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Elevated proportion of CD4+ effector memory T cells

MedGen UID:: 1690035
•Concept ID:: C5139096
•: Finding

Synonyms:	Increased proportion of CD4+ effector memory T cells; Increased proportion of CD4-positive effector memory T cells; Increased proportion of effector CD4-positive, alpha-beta T cells

HPO:	HP:0025625

Definition

An abnormally increased proportion of effector memory CD4+ T cells. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells may have a CD3/CD4/CD62L-/CD45RA phenotype. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVElevated proportion of CD4+ effector memory T cells

Abnormal leukocyte count
- Abnormal lymphocyte count
  - Abnormal T cell count
    - Abnormal T cell subset distribution
      - Abnormal proportion of CD4-positive T cells
        Increased proportion of CD4-positive T cells
        Elevated proportion of CD4+ effector memory T cells

Recent clinical studies

Etiology

Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients.

Lee Y, Baek J, Park S, Kim Y, Hwang SW, Lee JL, Park SH, Kim J, Yang SK, Han B, Kweon MN, Song K, Yoon YS, Ye BD, Lee HS
J Autoimmun 2024 May;145:103206. Epub 2024 Mar 29 doi: 10.1016/j.jaut.2024.103206. PMID: 38554656

CD81 and CD82 expressing tumor-infiltrating lymphocytes in the NSCLC tumor microenvironment play a crucial role in T-cell activation and cytokine production.

Na K, Lee S, Kim DK, Kim YS, Hwang JY, Kang SS, Baek S, Lee CY, Yang SM, Han YJ, Kim MH, Han H, Kim Y, Kim JH, Jeon S, Byeon Y, Lee JB, Lim SM, Hong MH, Pyo KH, Cho BC
Front Immunol 2024;15:1336246. Epub 2024 Mar 7 doi: 10.3389/fimmu.2024.1336246. PMID: 38515751 Free PMC Article

sLeX Expression Delineates Distinct Functional Subsets of Human Blood Central and Effector Memory T Cells.

Silva M, Martin KC, Mondal N, Sackstein R
J Immunol 2020 Oct 1;205(7):1920-1932. Epub 2020 Aug 31 doi: 10.4049/jimmunol.1900679. PMID: 32868410 Free PMC Article

Elevated circulating effector memory T cells but similar levels of regulatory T cells in patients with type 2 diabetes mellitus and cardiovascular disease.

Rattik S, Engelbertsen D, Wigren M, Ljungcrantz I, Östling G, Persson M, Nordin Fredrikson G, Bengtsson E, Nilsson J, Björkbacka H
Diab Vasc Dis Res 2019 May;16(3):270-280. Epub 2018 Dec 21 doi: 10.1177/1479164118817942. PMID: 30574794

Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy.

Ariyanto IA, Estiasari R, Waters S, Wulandari EAT, Fernandez S, Lee S, Price P
Viral Immunol 2018 Jul/Aug;31(6):472-479. Epub 2018 Apr 24 doi: 10.1089/vim.2018.0014. PMID: 29688840

See all (13)

Diagnosis

The Immune Cell Landscape in Renal Allografts.

Lu J, Zhang Y, Sun J, Huang S, Wu W, Tan J
Cell Transplant 2021 Jan-Dec;30:963689721995458. doi: 10.1177/0963689721995458. PMID: 33593079 Free PMC Article

Elevated circulating effector memory T cells but similar levels of regulatory T cells in patients with type 2 diabetes mellitus and cardiovascular disease.

Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis.

Zafranskaya M, Oschmann P, Engel R, Weishaupt A, van Noort JM, Jomaa H, Eberl M
Immunology 2007 May;121(1):29-39. Epub 2006 Dec 18 doi: 10.1111/j.1365-2567.2006.02518.x. PMID: 17239199 Free PMC Article

See all (3)

Therapy

Single-cell analysis reveals cellular and molecular factors counteracting HPV-positive oropharyngeal cancer immunotherapy outcomes.

Cha J, Kim DH, Kim G, Cho JW, Sung E, Baek S, Hong MH, Kim CG, Sim NS, Hong HJ, Lee JE, Hemberg M, Park S, Yoon SO, Ha SJ, Koh YW, Kim HR, Lee I
J Immunother Cancer 2024 Jun 10;12(6) doi: 10.1136/jitc-2023-008667. PMID: 38857913 Free PMC Article

Unraveling the connection between Hashimoto's Thyroiditis and non-alcoholic fatty liver disease: exploring the role of CD4(+)central memory T cells through integrated genetic approaches.

