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Abnormal circulating C-reactive protein concentration

MedGen UID:
1686782
•Concept ID:
C5139346
•
Finding
Synonym: Abnormal C-reactive protein level
 
HPO: HP:0032436

Definition

Any deviation from the normal concentration of C-reactive protein in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating C-reactive protein concentration

Professional guidelines

PubMed

Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment.
Yang K, Deng HB, Man AWC, Song E, Zhang J, Luo C, Cheung BMY, Yuen KY, Jensen PS, Irmukhamedov A, Elie AGIM, Vanhoutte PM, Xu A, De Mey JGR, Wang Y
ESC Heart Fail 2017 Nov;4(4):563-575. Epub 2017 Jun 27 doi: 10.1002/ehf2.12183. PMID: 29154418Free PMC Article
Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement.
Kosmaczewska A, Swierkot J, Ciszak L, Szteblich A, Chrobak A, Karabon L, Partyka A, Szechinski J, Wiland P, Frydecka I
Rheumatol Int 2014 Feb;34(2):243-53. Epub 2013 Nov 13 doi: 10.1007/s00296-013-2895-9. PMID: 24221190Free PMC Article

Recent clinical studies

Etiology

Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
C-Reactive Protein and Resistance Exercise in Community Dwelling Old Adults.
Ramel A, Geirsdottir OG, Jonsson PV, Thorsdottiri I
J Nutr Health Aging 2015 Aug;19(7):792-6. doi: 10.1007/s12603-015-0548-2. PMID: 26193865
C-reactive protein levels in subjects with Prader-Willi syndrome and obesity.
Butler MG, Bittel DC, Kibiryeva N, Garg U
Genet Med 2006 Apr;8(4):243-8. doi: 10.1097/01.gim.0000204469.30913.67. PMID: 16617245Free PMC Article
Abnormal soluble CD40 ligand and C-reactive protein concentrations in hypertension: relationship to indices of angiogenesis.
Patel JV, Lim HS, Nadar S, Tayebjee M, Hughes EA, Lip GY
J Hypertens 2006 Jan;24(1):117-21. doi: 10.1097/01.hjh.0000198034.09010.bc. PMID: 16331109

Diagnosis

Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity.
Kunz HE, Hart CR, Gries KJ, Parvizi M, Laurenti M, Dalla Man C, Moore N, Zhang X, Ryan Z, Polley EC, Jensen MD, Vella A, Lanza IR
Am J Physiol Endocrinol Metab 2021 Jul 1;321(1):E105-E121. Epub 2021 May 17 doi: 10.1152/ajpendo.00070.2021. PMID: 33998291Free PMC Article
Obesity, dyslipidemia, and high blood pressure are associated with cardiovascular risk, determined using high-sensitivity C-reactive protein concentration, in young adults.
Ramos-Arellano LE, Matia-Garcia I, Marino-Ortega LA, Castro-Alarcón N, Muñoz-Valle JF, Salgado-Goytia L, Salgado-Bernabé AB, Parra-Rojas I
J Int Med Res 2020 Dec;48(12):300060520980596. doi: 10.1177/0300060520980596. PMID: 33342336Free PMC Article
Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment.
Yang K, Deng HB, Man AWC, Song E, Zhang J, Luo C, Cheung BMY, Yuen KY, Jensen PS, Irmukhamedov A, Elie AGIM, Vanhoutte PM, Xu A, De Mey JGR, Wang Y
ESC Heart Fail 2017 Nov;4(4):563-575. Epub 2017 Jun 27 doi: 10.1002/ehf2.12183. PMID: 29154418Free PMC Article
Hypoaminoacidemia Characterizes Chronic Traumatic Brain Injury.
Durham WJ, Foreman JP, Randolph KM, Danesi CP, Spratt H, Masel BD, Summons JR, Singh CK, Morrison M, Robles C, Wolfram C, Kreber LA, Urban RJ, Sheffield-Moore M, Masel BE
J Neurotrauma 2017 Jan 15;34(2):385-390. Epub 2016 Jun 16 doi: 10.1089/neu.2015.4350. PMID: 27178787
Abnormal soluble CD40 ligand and C-reactive protein concentrations in hypertension: relationship to indices of angiogenesis.
Patel JV, Lim HS, Nadar S, Tayebjee M, Hughes EA, Lip GY
J Hypertens 2006 Jan;24(1):117-21. doi: 10.1097/01.hjh.0000198034.09010.bc. PMID: 16331109

