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Bladder Alveolar Rhabdomyosarcoma

MedGen UID:
1692406
•Concept ID:
C2212604
•
Neoplastic Process

Definition

An alveolar rhabdomyosarcoma arising from the bladder. It is the most common type of rhabdomyosarcoma of the bladder affecting older children and adolescents. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBladder Alveolar Rhabdomyosarcoma

Professional guidelines

PubMed

Comparison of outcomes based on treatment algorithms for rhabdomyosarcoma of the bladder/prostate: combined results from the Children's Oncology Group, German Cooperative Soft Tissue Sarcoma Study, Italian Cooperative Group, and International Society of Pediatric Oncology Malignant Mesenchymal Tumors Committee.
Rodeberg DA, Anderson JR, Arndt CA, Ferrer FA, Raney RB, Jenney ME, Brecht IB, Koscielniak E, Carli M, Bisogno G, Oberlin O, Rey A, Ullrich F, Stevens MC, Meyer WH
Int J Cancer 2011 Mar 1;128(5):1232-9. doi: 10.1002/ijc.25444. PMID: 20473932

Recent clinical studies

Etiology

Recent advances in pediatric bladder malignancies.
Lopes RI, Mello MF, Lorenzo AJ
F1000Res 2020;9 Epub 2020 Feb 25 doi: 10.12688/f1000research.19396.1. PMID: 32148770Free PMC Article
Patterns of failure and toxicity profile following proton beam therapy for pediatric bladder and prostate rhabdomyosarcoma.
Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC
Pediatr Blood Cancer 2019 Nov;66(11):e27952. Epub 2019 Aug 9 doi: 10.1002/pbc.27952. PMID: 31397065
Patterns of Failure in Pediatric Rhabdomyosarcoma After Proton Therapy.
Vern-Gross TZ, Indelicato DJ, Bradley JA, Rotondo RL
Int J Radiat Oncol Biol Phys 2016 Dec 1;96(5):1070-1077. Epub 2016 Aug 30 doi: 10.1016/j.ijrobp.2016.08.028. PMID: 27742542
Future directions in risk stratification and therapy for advanced pediatric genitourinary rhabdomyosarcoma.
Harel M, Ferrer FA, Shapiro LH, Makari JH
Urol Oncol 2016 Feb;34(2):103-15. Epub 2015 Oct 28 doi: 10.1016/j.urolonc.2015.09.013. PMID: 26519985
Conservative approach in localised rhabdomyosarcoma of the bladder and prostate: results from International Society of Paediatric Oncology (SIOP) studies: malignant mesenchymal tumour (MMT) 84, 89 and 95.
Jenney M, Oberlin O, Audry G, Stevens MC, Rey A, Merks JH, Kelsey A, Gallego S, Haie-Meder C, Martelli H
Pediatr Blood Cancer 2014 Feb;61(2):217-22. Epub 2013 Aug 29 doi: 10.1002/pbc.24727. PMID: 23997024

Diagnosis

A comparison of adult rhabdomyosarcoma and high-grade neuroendocrine carcinoma of the urinary bladder reveals novel PPP1R12A fusions in rhabdomyosarcoma.
Gupta S, Sosa CP, Kosari F, Folpe A, Bhinge KN, Yang L, Agahi A, Johnson SH, Frank I, Boorjian SA, Hansel DE, Al-Ahmadie HA, Reuter VE, Vasmatzis G, Jimenez RE, Herrera-Hernandez L, Cheville JC
Hum Pathol 2019 Jun;88:48-59. Epub 2019 Apr 1 doi: 10.1016/j.humpath.2019.03.007. PMID: 30946934Free PMC Article
Patterns of Failure in Pediatric Rhabdomyosarcoma After Proton Therapy.
Vern-Gross TZ, Indelicato DJ, Bradley JA, Rotondo RL
Int J Radiat Oncol Biol Phys 2016 Dec 1;96(5):1070-1077. Epub 2016 Aug 30 doi: 10.1016/j.ijrobp.2016.08.028. PMID: 27742542
FGF receptors: cancer biology and therapeutics.
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246
Soft tissue tumors of the urinary bladder Part II: malignant neoplasms.
Lott S, Lopez-Beltran A, Montironi R, MacLennan GT, Cheng L
Hum Pathol 2007 Jul;38(7):963-977. doi: 10.1016/j.humpath.2007.03.016. PMID: 17574946
Primary mesenchymal tumors of the urinary bladder. A histological and immunohistochemical study of 30 cases.
Kunze E, Theuring F, Krüger G
Pathol Res Pract 1994 Apr;190(4):311-32. doi: 10.1016/S0344-0338(11)80404-8. PMID: 8078801