Li D, Zhang Z, Zhang C, Guo Q, Chen C, Peng X
Endocrine 2024 Aug;85(2):751-765. Epub 2024 Feb 24 doi: 10.1007/s12020-024-03745-z. PMID: 38400881

Active and Persistent Cytomegalovirus Infections Affect T Cells in Young Adult HIV Patients Commencing Antiretroviral Therapy.

Ariyanto IA, Estiasari R, Waters S, Wulandari EAT, Fernandez S, Lee S, Price P
Viral Immunol 2018 Jul/Aug;31(6):472-479. Epub 2018 Apr 24 doi: 10.1089/vim.2018.0014. PMID: 29688840

Elevation of CD4+ differentiated memory T cells is associated with acute cellular and antibody-mediated rejection after liver transplantation.

Gerlach UA, Vogt K, Schlickeiser S, Meisel C, Streitz M, Kunkel D, Appelt C, Ahrlich S, Lachmann N, Neuhaus P, Pascher A, Sawitzki B
Transplantation 2013 Jun 27;95(12):1512-20. doi: 10.1097/TP.0b013e318290de18. PMID: 23619734

Interferon-beta therapy reduces CD4+ and CD8+ T-cell reactivity in multiple sclerosis.

See all (9)

Prognosis

Higher frequency of peripheral blood CD103(+)CD8(+) T cells with lower levels of PD-1 and TIGIT expression related to favorable outcomes in leukemia patients.

Liu L, Lai W, Zhuo X, Chen S, Luo X, Tan H
Front Immunol 2024;15:1437726. Epub 2024 Sep 25 doi: 10.3389/fimmu.2024.1437726. PMID: 39391310 Free PMC Article

Intratumor injection of BCG Ag85A high-affinity peptides enhanced anti-tumor efficacy in PPD-positive melanoma.

Qin L, Zhang G, Wu Y, Yang Y, Zou Z
Cancer Immunol Immunother 2024 Apr 17;73(6):103. doi: 10.1007/s00262-024-03693-7. PMID: 38630135 Free PMC Article

The Immune Cell Landscape in Renal Allografts.

Lu J, Zhang Y, Sun J, Huang S, Wu W, Tan J
Cell Transplant 2021 Jan-Dec;30:963689721995458. doi: 10.1177/0963689721995458. PMID: 33593079 Free PMC Article

Functional Heterogeneity of CD4(+) Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC.

Oja AE, Piet B, van der Zwan D, Blaauwgeers H, Mensink M, de Kivit S, Borst J, Nolte MA, van Lier RAW, Stark R, Hombrink P
Front Immunol 2018;9:2654. Epub 2018 Nov 16 doi: 10.3389/fimmu.2018.02654. PMID: 30505306 Free PMC Article

See all (4)

Clinical prediction guides

Single-cell analysis reveals cellular and molecular factors counteracting HPV-positive oropharyngeal cancer immunotherapy outcomes.

Characterization of Th17 tissue-resident memory cells in non-inflamed intestinal tissue of Crohn's disease patients.

Broad phenotypic alterations and potential dysfunction of lymphocytes in individuals clinically recovered from COVID-19.

Yang J, Zhong M, Zhang E, Hong K, Yang Q, Zhou D, Xia J, Chen YQ, Sun M, Zhao B, Xiang J, Liu Y, Han Y, Xu M, Zhou X, Huang C, Shang Y, Yan H
J Mol Cell Biol 2021 Jul 6;13(3):197-209. doi: 10.1093/jmcb/mjab014. PMID: 33751111 Free PMC Article

The Immune Cell Landscape in Renal Allografts.

Lu J, Zhang Y, Sun J, Huang S, Wu W, Tan J
Cell Transplant 2021 Jan-Dec;30:963689721995458. doi: 10.1177/0963689721995458. PMID: 33593079 Free PMC Article

Functional Heterogeneity of CD4(+) Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC.

See all (19)

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Elevated proportion of CD4+ effector memory T cells

Definition

Term Hierarchy

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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