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Monoclonal elevation of IgG heavy chain

MedGen UID:: 1689251
•Concept ID:: C5139250
•: Finding

HPO:	HP:0032293

Definition

A type of monoclonal elevation of IgG in which the involved immunoglobulin has an abnormal structure with a heavy chain but not a light chain. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMonoclonal elevation of IgG heavy chain

Abnormal lymphocyte physiology
- Abnormality of B cell physiology
  - Abnormal circulating immunoglobulin concentration
    - Abnormal circulating IgG concentration
      - Increased circulating IgG concentration
        Monoclonal elevation of IgG
        Monoclonal elevation of IgG heavy chain

Recent clinical studies

Etiology

Immunoglobulin heavy/light chain analysis enhances the detection of residual disease and monitoring of multiple myeloma patients.

Batinić J, Perić Z, Šegulja D, Last J, Prijić S, Dubravčić K, Volarić L, Sertić D, Radman I, Bašić-Kinda S, Matišić D, Batinić D, Labar B, Nemet D
Croat Med J 2015 Jun;56(3):263-71. doi: 10.3325/cmj.2015.56.263. PMID: 26088851 Free PMC Article

The relationship between hypogammaglobulinemia, monoclonal gammopathy of undetermined significance and humoral immunodeficiency: a case series.

Zemble RM, Takach PA, Levinson AI
J Clin Immunol 2011 Oct;31(5):737-43. Epub 2011 Jun 5 doi: 10.1007/s10875-011-9548-0. PMID: 21643891

Expression of IgE heavy chain transcripts in the sinus mucosa of atopic and nonatopic patients with chronic sinusitis.

Ghaffar O, Durham SR, Al-Ghamdi K, Wright E, Small P, Frenkiel S, Gould HJ, Hamid Q
Am J Respir Cell Mol Biol 1998 May;18(5):706-11. doi: 10.1165/ajrcmb.18.5.3030. PMID: 9569241

Analysis of three new idiotypes on human monoclonal autoantibodies.

Kalsi JK, Ravirajan CT, Wiloch-Winska H, Blanco F, Longhurst CM, Williams W, Chapman C, Hillson J, Youniou P, Latchman D
Lupus 1995 Oct;4(5):375-89. doi: 10.1177/096120339500400508. PMID: 8563732

Gammopathy associated with advanced prostate carcinoma.

Abdul M, Hoosein NM
Urol Res 1995;23(3):185-8. doi: 10.1007/BF00389571. PMID: 7483145

See all (6)

Diagnosis

Progression of proliferative glomerulonephritis with monoclonal IgG deposits in pediatric patients.

Miller P, Xiao AY, Kung VL, Sibley RK, Higgins JP, Kambham N, Charu V, Lenihan C, Uber AM, Talley EM, Arora N, Walavalkar V, Laszik ZG, Nast CC, Troxell ML
Pediatr Nephrol 2021 Apr;36(4):927-937. Epub 2020 Oct 12 doi: 10.1007/s00467-020-04763-5. PMID: 33044675

Gamma heavy chain disease complicated by pulmonary hypertension, which was successfully treated with lenalidomide.

Shibata S, Fukunaga A
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-236162. PMID: 33257362 Free PMC Article

Immunoglobulin heavy/light chain analysis enhances the detection of residual disease and monitoring of multiple myeloma patients.

The relationship between hypogammaglobulinemia, monoclonal gammopathy of undetermined significance and humoral immunodeficiency: a case series.

Zemble RM, Takach PA, Levinson AI
J Clin Immunol 2011 Oct;31(5):737-43. Epub 2011 Jun 5 doi: 10.1007/s10875-011-9548-0. PMID: 21643891

Gammopathy associated with advanced prostate carcinoma.

Abdul M, Hoosein NM
Urol Res 1995;23(3):185-8. doi: 10.1007/BF00389571. PMID: 7483145

See all (11)

Therapy

Gamma heavy chain disease complicated by pulmonary hypertension, which was successfully treated with lenalidomide.

Shibata S, Fukunaga A
BMJ Case Rep 2020 Nov 30;13(11) doi: 10.1136/bcr-2020-236162. PMID: 33257362 Free PMC Article

Sym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform.

Gjetting T, Gad M, Fröhlich C, Lindsted T, Melander MC, Bhatia VK, Grandal MM, Dietrich N, Uhlenbrock F, Galler GR, Strandh M, Lantto J, Bouquin T, Horak ID, Kragh M, Pedersen MW, Koefoed K
MAbs 2019 May/Jun;11(4):666-680. Epub 2019 May 3 doi: 10.1080/19420862.2019.1596514. PMID: 31046547 Free PMC Article

Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse.

