.
Kosmaczewska A, Swierkot J, Ciszak L, Szteblich A, Chrobak A, Karabon L, Partyka A, Szechinski J, Wiland P, Frydecka I
Rheumatol Int 2014 Feb;34(2):243-53. Epub 2013 Nov 13 doi: 10.1007/s00296-013-2895-9. PMID: 24221190Free PMC Article

Recent clinical studies

Etiology

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
C-Reactive Protein and Resistance Exercise in Community Dwelling Old Adults.
Ramel A, Geirsdottir OG, Jonsson PV, Thorsdottiri I
J Nutr Health Aging 2015 Aug;19(7):792-6. doi: 10.1007/s12603-015-0548-2. PMID: 26193865
Increased high sensitive CRP level and its significance in pathogenesis of slow coronary flow.
Barutcu I, Sezgin AT, Sezgin N, Gullu H, Esen AM, Topal E, Ozdemir R, Kosar F, Cehreli S
Angiology 2007 Aug-Sep;58(4):401-7. Epub 2007 Jul 24 doi: 10.1177/0003319707304943. PMID: 17652225

Diagnosis

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
l-ficolin-MASP arm of the complement system in schizophrenia.
Mayilyan KR, Krarup A, Soghoyan AF, Jensenius JC, Sim RB
Immunobiology 2023 Mar;228(2):152349. Epub 2023 Feb 15 doi: 10.1016/j.imbio.2023.152349. PMID: 36805857
Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity.
Kunz HE, Hart CR, Gries KJ, Parvizi M, Laurenti M, Dalla Man C, Moore N, Zhang X, Ryan Z, Polley EC, Jensen MD, Vella A, Lanza IR
Am J Physiol Endocrinol Metab 2021 Jul 1;321(1):E105-E121. Epub 2021 May 17 doi: 10.1152/ajpendo.00070.2021. PMID: 33998291Free PMC Article
Hypoaminoacidemia Characterizes Chronic Traumatic Brain Injury.
Durham WJ, Foreman JP, Randolph KM, Danesi CP, Spratt H, Masel BD, Summons JR, Singh CK, Morrison M, Robles C, Wolfram C, Kreber LA, Urban RJ, Sheffield-Moore M, Masel BE
J Neurotrauma 2017 Jan 15;34(2):385-390. Epub 2016 Jun 16 doi: 10.1089/neu.2015.4350. PMID: 27178787
Increased high sensitive CRP level and its significance in pathogenesis of slow coronary flow.
Barutcu I, Sezgin AT, Sezgin N, Gullu H, Esen AM, Topal E, Ozdemir R, Kosar F, Cehreli S
Angiology 2007 Aug-Sep;58(4):401-7. Epub 2007 Jul 24 doi: 10.1177/0003319707304943. PMID: 17652225

Therapy

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Altered Mineral Metabolism and Disequilibrium Between Calcification Promoters and Inhibitors in Chronic Hemodialysis Patients.
Wang CL, Lin KP, Hsu GW, Liu KL, Guo CH
Biol Trace Elem Res 2020 Jan;193(1):14-22. Epub 2019 Mar 7 doi: 10.1007/s12011-019-01685-8. PMID: 30847765
The immunological roles in acute-on-chronic liver failure: An update.
Chen P, Wang YY, Chen C, Guan J, Zhu HH, Chen Z
Hepatobiliary Pancreat Dis Int 2019 Oct;18(5):403-411. Epub 2019 Jul 5 doi: 10.1016/j.hbpd.2019.07.003. PMID: 31303562
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
C-Reactive Protein and Resistance Exercise in Community Dwelling Old Adults.
Ramel A, Geirsdottir OG, Jonsson PV, Thorsdottiri I
J Nutr Health Aging 2015 Aug;19(7):792-6. doi: 10.1007/s12603-015-0548-2. PMID: 26193865

Prognosis

Analysis of the levels of inflammatory parameters in persons over the age of 90.
Zabielska P, Wieder-Huszla S, Karakiewicz B, Skonieczna-Żydecka K, Lubkowska A, Jurczak A
Exp Gerontol 2021 Jun;148:111278. Epub 2021 Feb 13 doi: 10.1016/j.exger.2021.111278. PMID: 33592278
Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
The immunological roles in acute-on-chronic liver failure: An update.
Chen P, Wang YY, Chen C, Guan J, Zhu HH, Chen Z
Hepatobiliary Pancreat Dis Int 2019 Oct;18(5):403-411. Epub 2019 Jul 5 doi: 10.1016/j.hbpd.2019.07.003. PMID: 31303562
Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment.
Yang K, Deng HB, Man AWC, Song E, Zhang J, Luo C, Cheung BMY, Yuen KY, Jensen PS, Irmukhamedov A, Elie AGIM, Vanhoutte PM, Xu A, De Mey JGR, Wang Y
ESC Heart Fail 2017 Nov;4(4):563-575. Epub 2017 Jun 27 doi: 10.1002/ehf2.12183. PMID: 29154418Free PMC Article
Increased high sensitive CRP level and its significance in pathogenesis of slow coronary flow.
Barutcu I, Sezgin AT, Sezgin N, Gullu H, Esen AM, Topal E, Ozdemir R, Kosar F, Cehreli S
Angiology 2007 Aug-Sep;58(4):401-7. Epub 2007 Jul 24 doi: 10.1177/0003319707304943. PMID: 17652225

Clinical prediction guides

l-ficolin-MASP arm of the complement system in schizophrenia.
Mayilyan KR, Krarup A, Soghoyan AF, Jensenius JC, Sim RB
Immunobiology 2023 Mar;228(2):152349. Epub 2023 Feb 15 doi: 10.1016/j.imbio.2023.152349. PMID: 36805857
Analysis of the levels of inflammatory parameters in persons over the age of 90.
Zabielska P, Wieder-Huszla S, Karakiewicz B, Skonieczna-Żydecka K, Lubkowska A, Jurczak A
Exp Gerontol 2021 Jun;148:111278. Epub 2021 Feb 13 doi: 10.1016/j.exger.2021.111278. PMID: 33592278
Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
The immunological roles in acute-on-chronic liver failure: An update.
Chen P, Wang YY, Chen C, Guan J, Zhu HH, Chen Z
Hepatobiliary Pancreat Dis Int 2019 Oct;18(5):403-411. Epub 2019 Jul 5 doi: 10.1016/j.hbpd.2019.07.003. PMID: 31303562
C-reactive protein levels in subjects with Prader-Willi syndrome and obesity.
Butler MG, Bittel DC, Kibiryeva N, Garg U
Genet Med 2006 Apr;8(4):243-8. doi: 10.1097/01.gim.0000204469.30913.67. PMID: 16617245Free PMC Article

Recent systematic reviews

Circulating levels of inflammatory biomarkers in Huntington's disease: A systematic review and meta-analysis.
Soltani Khaboushan A, Moeinafshar A, Ersi MH, Teixeira AL, Majidi Zolbin M, Kajbafzadeh AM
J Neuroimmunol 2023 Dec 15;385:578243. Epub 2023 Nov 13 doi: 10.1016/j.jneuroim.2023.578243. PMID: 37984118
Influence of Statins on Circulating Inflammatory Cytokines in Patients With Abnormal Glucose Homeostasis: A Meta-analysis of Data From Randomized Controlled Trials.
Milajerdi A, Sadeghi A, Mousavi SM, Larijani B, Esmaillzadeh A
Clin Ther 2020 Feb;42(2):e13-e31. Epub 2020 Jan 17 doi: 10.1016/j.clinthera.2019.12.009. PMID: 31955966
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article

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