Therapy

Altered Mineral Metabolism and Disequilibrium Between Calcification Promoters and Inhibitors in Chronic Hemodialysis Patients.
Wang CL, Lin KP, Hsu GW, Liu KL, Guo CH
Biol Trace Elem Res 2020 Jan;193(1):14-22. Epub 2019 Mar 7 doi: 10.1007/s12011-019-01685-8. PMID: 30847765
The immunological roles in acute-on-chronic liver failure: An update.
Chen P, Wang YY, Chen C, Guan J, Zhu HH, Chen Z
Hepatobiliary Pancreat Dis Int 2019 Oct;18(5):403-411. Epub 2019 Jul 5 doi: 10.1016/j.hbpd.2019.07.003. PMID: 31303562
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article
Galectin-3 Is Elevated and Associated With Adverse Outcomes in Patients With Single-Ventricle Fontan Circulation.
Opotowsky AR, Baraona F, Owumi J, Loukas B, Singh MN, Valente AM, Wu F, Cheng S, Veldtman G, Rimm EB, Landzberg MJ
J Am Heart Assoc 2016 Jan 11;5(1) doi: 10.1161/JAHA.115.002706. PMID: 26755550Free PMC Article
C-Reactive Protein and Resistance Exercise in Community Dwelling Old Adults.
Ramel A, Geirsdottir OG, Jonsson PV, Thorsdottiri I
J Nutr Health Aging 2015 Aug;19(7):792-6. doi: 10.1007/s12603-015-0548-2. PMID: 26193865

Prognosis

Analysis of the levels of inflammatory parameters in persons over the age of 90.
Zabielska P, Wieder-Huszla S, Karakiewicz B, Skonieczna-Żydecka K, Lubkowska A, Jurczak A
Exp Gerontol 2021 Jun;148:111278. Epub 2021 Feb 13 doi: 10.1016/j.exger.2021.111278. PMID: 33592278
Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
The immunological roles in acute-on-chronic liver failure: An update.
Chen P, Wang YY, Chen C, Guan J, Zhu HH, Chen Z
Hepatobiliary Pancreat Dis Int 2019 Oct;18(5):403-411. Epub 2019 Jul 5 doi: 10.1016/j.hbpd.2019.07.003. PMID: 31303562
Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment.
Yang K, Deng HB, Man AWC, Song E, Zhang J, Luo C, Cheung BMY, Yuen KY, Jensen PS, Irmukhamedov A, Elie AGIM, Vanhoutte PM, Xu A, De Mey JGR, Wang Y
ESC Heart Fail 2017 Nov;4(4):563-575. Epub 2017 Jun 27 doi: 10.1002/ehf2.12183. PMID: 29154418Free PMC Article
C-reactive protein levels in subjects with Prader-Willi syndrome and obesity.
Butler MG, Bittel DC, Kibiryeva N, Garg U
Genet Med 2006 Apr;8(4):243-8. doi: 10.1097/01.gim.0000204469.30913.67. PMID: 16617245Free PMC Article

Clinical prediction guides

Analysis of the levels of inflammatory parameters in persons over the age of 90.
Zabielska P, Wieder-Huszla S, Karakiewicz B, Skonieczna-Żydecka K, Lubkowska A, Jurczak A
Exp Gerontol 2021 Jun;148:111278. Epub 2021 Feb 13 doi: 10.1016/j.exger.2021.111278. PMID: 33592278
Biomarkers for Risk Assessment in Atrial Fibrillation.
Berg DD, Ruff CT, Morrow DA
Clin Chem 2021 Jan 8;67(1):87-95. doi: 10.1093/clinchem/hvaa298. PMID: 33313695
The immunological roles in acute-on-chronic liver failure: An update.
Chen P, Wang YY, Chen C, Guan J, Zhu HH, Chen Z
Hepatobiliary Pancreat Dis Int 2019 Oct;18(5):403-411. Epub 2019 Jul 5 doi: 10.1016/j.hbpd.2019.07.003. PMID: 31303562
C-reactive protein levels in subjects with Prader-Willi syndrome and obesity.
Butler MG, Bittel DC, Kibiryeva N, Garg U
Genet Med 2006 Apr;8(4):243-8. doi: 10.1097/01.gim.0000204469.30913.67. PMID: 16617245Free PMC Article
Clinical evaluation of circulating interleukin-6 and interleukin-10 levels after surgery-induced inflammation.
Miyaoka K, Iwase M, Suzuki R, Kondo G, Watanabe H, Ito D, Nagumo M
J Surg Res 2005 May 15;125(2):144-50. doi: 10.1016/j.jss.2004.12.001. PMID: 15854666

Recent systematic reviews

Influence of Statins on Circulating Inflammatory Cytokines in Patients With Abnormal Glucose Homeostasis: A Meta-analysis of Data From Randomized Controlled Trials.
Milajerdi A, Sadeghi A, Mousavi SM, Larijani B, Esmaillzadeh A
Clin Ther 2020 Feb;42(2):e13-e31. Epub 2020 Jan 17 doi: 10.1016/j.clinthera.2019.12.009. PMID: 31955966
Milk and Dairy Product Consumption and Inflammatory Biomarkers: An Updated Systematic Review of Randomized Clinical Trials.
Ulven SM, Holven KB, Gil A, Rangel-Huerta OD
Adv Nutr 2019 May 1;10(suppl_2):S239-S250. doi: 10.1093/advances/nmy072. PMID: 31089732Free PMC Article

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