Boado RJ, Hui EK, Lu JZ, Pardridge WM
J Pharmacol Exp Ther 2010 Jun;333(3):961-9. Epub 2010 Mar 16 doi: 10.1124/jpet.109.165092. PMID: 20233799

Expression of IgE heavy chain transcripts in the sinus mucosa of atopic and nonatopic patients with chronic sinusitis.

Ghaffar O, Durham SR, Al-Ghamdi K, Wright E, Small P, Frenkiel S, Gould HJ, Hamid Q
Am J Respir Cell Mol Biol 1998 May;18(5):706-11. doi: 10.1165/ajrcmb.18.5.3030. PMID: 9569241

IgG subclasses in epileptic patients treated with phenytoin.

Gilhus NE, Lea T
J Neurol 1989 Mar;236(3):149-52. doi: 10.1007/BF00314330. PMID: 2496207

See all (6)

Prognosis

Progression of proliferative glomerulonephritis with monoclonal IgG deposits in pediatric patients.

Immunoglobulin heavy/light chain analysis enhances the detection of residual disease and monitoring of multiple myeloma patients.

Monoclonal proliferation of Epstein-Barr virus-infected T-cells in a patient with virus-associated haemophagocytic syndrome.

Noma T, Kou K, Yoshizawa I, Kawano Y, Miyashita T, Mizutani S, Yata J
Eur J Pediatr 1994 Oct;153(10):734-8. doi: 10.1007/BF01954490. PMID: 7813531

Immunoglobulin class switch from IgG to IgA in a patient with smoldering multiple myeloma.

Takahashi M, Tsukada T, Kojima M, Koide T, Koike T, Takahashi H, Sakai C, Kashimura M, Shibata A
Blood 1986 Jun;67(6):1710-3. PMID: 3085748

Benign monoclonal B cell lymphocytosis--a benign variant of CLL: clinical, immunologic, phenotypic, and cytogenetic studies in 20 patients.

Han T, Ozer H, Gavigan M, Gajera R, Minowada J, Bloom ML, Sadamori N, Sandberg AA, Gomez GA, Henderson ES
Blood 1984 Jul;64(1):244-52. PMID: 6610446

See all (5)

Clinical prediction guides

Analysis of B Cell Receptor Repertoires Reveals Key Signatures of the Systemic B Cell Response after SARS-CoV-2 Infection.

Zhang Y, Yan Q, Luo K, He P, Hou R, Zhao X, Wang Q, Yi H, Liang H, Deng Y, Hu F, Li F, Liu X, Feng Y, Li P, Qu L, Chen Z, Pan-Hammarström Q, Feng L, Niu X, Chen L
J Virol 2022 Feb 23;96(4):e0160021. Epub 2021 Dec 8 doi: 10.1128/JVI.01600-21. PMID: 34878902 Free PMC Article

Serum immunoglobulin free light chain measurements and heavy chain isotype usage provide insight into disease biology in patients with POEMS syndrome.

Stankowski-Drengler T, Gertz MA, Katzmann JA, Lacy MQ, Kumar S, Leung N, Hayman SR, Buadi F, Kyle RA, Rajkumar SV, Dispenzieri A
Am J Hematol 2010 Jun;85(6):431-4. doi: 10.1002/ajh.21707. PMID: 20513121 Free PMC Article

Elevated cleavage of human immunoglobulin gamma molecules containing a lambda light chain mediated by iron and histidine.

Ouellette D, Alessandri L, Piparia R, Aikhoje A, Chin A, Radziejewski C, Correia I
Anal Biochem 2009 Jun 15;389(2):107-17. Epub 2009 Mar 24 doi: 10.1016/j.ab.2009.03.027. PMID: 19318085

Expression of IgE heavy chain transcripts in the sinus mucosa of atopic and nonatopic patients with chronic sinusitis.

Ghaffar O, Durham SR, Al-Ghamdi K, Wright E, Small P, Frenkiel S, Gould HJ, Hamid Q
Am J Respir Cell Mol Biol 1998 May;18(5):706-11. doi: 10.1165/ajrcmb.18.5.3030. PMID: 9569241

Analysis of three new idiotypes on human monoclonal autoantibodies.

Kalsi JK, Ravirajan CT, Wiloch-Winska H, Blanco F, Longhurst CM, Williams W, Chapman C, Hillson J, Youniou P, Latchman D
Lupus 1995 Oct;4(5):375-89. doi: 10.1177/096120339500400508. PMID: 8563732

See all (9)

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Monoclonal elevation of IgG heavy chain

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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