Therapy

Durability of oncological outcomes of combination chemotherapy as a monotherapy for a select patient subset with non-metastatic non-alveolar bladder/prostate rhabdomyosarcoma.
Abdelhalim A, Atwa AM, Helmy TE, Dawaba ME, Elashry R, Hafez AT
J Pediatr Urol 2021 Aug;17(4):535.e1-535.e8. Epub 2021 May 17 doi: 10.1016/j.jpurol.2021.05.013. PMID: 34092511
Disease Control and Patterns of Failure After Proton Beam Therapy for Rhabdomyosarcoma.
Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC
Int J Radiat Oncol Biol Phys 2021 Mar 1;109(3):718-725. doi: 10.1016/j.ijrobp.2020.09.050. PMID: 33516439
Alveolar rhabdomyosarcoma of urinary bladder presenting as acute leukemia: A diagnostic trap.
Jagdale RV, Pol JN
Indian J Pathol Microbiol 2020 Oct-Dec;63(4):623-626. doi: 10.4103/IJPM.IJPM_850_19. PMID: 33154320
Patterns of failure and toxicity profile following proton beam therapy for pediatric bladder and prostate rhabdomyosarcoma.
Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC
Pediatr Blood Cancer 2019 Nov;66(11):e27952. Epub 2019 Aug 9 doi: 10.1002/pbc.27952. PMID: 31397065
FGF receptors: cancer biology and therapeutics.
Katoh M, Nakagama H
Med Res Rev 2014 Mar;34(2):280-300. Epub 2013 May 21 doi: 10.1002/med.21288. PMID: 23696246

Prognosis

Recent advances in pediatric bladder malignancies.
Lopes RI, Mello MF, Lorenzo AJ
F1000Res 2020;9 Epub 2020 Feb 25 doi: 10.12688/f1000research.19396.1. PMID: 32148770Free PMC Article
Patterns of failure and toxicity profile following proton beam therapy for pediatric bladder and prostate rhabdomyosarcoma.
Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC
Pediatr Blood Cancer 2019 Nov;66(11):e27952. Epub 2019 Aug 9 doi: 10.1002/pbc.27952. PMID: 31397065
Patterns of Failure in Pediatric Rhabdomyosarcoma After Proton Therapy.
Vern-Gross TZ, Indelicato DJ, Bradley JA, Rotondo RL
Int J Radiat Oncol Biol Phys 2016 Dec 1;96(5):1070-1077. Epub 2016 Aug 30 doi: 10.1016/j.ijrobp.2016.08.028. PMID: 27742542
Future directions in risk stratification and therapy for advanced pediatric genitourinary rhabdomyosarcoma.
Harel M, Ferrer FA, Shapiro LH, Makari JH
Urol Oncol 2016 Feb;34(2):103-15. Epub 2015 Oct 28 doi: 10.1016/j.urolonc.2015.09.013. PMID: 26519985
Soft tissue tumors of the urinary bladder Part II: malignant neoplasms.
Lott S, Lopez-Beltran A, Montironi R, MacLennan GT, Cheng L
Hum Pathol 2007 Jul;38(7):963-977. doi: 10.1016/j.humpath.2007.03.016. PMID: 17574946

Clinical prediction guides

Durability of oncological outcomes of combination chemotherapy as a monotherapy for a select patient subset with non-metastatic non-alveolar bladder/prostate rhabdomyosarcoma.
Abdelhalim A, Atwa AM, Helmy TE, Dawaba ME, Elashry R, Hafez AT
J Pediatr Urol 2021 Aug;17(4):535.e1-535.e8. Epub 2021 May 17 doi: 10.1016/j.jpurol.2021.05.013. PMID: 34092511
Disease Control and Patterns of Failure After Proton Beam Therapy for Rhabdomyosarcoma.
Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC
Int J Radiat Oncol Biol Phys 2021 Mar 1;109(3):718-725. doi: 10.1016/j.ijrobp.2020.09.050. PMID: 33516439
Patterns of failure and toxicity profile following proton beam therapy for pediatric bladder and prostate rhabdomyosarcoma.
Buszek SM, Ludmir EB, Grosshans DR, McAleer MF, McGovern SL, Harrison DJ, Okcu MF, Chintagumpala MM, Mahajan A, Paulino AC
Pediatr Blood Cancer 2019 Nov;66(11):e27952. Epub 2019 Aug 9 doi: 10.1002/pbc.27952. PMID: 31397065
Patterns of Failure in Pediatric Rhabdomyosarcoma After Proton Therapy.
Vern-Gross TZ, Indelicato DJ, Bradley JA, Rotondo RL
Int J Radiat Oncol Biol Phys 2016 Dec 1;96(5):1070-1077. Epub 2016 Aug 30 doi: 10.1016/j.ijrobp.2016.08.028. PMID: 27742542
Primary mesenchymal tumors of the urinary bladder. A histological and immunohistochemical study of 30 cases.
Kunze E, Theuring F, Krüger G
Pathol Res Pract 1994 Apr;190(4):311-32. doi: 10.1016/S0344-0338(11)80404-8. PMID: 8078801

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